The network for 'negative regulation of intracellular signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of intracellular signal transduction

Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.

Mus musculus
Name Description Probability Func Analog Organism
Apc adenomatosis polyposis coli 0.994
Cd44 CD44 antigen 0.993
Lyz2 lysozyme 2 0.991
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.959
Lepr leptin receptor 0.958
Stat3 signal transducer and activator of transcription 3 0.936
Mdm2 transformed mouse 3T3 cell double minute 2 0.912
Ptprc protein tyrosine phosphatase, receptor type, C 0.905
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.897
Mapk1 mitogen-activated protein kinase 1 0.892
Ptgs2 prostaglandin-endoperoxide synthase 2 0.890
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.876
Traf6 TNF receptor-associated factor 6 0.875
Cav1 caveolin 1, caveolae protein 0.871
Ctnnb1 catenin (cadherin associated protein), beta 1 0.870
Atf2 activating transcription factor 2 0.831
Rb1 retinoblastoma 1 0.810
Skil SKI-like 0.735
Sqstm1 sequestosome 1 0.732
Prkcc protein kinase C, gamma 0.725
Myd88 myeloid differentiation primary response gene 88 0.719
Ikbkb inhibitor of kappaB kinase beta 0.703
Yap1 yes-associated protein 1 0.697
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.697
Ghr growth hormone receptor 0.694
Mapk14 mitogen-activated protein kinase 14 0.673
Nf2 neurofibromatosis 2 0.664
Prkce protein kinase C, epsilon 0.653
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.649
Bmp4 bone morphogenetic protein 4 0.637
Pten phosphatase and tensin homolog 0.636
Ubc ubiquitin C 0.605
Smad1 MAD homolog 1 (Drosophila) 0.601
Ccnd1 cyclin D1 0.599
Trp53 transformation related protein 53 0.594
Cbl Casitas B-lineage lymphoma 0.593
Smad4 MAD homolog 4 (Drosophila) 0.576
Cyld cylindromatosis (turban tumor syndrome) 0.570
Tnf tumor necrosis factor 0.561
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.546
Spry4 sprouty homolog 4 (Drosophila) 0.541
Clock circadian locomotor output cycles kaput 0.536
Igh immunoglobulin heavy chain complex 0.534
Grb10 growth factor receptor bound protein 10 0.529
Selp selectin, platelet 0.523
Insr insulin receptor 0.522
Mdm4 transformed mouse 3T3 cell double minute 4 0.516
C1qc complement component 1, q subcomponent, C chain 0.515
Nos1 nitric oxide synthase 1, neuronal 0.512
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.510
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.505
Il1r1 interleukin 1 receptor, type I 0.497
Itga3 integrin alpha 3 0.495
Cd40 CD40 antigen 0.495
Was Wiskott-Aldrich syndrome homolog (human) 0.491
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.483
Thbs1 thrombospondin 1 0.480
Axl AXL receptor tyrosine kinase 0.471
Sfrp2 secreted frizzled-related protein 2 0.468
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.466
Plcg1 phospholipase C, gamma 1 0.466
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.465
Adam17 a disintegrin and metallopeptidase domain 17 0.451
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.446
Ldb3 LIM domain binding 3 0.445
Socs1 suppressor of cytokine signaling 1 0.442
Wt1 Wilms tumor 1 homolog 0.425
S1pr2 sphingosine-1-phosphate receptor 2 0.418
Vasp vasodilator-stimulated phosphoprotein 0.407
Socs3 suppressor of cytokine signaling 3 0.406
Grb2 growth factor receptor bound protein 2 0.399
Crebbp CREB binding protein 0.394
Nos3 nitric oxide synthase 3, endothelial cell 0.390
Ncoa3 nuclear receptor coactivator 3 0.388
Ahr aryl-hydrocarbon receptor 0.388
Btk Bruton agammaglobulinemia tyrosine kinase 0.387
Bdkrb2 bradykinin receptor, beta 2 0.385
Prkcb protein kinase C, beta 0.383
Hoxd13 homeobox D13 0.369
Pthlh parathyroid hormone-like peptide 0.368
Hic1 hypermethylated in cancer 1 0.365
Hif1a hypoxia inducible factor 1, alpha subunit 0.365
Tead3 TEA domain family member 3 0.361
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.360
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.355
Snai1 snail homolog 1 (Drosophila) 0.355
Foxf1a forkhead box F1a 0.353
Il1b interleukin 1 beta 0.352
Slc34a1 solute carrier family 34 (sodium phosphate), member 1 0.346
Cd86 CD86 antigen 0.343
Mapk11 mitogen-activated protein kinase 11 0.341
Cry2 cryptochrome 2 (photolyase-like) 0.339
Gsk3b glycogen synthase kinase 3 beta 0.337
Arrb2 arrestin, beta 2 0.337
Cacng2 calcium channel, voltage-dependent, gamma subunit 2 0.336
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.336
Hbegf heparin-binding EGF-like growth factor 0.336
S1pr3 sphingosine-1-phosphate receptor 3 0.334
Egfr epidermal growth factor receptor 0.333
Smad3 MAD homolog 3 (Drosophila) 0.329
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
goa-1 Protein GOA-1 0.021
pkg-1 Protein PKG-1 0.019
egl-18 Protein EGL-18 0.017
vab-3 Protein VAB-3 0.015
F36D4.5 Protein F36D4.5 0.014
mec-2 Protein MEC-2 0.014
plc-1 Protein PLC-1 0.013
inx-12 Protein INX-12 0.013
ida-1 Protein IDA-1 0.013
inx-13 Protein INX-13 0.012
pdfr-1 Protein PDFR-1 0.012
eps-8 Protein EPS-8 0.012
unc-7 Protein UNC-7 0.011
rhi-1 Protein RHI-1 0.011
puf-5 Protein PUF-5 0.011
exc-5 Protein EXC-5 0.011
unc-43 Protein UNC-43 0.010
nhr-6 Protein NHR-6 0.010
hgrs-1 Protein HGRS-1 0.010
lin-66 Protein LIN-66 0.010
pry-1 Protein PRY-1 0.010
plc-3 Protein PLC-3 0.010
kgb-1 Protein KGB-1 0.010
unc-104 Protein UNC-104 0.010
gpb-1 Protein GPB-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
fgf3 fibroblast growth factor 3 0.238
nf1a neurofibromin 1a 0.185
chd chordin 0.156
odc1 ornithine decarboxylase 1 0.151
spry4 sprouty (Drosophila) homolog 4 0.137
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.137
per3 period homolog 3 (Drosophila) 0.110
sox9b SRY-box containing gene 9b 0.106
mmp9 matrix metalloproteinase 9 0.088
myod1 myogenic differentiation 1 0.080
efnb2a ephrin B2a 0.078
acvr1b activin A receptor, type IB 0.076
rarab retinoic acid receptor, alpha b 0.072
tbx20 T-box 20 0.068
bcl2l1 bcl2-like 1 0.067
etv5a ets variant 5a 0.064
ptgs2a prostaglandin-endoperoxide synthase 2a 0.063
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.058
fgfr1a fibroblast growth factor receptor 1a 0.056
apoeb apolipoprotein Eb 0.056
mcl1b myeloid cell leukemia sequence 1b 0.055
epha4a eph receptor A4a 0.049
egr1 early growth response 1 0.049
fyna FYN oncogene related to SRC, FGR, YES a 0.049
mcl1a myeloid cell leukemia sequence 1a 0.048
zgc:113159 zgc:113159 0.046
wnt11r wingless-type MMTV integration site family, member 11, related 0.046
itgb1a integrin, beta 1a 0.044
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.044
mapk3 mitogen-activated protein kinase 3 0.044
crabp2b cellular retinoic acid binding protein 2, b 0.042
tob1a transducer of ERBB2, 1a 0.042
znf703 zinc finger protein 703 0.042
tlr3 toll-like receptor 3 0.041
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.040
adipor2 adiponectin receptor 2 0.039
ins preproinsulin 0.039
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.039
itgb1b.2 integrin, beta 1b.2 0.039
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.039
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.039
stat1a signal transduction and activation of transcription 1a 0.038
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.037
zgc:55813 zgc:55813 0.036
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.036
hcrt hypocretin (orexin) neuropeptide precursor 0.036
zgc:91870 zgc:91870 0.035
ocrl oculocerebrorenal syndrome of Lowe 0.035
ptprk protein tyrosine phosphatase, receptor type, K 0.035
spry2 sprouty homolog 2 0.035
cx43 connexin 43 0.033
lef1 lymphocyte enhancer binding factor 1 0.032
matn4 matrilin 4 0.031
socs3a suppressor of cytokine signaling 3a 0.031
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.031
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.030
foxi3b forkhead box I3b 0.030
ntn2 netrin 2 0.030
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.029
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.029
zbtb4 zinc finger and BTB domain containing 4 0.029
tbx2b T-box 2b 0.029
fzd8a frizzled homolog 8a 0.029
sema3aa semaphorin 3aa 0.028
bmp2b bone morphogenetic protein 2b 0.028
furina furin (paired basic amino acid cleaving enzyme) a 0.028
igf2a insulin-like growth factor 2a 0.027
atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.027
msi1 musashi homolog 1 (Drosophila) 0.027
sec24c SEC24 family, member C (S. cerevisiae) 0.027
esco2 establishment of cohesion 1 homolog 2 0.027
ip6k2 inositol hexaphosphate kinase 2 0.027
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.027
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.026
metrnl meteorin, glial cell differentiation regulator-like 0.026
gclc glutamate-cysteine ligase, catalytic subunit 0.026
tp53bp2 tumor protein p53 binding protein, 2 0.025
eno2 enolase 2 0.025
eya2 eyes absent homolog 2 (Drosophila) 0.025
sox10 SRY-box containing gene 10 0.025
LOC100537975 thyroid receptor-interacting protein 11-like 0.024
sid4 secreted immunoglobulin domain 4 0.024
ahi1 Abelson helper integration site 1 0.024
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.024
slit3 slit (Drosophila) homolog 3 0.024
im:7164961 im:7164961 0.023
mycbp2 MYC binding protein 2 0.023
itgb1b integrin, beta 1b 0.023
gpr126 G protein-coupled receptor 126 0.023
stk11 serine/threonine kinase 11 0.023
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.023
zc3h13 zinc finger CCCH-type containing 13 0.023
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.023
pcna proliferating cell nuclear antigen 0.023
sas sarcoma amplified sequence 0.022
phc2 polyhomeotic-like 2 (Drosophila) 0.022
zgc:172136 zgc:172136 0.022
sod1 superoxide dismutase 1, soluble 0.022
zgc:64114 zgc:64114 0.022
tpm3 tropomyosin 3 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
rl rolled 0.861
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.861
kay kayak 0.760
Akt1 CG4006 gene product from transcript CG4006-RA 0.731
krz kurtz 0.696
Atg1 Autophagy-specific gene 1 0.633
hpo hippo 0.611
key kenny 0.553
Pka-C1 cAMP-dependent protein kinase 1 0.513
put punt 0.507
InR Insulin-like receptor 0.470
hep hemipterous 0.450
dco discs overgrown 0.447
p53 CG33336 gene product from transcript CG33336-RB 0.372
NFAT NFAT homolog 0.369
shn schnurri 0.321
par-1 CG8201 gene product from transcript CG8201-RA 0.317
dm diminutive 0.312
puc puckered 0.304
S6k RPS6-p70-protein kinase 0.265
Tsc1 CG6147 gene product from transcript CG6147-RA 0.254
Ras64B Ras oncogene at 64B 0.251
hipk homeodomain interacting protein kinase 0.247
Lnk CG17367 gene product from transcript CG17367-RC 0.237
alph alphabet 0.233
AGO2 Argonaute 2 0.232
chico CG5686 gene product from transcript CG5686-RB 0.231
cher cheerio 0.228
p38b CG7393 gene product from transcript CG7393-RA 0.226
wts warts 0.216
Atg13 Autophagy-specific gene 13 0.203
ttk tramtrack 0.175
cindr CIN85 and CD2AP orthologue 0.171
ed echinoid 0.169
Mer Merlin 0.167
CG8155 CG8155 gene product from transcript CG8155-RA 0.162
mys myospheroid 0.157
Rab7 Rab-protein 7 0.151
capt capulet 0.149
dx deltex 0.145
Hsc70-4 Heat shock protein cognate 4 0.144
brk brinker 0.140
PGRP-LC Peptidoglycan recognition protein LC 0.136
Myo31DF Myosin 31DF 0.134
Caf1 Chromatin assembly factor 1 subunit 0.130
CycD Cyclin D 0.128
nct nicastrin 0.126
fs(1)h female sterile (1) homeotic 0.123
sxc super sex combs 0.121
mnb minibrain 0.120
AttA Attacin-A 0.116
nmo nemo 0.114
CycG Cyclin G 0.114
ap apterous 0.113
pan pangolin 0.110
ago archipelago 0.110
fz2 frizzled 2 0.107
Pk61C Protein kinase 61C 0.106
DptB Diptericin B 0.099
robo roundabout 0.097
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.096
drk downstream of receptor kinase 0.092
ash2 absent, small, or homeotic discs 2 0.091
raw CG12437 gene product from transcript CG12437-RB 0.091
sax saxophone 0.091
Atg18 Autophagy-specific gene 18 0.089
Cka Connector of kinase to AP-1 0.089
lin lines 0.088
Rheb CG1081 gene product from transcript CG1081-RA 0.085
POSH Plenty of SH3s 0.085
eIF-4a Eukaryotic initiation factor 4a 0.084
Tab2 TAK1-associated binding protein 2 0.082
Sin3A CG8815 gene product from transcript CG8815-RC 0.081
shi shibire 0.081
Mpk2 CG5475 gene product from transcript CG5475-RB 0.080
Ack CG14992 gene product from transcript CG14992-RA 0.079
kis kismet 0.079
Moe Moesin 0.079
Rel Relish 0.075
Ten-m Tenascin major 0.075
CG8090 CG8090 gene product from transcript CG8090-RB 0.075
PGRP-SD CG7496 gene product from transcript CG7496-RA 0.075
Arr2 Arrestin 2 0.074
Apc APC-like 0.073
cnk connector enhancer of ksr 0.072
Spn27A Serpin 27A 0.072
scb scab 0.071
phl pole hole 0.071
aop anterior open 0.071
smo smoothened 0.070
caz cabeza 0.070
CG5794 CG5794 gene product from transcript CG5794-RB 0.070
Egfr Epidermal growth factor receptor 0.070
Smr Smrter 0.070
Thor CG8846 gene product from transcript CG8846-RA 0.069
trp transient receptor potential 0.069
Mekk1 CG7717 gene product from transcript CG7717-RB 0.069
sog short gastrulation 0.069
Mtk Metchnikowin 0.069
chb chromosome bows 0.069
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.995
UBC ubiquitin C 0.992
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.991
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.989
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.973
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.970
FYN FYN oncogene related to SRC, FGR, YES 0.966
MAPK14 mitogen-activated protein kinase 14 0.952
ESR1 estrogen receptor 1 0.943
MAPK1 mitogen-activated protein kinase 1 0.938
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.907
GRB2 growth factor receptor-bound protein 2 0.895
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.891
TP53 tumor protein p53 0.876
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.875
PDCD6IP programmed cell death 6 interacting protein 0.873
EGFR epidermal growth factor receptor 0.857
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.854
HDAC1 histone deacetylase 1 0.846
BCL2 B-cell CLL/lymphoma 2 0.824
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.806
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.771
GHR growth hormone receptor 0.761
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.755
YAP1 Yes-associated protein 1 0.737
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.735
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.718
MAPK8 mitogen-activated protein kinase 8 0.707
SH3KBP1 SH3-domain kinase binding protein 1 0.694
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.693
MET met proto-oncogene (hepatocyte growth factor receptor) 0.683
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.649
ZNF43 zinc finger protein 43 0.618
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.607
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.599
BTRC beta-transducin repeat containing 0.583
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.557
PRKCZ protein kinase C, zeta 0.552
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.542
GSK3B glycogen synthase kinase 3 beta 0.506
FBXW11 F-box and WD repeat domain containing 11 0.502
BMI1 BMI1 polycomb ring finger oncogene 0.498
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.498
CFLAR CASP8 and FADD-like apoptosis regulator 0.494
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.479
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.465
SQSTM1 sequestosome 1 0.463
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.461
MPDZ multiple PDZ domain protein 0.442
JUN jun proto-oncogene 0.433
PML promyelocytic leukemia 0.422
FAS Fas (TNF receptor superfamily, member 6) 0.420
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.412
CREBBP CREB binding protein 0.412
DUSP1 dual specificity phosphatase 1 0.402
FHL2 four and a half LIM domains 2 0.400
TRAF6 TNF receptor-associated factor 6 0.387
TSC2 tuberous sclerosis 2 0.384
KEAP1 kelch-like ECH-associated protein 1 0.383
BIRC2 baculoviral IAP repeat containing 2 0.380
CHUK conserved helix-loop-helix ubiquitous kinase 0.371
PTK2B PTK2B protein tyrosine kinase 2 beta 0.364
RNF11 ring finger protein 11 0.352
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.349
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.344
PTK2 PTK2 protein tyrosine kinase 2 0.332
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.329
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.329
BCAR1 breast cancer anti-estrogen resistance 1 0.325
RICTOR RPTOR independent companion of MTOR, complex 2 0.322
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.318
INSR insulin receptor 0.314
MYD88 myeloid differentiation primary response gene (88) 0.304
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.302
CDC25A cell division cycle 25 homolog A (S. pombe) 0.300
ZNF746 zinc finger protein 746 0.297
PTEN phosphatase and tensin homolog 0.294
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.290
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.288
SMAD3 SMAD family member 3 0.281
ZNF253 zinc finger protein 253 0.279
SYK spleen tyrosine kinase 0.278
BMPR1A bone morphogenetic protein receptor, type IA 0.277
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.277
ZNF273 zinc finger protein 273 0.271
OPTN optineurin 0.264
LCK lymphocyte-specific protein tyrosine kinase 0.263
MAP2K4 mitogen-activated protein kinase kinase 4 0.262
VCP valosin containing protein 0.262
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.259
BCL2L1 BCL2-like 1 0.259
NCOR2 nuclear receptor corepressor 2 0.258
CBX5 chromobox homolog 5 0.255
MED28 mediator complex subunit 28 0.254
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.253
MAP2K3 mitogen-activated protein kinase kinase 3 0.253
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.253
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.251
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.250
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Rattus norvegicus
Name Description Probability Func Analog Organism
Vdac1 voltage-dependent anion channel 1 0.115
Klf2 Kruppel-like factor 2 (lung) 0.102
Errfi1 ERBB receptor feedback inhibitor 1 0.088
Klf6 Kruppel-like factor 6 0.083
Rab1b RAB1B, member RAS oncogene family 0.071
Anxa1 annexin A1 0.059
Dlg3 discs, large homolog 3 (Drosophila) 0.057
Capg capping protein (actin filament), gelsolin-like 0.051
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.048
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.048
LOC100362824 caveolin 2-like 0.046
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.046
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.045
Klf4 Kruppel-like factor 4 (gut) 0.045
Tsc22d3 TSC22 domain family, member 3 0.044
Jdp2 Jun dimerization protein 2 0.043
Prkcd protein kinase C, delta 0.042
Sirpa signal-regulatory protein alpha 0.041
Jak1 Janus kinase 1 0.040
Jak2 Janus kinase 2 0.040
Snrk SNF related kinase 0.039
Usf2 upstream transcription factor 2, c-fos interacting 0.038
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.036
Junb jun B proto-oncogene 0.035
Nos3 nitric oxide synthase 3, endothelial cell 0.035
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.035
Vegfa vascular endothelial growth factor A 0.035
Efnb1 ephrin B1 0.035
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.034
Crip2 cysteine-rich protein 2 0.034
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.033
Matk megakaryocyte-associated tyrosine kinase 0.033
Hoxa1 homeo box A1 0.032
Pacs1 phosphofurin acidic cluster sorting protein 1 0.032
Ddn dendrin 0.032
Fmnl1 formin-like 1 0.032
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.032
Tufm Tu translation elongation factor, mitochondrial 0.032
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.032
Adam10 ADAM metallopeptidase domain 10 0.031
Sh2b3 SH2B adaptor protein 3 0.031
Foxe3 forkhead box E3 0.031
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.030
Zfp36 zinc finger protein 36 0.029
Rara retinoic acid receptor, alpha 0.029
Cand1 cullin-associated and neddylation-dissociated 1 0.028
Gja1 gap junction protein, alpha 1 0.028
RT1-DMa RT1 class II, locus DMa 0.028
RT1-Db1 RT1 class II, locus Db1 0.027
Utrn utrophin 0.027
Myd88 myeloid differentiation primary response gene 88 0.027
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.027
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.027
Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform 0.027
Tgfb1 transforming growth factor, beta 1 0.026
Jun Jun oncogene 0.026
Tgfbr3 transforming growth factor, beta receptor III 0.026
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.025
Map3k3 mitogen activated protein kinase kinase kinase 3 0.025
Map2 microtubule-associated protein 2 0.025
Ralgds ral guanine nucleotide dissociation stimulator 0.025
Tcfe2a transcription factor E2a 0.025
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.025
Rcsd1 RCSD domain containing 1 0.025
Stat6 signal transducer and activator of transcription 6 0.025
Xpo1 exportin 1, CRM1 homolog (yeast) 0.024
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.024
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.024
Smad4 SMAD family member 4 0.024
Creb1 cAMP responsive element binding protein 1 0.024
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.024
Mapk3 mitogen activated protein kinase 3 0.024
Smad7 SMAD family member 7 0.024
Epn2 epsin 2 0.024
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.024
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.024
Baiap2 BAI1-associated protein 2 0.024
Scarb1 scavenger receptor class B, member 1 0.024
Homer1 homer homolog 1 (Drosophila) 0.023
Anxa5 annexin A5 0.023
Tcf12 transcription factor 12 0.023
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.023
Ifitm3 interferon induced transmembrane protein 3 0.023
Myo1b myosin Ib 0.023
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.023
Syt3 synaptotagmin III 0.022
Btg2 BTG family, member 2 0.022
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.022
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.022
Anxa2 annexin A2 0.022
RT1-DMb RT1 class II, locus DMb 0.021
Exoc5 exocyst complex component 5 0.021
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.021
Qars glutaminyl-tRNA synthetase 0.021
Slfn2 schlafen 2 0.021
Gprc5a G protein-coupled receptor, family C, group 5, member A 0.021
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.021
Cish cytokine inducible SH2-containing protein 0.020
Cldn2 claudin 2 0.020
Tspo translocator protein 0.020
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BCK1 Bck1p 0.926
CDC24 Cdc24p 0.599
KSS1 Kss1p 0.572
CLA4 Cla4p 0.564
GPB2 Gpb2p 0.532
BOI1 Boi1p 0.518
CAK1 Cak1p 0.423
FUS3 Fus3p 0.418
MSG5 Msg5p 0.370
IRA1 Ira1p 0.368
SLT2 Slt2p 0.345
RHO1 Rho1p 0.305
FAR1 Far1p 0.302
CDC25 Cdc25p 0.280
PBS2 Pbs2p 0.277
ROM2 Rom2p 0.270
DED1 Ded1p 0.258
MDS3 Mds3p 0.220
MKK1 Mkk1p 0.215
CDC55 Cdc55p 0.209
PPH21 Pph21p 0.174
STE7 Ste7p 0.171
PSP2 Psp2p 0.160
PHO85 Pho85p 0.147
PRR1 Prr1p 0.142
YDL233W hypothetical protein 0.140
RLM1 Rlm1p 0.140
FAB1 Fab1p 0.139
VPS5 Vps5p 0.137
STE20 Ste20p 0.136
GSC2 Gsc2p 0.136
STE12 Ste12p 0.134
KEM1 Kem1p 0.133
SAP190 Sap190p 0.120
ACK1 Ack1p 0.119
KDX1 Kdx1p 0.105
PIL1 Pil1p 0.103
CHS1 Chs1p 0.102
LHS1 Lhs1p 0.098
ENT1 Ent1p 0.097
URN1 Urn1p 0.096
MKK2 Mkk2p 0.096
MYO5 Myo5p 0.096
RAS2 Ras2p 0.094
DIG1 Dig1p 0.094
GPR1 Gpr1p 0.079
LSB1 Lsb1p 0.079
IWR1 Iwr1p 0.077
TPK2 Tpk2p 0.076
CYR1 Cyr1p 0.075
SAC7 Sac7p 0.073
BEM1 Bem1p 0.073
HKR1 Hkr1p 0.072
IRA2 Ira2p 0.071
YSC84 Ysc84p 0.071
NAT1 Nat1p 0.071
LEA1 Lea1p 0.070
HSM3 Hsm3p 0.068
PTC2 Ptc2p 0.065
CDC4 Cdc4p 0.063
STE11 Ste11p 0.063
BST1 Bst1p 0.062
SKT5 Skt5p 0.061
WWM1 Wwm1p 0.059
BOI2 Boi2p 0.057
BEM3 Bem3p 0.057
MRL1 Mrl1p 0.056
RTS1 Rts1p 0.054
CYK3 Cyk3p 0.053
DST1 Dst1p 0.052
INP53 Inp53p 0.051
YME1 Yme1p 0.051
SWE1 Swe1p 0.051
BEM2 Bem2p 0.051
SBE2 Sbe2p 0.050
PKH2 Pkh2p 0.048
YHB1 Yhb1p 0.048
SSN8 Ssn8p 0.048
MKT1 Mkt1p 0.048
HSL7 Hsl7p 0.047
UBP5 Ubp5p 0.046
FYV8 Fyv8p 0.046
SAK1 Sak1p 0.045
OSH3 Osh3p 0.045
PTP2 Ptp2p 0.045
CYC8 Cyc8p 0.044
TIP41 Tip41p 0.044
TPS1 Tps1p 0.044
ZRG8 Zrg8p 0.043
RRD1 Rrd1p 0.042
YJU2 Yju2p 0.042
SUR1 Sur1p 0.042
SLA2 Sla2p 0.042
ROM1 Rom1p 0.042
VAC7 Vac7p 0.041
MSS11 Mss11p 0.041
SCH9 Sch9p 0.040
RIM15 Rim15p 0.040
MUB1 Mub1p 0.040
BCK2 Bck2p 0.038