IMP
Process View
The network for 'macrophage activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
macrophage activation
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Tlr4 | toll-like receptor 4 | 0.996 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.931 | |
| Cd44 | CD44 antigen | 0.850 | |
| Fos | FBJ osteosarcoma oncogene | 0.793 | |
| Il1r1 | interleukin 1 receptor, type I | 0.700 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.675 | |
| Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 0.631 | |
| Cd14 | CD14 antigen | 0.601 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.561 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.490 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.480 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.410 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.404 | |
| Lyz2 | lysozyme 2 | 0.376 | |
| Il1b | interleukin 1 beta | 0.360 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.338 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.316 | |
| Ifng | interferon gamma | 0.299 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.277 | |
| Ldb3 | LIM domain binding 3 | 0.212 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.204 | |
| Mmp9 | matrix metallopeptidase 9 | 0.181 | |
| Slc30a3 | solute carrier family 30 (zinc transporter), member 3 | 0.178 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.177 | |
| Apoe | apolipoprotein E | 0.168 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.159 | |
| Zfp36 | zinc finger protein 36 | 0.159 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.144 | |
| Cd7 | CD7 antigen | 0.127 | |
| S1pr4 | sphingosine-1-phosphate receptor 4 | 0.125 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.109 | |
| Il13 | interleukin 13 | 0.106 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.105 | |
| Itk | IL2-inducible T-cell kinase | 0.099 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.092 | |
| Selp | selectin, platelet | 0.092 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.089 | |
| Dusp1 | dual specificity phosphatase 1 | 0.085 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.085 | |
| Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 0.084 | |
| Icos | inducible T-cell co-stimulator | 0.083 | |
| Mb | myoglobin | 0.079 | |
| Il4ra | interleukin 4 receptor, alpha | 0.079 | |
| Egr1 | early growth response 1 | 0.079 | |
| C1qa | complement component 1, q subcomponent, alpha polypeptide | 0.077 | |
| Cd247 | CD247 antigen | 0.075 | |
| Csf1r | colony stimulating factor 1 receptor | 0.074 | |
| Gbp5 | guanylate binding protein 5 | 0.069 | |
| Itgam | integrin alpha M | 0.069 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.069 | |
| Atf3 | activating transcription factor 3 | 0.068 | |
| Adora3 | adenosine A3 receptor | 0.065 | |
| H2-Ob | histocompatibility 2, O region beta locus | 0.064 | |
| Adam8 | a disintegrin and metallopeptidase domain 8 | 0.064 | |
| Btg2 | B-cell translocation gene 2, anti-proliferative | 0.062 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.062 | |
| Spp1 | secreted phosphoprotein 1 | 0.062 | |
| AF251705 | cDNA sequence AF251705 | 0.062 | |
| Mefv | Mediterranean fever | 0.061 | |
| Sftpd | surfactant associated protein D | 0.061 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.061 | |
| Hbb-b1 | hemoglobin, beta adult major chain | 0.060 | |
| Mapk8 | mitogen-activated protein kinase 8 | 0.059 | |
| Prnp | prion protein | 0.059 | |
| Fpr-rs3 | formyl peptide receptor, related sequence 3 | 0.056 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.054 | |
| Hspa9 | heat shock protein 9 | 0.053 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.053 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.052 | |
| Muc13 | mucin 13, epithelial transmembrane | 0.051 | |
| Pycard | PYD and CARD domain containing | 0.051 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.051 | |
| Slc6a3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.050 | |
| Cd22 | CD22 antigen | 0.050 | |
| Ticam1 | toll-like receptor adaptor molecule 1 | 0.049 | |
| Ier2 | immediate early response 2 | 0.049 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.049 | |
| Tfrc | transferrin receptor | 0.049 | |
| Ccr4 | chemokine (C-C motif) receptor 4 | 0.049 | |
| Aire | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 0.048 | |
| Nr4a1 | nuclear receptor subfamily 4, group A, member 1 | 0.048 | |
| Exoc6 | exocyst complex component 6 | 0.048 | |
| C1qc | complement component 1, q subcomponent, C chain | 0.047 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.046 | |
| Efna1 | ephrin A1 | 0.046 | |
| Bdkrb1 | bradykinin receptor, beta 1 | 0.045 | |
| U46068 | cDNA sequence U46068 | 0.045 | |
| Il18 | interleukin 18 | 0.045 | |
| Il6 | interleukin 6 | 0.045 | |
| Actn2 | actinin alpha 2 | 0.044 | |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.043 | |
| Mapk1 | mitogen-activated protein kinase 1 | 0.043 | |
| C1qb | complement component 1, q subcomponent, beta polypeptide | 0.043 | |
| Src | Rous sarcoma oncogene | 0.043 | |
| C3ar1 | complement component 3a receptor 1 | 0.043 | |
| Soat2 | sterol O-acyltransferase 2 | 0.042 | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.041 | |
| Sele | selectin, endothelial cell | 0.041 | |
| C5ar1 | complement component 5a receptor 1 | 0.040 | |
| Irf4 | interferon regulatory factor 4 | 0.039 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| MYD88 | myeloid differentiation primary response gene (88) | 0.282 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.212 | |
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.124 | |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.073 | |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.051 | |
| LY96 | lymphocyte antigen 96 | 0.038 | |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.037 | |
| DOCK7 | dedicator of cytokinesis 7 | 0.032 | |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 0.030 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.028 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.027 | |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.026 | |
| IL4 | interleukin 4 | 0.023 | |
| TLR1 | toll-like receptor 1 | 0.023 | |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | 0.021 | |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.019 | |
| MPO | myeloperoxidase | 0.019 | |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.018 | |
| FZD1 | frizzled homolog 1 (Drosophila) | 0.017 | |
| TLR2 | toll-like receptor 2 | 0.016 | |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 0.016 | |
| TLR4 | toll-like receptor 4 | 0.015 | |
| ELANE | elastase, neutrophil expressed | 0.013 | |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.013 | |
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.012 | |
| DUSP1 | dual specificity phosphatase 1 | 0.012 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.012 | |
| MYO9B | myosin IXB | 0.012 | |
| SNCAIP | synuclein, alpha interacting protein | 0.012 | |
| BCL2L1 | BCL2-like 1 | 0.011 | |
| TGFB1 | transforming growth factor, beta 1 | 0.011 | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.011 | |
| AZU1 | azurocidin 1 | 0.010 | |
| CYR61 | cysteine-rich, angiogenic inducer, 61 | 0.010 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Tlr4 | toll-like receptor 4 | 0.051 | |
| Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.036 | |
| Igsf6 | immunoglobulin superfamily, member 6 | 0.029 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.028 | |
| Casp1 | caspase 1 | 0.024 | |
| Adam17 | ADAM metallopeptidase domain 17 | 0.023 | |
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.022 | |
| Arl11 | ADP-ribosylation factor-like 11 | 0.022 | |
| Ereg | epiregulin | 0.018 | |
| Cp | ceruloplasmin | 0.018 | |
| Junb | jun B proto-oncogene | 0.017 | |
| Glipr1 | GLI pathogenesis-related 1 | 0.017 | |
| Slco2b1 | solute carrier organic anion transporter family, member 2b1 | 0.016 | |
| Serpinb7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | 0.015 | |
| Edn1 | endothelin 1 | 0.014 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.014 | |
| Cd38 | CD38 molecule | 0.014 | |
| Ctsc | cathepsin C | 0.013 | |
| Cnr2 | cannabinoid receptor 2 (macrophage) | 0.013 | |
| Nat1 | N-acetyltransferase 1 | 0.013 | |
| C3ar1 | complement component 3a receptor 1 | 0.013 | |
| Trpm8 | transient receptor potential cation channel, subfamily M, member 8 | 0.013 | |
| Ifi204 | interferon activated gene 204 | 0.013 | |
| Cdk11b | cyclin-dependent kinase 11B | 0.012 | |
| Fam38b | family with sequence similarity 38, member B | 0.012 | |
| Rab32 | RAB32, member RAS oncogene family | 0.012 | |
| Itpr2 | inositol 1,4,5-triphosphate receptor, type 2 | 0.012 | |
| Bcl3 | B-cell CLL/lymphoma 3 | 0.012 | |
| Myl7 | myosin, light chain 7, regulatory | 0.011 | |
| Pla2g4a | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.011 | |
| Cd86 | CD86 molecule | 0.011 | |
| Klrc2 | killer cell lectin-like receptor subfamily C, member 2 | 0.011 | |
| Tas2r118 | taste receptor, type 2, member 118 | 0.011 | |
| Fos | FBJ osteosarcoma oncogene | 0.011 | |
| Casp8 | caspase 8 | 0.010 | |
| Sla | src-like adaptor | 0.010 | |
| Hsph1 | heat shock 105/110 protein 1 | 0.010 | |
| Smad1 | SMAD family member 1 | 0.010 | |
| Capza3 | capping protein (actin filament) muscle Z-line, alpha 3 | 0.010 | |
| Zfp36 | zinc finger protein 36 | 0.010 | |
| Vom1r102 | vomeronasal 1 receptor 102 | 0.010 | |
| Gcnt1 | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 0.010 | |
| Chi3l1 | chitinase 3-like 1 | 0.010 | |
| Tas2r107 | taste receptor, type 2, member 107 | 0.010 |