The network for 'embryonic digestive tract development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic digestive tract development

The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus.

Homo sapiens
Name Description Probability Func Analog Organism
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.596
CXCL3 chemokine (C-X-C motif) ligand 3 0.564
IL8 interleukin 8 0.563
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.548
RBBP4 retinoblastoma binding protein 4 0.506
CXCL2 chemokine (C-X-C motif) ligand 2 0.435
RB1 retinoblastoma 1 0.317
FGF10 fibroblast growth factor 10 0.220
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.220
CCL20 chemokine (C-C motif) ligand 20 0.171
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.167
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.158
FGFR1 fibroblast growth factor receptor 1 0.148
DPP4 dipeptidyl-peptidase 4 0.141
RBBP7 retinoblastoma binding protein 7 0.127
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.109
HDAC1 histone deacetylase 1 0.103
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.094
RXRA retinoid X receptor, alpha 0.092
CXCL11 chemokine (C-X-C motif) ligand 11 0.088
JUN jun proto-oncogene 0.088
MAP2K4 mitogen-activated protein kinase kinase 4 0.078
CREBBP CREB binding protein 0.073
APC adenomatous polyposis coli 0.065
RBL2 retinoblastoma-like 2 (p130) 0.052
IL6 interleukin 6 (interferon, beta 2) 0.052
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.047
ARRB1 arrestin, beta 1 0.045
CXCL5 chemokine (C-X-C motif) ligand 5 0.045
PTCH1 patched 1 0.044
PKP4 plakophilin 4 0.043
ATF2 activating transcription factor 2 0.043
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.042
MAPK8 mitogen-activated protein kinase 8 0.040
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.037
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.035
MED25 mediator complex subunit 25 0.033
NCOR1 nuclear receptor corepressor 1 0.032
FGF7 fibroblast growth factor 7 0.031
SKI v-ski sarcoma viral oncogene homolog (avian) 0.030
IL1B interleukin 1, beta 0.028
FGF1 fibroblast growth factor 1 (acidic) 0.028
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.026
NLK nemo-like kinase 0.024
HIPK2 homeodomain interacting protein kinase 2 0.024
SOX2 SRY (sex determining region Y)-box 2 0.023
NCF2 neutrophil cytosolic factor 2 0.023
ENG endoglin 0.023
PSEN1 presenilin 1 0.022
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.022
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.022
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.021
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.020
ICAM1 intercellular adhesion molecule 1 0.020
TGFB3 transforming growth factor, beta 3 0.020
TRIP6 thyroid hormone receptor interactor 6 0.020
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.019
SAP30 Sin3A-associated protein, 30kDa 0.016
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.016
SORBS3 sorbin and SH3 domain containing 3 0.016
LIN9 lin-9 homolog (C. elegans) 0.016
CCL8 chemokine (C-C motif) ligand 8 0.015
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.015
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.014
ATF3 activating transcription factor 3 0.014
CLTC clathrin, heavy chain (Hc) 0.014
HIC1 hypermethylated in cancer 1 0.014
BCL2A1 BCL2-related protein A1 0.013
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.013
GATAD2B GATA zinc finger domain containing 2B 0.013
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.013
STK36 serine/threonine kinase 36 0.013
FSTL1 follistatin-like 1 0.013
RNF8 ring finger protein 8 0.013
RBBP8 retinoblastoma binding protein 8 0.012
PF4 platelet factor 4 0.012
FOS FBJ murine osteosarcoma viral oncogene homolog 0.012
NCOR2 nuclear receptor corepressor 2 0.012
FOXF1 forkhead box F1 0.012
NCOA6 nuclear receptor coactivator 6 0.012
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.012
TBX5 T-box 5 0.011
TGFBR1 transforming growth factor, beta receptor 1 0.011
ZFYVE9 zinc finger, FYVE domain containing 9 0.011
NRP1 neuropilin 1 0.010
CBX1 chromobox homolog 1 0.010
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.010
GLIS2 GLIS family zinc finger 2 0.010
MAPK14 mitogen-activated protein kinase 14 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
tam-1 Protein TAM-1 0.019
lin-40 Protein LIN-40 0.017
CELE_F54D5.5 Protein F54D5.5 0.014
elt-6 Protein ELT-6 0.013
unc-37 Protein UNC-37 0.011
bar-1 Protein BAR-1 0.011
pry-1 Protein PRY-1 0.011
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.938
ptch2 patched 2 0.771
shha sonic hedgehog a 0.741
hnf1ba HNF1 homeobox Ba 0.661
fgf8a fibroblast growth factor 8 a 0.631
ptch1 patched 1 0.512
smo smoothened homolog (Drosophila) 0.427
osr2 odd-skipped related 2 (Drosophila) 0.359
mib mind bomb 0.332
tp53 tumor protein p53 0.326
gata6 GATA-binding protein 6 0.251
lamc1 laminin, gamma 1 0.185
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.184
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.173
tbx5a T-box 5a 0.170
jag1b jagged 1b 0.165
col11a2 collagen type XI alpha-2 0.161
wnt5b wingless-type MMTV integration site family, member 5b 0.160
sox10 SRY-box containing gene 10 0.158
tll1 tolloid-like 1 0.155
wif1 wnt inhibitory factor 1 0.139
gata5 GATA-binding protein 5 0.138
gata4 GATA-binding protein 4 0.138
twist3 twist3 0.136
notch3 notch homolog 3 0.135
hand2 heart and neural crest derivatives expressed transcript 2 0.129
cdx4 caudal type homeo box transcription factor 4 0.122
pax8 paired box gene 8 0.119
gli2a GLI-Kruppel family member GLI2a 0.118
hhex hematopoietically expressed homeobox 0.116
hoxa2b homeo box A2b 0.115
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.113
sim1a single-minded homolog 1a (Drosophila) 0.111
pcna proliferating cell nuclear antigen 0.108
hnf4a hepatocyte nuclear factor 4, alpha 0.105
twist1a twist1a 0.101
pax2a paired box gene 2a 0.098
ahctf1 AT hook containing transcription factor 1 0.088
tbx20 T-box 20 0.079
fli1a friend leukemia integration 1a 0.077
sephs1 selenophosphate synthetase 1 0.077
fn1 fibronectin 1 0.076
pax9 paired box gene 9 0.073
lft2 lefty2 0.073
tbx24 T-box 24 0.072
nkx2.5 NK2 transcription factor related 5 0.072
tgfbi transforming growth factor, beta-induced 0.072
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.071
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.070
apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.070
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.067
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.067
sox17 SRY-box containing gene 17 0.060
vent ventral expressed homeobox 0.059
gata1a GATA binding protein 1a 0.055
tbx22 T-box 22 0.054
sfrp5 secreted frizzled-related protein 5 0.054
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.054
fli1b friend leukemia integration 1b 0.054
vangl2 vang-like 2 (van gogh, Drosophila) 0.053
elk4 ELK4, ETS-domain protein 0.053
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.052
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.052
ca15b carbonic anhydrase XV b 0.052
col8a1a collagen, type VIII, alpha 1a 0.052
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.051
lamb1a laminin, beta 1a 0.050
ndr2 nodal-related 2 0.050
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.049
ildr1b immunoglobulin-like domain containing receptor 1b 0.047
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.047
cse1l chromosome segregation 1-like (S. cerevisiae) 0.047
mecom MDS1 and EVI1 complex locus 0.046
epha4b eph receptor A4b 0.046
ptgs1 prostaglandin-endoperoxide synthase 1 0.045
foxa2 forkhead box A2 0.044
crip2 cysteine-rich protein 2 0.044
LOC100000500 sclerostin-like 0.043
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.043
pycrl pyrroline-5-carboxylate reductase-like 0.043
wt1b wilms tumor 1b 0.042
nkx2.2a NK2 transcription factor related 2a 0.042
col10a1 collagen, type X, alpha 1 0.041
cdh2 cadherin 2, neuronal 0.040
isl1 islet1 0.040
stat5.1 signal transducer and activator of transcription 5.1 0.039
wnt3 wingless-type MMTV integration site family, member 3 0.038
tal1 T-cell acute lymphocytic leukemia 1 0.037
dld deltaD 0.036
dbx1a developing brain homeobox 1a 0.036
buc bucky ball 0.036
nanos3 nanos homolog 3 0.035
or111-9 odorant receptor, family D, subfamily 111, member 9 0.035
fanca Fanconi anemia, complementation group A 0.035
hmgb1b high-mobility group box 1b 0.035
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.035
hnrnpul1 heterogeneous nuclear ribonucleoprotein U-like 1 0.035
loxl2b lysyl oxidase-like 2b 0.035
zgc:171553 zgc:171553 0.034
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.940
srp serpent 0.241
Cbl CG7037 gene product from transcript CG7037-RB 0.219
Rac1 CG2248 gene product from transcript CG2248-RA 0.217
Rho1 CG8416 gene product from transcript CG8416-RB 0.212
eya eyes absent 0.188
wg wingless 0.151
crb crumbs 0.139
Cdc42 CG12530 gene product from transcript CG12530-RA 0.126
bsk basket 0.104
frc fringe connection 0.091
rho rhomboid 0.077
aop anterior open 0.075
CG9772 CG9772 gene product from transcript CG9772-RB 0.073
hh hedgehog 0.062
bnl branchless 0.055
Kr-h1 Kruppel homolog 1 0.053
sqh spaghetti squash 0.053
myoglianin CG1838 gene product from transcript CG1838-RD 0.053
CycA Cyclin A 0.049
shn schnurri 0.044
twi twist 0.041
Rac2 CG8556 gene product from transcript CG8556-RA 0.040
Rel Relish 0.039
stumps CG31317 gene product from transcript CG31317-RC 0.037
kay kayak 0.034
repo reversed polarity 0.034
bin biniou 0.034
ap apterous 0.033
hbs hibris 0.032
Egfr Epidermal growth factor receptor 0.032
Smox Smad on X 0.031
pnr pannier 0.028
ik2 IkappaB kinase-like 2 0.025
kn knot 0.024
tld tolloid 0.024
emc extra macrochaetae 0.023
Myo31DF Myosin 31DF 0.022
scb scab 0.022
mirr mirror 0.021
ush u-shaped 0.020
RhoL rho-like 0.020
Rbf Retinoblastoma-family protein 0.019
babo baboon 0.019
caup caupolican 0.019
CG42863 CG42863 gene product from transcript CG42863-RB 0.018
Kap-alpha3 karyopherin alpha3 0.018
ena enabled 0.018
dsh dishevelled 0.018
Pvr PDGF- and VEGF-receptor related 0.018
Rab7 Rab-protein 7 0.018
ttv tout-velu 0.017
loqs loquacious 0.016
debcl death executioner Bcl-2 homologue 0.016
pnt pointed 0.016
scw screw 0.016
rst roughest 0.016
dpp decapentaplegic 0.016
Rab5 Rab-protein 5 0.015
gcm glial cells missing 0.015
drpr draper 0.015
dap dacapo 0.015
Cap-G CG34438 gene product from transcript CG34438-RF 0.014
Adgf-A Adenosine deaminase-related growth factor A 0.014
htl heartless 0.013
Mpk2 CG5475 gene product from transcript CG5475-RB 0.013
Hand CG18144 gene product from transcript CG18144-RA 0.012
S6k RPS6-p70-protein kinase 0.012
chic chickadee 0.012
Ser Serrate 0.011
Spn27A Serpin 27A 0.011
toy twin of eyeless 0.011
HLH54F CG5005 gene product from transcript CG5005-RA 0.010
Su(var)205 Suppressor of variegation 205 0.010
Upf2 CG2253 gene product from transcript CG2253-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 0.998
Shh sonic hedgehog 0.993
Fgfr2 fibroblast growth factor receptor 2 0.975
Pax3 paired box gene 3 0.955
Meox2 mesenchyme homeobox 2 0.931
Sox2 SRY-box containing gene 2 0.866
Fgf10 fibroblast growth factor 10 0.835
Tbx3 T-box 3 0.834
Fgf9 fibroblast growth factor 9 0.831
Sall4 sal-like 4 (Drosophila) 0.826
Gli2 GLI-Kruppel family member GLI2 0.815
Lef1 lymphoid enhancer binding factor 1 0.802
Bmp4 bone morphogenetic protein 4 0.770
Ctnnb1 catenin (cadherin associated protein), beta 1 0.729
Fgf8 fibroblast growth factor 8 0.726
Fgfr3 fibroblast growth factor receptor 3 0.707
Pax6 paired box gene 6 0.695
Rarg retinoic acid receptor, gamma 0.695
Id3 inhibitor of DNA binding 3 0.622
Sox9 SRY-box containing gene 9 0.617
Prrx1 paired related homeobox 1 0.583
Hes1 hairy and enhancer of split 1 (Drosophila) 0.583
Gata6 GATA binding protein 6 0.543
Sox4 SRY-box containing gene 4 0.534
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.532
Id1 inhibitor of DNA binding 1 0.493
Foxf1a forkhead box F1a 0.475
Hand1 heart and neural crest derivatives expressed transcript 1 0.443
Kdr kinase insert domain protein receptor 0.429
Pitx2 paired-like homeodomain transcription factor 2 0.405
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.387
Tbx2 T-box 2 0.383
Sox7 SRY-box containing gene 7 0.360
Eya1 eyes absent 1 homolog (Drosophila) 0.357
Sox11 SRY-box containing gene 11 0.330
Smad6 MAD homolog 6 (Drosophila) 0.320
Zeb1 zinc finger E-box binding homeobox 1 0.297
Hic1 hypermethylated in cancer 1 0.267
Gata4 GATA binding protein 4 0.257
Alx4 aristaless-like homeobox 4 0.249
Foxc2 forkhead box C2 0.229
Msx2 homeobox, msh-like 2 0.224
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.221
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.214
Rbl1 retinoblastoma-like 1 (p107) 0.211
Hdac1 histone deacetylase 1 0.202
Tcf21 transcription factor 21 0.199
Vegfa vascular endothelial growth factor A 0.195
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.172
Wnt5a wingless-related MMTV integration site 5A 0.169
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.167
Gbx2 gastrulation brain homeobox 2 0.160
Pax2 paired box gene 2 0.156
Pthlh parathyroid hormone-like peptide 0.153
Nog noggin 0.150
Atoh7 atonal homolog 7 (Drosophila) 0.150
Tcf4 transcription factor 4 0.146
Gsc goosecoid homeobox 0.142
Hdac2 histone deacetylase 2 0.136
Twist2 twist homolog 2 (Drosophila) 0.135
Jag1 jagged 1 0.133
Jarid2 jumonji, AT rich interactive domain 2 0.132
Edn3 endothelin 3 0.131
Hhex hematopoietically expressed homeobox 0.130
Mta2 metastasis-associated gene family, member 2 0.128
Arid1b AT rich interactive domain 1B (SWI-like) 0.118
Tal1 T-cell acute lymphocytic leukemia 1 0.115
Epha1 Eph receptor A1 0.114
Alx3 aristaless-like homeobox 3 0.113
Nf1 neurofibromatosis 1 0.113
Trp53 transformation related protein 53 0.111
Pten phosphatase and tensin homolog 0.110
Efnb2 ephrin B2 0.108
Foxc1 forkhead box C1 0.108
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.108
Nodal nodal 0.103
Arid1a AT rich interactive domain 1A (SWI-like) 0.097
Flt4 FMS-like tyrosine kinase 4 0.096
Tcf3 transcription factor 3 0.093
Tcfap2a transcription factor AP-2, alpha 0.091
Insm1 insulinoma-associated 1 0.090
Dll1 delta-like 1 (Drosophila) 0.089
En1 engrailed 1 0.088
She src homology 2 domain-containing transforming protein E 0.086
Zfpm2 zinc finger protein, multitype 2 0.085
Ikzf1 IKAROS family zinc finger 1 0.083
Pitx1 paired-like homeodomain transcription factor 1 0.083
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.082
Tcf7 transcription factor 7, T-cell specific 0.081
Robo3 roundabout homolog 3 (Drosophila) 0.081
Isl1 ISL1 transcription factor, LIM/homeodomain 0.081
Chd7 chromodomain helicase DNA binding protein 7 0.080
Flt1 FMS-like tyrosine kinase 1 0.078
Gata1 GATA binding protein 1 0.077
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.076
Mapk14 mitogen-activated protein kinase 14 0.076
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.075
Hoxa1 homeobox A1 0.073
Gata3 GATA binding protein 3 0.072
Btbd17 BTB (POZ) domain containing 17 0.071
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Rattus norvegicus
Name Description Probability Func Analog Organism
Pcna proliferating cell nuclear antigen 0.020
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.015
Syt4 synaptotagmin IV 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism