The network for 'negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation

Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Fgfr2 fibroblast growth factor receptor 2 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.998
Tbx3 T-box 3 0.998
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.978
Tbx5 T-box 5 0.967
Foxc1 forkhead box C1 0.966
Chd7 chromodomain helicase DNA binding protein 7 0.959
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.956
Foxg1 forkhead box G1 0.931
Hoxa1 homeobox A1 0.930
Gli3 GLI-Kruppel family member GLI3 0.923
Foxc2 forkhead box C2 0.920
Sox9 SRY-box containing gene 9 0.888
Pax2 paired box gene 2 0.888
Bmp4 bone morphogenetic protein 4 0.873
Eya1 eyes absent 1 homolog (Drosophila) 0.850
Tcfap2a transcription factor AP-2, alpha 0.834
Pitx1 paired-like homeodomain transcription factor 1 0.829
Vangl2 vang-like 2 (van gogh, Drosophila) 0.823
Pax3 paired box gene 3 0.796
Prrx1 paired related homeobox 1 0.779
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.692
Otx2 orthodenticle homolog 2 (Drosophila) 0.668
Msx1 homeobox, msh-like 1 0.652
Dlx5 distal-less homeobox 5 0.632
Fgfr3 fibroblast growth factor receptor 3 0.617
Jag1 jagged 1 0.608
Scn5a sodium channel, voltage-gated, type V, alpha 0.574
Hand1 heart and neural crest derivatives expressed transcript 1 0.567
Gbx2 gastrulation brain homeobox 2 0.497
Rarb retinoic acid receptor, beta 0.479
Runx2 runt related transcription factor 2 0.459
Alx1 ALX homeobox 1 0.447
Hand2 heart and neural crest derivatives expressed transcript 2 0.433
Fgf10 fibroblast growth factor 10 0.398
Fgf8 fibroblast growth factor 8 0.398
Zeb1 zinc finger E-box binding homeobox 1 0.396
Lef1 lymphoid enhancer binding factor 1 0.391
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.352
Tbx4 T-box 4 0.348
Sall4 sal-like 4 (Drosophila) 0.335
Bmp7 bone morphogenetic protein 7 0.319
Efnb2 ephrin B2 0.310
Chrd chordin 0.303
Rarg retinoic acid receptor, gamma 0.280
Lrp6 low density lipoprotein receptor-related protein 6 0.279
Hoxa3 homeobox A3 0.268
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.267
Tbx1 T-box 1 0.230
Sox2 SRY-box containing gene 2 0.209
Smo smoothened homolog (Drosophila) 0.206
Ednra endothelin receptor type A 0.199
Gata3 GATA binding protein 3 0.182
Zic3 zinc finger protein of the cerebellum 3 0.174
Sox11 SRY-box containing gene 11 0.173
Lmx1a LIM homeobox transcription factor 1 alpha 0.160
Rxra retinoid X receptor alpha 0.144
Pax9 paired box gene 9 0.139
Fgfr1 fibroblast growth factor receptor 1 0.137
Gli2 GLI-Kruppel family member GLI2 0.136
Gsc goosecoid homeobox 0.130
Wt1 Wilms tumor 1 homolog 0.120
Tcf21 transcription factor 21 0.115
Msx2 homeobox, msh-like 2 0.114
Tgfb2 transforming growth factor, beta 2 0.109
Smad6 MAD homolog 6 (Drosophila) 0.101
Ighmbp2 immunoglobulin mu binding protein 2 0.100
Isl1 ISL1 transcription factor, LIM/homeodomain 0.100
Trp63 transformation related protein 63 0.099
Bmp5 bone morphogenetic protein 5 0.097
Vegfa vascular endothelial growth factor A 0.092
Lrp5 low density lipoprotein receptor-related protein 5 0.090
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.084
Pou5f1 POU domain, class 5, transcription factor 1 0.084
Wnt5a wingless-related MMTV integration site 5A 0.076
Wnt3a wingless-related MMTV integration site 3A 0.074
Myf5 myogenic factor 5 0.074
Otx1 orthodenticle homolog 1 (Drosophila) 0.073
Prrx2 paired related homeobox 2 0.068
Mn1 meningioma 1 0.068
Hoxb3 homeobox B3 0.068
Emx2 empty spiracles homolog 2 (Drosophila) 0.063
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.063
Hoxa2 homeobox A2 0.063
Satb2 special AT-rich sequence binding protein 2 0.063
Sall1 sal-like 1 (Drosophila) 0.060
Dlx2 distal-less homeobox 2 0.059
Meox2 mesenchyme homeobox 2 0.057
Nanog Nanog homeobox 0.056
Gata4 GATA binding protein 4 0.055
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.055
Noto notochord homolog (Xenopus laevis) 0.047
Twist2 twist homolog 2 (Drosophila) 0.044
Ptch1 patched homolog 1 0.044
Dll4 delta-like 4 (Drosophila) 0.044
Gata6 GATA binding protein 6 0.043
Hoxd1 homeobox D1 0.043
Hoxa13 homeobox A13 0.042
Irx3 Iroquois related homeobox 3 (Drosophila) 0.041
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism