The network for 'transcription factor import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transcription factor import into nucleus

The directed movement of a transcription factor from the cytoplasm to the nucleus.

Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.930
Ctnnb1 catenin (cadherin associated protein), beta 1 0.859
Il1r1 interleukin 1 receptor, type I 0.671
Apc adenomatosis polyposis coli 0.489
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.300
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.298
Lta lymphotoxin A 0.297
Fgfr2 fibroblast growth factor receptor 2 0.238
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) 0.224
Trp63 transformation related protein 63 0.217
Edaradd EDAR (ectodysplasin-A receptor)-associated death domain 0.211
Il6st interleukin 6 signal transducer 0.206
Fgfr1 fibroblast growth factor receptor 1 0.200
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.198
Pten phosphatase and tensin homolog 0.173
Gli3 GLI-Kruppel family member GLI3 0.171
Ar androgen receptor 0.156
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.145
Casp1 caspase 1 0.140
Il6 interleukin 6 0.135
Rara retinoic acid receptor, alpha 0.134
Lyz2 lysozyme 2 0.126
Cd40 CD40 antigen 0.124
Fas Fas (TNF receptor superfamily member 6) 0.121
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.114
Trp53 transformation related protein 53 0.110
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.108
Rarg retinoic acid receptor, gamma 0.107
Mapkap1 mitogen-activated protein kinase associated protein 1 0.103
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.099
Htt huntingtin 0.098
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.092
Tgfb2 transforming growth factor, beta 2 0.091
Rxra retinoid X receptor alpha 0.086
Psen1 presenilin 1 0.085
Lrp6 low density lipoprotein receptor-related protein 6 0.081
Ncoa3 nuclear receptor coactivator 3 0.080
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.075
Cd44 CD44 antigen 0.075
Pkd1 polycystic kidney disease 1 homolog 0.074
Il7 interleukin 7 0.071
Cxcr5 chemokine (C-X-C motif) receptor 5 0.070
Dbp D site albumin promoter binding protein 0.067
Ikbkg inhibitor of kappaB kinase gamma 0.063
Per1 period homolog 1 (Drosophila) 0.062
Bmp4 bone morphogenetic protein 4 0.059
Grb10 growth factor receptor bound protein 10 0.056
Lepr leptin receptor 0.055
Smo smoothened homolog (Drosophila) 0.054
Il10 interleukin 10 0.053
Axin1 axin 1 0.052
Emx1 empty spiracles homolog 1 (Drosophila) 0.051
Cand1 cullin associated and neddylation disassociated 1 0.051
Sox9 SRY-box containing gene 9 0.049
Eya1 eyes absent 1 homolog (Drosophila) 0.049
Vdr vitamin D receptor 0.048
Myd88 myeloid differentiation primary response gene 88 0.048
Hs1bp3 HCLS1 binding protein 3 0.046
Smad3 MAD homolog 3 (Drosophila) 0.045
Srrt serrate RNA effector molecule homolog (Arabidopsis) 0.044
Il1b interleukin 1 beta 0.044
Stim2 stromal interaction molecule 2 0.044
Fam96a family with sequence similarity 96, member A 0.043
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.042
Ccl2 chemokine (C-C motif) ligand 2 0.041
Ccr1 chemokine (C-C motif) receptor 1 0.041
Rel reticuloendotheliosis oncogene 0.041
Gli2 GLI-Kruppel family member GLI2 0.041
Cd28 CD28 antigen 0.041
Il1r2 interleukin 1 receptor, type II 0.040
Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform 0.040
Rptor regulatory associated protein of MTOR, complex 1 0.039
Tlr4 toll-like receptor 4 0.039
Lancl2 LanC (bacterial lantibiotic synthetase component C)-like 2 0.038
Cux1 cut-like homeobox 1 0.038
Kif20a kinesin family member 20A 0.037
Yap1 yes-associated protein 1 0.037
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.037
Nodal nodal 0.037
Anapc2 anaphase promoting complex subunit 2 0.037
Ptch1 patched homolog 1 0.036
Notch2 Notch gene homolog 2 (Drosophila) 0.035
Bcl6 B-cell leukemia/lymphoma 6 0.035
Zeb1 zinc finger E-box binding homeobox 1 0.034
Rnf115 ring finger protein 115 0.034
Gspt1 G1 to S phase transition 1 0.034
Il18rap interleukin 18 receptor accessory protein 0.034
Smad2 MAD homolog 2 (Drosophila) 0.034
Traf3 TNF receptor-associated factor 3 0.034
Ltb lymphotoxin B 0.033
Bcl2 B-cell leukemia/lymphoma 2 0.033
Slc12a6 solute carrier family 12, member 6 0.032
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.032
Ikzf1 IKAROS family zinc finger 1 0.032
Lhx1 LIM homeobox protein 1 0.032
Pom121 nuclear pore membrane protein 121 0.031
Il1a interleukin 1 alpha 0.031
Bmpr1a bone morphogenetic protein receptor, type 1A 0.031
Kpna1 karyopherin (importin) alpha 1 0.031
Tox thymocyte selection-associated high mobility group box 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
sma-6 Protein SMA-6 0.010
gpb-1 Protein GPB-1 0.010
K02A6.2 Protein K02A6.2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD3 SMAD family member 3 0.992
LAT linker for activation of T cells 0.855
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.716
MYD88 myeloid differentiation primary response gene (88) 0.681
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.592
BTRC beta-transducin repeat containing 0.570
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.536
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.529
SMAD2 SMAD family member 2 0.502
GRB2 growth factor receptor-bound protein 2 0.483
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.436
IL1R1 interleukin 1 receptor, type I 0.427
SH2D4A SH2 domain containing 4A 0.398
SH3BP2 SH3-domain binding protein 2 0.338
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.331
CCR5 chemokine (C-C motif) receptor 5 0.309
RANBP3 RAN binding protein 3 0.275
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.272
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.253
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.199
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.196
SMAD7 SMAD family member 7 0.191
CCL4 chemokine (C-C motif) ligand 4 0.190
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.175
EGFR epidermal growth factor receptor 0.174
PSEN2 presenilin 2 (Alzheimer disease 4) 0.165
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.164
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.161
IL8 interleukin 8 0.157
KPNB1 karyopherin (importin) beta 1 0.145
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.145
ICAM1 intercellular adhesion molecule 1 0.135
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.127
RNF31 ring finger protein 31 0.118
SMAD4 SMAD family member 4 0.118
VAV1 vav 1 guanine nucleotide exchange factor 0.114
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.113
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.107
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.099
IGF1R insulin-like growth factor 1 receptor 0.098
IL1B interleukin 1, beta 0.096
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.094
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.088
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.086
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.075
HIPK3 homeodomain interacting protein kinase 3 0.074
CKAP5 cytoskeleton associated protein 5 0.070
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.070
CCR1 chemokine (C-C motif) receptor 1 0.068
FLNB filamin B, beta 0.068
YAP1 Yes-associated protein 1 0.067
SYK spleen tyrosine kinase 0.067
RACGAP1 Rac GTPase activating protein 1 0.065
LY96 lymphocyte antigen 96 0.065
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.064
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.063
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.063
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.062
AXIN1 axin 1 0.062
XIRP1 xin actin-binding repeat containing 1 0.062
PSEN1 presenilin 1 0.061
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.061
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.060
SMAD1 SMAD family member 1 0.060
ZNF84 zinc finger protein 84 0.060
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.060
WDR26 WD repeat domain 26 0.060
MAVS mitochondrial antiviral signaling protein 0.059
IRF7 interferon regulatory factor 7 0.058
RIPK2 receptor-interacting serine-threonine kinase 2 0.058
HDAC6 histone deacetylase 6 0.058
ACTN4 actinin, alpha 4 0.057
IL1R2 interleukin 1 receptor, type II 0.057
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.056
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.056
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.055
SKIL SKI-like oncogene 0.054
DSG2 desmoglein 2 0.054
TNF tumor necrosis factor 0.053
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.053
ZNF260 zinc finger protein 260 0.050
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.050
TRAF1 TNF receptor-associated factor 1 0.048
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.047
TXN thioredoxin 0.047
CCL8 chemokine (C-C motif) ligand 8 0.046
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.045
PML promyelocytic leukemia 0.045
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.045
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.045
VCL vinculin 0.045
TLR2 toll-like receptor 2 0.045
MAP2K5 mitogen-activated protein kinase kinase 5 0.044
FBXW11 F-box and WD repeat domain containing 11 0.044
ZNF420 zinc finger protein 420 0.043
CCL22 chemokine (C-C motif) ligand 22 0.043
RECQL RecQ protein-like (DNA helicase Q1-like) 0.042
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.042
CFLAR CASP8 and FADD-like apoptosis regulator 0.041
CCL5 chemokine (C-C motif) ligand 5 0.041
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism