The network for 'negative regulation of cellular amine metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cellular amine metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.

Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.996
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.994
ESR1 estrogen receptor 1 0.979
FYN FYN oncogene related to SRC, FGR, YES 0.978
BTK Bruton agammaglobulinemia tyrosine kinase 0.978
SMAD3 SMAD family member 3 0.977
GHR growth hormone receptor 0.974
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.859
LCK lymphocyte-specific protein tyrosine kinase 0.858
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.847
NCK1 NCK adaptor protein 1 0.821
FEM1B fem-1 homolog b (C. elegans) 0.791
PRKCB protein kinase C, beta 0.768
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.763
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.762
KLF4 Kruppel-like factor 4 (gut) 0.759
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.755
EGFR epidermal growth factor receptor 0.753
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.731
CTBP1 C-terminal binding protein 1 0.708
NOXA1 NADPH oxidase activator 1 0.697
CAV1 caveolin 1, caveolae protein, 22kDa 0.691
PRKCZ protein kinase C, zeta 0.687
SPRY2 sprouty homolog 2 (Drosophila) 0.684
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.664
SCHIP1 schwannomin interacting protein 1 0.648
VAV1 vav 1 guanine nucleotide exchange factor 0.639
BAK1 BCL2-antagonist/killer 1 0.638
PLCG1 phospholipase C, gamma 1 0.633
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.629
GRB2 growth factor receptor-bound protein 2 0.625
SH2D1A SH2 domain containing 1A 0.622
MAPK12 mitogen-activated protein kinase 12 0.615
DMD dystrophin 0.615
KLF6 Kruppel-like factor 6 0.613
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.602
SMAD7 SMAD family member 7 0.570
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.557
TBC1D10A TBC1 domain family, member 10A 0.542
SOCS2 suppressor of cytokine signaling 2 0.542
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.523
ITK IL2-inducible T-cell kinase 0.513
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.511
ZNF496 zinc finger protein 496 0.510
PROX1 prospero homeobox 1 0.503
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.477
BCL2L1 BCL2-like 1 0.475
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.471
DTNA dystrobrevin, alpha 0.461
NRIP1 nuclear receptor interacting protein 1 0.452
HIPK2 homeodomain interacting protein kinase 2 0.435
SOCS1 suppressor of cytokine signaling 1 0.434
EPOR erythropoietin receptor 0.426
SMAD1 SMAD family member 1 0.402
SCN5A sodium channel, voltage-gated, type V, alpha subunit 0.400
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.393
MED28 mediator complex subunit 28 0.392
SYK spleen tyrosine kinase 0.390
CD2AP CD2-associated protein 0.376
SMAD5 SMAD family member 5 0.375
MET met proto-oncogene (hepatocyte growth factor receptor) 0.374
TESK1 testis-specific kinase 1 0.370
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.370
CLCN3 chloride channel 3 0.370
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.369
HCK hemopoietic cell kinase 0.369
SETD8 SET domain containing (lysine methyltransferase) 8 0.355
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.355
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.354
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.354
SPRR2A small proline-rich protein 2A 0.352
FLNB filamin B, beta 0.337
PTEN phosphatase and tensin homolog 0.336
ARHGAP5 Rho GTPase activating protein 5 0.334
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.334
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.329
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.327
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.322
BLNK B-cell linker 0.321
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.319
PTPRB protein tyrosine phosphatase, receptor type, B 0.316
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.308
TGIF1 TGFB-induced factor homeobox 1 0.306
TSC22D1 TSC22 domain family, member 1 0.298
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.298
SH3KBP1 SH3-domain kinase binding protein 1 0.291
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.291
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.283
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.282
GAB1 GRB2-associated binding protein 1 0.277
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.277
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.275
BAD BCL2-associated agonist of cell death 0.272
TFF1 trefoil factor 1 0.266
HCFC1 host cell factor C1 (VP16-accessory protein) 0.261
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.253
SPTBN1 spectrin, beta, non-erythrocytic 1 0.242
SKI v-ski sarcoma viral oncogene homolog (avian) 0.241
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Fyn Fyn proto-oncogene 0.999
Pten phosphatase and tensin homolog 0.999
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.998
Trp53 transformation related protein 53 0.995
Egfr epidermal growth factor receptor 0.991
Smad3 MAD homolog 3 (Drosophila) 0.990
Lepr leptin receptor 0.989
Axin1 axin 1 0.982
Bcl2 B-cell leukemia/lymphoma 2 0.964
Grb2 growth factor receptor bound protein 2 0.957
Shc1 src homology 2 domain-containing transforming protein C1 0.947
Slamf1 signaling lymphocytic activation molecule family member 1 0.940
Notch1 Notch gene homolog 1 (Drosophila) 0.935
Arrb2 arrestin, beta 2 0.934
Smad1 MAD homolog 1 (Drosophila) 0.931
Atg12 autophagy-related 12 (yeast) 0.926
Apc adenomatosis polyposis coli 0.926
Zeb1 zinc finger E-box binding homeobox 1 0.921
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.918
Epor erythropoietin receptor 0.912
Igh immunoglobulin heavy chain complex 0.907
Sfrp2 secreted frizzled-related protein 2 0.905
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.899
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.894
En1 engrailed 1 0.851
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.843
Vegfa vascular endothelial growth factor A 0.842
Gsk3b glycogen synthase kinase 3 beta 0.840
Vhl von Hippel-Lindau tumor suppressor 0.840
Neurod1 neurogenic differentiation 1 0.835
Vasp vasodilator-stimulated phosphoprotein 0.825
Shh sonic hedgehog 0.823
Mcl1 myeloid cell leukemia sequence 1 0.817
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.813
Cd28 CD28 antigen 0.812
Foxp1 forkhead box P1 0.809
Ikzf1 IKAROS family zinc finger 1 0.777
Tcrb T-cell receptor beta chain 0.771
Spry4 sprouty homolog 4 (Drosophila) 0.766
Jak2 Janus kinase 2 0.760
Pax6 paired box gene 6 0.756
Arrb1 arrestin, beta 1 0.753
Vangl2 vang-like 2 (van gogh, Drosophila) 0.731
Notch2 Notch gene homolog 2 (Drosophila) 0.717
Gli2 GLI-Kruppel family member GLI2 0.717
Smad7 MAD homolog 7 (Drosophila) 0.716
Msx1 homeobox, msh-like 1 0.716
Smad4 MAD homolog 4 (Drosophila) 0.701
Gab1 growth factor receptor bound protein 2-associated protein 1 0.675
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.657
Icos inducible T-cell co-stimulator 0.649
Tcrd T-cell receptor delta chain 0.643
Braf Braf transforming gene 0.634
Cd44 CD44 antigen 0.628
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.626
Mdm2 transformed mouse 3T3 cell double minute 2 0.610
Neurod4 neurogenic differentiation 4 0.607
Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.601
Vav2 vav 2 oncogene 0.593
Sos1 son of sevenless homolog 1 (Drosophila) 0.590
Cxcr4 chemokine (C-X-C motif) receptor 4 0.580
Kit kit oncogene 0.574
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.571
Ldb3 LIM domain binding 3 0.562
Dusp1 dual specificity phosphatase 1 0.561
Nos3 nitric oxide synthase 3, endothelial cell 0.558
Irf8 interferon regulatory factor 8 0.557
Gata4 GATA binding protein 4 0.551
Cish cytokine inducible SH2-containing protein 0.539
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.522
Prkcz protein kinase C, zeta 0.520
Stat3 signal transducer and activator of transcription 3 0.519
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.517
Pparg peroxisome proliferator activated receptor gamma 0.502
Akt1 thymoma viral proto-oncogene 1 0.498
Mecom MDS1 and EVI1 complex locus 0.490
Rnf111 ring finger 111 0.482
Otx2 orthodenticle homolog 2 (Drosophila) 0.482
Mdm4 transformed mouse 3T3 cell double minute 4 0.480
Skil SKI-like 0.465
Drd2 dopamine receptor D2 0.461
Chuk conserved helix-loop-helix ubiquitous kinase 0.458
Gab2 growth factor receptor bound protein 2-associated protein 2 0.458
Sp1 trans-acting transcription factor 1 0.451
Socs2 suppressor of cytokine signaling 2 0.450
Spna1 spectrin alpha 1 0.447
Edn3 endothelin 3 0.446
Btk Bruton agammaglobulinemia tyrosine kinase 0.441
Gna13 guanine nucleotide binding protein, alpha 13 0.440
Bdkrb2 bradykinin receptor, beta 2 0.429
Ptf1a pancreas specific transcription factor, 1a 0.421
Nptx1 neuronal pentraxin 1 0.414
Rag1 recombination activating gene 1 0.412
Kl klotho 0.412
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.411
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.411
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.410
Ncoa3 nuclear receptor coactivator 3 0.402
Ank1 ankyrin 1, erythroid 0.402
Bach1 BTB and CNC homology 1 0.402
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Rattus norvegicus
Name Description Probability Func Analog Organism
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.018
Klf9 Kruppel-like factor 9 0.017
Slfn2 schlafen 2 0.016
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.016
Isg15 ISG15 ubiquitin-like modifier 0.016
Hck hemopoietic cell kinase 0.016
Lyz2 lysozyme 2 0.015
Creb1 cAMP responsive element binding protein 1 0.015
Sgk1 serum/glucocorticoid regulated kinase 1 0.015
Tgfbr2 transforming growth factor, beta receptor II 0.015
RT1-S3 RT1 class Ib, locus S3 0.015
RT1-EC2 RT1 class Ib, locus EC2 0.015
Tsc22d3 TSC22 domain family, member 3 0.014
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.014
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.014
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.014
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.014
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.014
Dtx3l deltex 3-like (Drosophila) 0.014
Gbp2 guanylate binding protein 2 0.014
Mx1 myxovirus (influenza virus) resistance 1 0.014
Lgals9 lectin, galactoside-binding, soluble, 9 0.013
Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.013
Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 0.013
Nos3 nitric oxide synthase 3, endothelial cell 0.013
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.013
Rsad2 radical S-adenosyl methionine domain containing 2 0.013
Stat6 signal transducer and activator of transcription 6 0.013
Tapbp TAP binding protein 0.013
Car5a carbonic anhydrase 5a, mitochondrial 0.013
Aif1 allograft inflammatory factor 1 0.013
Ripk3 receptor-interacting serine-threonine kinase 3 0.012
Usp18 ubiquitin specific peptidase 18 0.012
Dusp1 dual specificity phosphatase 1 0.012
LOC100360986 mCG1035404-like 0.012
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.012
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.012
Vav1 vav 1 guanine nucleotide exchange factor 0.012
Rps8 ribosomal protein S8 0.012
Ddit4 DNA-damage-inducible transcript 4 0.012
Litaf lipopolysaccharide-induced TNF factor 0.012
Foxa3 forkhead box A3 0.012
Rpl4 ribosomal protein L4 0.012
Masp1 mannan-binding lectin serine peptidase 1 0.012
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.012
Cd37 CD37 molecule 0.012
LOC100365106 rCG32755-like 0.012
Dctn1 dynactin 1 0.012
Ocln occludin 0.012
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.012
LOC688549 hypothetical protein LOC688549 0.012
Lgals5 lectin, galactose binding, soluble 5 0.012
Icam1 intercellular adhesion molecule 1 0.012
Oas1a 2'-5' oligoadenylate synthetase 1A 0.012
Zfp36 zinc finger protein 36 0.012
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.012
Efnb1 ephrin B1 0.012
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.012
Gna11 guanine nucleotide binding protein, alpha 11 0.012
Cd53 Cd53 molecule 0.012
Pink1 PTEN induced putative kinase 1 0.012
Fgfr4 fibroblast growth factor receptor 4 0.012
Clcn5 chloride channel 5 0.012
Apol3 apolipoprotein L, 3 0.011
Arrb1 arrestin, beta 1 0.011
RGD1359529 similar to chromosome 1 open reading frame 63 0.011
Cd44 Cd44 molecule 0.011
Gja5 gap junction protein, alpha 5 0.011
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.011
St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.011
Parp9 poly (ADP-ribose) polymerase family, member 9 0.011
Csnk1g2 casein kinase 1, gamma 2 0.011
Klk1b3 kallikrein 1-related peptidase b3 0.011
Adhfe1 alcohol dehydrogenase, iron containing, 1 0.011
Arhgap9 Rho GTPase activating protein 9 0.011
Tinagl1 tubulointerstitial nephritis antigen-like 1 0.011
RT1-Db1 RT1 class II, locus Db1 0.011
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.011
Nr1i2 nuclear receptor subfamily 1, group I, member 2 0.011
Gmfg glia maturation factor, gamma 0.011
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.011
Rab3a RAB3A, member RAS oncogene family 0.011
Hnf4a hepatocyte nuclear factor 4, alpha 0.011
Ass1 argininosuccinate synthetase 1 0.011
Usf2 upstream transcription factor 2, c-fos interacting 0.011
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.011
Klf2 Kruppel-like factor 2 (lung) 0.011
Egfr epidermal growth factor receptor 0.011
Spp2 secreted phosphoprotein 2 0.011
Lcp2 lymphocyte cytosolic protein 2 0.011
Fgfr2 fibroblast growth factor receptor 2 0.011
MGC112830 similar to transcription factor 0.011
Rabac1 Rab acceptor 1 (prenylated) 0.011
Mug1 murinoglobulin 1 0.011
Sox17 SRY (sex determining region Y)-box 17 0.011
RGD1560398 RGD1560398 0.011
Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.011
Ifngr1 interferon gamma receptor 1 0.011
Purb purine rich element binding protein B 0.011
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
UBI4 Ubi4p 0.019