IMP
Process View
The network for 'negative regulation of stem cell maintenance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of stem cell maintenance
Any process that stops, prevents or reduces the frequency, rate or extent of stem cell maintenance.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Bmp7 | bone morphogenetic protein 7 | 0.999 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.999 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.999 | |
| Msx1 | homeobox, msh-like 1 | 0.997 | |
| Foxc1 | forkhead box C1 | 0.995 | |
| Bmp4 | bone morphogenetic protein 4 | 0.994 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 0.994 | |
| Pax3 | paired box gene 3 | 0.988 | |
| Dlx5 | distal-less homeobox 5 | 0.983 | |
| Tbx1 | T-box 1 | 0.980 | |
| Prrx1 | paired related homeobox 1 | 0.974 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.960 | |
| Rarg | retinoic acid receptor, gamma | 0.957 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.956 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.941 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.933 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.919 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.914 | |
| Lhx1 | LIM homeobox protein 1 | 0.912 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.892 | |
| Fgf8 | fibroblast growth factor 8 | 0.889 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.833 | |
| Smo | smoothened homolog (Drosophila) | 0.816 | |
| Chrd | chordin | 0.812 | |
| Foxc2 | forkhead box C2 | 0.790 | |
| Rarb | retinoic acid receptor, beta | 0.757 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.755 | |
| Hoxd13 | homeobox D13 | 0.723 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.688 | |
| Prrx2 | paired related homeobox 2 | 0.664 | |
| Ptch1 | patched homolog 1 | 0.654 | |
| Msx2 | homeobox, msh-like 2 | 0.652 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.628 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.628 | |
| Runx2 | runt related transcription factor 2 | 0.619 | |
| Sox9 | SRY-box containing gene 9 | 0.567 | |
| Hoxa1 | homeobox A1 | 0.520 | |
| Fgf10 | fibroblast growth factor 10 | 0.508 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.507 | |
| Gsc | goosecoid homeobox | 0.490 | |
| Wnt9b | wingless-type MMTV integration site 9B | 0.475 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.475 | |
| Alx4 | aristaless-like homeobox 4 | 0.404 | |
| Bmper | BMP-binding endothelial regulator | 0.379 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.377 | |
| Jag1 | jagged 1 | 0.352 | |
| Bmp2 | bone morphogenetic protein 2 | 0.350 | |
| Tbx10 | T-box 10 | 0.340 | |
| Pax2 | paired box gene 2 | 0.323 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.315 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.313 | |
| Hoxa2 | homeobox A2 | 0.293 | |
| Tbx15 | T-box 15 | 0.291 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.270 | |
| Alx1 | ALX homeobox 1 | 0.258 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.239 | |
| Foxh1 | forkhead box H1 | 0.237 | |
| Fgf3 | fibroblast growth factor 3 | 0.231 | |
| Gdf6 | growth differentiation factor 6 | 0.220 | |
| Rara | retinoic acid receptor, alpha | 0.220 | |
| Foxg1 | forkhead box G1 | 0.210 | |
| Ret | ret proto-oncogene | 0.209 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.200 | |
| Gdf5 | growth differentiation factor 5 | 0.189 | |
| Hoxa11 | homeobox A11 | 0.184 | |
| Sox2 | SRY-box containing gene 2 | 0.172 | |
| Adra2b | adrenergic receptor, alpha 2b | 0.166 | |
| Nog | noggin | 0.162 | |
| Igl | immunoglobulin lambda chain complex | 0.160 | |
| Alx3 | aristaless-like homeobox 3 | 0.147 | |
| Nr5a1 | nuclear receptor subfamily 5, group A, member 1 | 0.147 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.144 | |
| T | brachyury | 0.143 | |
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.142 | |
| Tcf21 | transcription factor 21 | 0.133 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.123 | |
| Phex | phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) | 0.118 | |
| Hoxb3 | homeobox B3 | 0.113 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.105 | |
| Gdf1 | growth differentiation factor 1 | 0.104 | |
| Slc5a2 | solute carrier family 5 (sodium/glucose cotransporter), member 2 | 0.092 | |
| Fgfrl1 | fibroblast growth factor receptor-like 1 | 0.091 | |
| Gata3 | GATA binding protein 3 | 0.090 | |
| Ednra | endothelin receptor type A | 0.089 | |
| Mn1 | meningioma 1 | 0.088 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.087 | |
| Ihh | Indian hedgehog | 0.086 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.086 | |
| Hes1 | hairy and enhancer of split 1 (Drosophila) | 0.083 | |
| Hmx3 | H6 homeobox 3 | 0.083 | |
| Gas1 | growth arrest specific 1 | 0.082 | |
| Col2a1 | collagen, type II, alpha 1 | 0.076 | |
| Hoxa3 | homeobox A3 | 0.074 | |
| Hoxd11 | homeobox D11 | 0.073 | |
| Foxe1 | forkhead box E1 | 0.073 | |
| Thrb | thyroid hormone receptor beta | 0.072 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.068 | |
| Gdf3 | growth differentiation factor 3 | 0.068 | |
| Cdon | cell adhesion molecule-related/down-regulated by oncogenes | 0.067 |
