The network for 'cellular response to interleukin 1' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to interleukin 1

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.

Homo sapiens
Name Description Probability Func Analog Organism
ZNF43 zinc finger protein 43 0.998
IL8 interleukin 8 0.996
IL1B interleukin 1, beta 0.990
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.986
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.983
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.966
ZNF273 zinc finger protein 273 0.962
CXCL3 chemokine (C-X-C motif) ligand 3 0.951
ZNF253 zinc finger protein 253 0.931
ZNF675 zinc finger protein 675 0.885
CCL20 chemokine (C-C motif) ligand 20 0.879
IL6 interleukin 6 (interferon, beta 2) 0.868
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.845
CXCL2 chemokine (C-X-C motif) ligand 2 0.809
IL1R1 interleukin 1 receptor, type I 0.785
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.766
CCL4 chemokine (C-C motif) ligand 4 0.752
CXCL10 chemokine (C-X-C motif) ligand 10 0.734
MAPK3 mitogen-activated protein kinase 3 0.731
IL1RN interleukin 1 receptor antagonist 0.700
CCR5 chemokine (C-C motif) receptor 5 0.687
CXCL9 chemokine (C-X-C motif) ligand 9 0.684
CCL2 chemokine (C-C motif) ligand 2 0.673
CXCL5 chemokine (C-X-C motif) ligand 5 0.673
CCL8 chemokine (C-C motif) ligand 8 0.650
CCL5 chemokine (C-C motif) ligand 5 0.625
DPP4 dipeptidyl-peptidase 4 0.623
MAPK14 mitogen-activated protein kinase 14 0.600
MAPK1 mitogen-activated protein kinase 1 0.598
PLAU plasminogen activator, urokinase 0.591
CXCL11 chemokine (C-X-C motif) ligand 11 0.584
ZNF85 zinc finger protein 85 0.557
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.534
TRAF6 TNF receptor-associated factor 6 0.517
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.509
PAX3 paired box 3 0.509
ZNF117 zinc finger protein 117 0.508
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.486
ZNF430 zinc finger protein 430 0.482
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.443
ZNF254 zinc finger protein 254 0.420
ZNF708 zinc finger protein 708 0.419
ZNF93 zinc finger protein 93 0.405
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.392
ZC3H12A zinc finger CCCH-type containing 12A 0.385
BCL3 B-cell CLL/lymphoma 3 0.373
POU3F2 POU class 3 homeobox 2 0.363
ZNF91 zinc finger protein 91 0.361
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.358
IL1R2 interleukin 1 receptor, type II 0.358
ZNF680 zinc finger protein 680 0.356
TP53 tumor protein p53 0.332
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.308
CCL7 chemokine (C-C motif) ligand 7 0.297
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.296
PI3 peptidase inhibitor 3, skin-derived 0.272
MAP2K4 mitogen-activated protein kinase kinase 4 0.265
CCL22 chemokine (C-C motif) ligand 22 0.264
SOCS1 suppressor of cytokine signaling 1 0.255
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.250
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.245
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.239
MYD88 myeloid differentiation primary response gene (88) 0.232
FGA fibrinogen alpha chain 0.221
EGR2 early growth response 2 0.188
NLRC4 NLR family, CARD domain containing 4 0.176
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.176
IDE insulin-degrading enzyme 0.171
CCL11 chemokine (C-C motif) ligand 11 0.163
INHBA inhibin, beta A 0.158
CREBBP CREB binding protein 0.158
PLAT plasminogen activator, tissue 0.150
SELE selectin E 0.146
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.146
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.145
ICAM1 intercellular adhesion molecule 1 0.145
SP1 Sp1 transcription factor 0.141
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.140
PELI3 pellino homolog 3 (Drosophila) 0.136
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 0.134
CCL13 chemokine (C-C motif) ligand 13 0.132
CCR7 chemokine (C-C motif) receptor 7 0.126
CXCL13 chemokine (C-X-C motif) ligand 13 0.124
PLAUR plasminogen activator, urokinase receptor 0.117
THBS1 thrombospondin 1 0.113
IFNG interferon, gamma 0.111
TICAM2 toll-like receptor adaptor molecule 2 0.107
MMP10 matrix metallopeptidase 10 (stromelysin 2) 0.106
MEFV Mediterranean fever 0.105
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.104
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.091
GSK3B glycogen synthase kinase 3 beta 0.090
IL7R interleukin 7 receptor 0.088
STK11 serine/threonine kinase 11 0.088
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.085
BCL2A1 BCL2-related protein A1 0.084
ZNF92 zinc finger protein 92 0.084
UBD ubiquitin D 0.083
DDAH2 dimethylarginine dimethylaminohydrolase 2 0.083
IL10 interleukin 10 0.082
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Traf6 TNF receptor-associated factor 6 0.764
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.719
Ccl2 chemokine (C-C motif) ligand 2 0.691
Myd88 myeloid differentiation primary response gene 88 0.584
Cd44 CD44 antigen 0.277
Icam1 intercellular adhesion molecule 1 0.230
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.191
Stat3 signal transducer and activator of transcription 3 0.179
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.175
Fas Fas (TNF receptor superfamily member 6) 0.137
Il6 interleukin 6 0.133
Fgfr2 fibroblast growth factor receptor 2 0.125
Ptgs2 prostaglandin-endoperoxide synthase 2 0.122
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.093
Cd40 CD40 antigen 0.088
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.080
Cxcl2 chemokine (C-X-C motif) ligand 2 0.078
Ifng interferon gamma 0.072
Tlr4 toll-like receptor 4 0.069
Tnf tumor necrosis factor 0.062
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.058
Igh immunoglobulin heavy chain complex 0.055
Ccl7 chemokine (C-C motif) ligand 7 0.052
Cxcl1 chemokine (C-X-C motif) ligand 1 0.048
Birc3 baculoviral IAP repeat-containing 3 0.045
Csf1 colony stimulating factor 1 (macrophage) 0.042
Bcl3 B-cell leukemia/lymphoma 3 0.039
Nos2 nitric oxide synthase 2, inducible 0.035
Il1rn interleukin 1 receptor antagonist 0.035
Irf1 interferon regulatory factor 1 0.030
Traf3ip2 TRAF3 interacting protein 2 0.028
Gbp5 guanylate binding protein 5 0.027
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.025
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.025
Osmr oncostatin M receptor 0.023
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.023
Ccr2 chemokine (C-C motif) receptor 2 0.023
Mmp9 matrix metallopeptidase 9 0.022
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.020
Junb Jun-B oncogene 0.020
Il1r1 interleukin 1 receptor, type I 0.019
Lyz2 lysozyme 2 0.019
Ch25h cholesterol 25-hydroxylase 0.017
Socs3 suppressor of cytokine signaling 3 0.016
Ccl4 chemokine (C-C motif) ligand 4 0.016
Il10 interleukin 10 0.015
Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.015
Gfpt2 glutamine fructose-6-phosphate transaminase 2 0.015
Dab1 disabled homolog 1 (Drosophila) 0.015
Irak3 interleukin-1 receptor-associated kinase 3 0.015
Aim2 absent in melanoma 2 0.014
Il1b interleukin 1 beta 0.013
Tnip1 TNFAIP3 interacting protein 1 0.013
Ccl12 chemokine (C-C motif) ligand 12 0.013
Nlrp3 NLR family, pyrin domain containing 3 0.013
Ptgir prostaglandin I receptor (IP) 0.012
Casp1 caspase 1 0.012
Lox lysyl oxidase 0.012
Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 0.012
Fbn1 fibrillin 1 0.011
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.011
Mapk1 mitogen-activated protein kinase 1 0.011
Mavs mitochondrial antiviral signaling protein 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.832
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.826
Cd14 CD14 molecule 0.764
Timp1 TIMP metallopeptidase inhibitor 1 0.763
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.748
Icam1 intercellular adhesion molecule 1 0.731
Cxcl2 chemokine (C-X-C motif) ligand 2 0.688
Il6 interleukin 6 0.654
Junb jun B proto-oncogene 0.614
Cxcl10 chemokine (C-X-C motif) ligand 10 0.523
Socs3 suppressor of cytokine signaling 3 0.477
Egr2 early growth response 2 0.475
Il1b interleukin 1 beta 0.386
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.385
Ccl4 chemokine (C-C motif) ligand 4 0.343
Cd44 Cd44 molecule 0.315
Fosl1 fos-like antigen 1 0.303
A2m alpha-2-macroglobulin 0.294
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.292
Atf3 activating transcription factor 3 0.286
Ccl3 chemokine (C-C motif) ligand 3 0.277
Mmp3 matrix metallopeptidase 3 0.265
Cxcl3 chemokine (C-X-C motif) ligand 3 0.261
Fos FBJ osteosarcoma oncogene 0.258
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.250
Ifitm3 interferon induced transmembrane protein 3 0.240
Runx1 runt-related transcription factor 1 0.212
Ccl20 chemokine (C-C motif) ligand 20 0.201
Ptgs2 prostaglandin-endoperoxide synthase 2 0.201
Ier3 immediate early response 3 0.199
Plaur plasminogen activator, urokinase receptor 0.174
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.168
Mmp10 matrix metallopeptidase 10 0.168
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.158
Klf4 Kruppel-like factor 4 (gut) 0.147
Lbp lipopolysaccharide binding protein 0.139
Ripk3 receptor-interacting serine-threonine kinase 3 0.137
Mmp12 matrix metallopeptidase 12 0.135
Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) 0.133
Ccl7 chemokine (C-C motif) ligand 7 0.133
Sox17 SRY (sex determining region Y)-box 17 0.127
Thbd thrombomodulin 0.126
Gja5 gap junction protein, alpha 5 0.126
Hmox1 heme oxygenase (decycling) 1 0.118
PVR poliovirus receptor 0.114
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.113
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.112
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.111
Isg15 ISG15 ubiquitin-like modifier 0.108
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.108
Gbp2 guanylate binding protein 2 0.104
Cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.103
Sell selectin L 0.101
Vcan versican 0.101
Jun Jun oncogene 0.100
RGD1564599 RGD1564599 0.098
Trim47 tripartite motif-containing 47 0.095
Stat3 signal transducer and activator of transcription 3 0.093
Bglap bone gamma-carboxyglutamate (gla) protein 0.091
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.089
LOC299282 Serine protease inhibitor 0.088
Oas1a 2'-5' oligoadenylate synthetase 1A 0.086
Ccr1 chemokine (C-C motif) receptor 1 0.083
Cyr61 cysteine-rich, angiogenic inducer, 61 0.082
Gja1 gap junction protein, alpha 1 0.081
Col8a1 collagen, type VIII, alpha 1 0.079
Tgm1 transglutaminase 1, K polypeptide 0.078
Orm1 orosomucoid 1 0.077
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.073
Prelp proline/arginine-rich end leucine-rich repeat protein 0.072
Clu clusterin 0.072
Calcb calcitonin-related polypeptide, beta 0.071
LOC100361571 keratin associated protein 1-3-like 0.070
Litaf lipopolysaccharide-induced TNF factor 0.069
Igsf6 immunoglobulin superfamily, member 6 0.066
F2rl1 coagulation factor II (thrombin) receptor-like 1 0.064
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.063
Pla1a phospholipase A1 member A 0.063
Clec2d C-type lectin domain family 2, member d 0.063
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.062
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.062
Ngf nerve growth factor (beta polypeptide) 0.059
Ier2 immediate early response 2 0.058
Hbb hemoglobin, beta 0.057
Sycn syncollin 0.056
Neurl3 neuralized homolog 3 (Drosophila) 0.056
Cd200r1 CD200 receptor 1 0.055
Dmrta1 DMRT-like family A1 0.053
Igfals insulin-like growth factor binding protein, acid labile subunit 0.053
Apoc1 apolipoprotein C-I 0.052
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.051
Cd80 Cd80 molecule 0.050
Foxd3 forkhead box D3 0.050
Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 0.047
Il1a interleukin 1 alpha 0.046
Ptges prostaglandin E synthase 0.046
Rgr retinal G protein coupled receptor 0.045
Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 0.044
Hspb1 heat shock protein 1 0.043
Parp14 poly (ADP-ribose) polymerase family, member 14 0.043
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism