The network for 'regulation of transcription from rna polymerase ii promoter involved in heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transcription from rna polymerase ii promoter involved in heart development

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the development of the heart over time.

Mus musculus
Name Description Probability Func Analog Organism
Msx1 homeobox, msh-like 1 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 0.999
Gli3 GLI-Kruppel family member GLI3 0.992
Pitx2 paired-like homeodomain transcription factor 2 0.982
Pax3 paired box gene 3 0.977
Chrd chordin 0.968
Prrx1 paired related homeobox 1 0.960
Hand1 heart and neural crest derivatives expressed transcript 1 0.957
Foxc1 forkhead box C1 0.946
Eya1 eyes absent 1 homolog (Drosophila) 0.944
Dlx5 distal-less homeobox 5 0.943
Foxg1 forkhead box G1 0.934
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.933
Fgfr1 fibroblast growth factor receptor 1 0.917
Jag1 jagged 1 0.913
Otx2 orthodenticle homolog 2 (Drosophila) 0.901
Tcfap2a transcription factor AP-2, alpha 0.882
Pax2 paired box gene 2 0.869
Sall4 sal-like 4 (Drosophila) 0.869
Sox2 SRY-box containing gene 2 0.856
Notch1 Notch gene homolog 1 (Drosophila) 0.827
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.818
Hand2 heart and neural crest derivatives expressed transcript 2 0.814
Gsc goosecoid homeobox 0.771
Chd7 chromodomain helicase DNA binding protein 7 0.771
Hoxa1 homeobox A1 0.759
Pitx1 paired-like homeodomain transcription factor 1 0.730
Tbx3 T-box 3 0.713
Fgf8 fibroblast growth factor 8 0.713
Runx2 runt related transcription factor 2 0.678
Foxc2 forkhead box C2 0.625
Msx2 homeobox, msh-like 2 0.587
Bmp4 bone morphogenetic protein 4 0.585
Smo smoothened homolog (Drosophila) 0.544
Wt1 Wilms tumor 1 homolog 0.453
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.450
Sox9 SRY-box containing gene 9 0.445
Alx1 ALX homeobox 1 0.436
Alx4 aristaless-like homeobox 4 0.434
Nanog Nanog homeobox 0.418
Tbx5 T-box 5 0.415
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.396
Tgfb2 transforming growth factor, beta 2 0.395
Meox2 mesenchyme homeobox 2 0.380
Zeb1 zinc finger E-box binding homeobox 1 0.351
Nodal nodal 0.350
Bmp7 bone morphogenetic protein 7 0.334
Psen1 presenilin 1 0.330
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.309
Pax9 paired box gene 9 0.307
Dll1 delta-like 1 (Drosophila) 0.301
Prrx2 paired related homeobox 2 0.295
Fgf10 fibroblast growth factor 10 0.294
Gli2 GLI-Kruppel family member GLI2 0.291
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.280
Vangl2 vang-like 2 (van gogh, Drosophila) 0.272
Efnb2 ephrin B2 0.257
Notch2 Notch gene homolog 2 (Drosophila) 0.236
Gbx2 gastrulation brain homeobox 2 0.223
Ctnnb1 catenin (cadherin associated protein), beta 1 0.186
Pbx1 pre B-cell leukemia transcription factor 1 0.174
Fgfr3 fibroblast growth factor receptor 3 0.161
Gata3 GATA binding protein 3 0.158
Lef1 lymphoid enhancer binding factor 1 0.156
Sall1 sal-like 1 (Drosophila) 0.152
Gata4 GATA binding protein 4 0.144
Tbx1 T-box 1 0.130
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.126
Hoxa11 homeobox A11 0.125
Pax6 paired box gene 6 0.118
Lrp6 low density lipoprotein receptor-related protein 6 0.094
Hoxa2 homeobox A2 0.089
Dll4 delta-like 4 (Drosophila) 0.088
Zic3 zinc finger protein of the cerebellum 3 0.085
Ptch1 patched homolog 1 0.074
Otx1 orthodenticle homolog 1 (Drosophila) 0.072
Dlx2 distal-less homeobox 2 0.061
Alx3 aristaless-like homeobox 3 0.059
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.058
Tcfcp2l1 transcription factor CP2-like 1 0.057
Gata6 GATA binding protein 6 0.057
Emx2 empty spiracles homolog 2 (Drosophila) 0.056
Hes1 hairy and enhancer of split 1 (Drosophila) 0.053
Vegfa vascular endothelial growth factor A 0.050
Rarb retinoic acid receptor, beta 0.050
En1 engrailed 1 0.049
Hmx3 H6 homeobox 3 0.049
Isl1 ISL1 transcription factor, LIM/homeodomain 0.048
Lhx1 LIM homeobox protein 1 0.047
Sox11 SRY-box containing gene 11 0.044
Hoxd11 homeobox D11 0.044
Twist2 twist homolog 2 (Drosophila) 0.042
Tlx3 T-cell leukemia, homeobox 3 0.041
Tcf21 transcription factor 21 0.041
Rarg retinoic acid receptor, gamma 0.037
Lmx1a LIM homeobox transcription factor 1 alpha 0.037
Rxra retinoid X receptor alpha 0.036
Fgf3 fibroblast growth factor 3 0.036
Ptf1a pancreas specific transcription factor, 1a 0.035
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.994
tbx1 T-box 1 0.967
tbx16 T-box gene 16 0.955
flh floating head 0.890
bmp4 bone morphogenetic protein 4 0.888
chd chordin 0.871
ndr2 nodal-related 2 0.789
ntla no tail a 0.760
shha sonic hedgehog a 0.694
vent ventral expressed homeobox 0.658
msxe muscle segment homeobox E 0.591
tbx18 T-box 18 0.587
oep one-eyed pinhead 0.503
ved ventrally expressed dharma/bozozok antagonist 0.498
has2 hyaluronan synthase 2 0.477
ptch2 patched 2 0.447
fn1 fibronectin 1 0.445
evx1 even-skipped homeobox 1 0.435
twist1b twist1b 0.392
tbx20 T-box 20 0.380
mib mind bomb 0.355
sox32 SRY-box containing gene 32 0.351
tbx6 T-box gene 6 0.329
ndr1 nodal-related 1 0.321
tbx2a T-box gene 2a 0.319
foxh1 forkhead box H1 0.274
her7 hairy and enhancer of split related-7 0.254
tbx2b T-box 2b 0.244
tll1 tolloid-like 1 0.243
gli1 GLI-Kruppel family member 1 0.241
wnt5b wingless-type MMTV integration site family, member 5b 0.226
myf5 myogenic factor 5 0.224
bmp2a bone morphogenetic protein 2a 0.220
smo smoothened homolog (Drosophila) 0.209
gro1 groucho 1 0.192
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.179
twist3 twist3 0.174
nkx3.2 NK3 homeobox 2 0.166
fgf4 fibroblast growth factor 4 0.157
myod1 myogenic differentiation 1 0.156
lft2 lefty2 0.156
six4a sine oculis homeobox homolog 4a 0.155
lft1 lefty1 0.149
pcdh8 protocadherin 8 0.143
lmna lamin A 0.141
dusp6 dual specificity phosphatase 6 0.140
foxd5 forkhead box D5 0.136
admp anti-dorsalizing morphogenic protein 0.128
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.123
nkx2.5 NK2 transcription factor related 5 0.122
runx2b runt-related transcription factor 2b 0.119
foxi1 forkhead box I1 0.115
nkx1.2la NK1 transcription factor related 2-like,a 0.114
snai1b snail homolog 1b (Drosophila) 0.113
tbx5a T-box 5a 0.111
vangl2 vang-like 2 (van gogh, Drosophila) 0.111
mespa mesoderm posterior a 0.111
dharma dharma 0.109
axin1 axin 1 0.105
ptch1 patched 1 0.104
wnt10a wingless-type MMTV integration site family, member 10a 0.103
sp7 Sp7 transcription factor 0.100
bon bonnie and clyde 0.095
gsc goosecoid 0.092
mespb mesoderm posterior b 0.089
igf1rb insulin-like growth factor 1b receptor 0.089
ephb4b eph receptor B4b 0.089
nanos3 nanos homolog 3 0.086
rest RE1-silencing transcription factor 0.083
hand2 heart and neural crest derivatives expressed transcript 2 0.080
lhx1b LIM homeobox 1b 0.079
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.073
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.072
fzd5 frizzled homolog 5 0.069
wnt9a wingless-type MMTV integration site family, member 9A 0.067
wnt11 wingless-type MMTV integration site family, member 11 0.065
msxb muscle segment homeobox B 0.065
hoxa11a homeo box A11a 0.065
sim2 single-minded homolog 2 (Drosophila) 0.065
gro2 groucho 2 0.061
lamb1a laminin, beta 1a 0.060
szl sizzled 0.059
gbx2 gastrulation brain homeo box 2 0.059
her1 hairy-related 1 0.059
sox17 SRY-box containing gene 17 0.058
si:ch211-173o4.2 si:ch211-173o4.2 0.057
msxd muscle segment homeobox D 0.053
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.052
cdx4 caudal type homeo box transcription factor 4 0.052
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.052
fbln1 fibulin 1 0.052
dkk1b dickkopf 1b 0.051
chrna2a cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) 0.049
gpc4 glypican 4 0.047
hoxa1a homeo box A1a 0.047
cdh2 cadherin 2, neuronal 0.047
hmx4 H6 family homeobox 4 0.047
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.046
gja3 gap junction protein, alpha 3 0.045
fgf17 fibroblast growth factor 17 0.045
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.986
MAML1 mastermind-like 1 (Drosophila) 0.508
NCOR2 nuclear receptor corepressor 2 0.477
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.303
NOTCH1 notch 1 0.268
SP1 Sp1 transcription factor 0.241
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.233
FOXD3 forkhead box D3 0.164
JAG1 jagged 1 0.155
BMPR1A bone morphogenetic protein receptor, type IA 0.153
MKL1 megakaryoblastic leukemia (translocation) 1 0.108
PAX3 paired box 3 0.107
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.099
ATXN1L ataxin 1-like 0.086
SPEN spen homolog, transcriptional regulator (Drosophila) 0.083
SMAD3 SMAD family member 3 0.053
SOX10 SRY (sex determining region Y)-box 10 0.047
NOTCH3 notch 3 0.047
MYOCD myocardin 0.042
SOX2 SRY (sex determining region Y)-box 2 0.036
MYOD1 myogenic differentiation 1 0.030
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.025
SMAD7 SMAD family member 7 0.020
ESR1 estrogen receptor 1 0.019
MSX1 msh homeobox 1 0.019
SNW1 SNW domain containing 1 0.019
MYOG myogenin (myogenic factor 4) 0.015
HCFC1 host cell factor C1 (VP16-accessory protein) 0.015
GATA4 GATA binding protein 4 0.015
XIAP X-linked inhibitor of apoptosis 0.015
EP300 E1A binding protein p300 0.014
MKL2 MKL/myocardin-like 2 0.014
FSTL1 follistatin-like 1 0.013
HMGA1 high mobility group AT-hook 1 0.012
SMAD1 SMAD family member 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism