The network for 'regulation of transcription involved in primary germ layer cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transcription involved in primary germ layer cell fate commitment

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in cells adopting an endoderm, ectoderm or mesoderm cell fate.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Bmp4 bone morphogenetic protein 4 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Foxc1 forkhead box C1 1.000
Pax3 paired box gene 3 1.000
Isl1 ISL1 transcription factor, LIM/homeodomain 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Fgf8 fibroblast growth factor 8 0.999
Tcfap2a transcription factor AP-2, alpha 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Tgfb2 transforming growth factor, beta 2 0.996
Tbx1 T-box 1 0.995
Pitx2 paired-like homeodomain transcription factor 2 0.995
Sox9 SRY-box containing gene 9 0.995
Prrx1 paired related homeobox 1 0.993
Foxc2 forkhead box C2 0.992
Smo smoothened homolog (Drosophila) 0.991
Fgfr1 fibroblast growth factor receptor 1 0.990
Msx1 homeobox, msh-like 1 0.989
Hand2 heart and neural crest derivatives expressed transcript 2 0.988
Meox2 mesenchyme homeobox 2 0.987
Bmp7 bone morphogenetic protein 7 0.983
Hand1 heart and neural crest derivatives expressed transcript 1 0.980
Zeb1 zinc finger E-box binding homeobox 1 0.979
Pax6 paired box gene 6 0.978
Ctnnb1 catenin (cadherin associated protein), beta 1 0.977
Ednra endothelin receptor type A 0.971
Rarb retinoic acid receptor, beta 0.969
Pax2 paired box gene 2 0.964
Dlx5 distal-less homeobox 5 0.956
Rarg retinoic acid receptor, gamma 0.949
Chd7 chromodomain helicase DNA binding protein 7 0.939
Jag1 jagged 1 0.933
Vegfa vascular endothelial growth factor A 0.915
Efnb2 ephrin B2 0.905
Foxg1 forkhead box G1 0.900
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.893
Ntf3 neurotrophin 3 0.881
Gbx2 gastrulation brain homeobox 2 0.873
Fgfr3 fibroblast growth factor receptor 3 0.856
Sox2 SRY-box containing gene 2 0.855
Gli2 GLI-Kruppel family member GLI2 0.848
Gata4 GATA binding protein 4 0.810
Fgf10 fibroblast growth factor 10 0.773
Sox11 SRY-box containing gene 11 0.756
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.755
Chrd chordin 0.735
Rara retinoic acid receptor, alpha 0.696
Hoxa1 homeobox A1 0.672
Hes1 hairy and enhancer of split 1 (Drosophila) 0.660
Nf1 neurofibromatosis 1 0.623
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.615
Acvr1 activin A receptor, type 1 0.600
Sox4 SRY-box containing gene 4 0.592
Vangl2 vang-like 2 (van gogh, Drosophila) 0.589
Pbx1 pre B-cell leukemia transcription factor 1 0.544
Nog noggin 0.522
Alx4 aristaless-like homeobox 4 0.519
Msx2 homeobox, msh-like 2 0.511
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.497
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.478
Otx1 orthodenticle homolog 1 (Drosophila) 0.473
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.470
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.469
Gsc goosecoid homeobox 0.459
Prrx2 paired related homeobox 2 0.453
Alx1 ALX homeobox 1 0.423
Emx2 empty spiracles homolog 2 (Drosophila) 0.399
Rxra retinoid X receptor alpha 0.381
Lef1 lymphoid enhancer binding factor 1 0.376
Runx2 runt related transcription factor 2 0.360
Hoxa3 homeobox A3 0.306
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.288
Hesx1 homeobox gene expressed in ES cells 0.273
Ece1 endothelin converting enzyme 1 0.273
Ptch1 patched homolog 1 0.269
Ret ret proto-oncogene 0.268
Bmper BMP-binding endothelial regulator 0.256
Pou5f1 POU domain, class 5, transcription factor 1 0.242
Bmpr1a bone morphogenetic protein receptor, type 1A 0.234
Bmp2 bone morphogenetic protein 2 0.232
Lmx1b LIM homeobox transcription factor 1 beta 0.231
Fgf3 fibroblast growth factor 3 0.195
Mesp1 mesoderm posterior 1 0.189
Sall4 sal-like 4 (Drosophila) 0.182
Cdh5 cadherin 5 0.167
Col2a1 collagen, type II, alpha 1 0.163
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.161
Sall3 sal-like 3 (Drosophila) 0.156
Pitx1 paired-like homeodomain transcription factor 1 0.152
Rasip1 Ras interacting protein 1 0.146
Emx1 empty spiracles homolog 1 (Drosophila) 0.141
Lrp6 low density lipoprotein receptor-related protein 6 0.138
Trp53 transformation related protein 53 0.120
Lhx1 LIM homeobox protein 1 0.113
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.105
Hes5 hairy and enhancer of split 5 (Drosophila) 0.101
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.095
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.758
vent ventral expressed homeobox 0.014
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism