The network for 'positive regulation of gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of gtpase activity

Any process that activates or increases the activity of a GTPase.

Mus musculus
Name Description Probability Func Analog Organism
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.973
Dlg4 discs, large homolog 4 (Drosophila) 0.961
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.949
Arrb2 arrestin, beta 2 0.946
Grb2 growth factor receptor bound protein 2 0.930
Lepr leptin receptor 0.922
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.904
Braf Braf transforming gene 0.899
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.842
Akt1 thymoma viral proto-oncogene 1 0.837
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.818
Drd2 dopamine receptor D2 0.809
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.804
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.779
Prkcc protein kinase C, gamma 0.777
Ccl2 chemokine (C-C motif) ligand 2 0.758
Epha4 Eph receptor A4 0.695
Nf1 neurofibromatosis 1 0.690
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.684
Selplg selectin, platelet (p-selectin) ligand 0.676
Hmha1 histocompatibility (minor) HA-1 0.651
Cd44 CD44 antigen 0.647
Kl klotho 0.642
Cbl Casitas B-lineage lymphoma 0.635
Bax BCL2-associated X protein 0.632
Sh3bgrl SH3-binding domain glutamic acid-rich protein like 0.632
Ilk integrin linked kinase 0.614
Tsc1 tuberous sclerosis 1 0.590
Ephb2 Eph receptor B2 0.589
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.585
Plxna3 plexin A3 0.574
Sox10 SRY-box containing gene 10 0.568
Plxna1 plexin A1 0.560
Stag2 stromal antigen 2 0.557
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.555
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.547
Rac1 RAS-related C3 botulinum substrate 1 0.544
Pxn paxillin 0.533
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.528
Arhgap30 Rho GTPase activating protein 30 0.516
Bcl2 B-cell leukemia/lymphoma 2 0.513
Lrrk2 leucine-rich repeat kinase 2 0.483
Wipf1 WAS/WASL interacting protein family, member 1 0.483
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.483
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.479
Vav3 vav 3 oncogene 0.474
Ccr2 chemokine (C-C motif) receptor 2 0.460
Cd37 CD37 antigen 0.460
Gpsm3 G-protein signalling modulator 3 (AGS3-like, C. elegans) 0.458
Efnb2 ephrin B2 0.449
Mark4 MAP/microtubule affinity-regulating kinase 4 0.449
Adrbk1 adrenergic receptor kinase, beta 1 0.449
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.441
Pparg peroxisome proliferator activated receptor gamma 0.414
Rasgrp1 RAS guanyl releasing protein 1 0.405
Tmod3 tropomodulin 3 0.404
Vav1 vav 1 oncogene 0.398
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.393
Srgap2 SLIT-ROBO Rho GTPase activating protein 2 0.386
Bcr breakpoint cluster region 0.378
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.375
Vdr vitamin D receptor 0.371
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.363
Sh3bp1 SH3-domain binding protein 1 0.359
Cdk14 cyclin-dependent kinase 14 0.355
Nrbp2 nuclear receptor binding protein 2 0.354
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.353
Ctnnb1 catenin (cadherin associated protein), beta 1 0.353
Stxbp3a syntaxin binding protein 3A 0.347
Sstr4 somatostatin receptor 4 0.346
Eps15 epidermal growth factor receptor pathway substrate 15 0.342
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.340
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.338
Itga3 integrin alpha 3 0.337
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.333
Adrb1 adrenergic receptor, beta 1 0.328
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.325
Wnt7a wingless-related MMTV integration site 7A 0.322
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.322
Ntf3 neurotrophin 3 0.314
Pnpla2 patatin-like phospholipase domain containing 2 0.312
Nf2 neurofibromatosis 2 0.305
Parva parvin, alpha 0.301
Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 0.295
Plcg1 phospholipase C, gamma 1 0.293
Grid1 glutamate receptor, ionotropic, delta 1 0.292
Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.291
Fzd1 frizzled homolog 1 (Drosophila) 0.289
Laptm5 lysosomal-associated protein transmembrane 5 0.285
Rasgrp2 RAS, guanyl releasing protein 2 0.281
Apc adenomatosis polyposis coli 0.281
Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) 0.274
Ptk2 PTK2 protein tyrosine kinase 2 0.273
Npas2 neuronal PAS domain protein 2 0.271
Shc1 src homology 2 domain-containing transforming protein C1 0.268
Prkcd protein kinase C, delta 0.265
Vav2 vav 2 oncogene 0.265
Kalrn kalirin, RhoGEF kinase 0.261
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.251
Src Rous sarcoma oncogene 0.250
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
mpk-1 Protein MPK-1 0.524
goa-1 Protein GOA-1 0.439
CELE_F47G4.4 Protein F47G4.4 0.389
lag-1 Protein LAG-1 0.360
rpm-1 Protein RPM-1 0.267
plc-3 Protein PLC-3 0.259
sem-5 Protein SEM-5 0.243
C11E4.6 Protein C11E4.6 0.218
abl-1 Protein ABL-1 0.208
let-60 Protein LET-60 0.186
rig-6 Protein RIG-6 0.176
unc-53 Protein UNC-53 0.159
sad-1 Protein SAD-1 0.151
CELE_T10D4.6 Protein T10D4.6 0.147
pry-1 Protein PRY-1 0.144
itr-1 Protein ITR-1 0.135
egrh-1 Protein EGRH-1 0.127
zfp-3 Protein ZFP-3 0.124
snf-1 Protein SNF-1 0.117
egl-18 Protein EGL-18 0.113
sup-17 Protein SUP-17 0.107
eor-2 Protein EOR-2 0.107
lin-45 Protein LIN-45 0.106
fhod-1 Protein FHOD-1 0.106
afd-1 Protein AFD-1 0.101
Y54E5A.7 Protein Y54E5A.7 0.101
zoo-1 Protein ZOO-1 0.098
cyld-1 Protein CYLD-1 0.098
mei-1 Protein MEI-1 0.094
unc-71 Protein UNC-71 0.093
C15H9.5 Protein C15H9.5 0.093
flh-2 Protein FLH-2 0.092
rps-2 Protein RPS-2 0.092
morc-1 Protein MORC-1 0.091
pat-3 Protein PAT-3 0.090
rme-4 Protein RME-4 0.088
ptp-4 Protein PTP-4 0.080
stau-1 Protein STAU-1 0.077
chc-1 Protein CHC-1 0.076
T28B11.1 Protein T28B11.1 0.073
egl-8 Protein EGL-8 0.073
atg-2 Protein ATG-2 0.071
tmd-2 Protein TMD-2 0.070
atg-11 Protein ATG-11 0.070
sax-3 Protein SAX-3 0.069
unc-73 Protein UNC-73 0.068
F52G3.1 Protein F52G3.1 0.065
vab-8 Protein VAB-8 0.064
rab-5 Protein RAB-5 0.064
unc-26 Protein UNC-26 0.064
coh-3 Protein COH-3 0.064
tag-343 Protein TAG-343 0.061
magi-1 Protein MAGI-1 0.061
iglr-1 Protein IGLR-1 0.060
dpy-21 Protein DPY-21 0.060
unc-16 Protein UNC-16 0.060
T23F11.1 Protein T23F11.1 0.058
R90.1 Protein R90.1 0.056
miro-1 Protein MIRO-1 0.056
ptr-5 Protein PTR-5 0.056
cah-6 Protein CAH-6 0.056
ptp-1 Protein PTP-1 0.056
sav-1 Protein SAV-1 0.055
rgr-1 Protein RGR-1 0.054
tmc-2 Protein TMC-2 0.054
cgef-1 Protein CGEF-1 0.054
mel-28 Protein MEL-28 0.054
gap-2 Protein GAP-2 0.053
ash-2 Protein ASH-2 0.051
CELE_W07A8.2 Protein W07A8.2 0.051
pqn-39 Protein PQN-39 0.051
ajm-1 Protein AJM-1 0.050
skn-1 Protein SKN-1 0.050
etr-1 Protein ETR-1 0.050
sym-4 Protein SYM-4 0.049
tbc-12 Protein TBC-12 0.047
Y48C3A.14 Protein Y48C3A.14 0.046
B0001.7 Protein B0001.7 0.046
pfd-6 Protein PFD-6 0.046
par-3 Protein PAR-3 0.045
ykt-6 Protein YKT-6 0.045
K09E4.4 Protein K09E4.4 0.044
F28B3.1 Protein F28B3.1 0.044
pak-1 Protein PAK-1 0.043
unc-79 Protein UNC-79 0.043
mtm-3 Protein MTM-3 0.043
dpy-27 Protein DPY-27 0.043
CELE_C52D10.12 Protein C52D10.12 0.043
frm-7 Protein FRM-7 0.042
C06G1.5 Protein C06G1.5 0.041
rhgf-2 Protein RHGF-2 0.041
ist-1 Protein IST-1 0.039
rpl-3 Protein RPL-3 0.039
par-6 Protein PAR-6 0.039
T23F2.2 Protein T23F2.2 0.039
nep-21 Protein NEP-21 0.039
gly-7 Protein GLY-7 0.038
rgl-1 Protein RGL-1 0.038
sam-10 Protein SAM-10 0.037
larp-5 Protein LARP-5 0.037
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Danio rerio
Name Description Probability Func Analog Organism
adrb2a adrenergic receptor, beta 2a 0.315
nf1a neurofibromin 1a 0.286
rtcd1 RNA terminal phosphate cyclase domain 1 0.268
cnn2 calponin 2 0.262
bida BH3 interacting domain death agonist 0.236
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.203
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.199
bcl2 B-cell leukemia/lymphoma 2 0.198
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.191
mcl1b myeloid cell leukemia sequence 1b 0.180
zgc:77517 zgc:77517 0.155
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.148
tm9sf2 transmembrane 9 superfamily member 2 0.147
tpm4 tropomyosin 4 0.132
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.126
msna moesin a 0.112
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.109
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.107
yrk Yes-related kinase 0.101
acsl4a acyl-CoA synthetase long-chain family member 4a 0.099
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.088
iqgap1 IQ motif containing GTPase activating protein 1 0.083
mcl1a myeloid cell leukemia sequence 1a 0.079
ilk integrin linked kinase 0.078
krt8 keratin 8 0.078
tsc22d3 TSC22 domain family, member 3 0.077
nf1b neurofibromin 1b 0.076
rtn1a reticulon 1a 0.072
arpc1a actin related protein 2/3 complex, subunit 1A 0.071
si:ch211-232m7.1 si:ch211-232m7.1 0.071
yap1 Yes-associated protein 1 0.068
stmn4 stathmin-like 4 0.068
dmbx1b diencephalon/mesencephalon homeobox 1b 0.067
zgc:112329 zgc:112329 0.067
gng12a guanine nucleotide binding protein (G protein), gamma 12a 0.066
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.066
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.065
ptgs2a prostaglandin-endoperoxide synthase 2a 0.065
lifrb leukemia inhibitory factor receptor alpha b 0.063
anxa2a annexin A2a 0.063
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.062
icn ictacalcin 0.062
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.061
zgc:92392 zgc:92392 0.061
ldb1a LIM-domain binding factor 1a 0.060
cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.059
jun jun proto-oncogene 0.059
gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.059
tbeta-a beta thymosin-like protein 2 0.057
pfn1 profilin 1 0.056
nus1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.056
pparg peroxisome proliferator activated receptor gamma 0.055
rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.055
unc5b unc-5 homolog B (C. elegans) 0.055
zgc:64106 zgc:64106 0.055
b3gnt5a UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5a 0.054
bcl2l1 bcl2-like 1 0.054
slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.054
pak2a p21 (CDKN1A)-activated kinase 2a 0.054
birc2 baculoviral IAP repeat-containing 2 0.053
LOC565839 tumor necrosis factor alpha-induced protein 2-like 0.053
pdlim1 PDZ and LIM domain 1 (elfin) 0.053
perp PERP, TP53 apoptosis effector 0.050
zbtb4 zinc finger and BTB domain containing 4 0.050
rps6ka3a ribosomal protein S6 kinase, polypeptide 3a 0.050
dusp4 dual specificity phosphatase 4 0.049
adrb3a adrenergic receptor, beta 3a 0.049
scinlb scinderin like b 0.049
zgc:153997 zgc:153997 0.048
rorca RAR-related orphan receptor C a 0.048
mycbp2 MYC binding protein 2 0.048
s100v2 S100 calcium binding protein V2 0.047
optc opticin 0.047
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.046
vdrb vitamin D receptor b 0.046
rrm2 ribonucleotide reductase M2 polypeptide 0.045
robo4 roundabout homolog 4 0.045
gltscr1 glioma tumor suppressor candidate region gene 1 0.045
zgc:63587 zgc:63587 0.045
gstal glutathione S-transferase, alpha-like 0.045
dzip1 DAZ interacting protein 1 0.044
mapk14a mitogen-activated protein kinase 14a 0.044
si:dkey-21k24.2 si:dkey-21k24.2 0.044
efna1b ephrin A1b 0.044
smyd3 SET and MYND domain containing 3 0.044
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.044
zgc:101810 zgc:101810 0.043
copeb core promoter element binding protein 0.043
fbxw11b F-box and WD-40 domain protein 11b 0.043
zgc:56466 zgc:56466 0.043
slc4a2a solute carrier family 4, anion exchanger, member 2a 0.043
eprs glutamyl-prolyl-tRNA synthetase 0.043
fam107b family with sequence similarity 107, member B 0.043
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.042
baxa bcl2-associated X protein, a 0.042
phlda2 pleckstrin homology-like domain, family A, member 2 0.042
lingo1a leucine rich repeat and Ig domain containing 1a 0.042
ctsba cathepsin B, a 0.042
im:7137453 im:7137453 0.042
sgpp1 sphingosine-1-phosphate phosphatase 1 0.042
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mbc myoblast city 0.939
cno canoe 0.793
rok Rho-kinase 0.749
LIMK1 LIM-kinase1 0.730
Pkn Protein kinase related to protein kinase N 0.655
plexB plexin B 0.636
Pten CG5671 gene product from transcript CG5671-RB 0.623
ena enabled 0.616
Wnk CG7177 gene product from transcript CG7177-RA 0.601
baz bazooka 0.511
Sbf SET domain binding factor 0.470
pod1 CG4532 gene product from transcript CG4532-RF 0.468
pbl pebble 0.440
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.365
RhoBTB CG5701 gene product from transcript CG5701-RA 0.361
Abi Abelson interacting protein 0.361
puc puckered 0.356
N Notch 0.354
tutl turtle 0.333
CalpB Calpain-B 0.322
Myo31DF Myosin 31DF 0.303
CG9426 CG9426 gene product from transcript CG9426-RA 0.293
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.291
lgs legless 0.286
mys myospheroid 0.282
Smg1 CG32743 gene product from transcript CG32743-RA 0.282
Hph HIF prolyl hydroxylase 0.276
Vps35 Vacuolar protein sorting 35 0.274
NaCP60E Na channel protein 60E 0.239
dia diaphanous 0.231
Vps45 Vacuolar protein sorting 45 0.226
raps rapsynoid 0.224
CG7158 CG7158 gene product from transcript CG7158-RA 0.218
sima similar 0.212
CycA Cyclin A 0.208
cenG1A centaurin gamma 1A 0.207
neur neuralized 0.206
Prp31 CG6876 gene product from transcript CG6876-RA 0.201
synj synaptojanin 0.192
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.190
CG32772 CG32772 gene product from transcript CG32772-RC 0.174
CG8334 CG8334 gene product from transcript CG8334-RA 0.170
smo smoothened 0.167
l(2)k16918 lethal (2) k16918 0.164
stai stathmin 0.161
stg string 0.159
Stat92E Signal-transducer and activator of transcription protein at 92E 0.158
CG6509 CG6509 gene product from transcript CG6509-RB 0.150
mbt mushroom bodies tiny 0.146
yata CG1973 gene product from transcript CG1973-RA 0.145
Zyx102EF CG32018 gene product from transcript CG32018-RA 0.143
neuroligin CG13772 gene product from transcript CG13772-RA 0.142
Sos Son of sevenless 0.139
nwk nervous wreck 0.134
jar jaguar 0.127
CG17233 CG17233 gene product from transcript CG17233-RA 0.125
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.125
Rho1 CG8416 gene product from transcript CG8416-RB 0.121
NELF-A CG5874 gene product from transcript CG5874-RA 0.119
siz schizo 0.117
Mtl Mig-2-like 0.115
cta concertina 0.115
ken ken and barbie 0.114
CG2991 CG2991 gene product from transcript CG2991-RA 0.113
Tre1 trapped in endoderm-1 0.108
ptc patched 0.108
Dap160 Dynamin associated protein 160 0.106
Jra Jun-related antigen 0.100
DAAM Dishevelled Associated Activator of Morphogenesis 0.099
CG8155 CG8155 gene product from transcript CG8155-RA 0.099
flw flapwing 0.098
klar klarsicht 0.097
kuz kuzbanian 0.096
Cdk5alpha Cdk5 activator-like protein 0.094
l(2)k05819 lethal (2) k05819 0.093
Hem HEM-protein 0.089
CG4552 CG4552 gene product from transcript CG4552-RA 0.088
unc-104 CG8566 gene product from transcript CG8566-RB 0.086
sgl sugarless 0.085
alpha-Man-II alpha Mannosidase II 0.084
ttk tramtrack 0.084
drpr draper 0.081
rhea CG6831 gene product from transcript CG6831-RA 0.081
rl rolled 0.080
Traf4 TNF-receptor-associated factor 4 0.079
Hira CG12153 gene product from transcript CG12153-RA 0.079
Pk61C Protein kinase 61C 0.078
Rheb CG1081 gene product from transcript CG1081-RA 0.077
UBL3 CG9038 gene product from transcript CG9038-RC 0.075
Unc-76 CG3981 gene product from transcript CG3981-RB 0.075
Graf CG8948 gene product from transcript CG8948-RB 0.073
tmod tropomodulin 0.073
dock dreadlocks 0.071
CG9063 CG9063 gene product from transcript CG9063-RA 0.071
slpr slipper 0.070
synaptogyrin CG10808 gene product from transcript CG10808-RA 0.070
CG15118 CG15118 gene product from transcript CG15118-RC 0.070
p120ctn Adherens junction protein p120 0.069
Act5C Actin 5C 0.069
Hnf4 Hepatocyte nuclear factor 4 0.068
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.999
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.998
RHOA ras homolog gene family, member A 0.992
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.990
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.984
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.977
SFN stratifin 0.976
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.973
ARRB1 arrestin, beta 1 0.966
S100A8 S100 calcium binding protein A8 0.964
PTK2 PTK2 protein tyrosine kinase 2 0.963
S100A6 S100 calcium binding protein A6 0.960
GRB2 growth factor receptor-bound protein 2 0.960
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.939
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.924
S100B S100 calcium binding protein B 0.923
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.913
ERBB2IP erbb2 interacting protein 0.902
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.895
ITSN1 intersectin 1 (SH3 domain protein) 0.889
S100A11 S100 calcium binding protein A11 0.888
SH3BP2 SH3-domain binding protein 2 0.880
DNM1 dynamin 1 0.879
IGF1R insulin-like growth factor 1 receptor 0.877
SH3RF1 SH3 domain containing ring finger 1 0.872
VAV1 vav 1 guanine nucleotide exchange factor 0.860
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.847
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.834
TSC2 tuberous sclerosis 2 0.820
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.816
DOCK1 dedicator of cytokinesis 1 0.799
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.792
BBS10 Bardet-Biedl syndrome 10 0.785
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.776
RGS2 regulator of G-protein signaling 2, 24kDa 0.774
SNX9 sorting nexin 9 0.771
NCF2 neutrophil cytosolic factor 2 0.761
MYO9B myosin IXB 0.745
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.742
SYNJ1 synaptojanin 1 0.739
SH3KBP1 SH3-domain kinase binding protein 1 0.735
DNM2 dynamin 2 0.732
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.730
WASL Wiskott-Aldrich syndrome-like 0.716
S100A9 S100 calcium binding protein A9 0.712
CCR5 chemokine (C-C motif) receptor 5 0.708
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.708
ADRBK1 adrenergic, beta, receptor kinase 1 0.702
GRB7 growth factor receptor-bound protein 7 0.696
EXOSC10 exosome component 10 0.695
SOS1 son of sevenless homolog 1 (Drosophila) 0.673
TNK2 tyrosine kinase, non-receptor, 2 0.673
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.660
NCKAP1 NCK-associated protein 1 0.656
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.652
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.650
PLCG1 phospholipase C, gamma 1 0.642
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.640
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.632
S100A1 S100 calcium binding protein A1 0.628
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.620
DSP desmoplakin 0.611
RAB5A RAB5A, member RAS oncogene family 0.592
RABGAP1 RAB GTPase activating protein 1 0.590
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.585
RND1 Rho family GTPase 1 0.580
ABI1 abl-interactor 1 0.573
SNAP23 synaptosomal-associated protein, 23kDa 0.564
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.563
ZYX zyxin 0.561
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.559
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.557
FMNL1 formin-like 1 0.542
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.537
TSC1 tuberous sclerosis 1 0.536
LMNA lamin A/C 0.534
RACGAP1 Rac GTPase activating protein 1 0.531
ZMYND11 zinc finger, MYND-type containing 11 0.529
GAS7 growth arrest-specific 7 0.527
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.527
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.526
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.522
MARK3 MAP/microtubule affinity-regulating kinase 3 0.511
HDAC6 histone deacetylase 6 0.507
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.505
BCL2L1 BCL2-like 1 0.502
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.495
MPRIP myosin phosphatase Rho interacting protein 0.485
BCR breakpoint cluster region 0.477
CCL4 chemokine (C-C motif) ligand 4 0.474
TRAF5 TNF receptor-associated factor 5 0.459
ZBED1 zinc finger, BED-type containing 1 0.458
SMAD2 SMAD family member 2 0.453
PLEC plectin 0.445
NCK2 NCK adaptor protein 2 0.433
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.430
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.191
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.159
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.132
Flt1 FMS-related tyrosine kinase 1 0.101
Inpp5d inositol polyphosphate-5-phosphatase D 0.087
Pctk2 PCTAIRE protein kinase 2 0.086
Arf4 ADP-ribosylation factor 4 0.083
Cyth1 cytohesin 1 0.079
Sirpa signal-regulatory protein alpha 0.075
Epas1 endothelial PAS domain protein 1 0.072
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.072
Lcp2 lymphocyte cytosolic protein 2 0.071
Mapk9 mitogen-activated protein kinase 9 0.070
Dlg3 discs, large homolog 3 (Drosophila) 0.069
Bin2 bridging integrator 2 0.068
Zfp238 zinc finger protein 238 0.068
Hand2 heart and neural crest derivatives expressed 2 0.067
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.066
Cfp complement factor properdin 0.065
Adrbk1 adrenergic, beta, receptor kinase 1 0.064
Camk4 calcium/calmodulin-dependent protein kinase IV 0.063
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.060
Copb1 coatomer protein complex, subunit beta 1 0.059
Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.058
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.056
Prkch protein kinase C, eta 0.054
Homer1 homer homolog 1 (Drosophila) 0.053
Shank2 SH3 and multiple ankyrin repeat domains 2 0.052
Dapk3 death-associated protein kinase 3 0.049
Sdc3 syndecan 3 0.048
Prkcb protein kinase C, beta 0.048
Clcn7 chloride channel 7 0.047
Pja2 praja 2, RING-H2 motif containing 0.046
Cd37 CD37 molecule 0.046
Tgfbr2 transforming growth factor, beta receptor II 0.046
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.045
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.044
Plekha6 pleckstrin homology domain containing, family A member 6 0.043
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.043
Dnm2 dynamin 2 0.041
Mmp17 matrix metallopeptidase 17 0.041
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.040
Pi4ka phosphatidylinositol 4-kinase, catalytic, alpha 0.040
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.040
Kif16b kinesin family member 16B 0.040
Ptafr platelet-activating factor receptor 0.040
Sox17 SRY (sex determining region Y)-box 17 0.040
Arhgap4 Rho GTPase activating protein 4 0.040
Wdr7 WD repeat domain 7 0.038
Tgfb1 transforming growth factor, beta 1 0.038
Ptprs protein tyrosine phosphatase, receptor type, S 0.038
Mcpt4 mast cell protease 4 0.038
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.038
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.038
Tek TEK tyrosine kinase, endothelial 0.037
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.036
Gria2 glutamate receptor, ionotropic, AMPA 2 0.035
Rara retinoic acid receptor, alpha 0.035
Nckap1 NCK-associated protein 1 0.035
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.035
Adcy5 adenylate cyclase 5 0.035
Cyyr1 cysteine/tyrosine-rich 1 0.034
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.034
Vps52 vacuolar protein sorting 52 homolog (S. cerevisiae) 0.034
Abcf3 ATP-binding cassette, subfamily F (GCN20), member 3 0.034
Macf1 microtubule-actin crosslinking factor 1 0.033
Sh3kbp1 SH3-domain kinase binding protein 1 0.033
Rgs4 regulator of G-protein signaling 4 0.032
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.032
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.032
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.031
Mertk c-mer proto-oncogene tyrosine kinase 0.031
Add3 adducin 3 (gamma) 0.031
Unc13b unc-13 homolog B (C. elegans) 0.031
Elf1 E74-like factor 1 0.030
Med23 mediator complex subunit 23 0.030
Nsf N-ethylmaleimide-sensitive factor 0.030
Adora2a adenosine A2a receptor 0.030
Hk1 hexokinase 1 0.030
Braf v-raf murine sarcoma viral oncogene homolog B1 0.030
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.030
Mospd2 motile sperm domain containing 2 0.030
Arpc2 actin related protein 2/3 complex, subunit 2 0.030
Pde2a phosphodiesterase 2A, cGMP-stimulated 0.030
Plcg1 phospholipase C, gamma 1 0.029
RGD621098 similar to RIKEN cDNA D230025D16Rik 0.029
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.028
Extl3 exostoses (multiple)-like 3 0.028
Glra1 glycine receptor, alpha 1 0.028
Stx2 syntaxin 2 0.028
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.028
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.028
Gpr116 G protein-coupled receptor 116 0.028
Pld2 phospholipase D2 0.028
Scn8a sodium channel, voltage gated, type VIII, alpha subunit 0.027
Coro1a coronin, actin binding protein 1A 0.027
Mxd1 max dimerization protein 1 0.027
Ncr1 natural cytotoxicity triggering receptor 1 0.027
Ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.027
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.027
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GYL1 Gyl1p 0.439
GCD6 Gcd6p 0.402
SUI3 Sui3p 0.298
STE11 Ste11p 0.294
IRA1 Ira1p 0.263
STE5 Ste5p 0.260
CDC24 Cdc24p 0.246
RHO1 Rho1p 0.246
SPA2 Spa2p 0.211
BEM3 Bem3p 0.142
MKK1 Mkk1p 0.122
FYV8 Fyv8p 0.121
BEM2 Bem2p 0.109
FAR1 Far1p 0.102
MDS3 Mds3p 0.099
MNN9 Mnn9p 0.082
FMS1 Fms1p 0.078
GIC2 Gic2p 0.072
ROM2 Rom2p 0.068
CHC1 Chc1p 0.067
HRP1 Hrp1p 0.063
SLT2 Slt2p 0.060
CHS1 Chs1p 0.060
GCD7 Gcd7p 0.057
MSG5 Msg5p 0.057
PKC1 Pkc1p 0.057
ENT1 Ent1p 0.057
SAC7 Sac7p 0.056
GCD11 Gcd11p 0.056
VPS15 Vps15p 0.056
INP53 Inp53p 0.055
FUS2 Fus2p 0.053
SUI2 Sui2p 0.053
PRS2 Prs2p 0.051
YPT53 Ypt53p 0.050
CDC25 Cdc25p 0.050
VPS9 Vps9p 0.045
HSV2 Hsv2p 0.044
KEL1 Kel1p 0.043
SEC13 Sec13p 0.043
CCT4 Cct4p 0.043
YML002W hypothetical protein 0.043
CYK3 Cyk3p 0.043
YIP3 Yip3p 0.043
PEP5 Pep5p 0.042
PTP2 Ptp2p 0.042
CRG1 Crg1p 0.039
STE4 Ste4p 0.039
SRP54 Srp54p 0.038
SOG2 Sog2p 0.038
SEC16 Sec16p 0.038
YNL108C hypothetical protein 0.038
CDC50 Cdc50p 0.037
SES1 Ses1p 0.036
CMK2 Cmk2p 0.036
YDR186C hypothetical protein 0.035
YRB1 Yrb1p 0.035
AVO1 Avo1p 0.035
SKT5 Skt5p 0.034
BST1 Bst1p 0.034
PDE2 Pde2p 0.033
SPR6 Spr6p 0.033
CUE5 Cue5p 0.032
MOB2 Mob2p 0.032
YLR264C-A hypothetical protein 0.032
KES1 Kes1p 0.031
FUS1 Fus1p 0.031
MEX67 Mex67p 0.031
SIA1 Sia1p 0.031
SSK2 Ssk2p 0.030
CIK1 Cik1p 0.030
AKL1 Akl1p 0.029
SVF1 Svf1p 0.029
PEA2 Pea2p 0.029
INO2 Ino2p 0.029
ACK1 Ack1p 0.029
GLO3 Glo3p 0.029
URA4 Ura4p 0.028
GCD1 Gcd1p 0.028
SKI8 Ski8p 0.028
YGR126W hypothetical protein 0.028
GPB2 Gpb2p 0.028
SRD1 Srd1p 0.027
RIM21 Rim21p 0.027
YFR016C hypothetical protein 0.027
NYV1 Nyv1p 0.027
TRR1 Trr1p 0.027
STE20 Ste20p 0.026
URA3 Ura3p 0.026
BFR1 Bfr1p 0.026
BCP1 Bcp1p 0.026
ATG20 Atg20p 0.026
RPN14 Rpn14p 0.026
LEU2 Leu2p 0.026
ITR2 Itr2p 0.026
KIC1 Kic1p 0.026
FAA2 Faa2p 0.026
NUP49 Nup49p 0.025
MID1 Mid1p 0.025
KTR4 Ktr4p 0.025