The network for 'extrinsic apoptotic signaling pathway in absence of ligand' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

extrinsic apoptotic signaling pathway in absence of ligand

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.

Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 0.996
Fas Fas (TNF receptor superfamily member 6) 0.991
Trp53 transformation related protein 53 0.979
Tnf tumor necrosis factor 0.968
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.967
Lepr leptin receptor 0.950
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.949
Ctnnb1 catenin (cadherin associated protein), beta 1 0.943
Il1b interleukin 1 beta 0.902
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.895
Il2rg interleukin 2 receptor, gamma chain 0.891
Ifng interferon gamma 0.887
Ptprc protein tyrosine phosphatase, receptor type, C 0.884
Rb1 retinoblastoma 1 0.879
Bax BCL2-associated X protein 0.840
Foxp3 forkhead box P3 0.837
Esr1 estrogen receptor 1 (alpha) 0.816
Lyz2 lysozyme 2 0.808
Inpp5d inositol polyphosphate-5-phosphatase D 0.807
Pten phosphatase and tensin homolog 0.793
Kit kit oncogene 0.770
Ret ret proto-oncogene 0.737
Bcl2 B-cell leukemia/lymphoma 2 0.680
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.678
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.676
Pax2 paired box gene 2 0.669
Ccr1 chemokine (C-C motif) receptor 1 0.617
Selp selectin, platelet 0.573
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.556
Tcra T-cell receptor alpha chain 0.551
Bdnf brain derived neurotrophic factor 0.531
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.512
Ntf3 neurotrophin 3 0.457
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.442
Smad3 MAD homolog 3 (Drosophila) 0.439
Bmp5 bone morphogenetic protein 5 0.438
Pax3 paired box gene 3 0.436
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.386
Zeb1 zinc finger E-box binding homeobox 1 0.385
Runx1 runt related transcription factor 1 0.385
Casp8 caspase 8 0.373
Tcf21 transcription factor 21 0.373
Lck lymphocyte protein tyrosine kinase 0.372
Foxn1 forkhead box N1 0.361
Rxra retinoid X receptor alpha 0.357
Lum lumican 0.342
Apc adenomatosis polyposis coli 0.339
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.324
Ar androgen receptor 0.320
Itgal integrin alpha L 0.312
Hoxa11 homeobox A11 0.308
Mapk11 mitogen-activated protein kinase 11 0.308
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.307
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.303
Phox2b paired-like homeobox 2b 0.303
Cd44 CD44 antigen 0.302
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.299
Nos3 nitric oxide synthase 3, endothelial cell 0.297
Rbl1 retinoblastoma-like 1 (p107) 0.296
Fst follistatin 0.295
Sharpin SHANK-associated RH domain interacting protein 0.294
Shh sonic hedgehog 0.291
Fbn1 fibrillin 1 0.288
Prrx2 paired related homeobox 2 0.286
Cdk4 cyclin-dependent kinase 4 0.285
Chrd chordin 0.285
Cd247 CD247 antigen 0.284
Rag1 recombination activating gene 1 0.283
Il1a interleukin 1 alpha 0.281
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.279
Vhl von Hippel-Lindau tumor suppressor 0.274
Col6a2 collagen, type VI, alpha 2 0.271
Ins2 insulin II 0.269
Ins1 insulin I 0.269
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.259
Axin1 axin 1 0.258
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.254
Gata3 GATA binding protein 3 0.250
Foxc1 forkhead box C1 0.249
Lta lymphotoxin A 0.249
Itgb3 integrin beta 3 0.249
Isl1 ISL1 transcription factor, LIM/homeodomain 0.248
Sox10 SRY-box containing gene 10 0.245
Snai1 snail homolog 1 (Drosophila) 0.243
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.243
Tgfbr2 transforming growth factor, beta receptor II 0.240
Acan aggrecan 0.234
Capn6 calpain 6 0.233
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.232
Lyst lysosomal trafficking regulator 0.231
Rara retinoic acid receptor, alpha 0.231
Efnb2 ephrin B2 0.230
Smad4 MAD homolog 4 (Drosophila) 0.228
Hoxd11 homeobox D11 0.225
Sell selectin, lymphocyte 0.215
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.214
Ccl2 chemokine (C-C motif) ligand 2 0.204
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.191
Il10 interleukin 10 0.190
Phox2a paired-like homeobox 2a 0.186
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.874
ptgs2a prostaglandin-endoperoxide synthase 2a 0.504
mpx myeloid-specific peroxidase 0.500
mcl1b myeloid cell leukemia sequence 1b 0.478
lef1 lymphocyte enhancer binding factor 1 0.454
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.445
mcl1a myeloid cell leukemia sequence 1a 0.426
lhx2b LIM homeobox 2b 0.398
nf1a neurofibromin 1a 0.364
bcl2l1 bcl2-like 1 0.355
dlx5a distal-less homeobox gene 5a 0.310
igf1 insulin-like growth factor 1 0.289
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.213
six1b sine oculis homeobox homolog 1b 0.184
hmgb1a high-mobility group box 1a 0.183
gpr126 G protein-coupled receptor 126 0.183
nrg1 neuregulin 1 0.182
alas2 aminolevulinate, delta-, synthetase 2 0.181
bcl2 B-cell leukemia/lymphoma 2 0.178
bdnf brain-derived neurotrophic factor 0.175
slc4a1a solute carrier family 4, anion exchanger, member 1a 0.170
acvr2a activin receptor IIa 0.167
tgfb3 transforming growth factor, beta 3 0.164
hug HuG 0.162
bmp3 bone morphogenetic protein 3 0.160
inha inhibin, alpha 0.158
ptgds prostaglandin D2 synthase 0.149
rag1 recombination activating gene 1 0.145
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.138
evx1 even-skipped homeobox 1 0.133
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.133
cldni claudin i 0.126
tgfb1a transforming growth factor, beta 1a 0.124
ptgs1 prostaglandin-endoperoxide synthase 1 0.119
igf3 insulin-like growth factor 3 0.118
tal1 T-cell acute lymphocytic leukemia 1 0.116
mmp9 matrix metalloproteinase 9 0.115
cited3 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 3 0.110
cmyb transcription factor cmyb 0.109
bida BH3 interacting domain death agonist 0.109
stc1l stanniocalcin 1, like 0.109
wnt11r wingless-type MMTV integration site family, member 11, related 0.104
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.101
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.096
twist1b twist1b 0.094
dusp1 dual specificity phosphatase 1 0.092
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.091
mapk6 mitogen-activated protein kinase 6 0.091
epha4b eph receptor A4b 0.089
zgc:162126 zgc:162126 0.089
urod uroporphyrinogen decarboxylase 0.083
scinla scinderin like a 0.082
runx1 runt-related transcription factor 1 0.082
col10a1 collagen, type X, alpha 1 0.080
ck2b casein kinase 2 beta 0.080
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.078
ptmaa prothymosin, alpha a 0.077
osr1 odd-skipped related 1 (Drosophila) 0.077
zgc:136878 zgc:136878 0.076
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.076
itgb3b integrin beta 3b 0.074
cpla2 cytosolic phospholipase a2 0.072
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.071
si:ch211-197h24.9 si:ch211-197h24.9 0.070
spry1 sprouty homolog 1 (Drosophila) 0.070
tgfbi transforming growth factor, beta-induced 0.068
notch3 notch homolog 3 0.068
ptpra protein tyrosine phosphatase, receptor type, A 0.068
per2 period homolog 2 (Drosophila) 0.068
mmp13a matrix metalloproteinase 13a 0.068
fkbp5 FK506 binding protein 5 0.067
notch2 notch homolog 2 0.066
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.066
nkd1 naked cuticle homolog 1 (Drosophila) 0.065
wu:fv91b12 wu:fv91b12 0.064
eif4a1b eukaryotic translation initiation factor 4A, isoform 1B 0.064
bmf1 Bcl2 modifying factor 1 0.064
pea3 ETS-domain transcription factor pea3 0.063
mfn2 mitofusin 2 0.062
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.061
olig1 oligodendrocyte lineage transcription factor 1 0.061
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.059
cnih cornichon homolog (Drosophila) 0.059
clock3 clock homolog 3 (mouse) 0.058
lmo2 LIM domain only 2 (rhombotin-like 1) 0.058
uba1 ubiquitin-like modifier activating enzyme 1 0.057
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.056
lhcgr luteinizing hormone/choriogonadotropin receptor 0.055
th tyrosine hydroxylase 0.055
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.054
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.054
slc6a6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 0.053
il7r interleukin 7 receptor 0.053
zgc:64115 zgc:64115 0.053
stmn2b stathmin-like 2b 0.053
notch1a notch homolog 1a 0.052
comta catechol-O-methyltransferase a 0.052
pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 0.051
cpox coproporphyrinogen oxidase 0.051
abhd2a abhydrolase domain containing 2a 0.051
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 1.000
BCL2L1 BCL2-like 1 0.999
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.991
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.985
TAL1 T-cell acute lymphocytic leukemia 1 0.971
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.970
BAX BCL2-associated X protein 0.965
HSPA1B heat shock 70kDa protein 1B 0.931
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.870
BAD BCL2-associated agonist of cell death 0.834
FAS Fas (TNF receptor superfamily, member 6) 0.832
BID BH3 interacting domain death agonist 0.774
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.621
EGFR epidermal growth factor receptor 0.609
IL1R1 interleukin 1 receptor, type I 0.589
B2M beta-2-microglobulin 0.514
CFLAR CASP8 and FADD-like apoptosis regulator 0.501
CXCL10 chemokine (C-X-C motif) ligand 10 0.475
PML promyelocytic leukemia 0.437
HSPA1A heat shock 70kDa protein 1A 0.406
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.391
CXCL2 chemokine (C-X-C motif) ligand 2 0.376
FADD Fas (TNFRSF6)-associated via death domain 0.373
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.373
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.373
TRADD TNFRSF1A-associated via death domain 0.342
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.336
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.276
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.240
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.231
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.226
BIRC2 baculoviral IAP repeat containing 2 0.201
TRAF1 TNF receptor-associated factor 1 0.197
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.188
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.182
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.168
APAF1 apoptotic peptidase activating factor 1 0.139
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.135
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.132
IL1B interleukin 1, beta 0.127
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.126
IL4R interleukin 4 receptor 0.125
BAG3 BCL2-associated athanogene 3 0.122
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.120
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.118
GSK3B glycogen synthase kinase 3 beta 0.115
MAPK14 mitogen-activated protein kinase 14 0.113
IL8 interleukin 8 0.113
TRAF2 TNF receptor-associated factor 2 0.110
CXCL11 chemokine (C-X-C motif) ligand 11 0.102
IL1R2 interleukin 1 receptor, type II 0.102
MAPK7 mitogen-activated protein kinase 7 0.101
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.095
TNF tumor necrosis factor 0.093
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.085
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.083
BAK1 BCL2-antagonist/killer 1 0.081
MAP2K5 mitogen-activated protein kinase kinase 5 0.080
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.077
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.076
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.074
DAXX death-domain associated protein 0.073
XIAP X-linked inhibitor of apoptosis 0.073
IL6 interleukin 6 (interferon, beta 2) 0.072
CXCL5 chemokine (C-X-C motif) ligand 5 0.062
HSPB1 heat shock 27kDa protein 1 0.060
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.059
BCL2A1 BCL2-related protein A1 0.058
HSPB8 heat shock 22kDa protein 8 0.055
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.055
MAPK1 mitogen-activated protein kinase 1 0.055
CXCL3 chemokine (C-X-C motif) ligand 3 0.053
THBS1 thrombospondin 1 0.053
FASLG Fas ligand (TNF superfamily, member 6) 0.052
BIRC3 baculoviral IAP repeat containing 3 0.049
PF4 platelet factor 4 0.048
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.047
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.046
CCL4 chemokine (C-C motif) ligand 4 0.046
JUP junction plakoglobin 0.044
CCL8 chemokine (C-C motif) ligand 8 0.043
STIP1 stress-induced-phosphoprotein 1 0.042
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.041
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.041
IL2RG interleukin 2 receptor, gamma 0.041
PLCG1 phospholipase C, gamma 1 0.039
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.039
FGF2 fibroblast growth factor 2 (basic) 0.037
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.037
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.037
GRB7 growth factor receptor-bound protein 7 0.036
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.036
AXIN1 axin 1 0.036
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.035
CCL20 chemokine (C-C motif) ligand 20 0.035
BANP BTG3 associated nuclear protein 0.034
IFI27 interferon, alpha-inducible protein 27 0.033
PTK6 PTK6 protein tyrosine kinase 6 0.033
BIK BCL2-interacting killer (apoptosis-inducing) 0.031
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.031
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Rattus norvegicus
Name Description Probability Func Analog Organism
Unc5b unc-5 homolog B (C. elegans) 0.218
Sirpa signal-regulatory protein alpha 0.186
Ptafr platelet-activating factor receptor 0.172
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.139
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.095
Ddr1 discoidin domain receptor tyrosine kinase 1 0.087
Igsf6 immunoglobulin superfamily, member 6 0.086
Rara retinoic acid receptor, alpha 0.071
Ralgds ral guanine nucleotide dissociation stimulator 0.068
Glg1 golgi apparatus protein 1 0.061
Pacs1 phosphofurin acidic cluster sorting protein 1 0.049
Ptprc protein tyrosine phosphatase, receptor type, C 0.042
Epn1 Epsin 1 0.040
Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.037
Met met proto-oncogene 0.036
Epn2 epsin 2 0.035
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.032
Cd37 CD37 molecule 0.031
Usf2 upstream transcription factor 2, c-fos interacting 0.030
Csf1 colony stimulating factor 1 (macrophage) 0.030
Dock8 dedicator of cytokinesis 8 0.029
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.027
Prdm2 PR domain containing 2, with ZNF domain 0.027
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.026
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.025
Csnk2b casein kinase 2, beta polypeptide 0.021
Smad7 SMAD family member 7 0.020
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.020
Klhl6 kelch-like 6 (Drosophila) 0.019
Mprip myosin phosphatase Rho interacting protein 0.019
Fam70b family with sequence similarity 70, member B 0.019
Rgs19 regulator of G-protein signaling 19 0.018
Creb1 cAMP responsive element binding protein 1 0.018
Ptpn7 protein tyrosine phosphatase, non-receptor type 7 0.018
C5ar1 complement component 5a receptor 1 0.017
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.016
Adap1 ArfGAP with dual PH domains 1 0.016
Il2rb interleukin 2 receptor, beta 0.016
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.016
Ccl4 chemokine (C-C motif) ligand 4 0.016
Tgfb1 transforming growth factor, beta 1 0.016
Map3k3 mitogen activated protein kinase kinase kinase 3 0.015
Sdc3 syndecan 3 0.015
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.015
Cd86 CD86 molecule 0.015
Megf10 multiple EGF-like domains 10 0.015
Pcnxl3 pecanex-like 3 (Drosophila) 0.015
Adora2a adenosine A2a receptor 0.015
Stub1 STIP1 homology and U-Box containing protein 1 0.014
Prkcd protein kinase C, delta 0.014
Adrbk1 adrenergic, beta, receptor kinase 1 0.014
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.014
Acan aggrecan 0.013
Ccl3 chemokine (C-C motif) ligand 3 0.013
Il1r2 interleukin 1 receptor, type II 0.013
Irf2 interferon regulatory factor 2 0.013
Dchs1 dachsous 1 (Drosophila) 0.013
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.012
Ccnd3 cyclin D3 0.011
Prrx1 paired related homeobox 1 0.011
Homer3 homer homolog 3 (Drosophila) 0.011
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.011
Nxph3 neurexophilin 3 0.011
Il1a interleukin 1 alpha 0.011
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism