The network for 'collagen fibril organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

collagen fibril organization

Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.

Mus musculus
Name Description Probability Func Analog Organism
Lox lysyl oxidase 0.992
Fbn1 fibrillin 1 0.989
Pax6 paired box gene 6 0.950
Hoxa1 homeobox A1 0.902
Eln elastin 0.888
Otx2 orthodenticle homolog 2 (Drosophila) 0.882
Gata4 GATA binding protein 4 0.863
Dysf dysferlin 0.765
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.750
Neurod1 neurogenic differentiation 1 0.730
Col3a1 collagen, type III, alpha 1 0.697
Mmp2 matrix metallopeptidase 2 0.676
Tgfb2 transforming growth factor, beta 2 0.671
Col11a1 collagen, type XI, alpha 1 0.666
Foxf1a forkhead box F1a 0.611
Loxl1 lysyl oxidase-like 1 0.604
Pitx2 paired-like homeodomain transcription factor 2 0.573
Col6a3 collagen, type VI, alpha 3 0.560
Thbs2 thrombospondin 2 0.560
Tgfbr2 transforming growth factor, beta receptor II 0.545
Bgn biglycan 0.535
Col6a2 collagen, type VI, alpha 2 0.534
Col1a2 collagen, type I, alpha 2 0.533
Fgf8 fibroblast growth factor 8 0.520
Pdx1 pancreatic and duodenal homeobox 1 0.518
Mrc2 mannose receptor, C type 2 0.517
Adamts2 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 0.502
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.464
Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.463
Bmp1 bone morphogenetic protein 1 0.418
Srpx sushi-repeat-containing protein 0.416
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.403
Col5a2 collagen, type V, alpha 2 0.395
Foxf2 forkhead box F2 0.377
Snai1 snail homolog 1 (Drosophila) 0.362
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.350
Gata6 GATA binding protein 6 0.346
En1 engrailed 1 0.328
Hand2 heart and neural crest derivatives expressed transcript 2 0.328
Kiss1 KiSS-1 metastasis-suppressor 0.312
Col14a1 collagen, type XIV, alpha 1 0.293
Tgfbr1 transforming growth factor, beta receptor I 0.282
Bmp4 bone morphogenetic protein 4 0.265
Mfap5 microfibrillar associated protein 5 0.265
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.252
Tmem45a transmembrane protein 45a 0.243
Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 0.241
Hoxd11 homeobox D11 0.237
Prrx1 paired related homeobox 1 0.232
Twist1 twist homolog 1 (Drosophila) 0.224
Foxc2 forkhead box C2 0.220
Irx1 Iroquois related homeobox 1 (Drosophila) 0.217
Onecut1 one cut domain, family member 1 0.209
Eng endoglin 0.204
Col12a1 collagen, type XII, alpha 1 0.203
Capn6 calpain 6 0.201
Ptf1a pancreas specific transcription factor, 1a 0.198
Isl1 ISL1 transcription factor, LIM/homeodomain 0.194
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.194
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.191
Amh anti-Mullerian hormone 0.182
Thbs1 thrombospondin 1 0.177
Wisp1 WNT1 inducible signaling pathway protein 1 0.176
Irx3 Iroquois related homeobox 3 (Drosophila) 0.174
Foxc1 forkhead box C1 0.173
Has2 hyaluronan synthase 2 0.172
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.171
Gata1 GATA binding protein 1 0.171
Lhx3 LIM homeobox protein 3 0.169
Ltbp2 latent transforming growth factor beta binding protein 2 0.169
Bnc1 basonuclin 1 0.166
Dpt dermatopontin 0.166
Gdnf glial cell line derived neurotrophic factor 0.162
Tlx3 T-cell leukemia, homeobox 3 0.162
Hic1 hypermethylated in cancer 1 0.161
Ceacam16 carcinoembryonic antigen-related cell adhesion molecule 16 0.160
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.158
Col13a1 collagen, type XIII, alpha 1 0.154
Pcolce procollagen C-endopeptidase enhancer protein 0.150
Vegfa vascular endothelial growth factor A 0.146
Inhbb inhibin beta-B 0.141
Loxl3 lysyl oxidase-like 3 0.139
Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.137
Pax3 paired box gene 3 0.137
Col6a1 collagen, type VI, alpha 1 0.136
Ebf3 early B-cell factor 3 0.133
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.125
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.123
Mlph melanophilin 0.119
Masp1 mannan-binding lectin serine peptidase 1 0.119
Col8a1 collagen, type VIII, alpha 1 0.116
Pitx3 paired-like homeodomain transcription factor 3 0.115
Col5a1 collagen, type V, alpha 1 0.115
Nppc natriuretic peptide type C 0.115
Col2a1 collagen, type II, alpha 1 0.114
Sox7 SRY-box containing gene 7 0.114
Fbn2 fibrillin 2 0.114
Mybpc3 myosin binding protein C, cardiac 0.113
Atoh7 atonal homolog 7 (Drosophila) 0.109
Foxe3 forkhead box E3 0.109
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
col1a1a collagen, type I, alpha 1a 0.961
col1a2 collagen, type I, alpha 2 0.950
col5a1 procollagen, type V, alpha 1 0.932
sparc secreted acidic cysteine rich glycoprotein 0.812
col5a2l collagen, type V, alpha 2-like 0.745
dcn decorin 0.681
col10a1 collagen, type X, alpha 1 0.557
postn periostin, osteoblast specific factor 0.504
olfml3b olfactomedin-like 3b 0.474
col1a1b collagen, type I, alpha 1b 0.462
tagln2 transgelin 2 0.388
matn4 matrilin 4 0.360
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.293
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.174
col11a1b collagen type XI alpha-1b and collagen, type XI, alpha 1b 0.155
s100a10b S100 calcium binding protein A10b 0.154
zgc:55418 zgc:55418 0.139
col12a1 collagen, type XII, alpha 1 0.133
serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 0.124
nf1a neurofibromin 1a 0.118
cnn2 calponin 2 0.113
pmp22a peripheral myelin protein 22a 0.108
xylt1 xylosyltransferase 1 0.099
thbs1 thrombospondin 1 0.097
lox lysyl oxidase 0.096
col6a3 collagen, type VI, alpha 3 0.091
anxa1a annexin A1a 0.089
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.089
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.087
fn1b fibronectin 1b 0.086
pdgfrl platelet-derived growth factor receptor-like 0.084
cdh4 cadherin 4, retinal 0.084
col6a2 collagen, type VI, alpha 2 0.080
mmp2 matrix metalloproteinase 2 0.077
ecrg4a esophageal cancer related gene 4a 0.075
tbx22 T-box 22 0.072
prrx1a paired related homeobox 1a 0.070
alpi alkaline phosphatase, intestinal 0.062
spon2b spondin 2b, extracellular matrix protein 0.061
enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.060
prrx1b paired related homeobox 1b 0.059
vcanb versican b 0.058
twist2 twist2 0.056
lmna lamin A 0.055
frzb frizzled-related protein 0.051
tgfbi transforming growth factor, beta-induced 0.050
zgc:111821 zgc:111821 0.050
nf1b neurofibromin 1b 0.050
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.049
ehd2 EH-domain containing 2 0.048
thbs4b thrombospondin 4b 0.047
si:dkey-22i16.3 si:dkey-22i16.3 0.043
copa coatomer protein complex, subunit alpha 0.043
dlx5a distal-less homeobox gene 5a 0.043
pax9 paired box gene 9 0.042
rpz rapunzel 0.041
col27a1a collagen, type XXVII, alpha 1a 0.040
LOC100000500 sclerostin-like 0.040
lhfp lipoma HMGIC fusion partner 0.040
hapln1a hyaluronan and proteoglycan link protein 1a 0.039
pdlim4 PDZ and LIM domain 4 0.038
zgc:85975 zgc:85975 0.037
zgc:114201 zgc:114201 0.036
lrrc17 leucine rich repeat containing 17 0.035
matn1 matrilin 1 0.035
rpl35 ribosomal protein L35 0.034
sema3d semaphorin 3d 0.033
ssr3 signal sequence receptor, gamma 0.031
ptrfb polymerase I and transcript release factor b 0.031
zgc:112329 zgc:112329 0.028
ccl25b chemokine (C-C motif) ligand 25b 0.028
si:ch211-173b8.2 si:ch211-173b8.2 0.028
rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.027
zgc:85866 zgc:85866 0.027
tsc2 tuberous sclerosis 2 0.026
si:ch73-60e21.1 si:ch73-60e21.1 0.026
bmp1a bone morphogenetic protein 1a 0.026
col11a1a collagen, type XI, alpha 1a 0.026
ldb2b LIM-domain binding factor 2b 0.026
igfbp3 insulin-like growth factor binding protein 3 0.025
angptl7 angiopoietin-like 7 0.025
surf4l surfeit gene 4, like 0.025
fbn2b fibrillin 2b 0.024
wu:fj39b01 wu:fj39b01 0.024
foxa forkhead box A sequence 0.024
lhx6 LIM homeobox 6 0.024
si:ch211-212m21.5 si:ch211-212m21.5 0.024
c8a complement component 8, alpha polypeptide 0.024
fgf20a fibroblast growth factor 20a 0.023
hsp47 heat shock protein 47 0.022
dlx4a distal-less homeobox gene 4a 0.022
tgfb3 transforming growth factor, beta 3 0.022
zgc:92411 zgc:92411 0.022
sulf2l sulfatase 2, like 0.021
ctsk cathepsin K 0.021
slco2b1 solute carrier organic anion transporter family, member 2B1 0.021
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.021
vdra vitamin D receptor a 0.021
xirp2a xin actin-binding repeat containing 2a 0.021
si:dkey-12o15.1 si:dkey-12o15.1 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.989
COL3A1 collagen, type III, alpha 1 0.978
COL1A2 collagen, type I, alpha 2 0.938
FBN1 fibrillin 1 0.769
S100A10 S100 calcium binding protein A10 0.374
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.362
COL4A1 collagen, type IV, alpha 1 0.299
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.261
COL6A1 collagen, type VI, alpha 1 0.230
COL5A2 collagen, type V, alpha 2 0.213
DDR2 discoidin domain receptor tyrosine kinase 2 0.207
COL5A1 collagen, type V, alpha 1 0.154
FSTL1 follistatin-like 1 0.148
POSTN periostin, osteoblast specific factor 0.145
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.128
ENG endoglin 0.104
PDZD11 PDZ domain containing 11 0.099
TGFB3 transforming growth factor, beta 3 0.099
BGN biglycan 0.085
MXRA5 matrix-remodelling associated 5 0.081
THBS1 thrombospondin 1 0.081
LOX lysyl oxidase 0.072
COL6A2 collagen, type VI, alpha 2 0.064
COL4A2 collagen, type IV, alpha 2 0.059
PXDN peroxidasin homolog (Drosophila) 0.057
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.054
COL11A1 collagen, type XI, alpha 1 0.053
DCN decorin 0.050
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.041
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.034
PLOD1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.034
ADAM12 ADAM metallopeptidase domain 12 0.034
TMEM214 transmembrane protein 214 0.027
WISP1 WNT1 inducible signaling pathway protein 1 0.023
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.019
IGFBP3 insulin-like growth factor binding protein 3 0.017
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.017
ELN elastin 0.016
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.016
GLT25D1 glycosyltransferase 25 domain containing 1 0.016
NID2 nidogen 2 (osteonidogen) 0.015
FNDC1 fibronectin type III domain containing 1 0.015
FBLN5 fibulin 5 0.014
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.014
PDIA3 protein disulfide isomerase family A, member 3 0.014
COL10A1 collagen, type X, alpha 1 0.013
THY1 Thy-1 cell surface antigen 0.013
SULF1 sulfatase 1 0.013
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.012
FKBP10 FK506 binding protein 10, 65 kDa 0.012
COL6A3 collagen, type VI, alpha 3 0.012
COL11A2 collagen, type XI, alpha 2 0.011
SFRP4 secreted frizzled-related protein 4 0.011
LEPRE1 leucine proline-enriched proteoglycan (leprecan) 1 0.011
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.991
Col1a2 collagen, type I, alpha 2 0.990
Col3a1 collagen, type III, alpha 1 0.959
Fbn1 fibrillin 1 0.628
Col5a1 collagen, type V, alpha 1 0.617
Col5a2 collagen, type V, alpha 2 0.595
Vim vimentin 0.323
Loxl1 lysyl oxidase-like 1 0.288
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.206
Bgn biglycan 0.187
Col12a1 collagen, type XII, alpha 1 0.180
Postn periostin, osteoblast specific factor 0.155
Col14a1 collagen, type XIV, alpha 1 0.143
Pcolce procollagen C-endopeptidase enhancer 0.138
Rcn3 reticulocalbin 3, EF-hand calcium binding domain 0.105
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.105
Fstl1 follistatin-like 1 0.096
Col4a1 collagen, type IV, alpha 1 0.077
Fn1 fibronectin 1 0.075
Col6a2 collagen, type VI, alpha 2 0.065
Dcn decorin 0.061
Lamc1 laminin, gamma 1 0.056
Col15a1 collagen, type XV, alpha 1 0.047
Aebp1 AE binding protein 1 0.046
Ccdc80 coiled-coil domain containing 80 0.043
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.041
Eln elastin 0.040
Lum lumican 0.039
Ctsk cathepsin K 0.038
Mfap4 microfibrillar-associated protein 4 0.036
Col4a5 collagen, type IV, alpha 5 0.033
Prkcdbp protein kinase C, delta binding protein 0.027
Kdelr3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.026
Fkbp10 FK506 binding protein 10 0.022
Tgfb3 transforming growth factor, beta 3 0.021
Dab2 disabled homolog 2 (Drosophila) 0.020
Cpz carboxypeptidase Z 0.018
Ggcx gamma-glutamyl carboxylase 0.018
Copz2 coatomer protein complex, subunit zeta 2 0.018
Myl9 myosin, light chain 9, regulatory 0.017
Srpx sushi-repeat-containing protein, X-linked 0.017
Crtap cartilage associated protein 0.015
Rhoj ras homolog gene family, member J 0.015
Lox lysyl oxidase 0.014
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.013
Lnpep leucyl/cystinyl aminopeptidase 0.013
C1qtnf2 C1q and tumor necrosis factor related protein 2 0.013
Mmp23 matrix metallopeptidase 23 0.013
Atp13a1 ATPase type 13A1 0.012
Srpx2 sushi-repeat-containing protein, X-linked 2 0.012
Plod1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.012
Nid2 nidogen 2 0.012
Acta2 smooth muscle alpha-actin 0.012
Ptgis prostaglandin I2 (prostacyclin) synthase 0.011
Calu calumenin 0.011
Ogn osteoglycin 0.011
Timp2 TIMP metallopeptidase inhibitor 2 0.011
Efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism