The network for 'regulation of protein kinase b signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein kinase b signaling

Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

Mus musculus
Name Description Probability Func Analog Organism
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.944
Grb2 growth factor receptor bound protein 2 0.868
Pten phosphatase and tensin homolog 0.855
Egfr epidermal growth factor receptor 0.836
Ntf3 neurotrophin 3 0.816
Nos1 nitric oxide synthase 1, neuronal 0.653
Rb1 retinoblastoma 1 0.600
Cav1 caveolin 1, caveolae protein 0.597
Axl AXL receptor tyrosine kinase 0.586
Dlg4 discs, large homolog 4 (Drosophila) 0.567
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.548
Apoe apolipoprotein E 0.480
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.470
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.455
Gli3 GLI-Kruppel family member GLI3 0.412
LOC100048884 novel member of the major urinary protein (Mup) gene family 0.403
Apc adenomatosis polyposis coli 0.389
Efnb2 ephrin B2 0.369
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.348
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.327
Arrb1 arrestin, beta 1 0.319
Ghr growth hormone receptor 0.303
Bdnf brain derived neurotrophic factor 0.295
Grb10 growth factor receptor bound protein 10 0.275
Parva parvin, alpha 0.271
Phox2a paired-like homeobox 2a 0.262
Fgf3 fibroblast growth factor 3 0.261
Ret ret proto-oncogene 0.260
Fzd1 frizzled homolog 1 (Drosophila) 0.253
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.244
Insr insulin receptor 0.241
Cxcl13 chemokine (C-X-C motif) ligand 13 0.221
Cbl Casitas B-lineage lymphoma 0.219
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.214
Nos3 nitric oxide synthase 3, endothelial cell 0.212
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.209
Tyro3 TYRO3 protein tyrosine kinase 3 0.206
Ramp2 receptor (calcitonin) activity modifying protein 2 0.194
Dmd dystrophin, muscular dystrophy 0.192
Spry4 sprouty homolog 4 (Drosophila) 0.188
Mup10 major urinary protein 10 0.185
Fzd4 frizzled homolog 4 (Drosophila) 0.181
Esr1 estrogen receptor 1 (alpha) 0.174
Pparg peroxisome proliferator activated receptor gamma 0.167
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.164
Klf3 Kruppel-like factor 3 (basic) 0.162
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.162
Col1a1 collagen, type I, alpha 1 0.160
Cd80 CD80 antigen 0.160
Eps15 epidermal growth factor receptor pathway substrate 15 0.160
C1qc complement component 1, q subcomponent, C chain 0.158
Cd44 CD44 antigen 0.156
Sox2 SRY-box containing gene 2 0.156
Bmp4 bone morphogenetic protein 4 0.152
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.151
Fgfr2 fibroblast growth factor receptor 2 0.146
Gab1 growth factor receptor bound protein 2-associated protein 1 0.145
C3ar1 complement component 3a receptor 1 0.144
Pou3f3 POU domain, class 3, transcription factor 3 0.144
Hoxa11 homeobox A11 0.138
Arrb2 arrestin, beta 2 0.137
Tsc1 tuberous sclerosis 1 0.132
Adam17 a disintegrin and metallopeptidase domain 17 0.129
S1pr2 sphingosine-1-phosphate receptor 2 0.125
C1qa complement component 1, q subcomponent, alpha polypeptide 0.124
Ccl4 chemokine (C-C motif) ligand 4 0.123
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.123
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.123
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.121
Hoxa1 homeobox A1 0.119
Htra3 HtrA serine peptidase 3 0.119
Bai1 brain-specific angiogenesis inhibitor 1 0.117
Trp53 transformation related protein 53 0.117
Ccr1 chemokine (C-C motif) receptor 1 0.117
Jag1 jagged 1 0.115
Hif1a hypoxia inducible factor 1, alpha subunit 0.113
Tenc1 tensin like C1 domain-containing phosphatase 0.112
Fzd7 frizzled homolog 7 (Drosophila) 0.112
Msr1 macrophage scavenger receptor 1 0.111
Pax2 paired box gene 2 0.111
Igf2 insulin-like growth factor 2 0.111
Cxcr7 chemokine (C-X-C motif) receptor 7 0.110
Timp3 tissue inhibitor of metalloproteinase 3 0.108
Pbx1 pre B-cell leukemia transcription factor 1 0.107
Mup19 major urinary protein 19 0.105
Clec4d C-type lectin domain family 4, member d 0.103
Sin3a transcriptional regulator, SIN3A (yeast) 0.103
Leprel2 leprecan-like 2 0.100
Fxyd7 FXYD domain-containing ion transport regulator 7 0.098
Eya1 eyes absent 1 homolog (Drosophila) 0.097
Aebp1 AE binding protein 1 0.096
Wnt5a wingless-related MMTV integration site 5A 0.095
Mup1 major urinary protein 1 0.094
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.094
Plau plasminogen activator, urokinase 0.091
Prss28 protease, serine, 28 0.091
Lamb2 laminin, beta 2 0.090
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.090
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.090
Mup7 major urinary protein 7 0.090
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
igf1rb insulin-like growth factor 1b receptor 0.460
ighz immunoglobulin heavy constant zeta 0.201
igf1 insulin-like growth factor 1 0.172
fn1b fibronectin 1b 0.126
rag1 recombination activating gene 1 0.119
tpm3 tropomyosin 3 0.108
igf2b insulin-like growth factor 2b 0.103
srf serum response factor 0.087
tp53bp2 tumor protein p53 binding protein, 2 0.081
pxn paxillin 0.078
robo1 roundabout homolog 1 0.073
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.072
psen1 presenilin 1 0.070
mmp9 matrix metalloproteinase 9 0.070
igfbp2b insulin-like growth factor binding protein 2b 0.069
emp2 epithelial membrane protein 2 0.069
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.067
zgc:85866 zgc:85866 0.066
clock clock 0.065
drd2a dopamine receptor D2a 0.061
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.054
lama4 laminin, alpha 4 0.051
ptgs1 prostaglandin-endoperoxide synthase 1 0.047
ahr2 aryl hydrocarbon receptor 2 0.045
irx5a iroquois homeobox protein 5a 0.043
LOC567965 rho GTPase-activating protein 7-like 0.038
ocrl oculocerebrorenal syndrome of Lowe 0.038
si:dkeyp-34c12.2 si:dkeyp-34c12.2 0.038
colec11 collectin sub-family member 11 0.037
casz1 castor zinc finger 1 0.036
ca10a carbonic anhydrase Xa 0.036
igf2a insulin-like growth factor 2a 0.035
notch2 notch homolog 2 0.035
rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 0.034
ldb2a LIM-domain binding factor 2a 0.034
syce2 synaptonemal complex central element protein 2 0.033
furinb furin (paired basic amino acid cleaving enzyme) b 0.032
zbtb4 zinc finger and BTB domain containing 4 0.031
pvrl1b poliovirus receptor-related 1b 0.030
aplp2 amyloid beta (A4) precursor-like protein 2 0.026
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.026
pak2a p21 (CDKN1A)-activated kinase 2a 0.026
pomt1 protein-O-mannosyltransferase 1 0.026
metrn meteorin, glial cell differentiation regulator 0.025
ncf1 neutrophil cytosolic factor 1 0.025
fxr2 fragile X mental retardation, autosomal homolog 2 0.025
insra insulin receptor a 0.025
mc2r melanocortin 2 receptor 0.025
sla1 Src-like-adaptor 1 0.025
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.025
zgc:136894 zgc:136894 0.024
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.024
evx1 even-skipped homeobox 1 0.024
arntl1a aryl hydrocarbon receptor nuclear translocator-like 1a 0.024
pabpc1b poly A binding protein, cytoplasmic 1 b 0.023
mpz myelin protein zero 0.023
sat1a spermidine/spermine N1-acetyltransferase 1a 0.022
ripk2 receptor-interacting serine-threonine kinase 2 0.022
esr1 estrogen receptor 1 0.022
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.022
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.022
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.022
odc1 ornithine decarboxylase 1 0.021
lama2 laminin, alpha 2 0.021
LOC100534970 hypothetical protein LOC100534970 0.021
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.021
fgfr3 fibroblast growth factor receptor 3 0.020
scn1a sodium channel, voltage-gated, type I, alpha 0.019
ctgf connective tissue growth factor 0.019
si:ch211-195h23.3 si:ch211-195h23.3 0.019
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.019
appb amyloid beta (A4) precursor protein b 0.019
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.018
LOC100000934 hypothetical protein LOC100000934 0.018
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.018
ptk2.1 protein tyrosine kinase 2a 0.018
hoxd4a homeo box D4a 0.017
hoxa1a homeo box A1a 0.017
il1b interleukin 1, beta and interleukin 1, beta 0.017
im:7154036 im:7154036 0.016
egfra epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 0.016
desma desmin a 0.015
bcar1 breast cancer anti-estrogen resistance 1 0.015
prkcz protein kinase C, zeta 0.015
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.015
fn1 fibronectin 1 0.015
rc3 rabconnectin 3 0.015
pomt2 protein-O-mannosyltransferase 2 0.015
cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.015
tln1 talin 1 0.015
st5 suppression of tumorigenicity 5 0.015
adora2aa adenosine A2a receptor a 0.015
zgc:112257 zgc:112257 0.014
mybpc2b myosin binding protein C, fast type b 0.014
slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 0.014
lta4h leukotriene A4 hydrolase 0.014
trim55a tripartite motif-containing 55a 0.014
bmp2a bone morphogenetic protein 2a 0.014
oaz2b ornithine decarboxylase antizyme 2b 0.014
tes testis derived transcript (3 LIM domains) 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.998
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.991
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.984
GRB2 growth factor receptor-bound protein 2 0.973
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.968
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.961
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.906
FYN FYN oncogene related to SRC, FGR, YES 0.869
SH3KBP1 SH3-domain kinase binding protein 1 0.809
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.762
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.715
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.604
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.601
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.559
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.456
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.439
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.389
LAT linker for activation of T cells 0.382
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.381
SYK spleen tyrosine kinase 0.374
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.361
WIPF1 WAS/WASL interacting protein family, member 1 0.359
GRB7 growth factor receptor-bound protein 7 0.355
AKR1C2 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) 0.340
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.322
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.301
AXL AXL receptor tyrosine kinase 0.285
WASL Wiskott-Aldrich syndrome-like 0.273
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.264
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.244
SH2D4A SH2 domain containing 4A 0.239
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.237
BMP2 bone morphogenetic protein 2 0.226
PLCG1 phospholipase C, gamma 1 0.215
FKBP1A FK506 binding protein 1A, 12kDa 0.212
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.210
ENG endoglin 0.208
BCAR1 breast cancer anti-estrogen resistance 1 0.206
BCR breakpoint cluster region 0.205
TGFB1 transforming growth factor, beta 1 0.205
CCR5 chemokine (C-C motif) receptor 5 0.182
GRAP2 GRB2-related adaptor protein 2 0.181
PTK2 PTK2 protein tyrosine kinase 2 0.159
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.157
MPDZ multiple PDZ domain protein 0.157
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.150
CAV1 caveolin 1, caveolae protein, 22kDa 0.144
ADRB1 adrenergic, beta-1-, receptor 0.138
FGA fibrinogen alpha chain 0.132
SNX9 sorting nexin 9 0.128
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.127
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.124
FGFR1 fibroblast growth factor receptor 1 0.122
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.121
TAL1 T-cell acute lymphocytic leukemia 1 0.120
SMAD7 SMAD family member 7 0.117
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.116
GHR growth hormone receptor 0.112
ILK integrin-linked kinase 0.106
NCK1 NCK adaptor protein 1 0.103
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.095
NRP1 neuropilin 1 0.095
RXRA retinoid X receptor, alpha 0.092
IRS1 insulin receptor substrate 1 0.090
ADAM17 ADAM metallopeptidase domain 17 0.090
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.089
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.088
CCL2 chemokine (C-C motif) ligand 2 0.087
STK4 serine/threonine kinase 4 0.086
MED28 mediator complex subunit 28 0.085
CCL4 chemokine (C-C motif) ligand 4 0.079
ADORA2A adenosine A2a receptor 0.079
DPP4 dipeptidyl-peptidase 4 0.078
GAB1 GRB2-associated binding protein 1 0.077
ZNF746 zinc finger protein 746 0.076
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.075
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.075
FAF1 Fas (TNFRSF6) associated factor 1 0.074
IGF1R insulin-like growth factor 1 receptor 0.073
STRADA STE20-related kinase adaptor alpha 0.072
TGFB3 transforming growth factor, beta 3 0.072
CXCL9 chemokine (C-X-C motif) ligand 9 0.071
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 0.071
GAS6 growth arrest-specific 6 0.071
HDAC1 histone deacetylase 1 0.068
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.067
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.067
UTRN utrophin 0.066
PARVA parvin, alpha 0.065
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.064
SPRR2A small proline-rich protein 2A 0.064
SMAD2 SMAD family member 2 0.061
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.060
CCL8 chemokine (C-C motif) ligand 8 0.059
DARC Duffy blood group, chemokine receptor 0.059
CSNK1E casein kinase 1, epsilon 0.058
S100A4 S100 calcium binding protein A4 0.057
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.056
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.055
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.054
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ddr1 discoidin domain receptor tyrosine kinase 1 0.016
Dbp D site of albumin promoter (albumin D-box) binding protein 0.014
Fosl1 fos-like antigen 1 0.013
Ralgds ral guanine nucleotide dissociation stimulator 0.010
Gja5 gap junction protein, alpha 5 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism