The network for 'leukocyte mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

Homo sapiens
Name Description Probability Func Analog Organism
NCF1 neutrophil cytosolic factor 1 0.982
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.936
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.882
BIRC3 baculoviral IAP repeat containing 3 0.844
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.826
CD80 CD80 molecule 0.810
HLA-C major histocompatibility complex, class I, C 0.789
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.784
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.772
IL4R interleukin 4 receptor 0.764
HLA-B major histocompatibility complex, class I, B 0.760
CCL4 chemokine (C-C motif) ligand 4 0.725
SLAMF1 signaling lymphocytic activation molecule family member 1 0.711
HLA-DRA major histocompatibility complex, class II, DR alpha 0.701
IL8 interleukin 8 0.674
CD40 CD40 molecule, TNF receptor superfamily member 5 0.671
BTN3A2 butyrophilin, subfamily 3, member A2 0.669
SYK spleen tyrosine kinase 0.661
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.648
NOTCH1 notch 1 0.632
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.582
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.571
SNAP23 synaptosomal-associated protein, 23kDa 0.559
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.555
HLA-G major histocompatibility complex, class I, G 0.548
BTN3A1 butyrophilin, subfamily 3, member A1 0.542
IL2RG interleukin 2 receptor, gamma 0.519
CCR5 chemokine (C-C motif) receptor 5 0.507
IL2RB interleukin 2 receptor, beta 0.493
NCF2 neutrophil cytosolic factor 2 0.492
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.486
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.484
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.467
HLA-F major histocompatibility complex, class I, F 0.463
CARD11 caspase recruitment domain family, member 11 0.461
HLA-DMB major histocompatibility complex, class II, DM beta 0.460
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.438
HLA-DMA major histocompatibility complex, class II, DM alpha 0.436
APLF aprataxin and PNKP like factor 0.435
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.431
C1QB complement component 1, q subcomponent, B chain 0.428
CCR1 chemokine (C-C motif) receptor 1 0.419
BTN3A3 butyrophilin, subfamily 3, member A3 0.412
CCR7 chemokine (C-C motif) receptor 7 0.393
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.390
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.382
TAPBP TAP binding protein (tapasin) 0.374
TRAF6 TNF receptor-associated factor 6 0.368
CD2 CD2 molecule 0.367
BRCA1 breast cancer 1, early onset 0.364
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.361
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.358
HLA-A major histocompatibility complex, class I, A 0.339
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.322
TLR2 toll-like receptor 2 0.319
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.319
CD84 CD84 molecule 0.316
HK3 hexokinase 3 (white cell) 0.315
TNF tumor necrosis factor 0.314
SIGLEC7 sialic acid binding Ig-like lectin 7 0.311
NCF4 neutrophil cytosolic factor 4, 40kDa 0.287
NOTCH3 notch 3 0.287
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.282
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.282
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.279
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.277
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.274
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.253
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.242
GNLY granulysin 0.241
JAK2 Janus kinase 2 0.232
PCNA proliferating cell nuclear antigen 0.228
PILRA paired immunoglobin-like type 2 receptor alpha 0.228
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.227
CCL2 chemokine (C-C motif) ligand 2 0.219
BLNK B-cell linker 0.219
C1QC complement component 1, q subcomponent, C chain 0.219
H2AFX H2A histone family, member X 0.218
B2M beta-2-microglobulin 0.215
CXCR6 chemokine (C-X-C motif) receptor 6 0.214
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.210
TRAF3 TNF receptor-associated factor 3 0.207
VEGFA vascular endothelial growth factor A 0.205
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.204
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.204
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.202
CXCL2 chemokine (C-X-C motif) ligand 2 0.196
HLA-E major histocompatibility complex, class I, E 0.196
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.194
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.176
IL10 interleukin 10 0.173
TYMP thymidine phosphorylase 0.172
C19orf50 chromosome 19 open reading frame 50 0.165
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.165
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.156
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.156
SLA Src-like-adaptor 0.155
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.155
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.155
CCL20 chemokine (C-C motif) ligand 20 0.150
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
zgc:64115 zgc:64115 0.216
nod1 nucleotide-binding oligomerization domain containing 1 0.180
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.093
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.072
ren renin 0.058
dlg2 discs, large (Drosophila) homolog 2 0.055
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.051
tlr9 toll-like receptor 9 0.048
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.043
LOC100000934 hypothetical protein LOC100000934 0.040
zgc:110010 zgc:110010 0.032
irak4 interleukin-1 receptor-associated kinase 4 0.031
sult2st1 sulfotransferase family 2, cytosolic sulfotransferase 1 0.030
lrrc33 leucine rich repeat containing 33 0.025
sqstm1 sequestosome 1 0.024
tlr3 toll-like receptor 3 0.024
pcsk7 proprotein convertase subtilisin/kexin type 7 0.024
grna granulin a 0.022
iqgap1 IQ motif containing GTPase activating protein 1 0.022
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.022
ctsba cathepsin B, a 0.021
rhogb ras homolog gene family, member Gb 0.020
kitlga kit ligand a 0.020
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.019
ecrg4a esophageal cancer related gene 4a 0.019
tbp TATA box binding protein 0.018
lndc1 ly6/neurotoxin domain containing 1 0.018
coro1a coronin, actin binding protein, 1A 0.018
foxp3a forkhead box P3a 0.016
nt5e 5'-nucleotidase, ecto (CD73) 0.016
zgc:64051 zgc:64051 0.016
ints6 integrator complex subunit 6 0.016
mybl2 myeloblastosis oncogene-like 2 0.015
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.015
wu:fc23b05 wu:fc23b05 0.015
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.014
c3b complement component c3b 0.014
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.014
nitr8 novel immune-type receptor 8 0.013
ror2 receptor tyrosine kinase-like orphan receptor 2 0.013
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.013
tlr21 toll-like receptor 21 0.013
foxe3 forkhead box E3 0.013
calcrla calcitonin receptor-like a 0.013
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.013
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.013
phex phosphate regulating gene with homologues to endopeptidases on the X chromosome 0.013
illr1 immune-related, lectin-like receptor 1 0.012
bon bonnie and clyde 0.012
c1qa complement component 1, q subcomponent, A chain 0.012
notch2 notch homolog 2 0.012
st8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.011
rorca RAR-related orphan receptor C a 0.011
g6pd glucose-6-phosphate dehydrogenase 0.011
mxa myxovirus (influenza) resistance A 0.011
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.011
c3c complement component c3c 0.011
mtmr8 myotubularin related protein 8 0.011
pou1f1 POU domain, class 1, transcription factor 1 0.010
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.010
gpr126 G protein-coupled receptor 126 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.999
Cd19 CD19 antigen 0.997
Icos inducible T-cell co-stimulator 0.997
Cd40 CD40 antigen 0.995
Batf basic leucine zipper transcription factor, ATF-like 0.992
Igh immunoglobulin heavy chain complex 0.992
Fasl Fas ligand (TNF superfamily, member 6) 0.983
Prf1 perforin 1 (pore forming protein) 0.977
Ccl2 chemokine (C-C motif) ligand 2 0.974
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.974
Il2rg interleukin 2 receptor, gamma chain 0.972
Il2rb interleukin 2 receptor, beta chain 0.972
Ccr1 chemokine (C-C motif) receptor 1 0.959
Ifng interferon gamma 0.958
Ikzf1 IKAROS family zinc finger 1 0.957
Il4 interleukin 4 0.955
Itgal integrin alpha L 0.942
Inpp5d inositol polyphosphate-5-phosphatase D 0.936
Il10 interleukin 10 0.936
Itk IL2-inducible T-cell kinase 0.934
Clec4d C-type lectin domain family 4, member d 0.933
Pax2 paired box gene 2 0.930
Lyz2 lysozyme 2 0.920
Ccr2 chemokine (C-C motif) receptor 2 0.920
Lta lymphotoxin A 0.919
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.914
Tyrobp TYRO protein tyrosine kinase binding protein 0.911
Il10ra interleukin 10 receptor, alpha 0.910
Il2 interleukin 2 0.905
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.899
Btk Bruton agammaglobulinemia tyrosine kinase 0.897
Ccl22 chemokine (C-C motif) ligand 22 0.887
Gpr132 G protein-coupled receptor 132 0.886
S1pr2 sphingosine-1-phosphate receptor 2 0.882
Nos2 nitric oxide synthase 2, inducible 0.878
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.868
Cd22 CD22 antigen 0.868
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.864
H2-K1 histocompatibility 2, K1, K region 0.862
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.862
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.861
Ctsw cathepsin W 0.859
Acvrl1 activin A receptor, type II-like 1 0.856
Cd44 CD44 antigen 0.855
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.855
Il6 interleukin 6 0.844
Ccl4 chemokine (C-C motif) ligand 4 0.844
Sh2d2a SH2 domain protein 2A 0.842
Ifngr1 interferon gamma receptor 1 0.833
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.831
Cd28 CD28 antigen 0.827
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.827
Zeb1 zinc finger E-box binding homeobox 1 0.825
Tapbp TAP binding protein 0.814
Ccl8 chemokine (C-C motif) ligand 8 0.802
Ptgir prostaglandin I receptor (IP) 0.795
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.789
Lepr leptin receptor 0.788
Gzmk granzyme K 0.786
Cd160 CD160 antigen 0.780
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.771
H2-Aa histocompatibility 2, class II antigen A, alpha 0.761
Cd7 CD7 antigen 0.758
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.755
Pten phosphatase and tensin homolog 0.754
Stat1 signal transducer and activator of transcription 1 0.753
Apoe apolipoprotein E 0.744
H2-Eb1 histocompatibility 2, class II antigen E beta 0.725
Ccr7 chemokine (C-C motif) receptor 7 0.722
Mefv Mediterranean fever 0.720
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.719
Lat linker for activation of T cells 0.718
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.717
Tlr2 toll-like receptor 2 0.714
B2m beta-2 microglobulin 0.708
Sykb spleen tyrosine kinase 0.700
Cxcr3 chemokine (C-X-C motif) receptor 3 0.699
Csf1r colony stimulating factor 1 receptor 0.698
Slamf1 signaling lymphocytic activation molecule family member 1 0.695
Il18rap interleukin 18 receptor accessory protein 0.680
Ncr1 natural cytotoxicity triggering receptor 1 0.671
Il12rb1 interleukin 12 receptor, beta 1 0.664
Casp8 caspase 8 0.660
Chd7 chromodomain helicase DNA binding protein 7 0.659
Socs1 suppressor of cytokine signaling 1 0.653
Elane elastase, neutrophil expressed 0.647
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.646
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.643
Rab27a RAB27A, member RAS oncogene family 0.642
Irf5 interferon regulatory factor 5 0.642
Xcl1 chemokine (C motif) ligand 1 0.640
Il1rn interleukin 1 receptor antagonist 0.632
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.628
C3ar1 complement component 3a receptor 1 0.626
Clec7a C-type lectin domain family 7, member a 0.624
Cd180 CD180 antigen 0.622
Stat3 signal transducer and activator of transcription 3 0.616
H2-D1 histocompatibility 2, D region locus 1 0.615
Itgax integrin alpha X 0.606
Cd4 CD4 antigen 0.604
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cp ceruloplasmin 0.332
Icam1 intercellular adhesion molecule 1 0.289
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.269
Il1b interleukin 1 beta 0.266
RT1-EC2 RT1 class Ib, locus EC2 0.257
Cd247 Cd247 molecule 0.254
Cd37 CD37 molecule 0.250
Ccr5 chemokine (C-C motif) receptor 5 0.243
Csf1 colony stimulating factor 1 (macrophage) 0.241
C1qb complement component 1, q subcomponent, B chain 0.205
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.194
Neurl3 neuralized homolog 3 (Drosophila) 0.161
Nkg7 natural killer cell group 7 sequence 0.156
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.156
Cfb complement factor B 0.147
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.142
Oas1a 2'-5' oligoadenylate synthetase 1A 0.135
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.130
C3 complement component 3 0.129
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.121
Inpp5d inositol polyphosphate-5-phosphatase D 0.118
RT1-Da RT1 class II, locus Da 0.115
Arl11 ADP-ribosylation factor-like 11 0.114
Hsph1 heat shock 105/110 protein 1 0.113
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.113
Plcg2 phospholipase C, gamma 2 0.113
Hspb1 heat shock protein 1 0.109
Sell selectin L 0.108
Gzmk granzyme K 0.106
Cxcl10 chemokine (C-X-C motif) ligand 10 0.106
LOC100363783 rCG53773-like 0.103
Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 0.102
Arhgap4 Rho GTPase activating protein 4 0.102
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.100
Cd2 Cd2 molecule 0.098
Cd8a CD8a molecule 0.094
Hck hemopoietic cell kinase 0.093
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.093
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.092
Il2rb interleukin 2 receptor, beta 0.088
Cd14 CD14 molecule 0.083
Reg3b regenerating islet-derived 3 beta 0.082
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.080
Fgg fibrinogen gamma chain 0.079
Xcl1 chemokine (C motif) ligand 1 0.074
RT1-Ba RT1 class II, locus Ba 0.072
Serpind1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.072
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.072
Dock8 dedicator of cytokinesis 8 0.069
Apob apolipoprotein B 0.069
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.068
Calm1 calmodulin 1 0.066
Casp1 caspase 1 0.066
Pgam1 phosphoglycerate mutase 1 (brain) 0.066
Cd53 Cd53 molecule 0.065
Gzmb granzyme B 0.064
Ptafr platelet-activating factor receptor 0.061
Gck glucokinase 0.061
Ciita class II, major histocompatibility complex, transactivator 0.060
Gbp2 guanylate binding protein 2 0.059
Mmp12 matrix metallopeptidase 12 0.057
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.056
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.055
Klrc2 killer cell lectin-like receptor subfamily C, member 2 0.054
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.054
Pon1 paraoxonase 1 0.053
Tuba1c tubulin, alpha 1C 0.052
Cd4 Cd4 molecule 0.052
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.051
Rhoh ras homolog gene family, member H 0.051
Ccl7 chemokine (C-C motif) ligand 7 0.051
Uncx UNC homeobox 0.050
Ccl5 chemokine (C-C motif) ligand 5 0.050
Ccl4 chemokine (C-C motif) ligand 4 0.049
Prf1 perforin 1 (pore forming protein) 0.049
Myo1f myosin IF 0.047
Hmox1 heme oxygenase (decycling) 1 0.047
Prm2 protamine 2 0.046
Faslg Fas ligand (TNF superfamily, member 6) 0.046
RGD1304644 similar to RIKEN cDNA 2310046K01 0.045
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.045
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.045
Lcp1 lymphocyte cytosolic protein 1 0.045
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.045
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.044
Fgf16 fibroblast growth factor 16 0.044
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.043
Grpr gastrin releasing peptide receptor 0.043
Klhl6 kelch-like 6 (Drosophila) 0.043
Tlr7 toll-like receptor 7 0.043
Dnase1l3 deoxyribonuclease 1-like 3 0.042
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.042
Gckr glucokinase (hexokinase 4) regulator 0.041
Il7r interleukin 7 receptor 0.041
Plau plasminogen activator, urokinase 0.040
Bcl2l1 Bcl2-like 1 0.040
Tfec transcription factor EC 0.040
Pde3a phosphodiesterase 3A, cGMP inhibited 0.039
Igsf6 immunoglobulin superfamily, member 6 0.039
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.039
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism