The network for 'guanosine containing compound catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

guanosine containing compound catabolic process

The chemical reactions and pathways resulting in the breakdown of guanosine-containing compounds (guanosines).

Name Description Probability Func Analog Organism
Arl1 ADP-ribosylation factor-like 1 0.417
Pja2 praja 2, RING-H2 motif containing 0.218
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.199
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.163
Pfn1 profilin 1 0.163
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.158
Amph amphiphysin 0.140
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.128
Epas1 endothelial PAS domain protein 1 0.121
Arf4 ADP-ribosylation factor 4 0.109
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.109
Dlg1 discs, large homolog 1 (Drosophila) 0.104
Hr hairless 0.103
Jarid1a jumonji, AT rich interactive domain 1A (Rbp2 like) 0.094
RT1-DMa RT1 class II, locus DMa 0.093
Jtb jumping translocation breakpoint 0.089
Scn3b sodium channel, voltage-gated, type III, beta 0.089
Dlg3 discs, large homolog 3 (Drosophila) 0.087
Tgfbr2 transforming growth factor, beta receptor II 0.084
Sdc3 syndecan 3 0.083
Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.078
Nckap1 NCK-associated protein 1 0.078
Arpc2 actin related protein 2/3 complex, subunit 2 0.077
Svop SV2 related protein 0.077
Dapk3 death-associated protein kinase 3 0.075
Hk1 hexokinase 1 0.073
Sstr1 somatostatin receptor 1 0.071
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.070
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.068
Fgfr1 Fibroblast growth factor receptor 1 0.068
Ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.067
Utrn utrophin 0.067
Exoc5 exocyst complex component 5 0.066
Dnm1 dynamin 1 0.066
Rab1 RAB1, member RAS oncogene family 0.065
Rab18 RAB18, member RAS oncogene family 0.063
Snap23 synaptosomal-associated protein 23 0.063
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.062
Zfp37 zinc finger protein 37 0.061
Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.060
Sh3gl2 SH3-domain GRB2-like 2 0.058
Rala v-ral simian leukemia viral oncogene homolog A (ras related) 0.058
Shank2 SH3 and multiple ankyrin repeat domains 2 0.057
Eif5 eukaryotic translation initiation factor 5 0.056
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.056
Dock9 dedicator of cytokinesis 9 0.056
Pum1 pumilio homolog 1 (Drosophila) 0.056
Mtpn myotrophin 0.055
Dnm2 dynamin 2 0.055
Braf v-raf murine sarcoma viral oncogene homolog B1 0.055
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.054
Gipc1 GIPC PDZ domain containing family, member 1 0.054
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.053
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.053
Wdr7 WD repeat domain 7 0.052
Cfp complement factor properdin 0.051
Sept10 septin 10 0.051
Sec11a SEC11 homolog A (S. cerevisiae) 0.050
Prkch protein kinase C, eta 0.050
Pdp1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.050
Rab5a RAB5A, member RAS oncogene family 0.049
Dctn1 dynactin 1 0.049
Cyth3 cytohesin 3 0.049
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.048
Sox17 SRY (sex determining region Y)-box 17 0.048
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.048
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.048
Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase 0.047
Tek TEK tyrosine kinase, endothelial 0.047
Clps colipase, pancreatic 0.047
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.047
Ephb1 Eph receptor B1 0.046
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.045
Pls3 plastin 3 (T-isoform) 0.045
Homer1 homer homolog 1 (Drosophila) 0.045
Sbf1 SET binding factor 1 0.045
Usf2 upstream transcription factor 2, c-fos interacting 0.044
Bin1 bridging integrator 1 0.044
Gria2 glutamate receptor, ionotropic, AMPA 2 0.044
Eif4e2 eukaryotic translation initiation factor 4E family member 2 0.044
Myo1c myosin IC 0.044
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.044
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.044
Cd8b CD8b molecule 0.044
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.043
Mcpt4 mast cell protease 4 0.043
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.043
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.042
Camk4 calcium/calmodulin-dependent protein kinase IV 0.042
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.042
Itpka inositol 1,4,5-trisphosphate 3-kinase A 0.042
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.041
Rab7a RAB7A, member RAS oncogene family 0.041
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.041
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.041
Pdcd10 programmed cell death 10 0.041
Akap12 A kinase (PRKA) anchor protein 12 0.041
Epb41l1 erythrocyte membrane protein band 4.1-like 1 0.041
Mertk c-mer proto-oncogene tyrosine kinase 0.041
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.041
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
sem-5 Protein SEM-5 0.657
lag-1 Protein LAG-1 0.530
gpr-1 Protein GPR-1 0.447
rgl-1 Protein RGL-1 0.421
goa-1 Protein GOA-1 0.420
etr-1 Protein ETR-1 0.370
snf-1 Protein SNF-1 0.334
mig-2 Protein MIG-2 0.329
eor-2 Protein EOR-2 0.291
itr-1 Protein ITR-1 0.244
csnk-1 Protein CSNK-1 0.236
sma-6 Protein SMA-6 0.225
kin-2 Protein KIN-2 0.212
cmd-1 Protein CMD-1 0.204
madf-5 Protein MADF-5 0.201
CELE_F47G4.4 Protein F47G4.4 0.201
mtm-3 Protein MTM-3 0.182
gpb-1 Protein GPB-1 0.180
dpm-1 Protein DPM-1 0.177
ced-10 Protein CED-10 0.176
CELE_T10D4.6 Protein T10D4.6 0.172
gly-7 Protein GLY-7 0.169
dpf-3 Protein DPF-3 0.162
ykt-6 Protein YKT-6 0.161
gei-18 Protein GEI-18 0.151
T23F11.1 Protein T23F11.1 0.141
cyld-1 Protein CYLD-1 0.140
sli-1 Protein SLI-1 0.139
C11E4.6 Protein C11E4.6 0.135
unc-62 Protein UNC-62 0.129
unc-26 Protein UNC-26 0.127
gar-3 Protein GAR-3 0.116
lec-1 Protein LEC-1 0.114
fhod-1 Protein FHOD-1 0.114
unc-60 Protein UNC-60 0.106
T04F8.6 Protein T04F8.6 0.103
let-60 Protein LET-60 0.099
F52G3.1 Protein F52G3.1 0.098
tag-123 Protein TAG-123 0.098
tat-1 Protein TAT-1 0.096
zoo-1 Protein ZOO-1 0.094
stau-1 Protein STAU-1 0.092
Y110A7A.4 Protein Y110A7A.4 0.092
dpy-21 Protein DPY-21 0.092
tpxl-1 Protein TPXL-1 0.091
ddr-2 Protein DDR-2 0.088
CELE_F53C11.5 Protein F53C11.5 0.086
sup-17 Protein SUP-17 0.085
rab-11.1 Protein RAB-11.1 0.085
spd-2 Protein SPD-2 0.085
rps-2 Protein RPS-2 0.084
zfp-3 Protein ZFP-3 0.084
pdl-1 Protein PDL-1 0.084
CELE_W07A8.2 Protein W07A8.2 0.082
ina-1 Protein INA-1 0.082
unc-119 Protein UNC-119 0.080
smp-1 Protein SMP-1 0.080
CELE_Y53F4B.5 Protein Y53F4B.5 0.080
daf-19 Protein DAF-19 0.078
klp-7 Protein KLP-7 0.077
tag-335 Protein TAG-335 0.076
rars-2 Protein RARS-2 0.075
unc-53 Protein UNC-53 0.075
C18E9.2 Protein C18E9.2 0.075
abts-1 Protein ABTS-1 0.074
F35G2.1 Protein F35G2.1 0.074
zfp-1 Protein ZFP-1 0.073
pfn-2 Protein PFN-2 0.073
mpk-1 Protein MPK-1 0.072
C06G3.9 Protein C06G3.9 0.071
vps-32.1 Protein VPS-32.1 0.071
rpl-5 Protein RPL-5 0.071
sam-10 Protein SAM-10 0.070
egrh-1 Protein EGRH-1 0.070
sto-4 Protein STO-4 0.069
C27H2.2 Protein C27H2.2 0.069
F54D12.4 Protein F54D12.4 0.069
R10E12.2 Protein R10E12.2 0.069
osm-5 Protein OSM-5 0.067
rab-39 Protein RAB-39 0.067
CELE_Y60A3A.9 Protein Y60A3A.9 0.066
dgk-4 Protein DGK-4 0.066
ulp-2 Protein ULP-2 0.065
rab-5 Protein RAB-5 0.064
dnj-16 Protein DNJ-16 0.063
CELE_K08E7.6 Protein K08E7.6 0.063
cgef-2 Protein CGEF-2 0.063
gcs-1 Protein GCS-1 0.062
svh-2 Protein SVH-2 0.060
mrck-1 Protein MRCK-1 0.059
CELE_F25B4.8 Protein F25B4.8 0.058
apg-1 Protein APG-1 0.058
cdk-1 Protein CDK-1 0.058
unc-79 Protein UNC-79 0.057
unc-71 Protein UNC-71 0.057
stim-1 Protein STIM-1 0.057
jbts-14 Protein JBTS-14 0.056
unc-31 Protein UNC-31 0.056
pat-3 Protein PAT-3 0.056
upp-1 Protein UPP-1 0.056
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pak2a p21 (CDKN1A)-activated kinase 2a 0.602
bida BH3 interacting domain death agonist 0.577
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.375
arf5 ADP-ribosylation factor 5 0.366
gsna gelsolin a 0.358
copeb core promoter element binding protein 0.319
plxnb2a plexin b2a 0.316
nf1a neurofibromin 1a 0.301
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.280
c10orf11 c10orf11 homolog (H. sapiens) 0.273
mcl1b myeloid cell leukemia sequence 1b 0.272
pvrl1b poliovirus receptor-related 1b 0.269
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.260
rab1a RAB1A, member RAS oncogene family 0.249
zgc:56085 zgc:56085 0.248
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.244
sept2 septin 2 0.232
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.229
adrb2a adrenergic receptor, beta 2a 0.228
zbtb4 zinc finger and BTB domain containing 4 0.224
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.223
heatr3 HEAT repeat containing 3 0.218
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.218
si:ch211-232m7.1 si:ch211-232m7.1 0.216
cnn2 calponin 2 0.216
iqgap1 IQ motif containing GTPase activating protein 1 0.213
esyt3 extended synaptotagmin-like protein 3 0.210
gnai2l guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like 0.210
ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme 0.210
tm9sf2 transmembrane 9 superfamily member 2 0.204
bcl2 B-cell leukemia/lymphoma 2 0.203
alcamb activated leukocyte cell adhesion molecule b 0.198
pvrl1a poliovirus receptor-related 1a 0.198
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.193
bactin2 bactin2 0.178
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.176
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.172
atp1b3a ATPase, Na+/K+ transporting, beta 3a polypeptide 0.169
srpr signal recognition particle receptor (docking protein) 0.168
rhoaa ras homolog gene family, member Aa 0.168
mecp2 methyl CpG binding protein 2 0.166
arpc5a actin related protein 2/3 complex, subunit 5A 0.166
s100a10a S100 calcium binding protein A10a 0.164
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.162
zgc:77517 zgc:77517 0.161
s100b S100 calcium binding protein, beta (neural) 0.159
stc1l stanniocalcin 1, like 0.158
pob partial optokinetic response b 0.157
sbf1 SET binding factor 1 0.155
arf2 ADP-ribosylation factor 2 0.155
ccdc47 coiled-coil domain containing 47 0.153
ddx56 DEAD (Asp-Glu-Ala-Asp) box polypeptide 56 0.149
dlg1 discs, large (Drosophila) homolog 1 0.148
tmf1 TATA element modulatory factor 1 0.145
tpm4 tropomyosin 4 0.143
rtcd1 RNA terminal phosphate cyclase domain 1 0.141
pfn1 profilin 1 0.139
pparg peroxisome proliferator activated receptor gamma 0.138
zeb1 zinc finger E-box binding homeobox 1 0.137
tm9sf4 transmembrane 9 superfamily protein member 4 0.136
zgc:63637 zgc:63637 0.135
srm spermidine synthase 0.132
sox11b SRY-box containing gene 11b 0.129
dusp4 dual specificity phosphatase 4 0.129
snx6 sorting nexin 6 0.129
kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.129
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.128
arpc5b actin related protein 2/3 complex, subunit 5B 0.127
rap1b RAS related protein 1b 0.126
trpa1b transient receptor potential cation channel, subfamily A, member 1b 0.126
mcl1a myeloid cell leukemia sequence 1a 0.125
nf1b neurofibromin 1b 0.125
vps26bl vacuolar protein sorting 26 homolog B, like 0.124
zgc:153129 zgc:153129 0.123
sypl2b synaptophysin-like 2b 0.120
rock2a rho-associated, coiled-coil containing protein kinase 2a 0.120
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.118
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.116
ef1a elongation factor 1-alpha 0.115
yrk Yes-related kinase 0.114
baxa bcl2-associated X protein, a 0.113
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.113
gro2 groucho 2 0.113
ptrfb polymerase I and transcript release factor b 0.113
rab7 RAB7, member RAS oncogene family 0.111
zgc:63831 zgc:63831 0.110
dopey1 dopey family member 1 0.108
lrrn1 leucine rich repeat neuronal 1 0.107
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.107
zgc:172028 zgc:172028 0.107
nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.105
atf3 activating transcription factor 3 0.105
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.105
si:dkey-91i17.1 si:dkey-91i17.1 0.103
zgc:56272 zgc:56272 0.103
icn ictacalcin 0.102
ap3m2 adaptor-related protein complex 3, mu 2 subunit 0.102
gnat2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 0.102
cdkl1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.102
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.101
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Rac1 CG2248 gene product from transcript CG2248-RA 0.990
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.980
rl rolled 0.858
drk downstream of receptor kinase 0.767
Ras85D Ras oncogene at 85D 0.756
ben bendless 0.744
Rho1 CG8416 gene product from transcript CG8416-RB 0.727
Rheb CG1081 gene product from transcript CG1081-RA 0.703
flw flapwing 0.683
cno canoe 0.672
CG8155 CG8155 gene product from transcript CG8155-RA 0.664
mbc myoblast city 0.657
ttk tramtrack 0.622
Pten CG5671 gene product from transcript CG5671-RB 0.585
Vps35 Vacuolar protein sorting 35 0.544
Rab7 Rab-protein 7 0.526
Stat92E Signal-transducer and activator of transcription protein at 92E 0.507
Su(H) Suppressor of Hairless 0.474
car carnation 0.454
mbt mushroom bodies tiny 0.427
Syx7 Syntaxin 7 0.415
rok Rho-kinase 0.387
Abi Abelson interacting protein 0.378
Pk61C Protein kinase 61C 0.368
Sos Son of sevenless 0.367
stumps CG31317 gene product from transcript CG31317-RC 0.365
dos daughter of sevenless 0.355
chic chickadee 0.354
lgs legless 0.354
baz bazooka 0.318
dys dysfusion 0.311
drpr draper 0.306
Rab11 Rab-protein 11 0.304
raps rapsynoid 0.296
synj synaptojanin 0.286
Pkn Protein kinase related to protein kinase N 0.271
Gie novel GTPase indispensable for equal segregation of chromosomes 0.271
TSG101 tumor suppressor protein 101 0.270
Mtl Mig-2-like 0.260
S6k RPS6-p70-protein kinase 0.256
pod1 CG4532 gene product from transcript CG4532-RF 0.253
Gyc-89Da Guanylyl cyclase at 89Da 0.246
aux auxillin 0.246
ave aveugle 0.240
Moe Moesin 0.234
Mad Mothers against dpp 0.234
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.221
edl ETS-domain lacking 0.221
smo smoothened 0.216
Gap69C GTPase-activating protein 69C 0.216
Shc SHC-adaptor protein 0.213
NaCP60E Na channel protein 60E 0.211
Pli Pellino 0.210
gek genghis khan 0.206
Tl Toll 0.204
Ras64B Ras oncogene at 64B 0.203
Arf79F ADP ribosylation factor 79F 0.203
stg string 0.203
jeb jelly belly 0.200
Rala Ras-related protein 0.190
Rab6 Rab-protein 6 0.180
klg klingon 0.172
Pak3 CG14895 gene product from transcript CG14895-RA 0.170
didum dilute class unconventional myosin 0.170
CG32772 CG32772 gene product from transcript CG32772-RC 0.163
Rbsn-5 Rabenosyn-5 0.160
Lnk CG17367 gene product from transcript CG17367-RC 0.160
trp transient receptor potential 0.159
cta concertina 0.156
gig gigas 0.155
Vps16A Vacuolar protein sorting 16A 0.154
MTF-1 Metal response element-binding Transcription Factor-1 0.153
dm diminutive 0.153
Ephrin CG1862 gene product from transcript CG1862-RA 0.151
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.148
Gyc-89Db Guanylyl cyclase at 89Db 0.146
CG17082 CG17082 gene product from transcript CG17082-RD 0.146
Wnk CG7177 gene product from transcript CG7177-RA 0.142
arm armadillo 0.137
l(2)k16918 lethal (2) k16918 0.134
ninaE neither inactivation nor afterpotential E 0.133
Galpha49B G protein alpha49B 0.132
Rab2 Rab-protein 2 0.132
futsch CG34387 gene product from transcript CG34387-RC 0.132
cpb capping protein beta 0.131
trio CG18214 gene product from transcript CG18214-RA 0.127
Pak PAK-kinase 0.124
rhea CG6831 gene product from transcript CG6831-RA 0.124
LanA Laminin A 0.123
ken ken and barbie 0.123
egl egalitarian 0.123
SNF1A SNF1A/AMP-activated protein kinase 0.120
p130CAS CG1212 gene product from transcript CG1212-RA 0.120
galectin CG11372 gene product from transcript CG11372-RA 0.120
bbg big bang 0.120
G-ialpha65A G protein alphai subunit 65A 0.118
Eip63E Ecdysone-induced protein 63E 0.118
CG12004 CG12004 gene product from transcript CG12004-RC 0.116
sev sevenless 0.113
RhoGAPp190 CG32555 gene product from transcript CG32555-RB 0.112
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 1.000
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 1.000
DNM2 dynamin 2 0.999
SFN stratifin 0.998
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.998
PTK2 PTK2 protein tyrosine kinase 2 0.997
WDYHV1 WDYHV motif containing 1 0.994
RAB5A RAB5A, member RAS oncogene family 0.990
DNM1 dynamin 1 0.989
OCRL oculocerebrorenal syndrome of Lowe 0.988
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.988
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.986
SH3KBP1 SH3-domain kinase binding protein 1 0.985
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.984
ITSN1 intersectin 1 (SH3 domain protein) 0.981
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.974
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.973
EGFR epidermal growth factor receptor 0.971
NCK2 NCK adaptor protein 2 0.968
GRB7 growth factor receptor-bound protein 7 0.954
DOCK1 dedicator of cytokinesis 1 0.947
S100A6 S100 calcium binding protein A6 0.931
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.931
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.929
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.922
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.919
MARK3 MAP/microtubule affinity-regulating kinase 3 0.916
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.904
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.894
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.894
ARRB1 arrestin, beta 1 0.892
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.887
RHOA ras homolog gene family, member A 0.883
RIN3 Ras and Rab interactor 3 0.880
EEA1 early endosome antigen 1 0.877
BCL2L1 BCL2-like 1 0.872
ADAM15 ADAM metallopeptidase domain 15 0.858
ADRBK1 adrenergic, beta, receptor kinase 1 0.853
SH3BP2 SH3-domain binding protein 2 0.849
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.848
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.847
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.844
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.832
S100A8 S100 calcium binding protein A8 0.831
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.828
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.823
EEF1G eukaryotic translation elongation factor 1 gamma 0.821
S100A11 S100 calcium binding protein A11 0.820
ABI1 abl-interactor 1 0.819
RAB1A RAB1A, member RAS oncogene family 0.817
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.813
SH3RF1 SH3 domain containing ring finger 1 0.804
PTK2B PTK2B protein tyrosine kinase 2 beta 0.791
SEC24A SEC24 family, member A (S. cerevisiae) 0.786
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.779
TSC2 tuberous sclerosis 2 0.779
JUN jun proto-oncogene 0.776
RHEB Ras homolog enriched in brain 0.746
STAT5A signal transducer and activator of transcription 5A 0.731
NCK1 NCK adaptor protein 1 0.728
SOS1 son of sevenless homolog 1 (Drosophila) 0.718
ARL2 ADP-ribosylation factor-like 2 0.701
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.701
RGS2 regulator of G-protein signaling 2, 24kDa 0.697
BCAR1 breast cancer anti-estrogen resistance 1 0.696
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.695
TNK2 tyrosine kinase, non-receptor, 2 0.683
NCKAP1 NCK-associated protein 1 0.679
NCF2 neutrophil cytosolic factor 2 0.679
GRB2 growth factor receptor-bound protein 2 0.674
S100B S100 calcium binding protein B 0.656
S100A9 S100 calcium binding protein A9 0.651
RRAGA Ras-related GTP binding A 0.642
CCR5 chemokine (C-C motif) receptor 5 0.634
GIMAP7 GTPase, IMAP family member 7 0.625
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.622
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.619
ANKRD28 ankyrin repeat domain 28 0.619
RABAC1 Rab acceptor 1 (prenylated) 0.609
SEPT2 septin 2 0.600
ZMYND11 zinc finger, MYND-type containing 11 0.596
RAB14 RAB14, member RAS oncogene family 0.595
SYNJ1 synaptojanin 1 0.594
GOLGA2 golgin A2 0.592
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.587
GDI2 GDP dissociation inhibitor 2 0.583
TRAF3 TNF receptor-associated factor 3 0.581
RANBP9 RAN binding protein 9 0.581
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.574
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.572
RAP1B RAP1B, member of RAS oncogene family 0.570
FNBP1 formin binding protein 1 0.569
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.560
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.553
SQSTM1 sequestosome 1 0.544
PKN3 protein kinase N3 0.540
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.538
TSC1 tuberous sclerosis 1 0.536
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Epha4 Eph receptor A4 0.996
Grb2 growth factor receptor bound protein 2 0.986
Rac1 RAS-related C3 botulinum substrate 1 0.980
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.971
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.964
Efnb2 ephrin B2 0.950
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.945
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.931
Braf Braf transforming gene 0.910
Arrb2 arrestin, beta 2 0.893
Ntf3 neurotrophin 3 0.881
Bcl2 B-cell leukemia/lymphoma 2 0.870
Plxna1 plexin A1 0.852
Plxnb1 plexin B1 0.841
Parva parvin, alpha 0.817
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.807
Dock1 dedicator of cytokinesis 1 0.799
Igtp interferon gamma induced GTPase 0.798
Git1 G protein-coupled receptor kinase-interactor 1 0.793
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.778
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.764
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.758
Cbl Casitas B-lineage lymphoma 0.700
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.699
Spry2 sprouty homolog 2 (Drosophila) 0.697
Mapkap1 mitogen-activated protein kinase associated protein 1 0.670
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.649
Spry4 sprouty homolog 4 (Drosophila) 0.641
Pxn paxillin 0.623
Vav1 vav 1 oncogene 0.622
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.622
Selplg selectin, platelet (p-selectin) ligand 0.620
Drd2 dopamine receptor D2 0.613
Eea1 early endosome antigen 1 0.599
Rgnef Rho-guanine nucleotide exchange factor 0.592
Gbp2 guanylate binding protein 2 0.564
Ilk integrin linked kinase 0.560
Fscn1 fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus) 0.559
Tmem30a transmembrane protein 30A 0.559
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.553
Bax BCL2-associated X protein 0.553
Plcg1 phospholipase C, gamma 1 0.550
Ccl2 chemokine (C-C motif) ligand 2 0.546
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.541
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.541
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.541
Prkcc protein kinase C, gamma 0.538
Plxna3 plexin A3 0.531
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.529
Ephb4 Eph receptor B4 0.521
Cd44 CD44 antigen 0.521
Sox10 SRY-box containing gene 10 0.507
Iigp1 interferon inducible GTPase 1 0.501
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.498
Pdgfb platelet derived growth factor, B polypeptide 0.493
Rtkn rhotekin 0.490
Rasgrp1 RAS guanyl releasing protein 1 0.485
Epha1 Eph receptor A1 0.482
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.479
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.475
Vasp vasodilator-stimulated phosphoprotein 0.467
Tsc1 tuberous sclerosis 1 0.466
Ccr2 chemokine (C-C motif) receptor 2 0.454
Fgfr3 fibroblast growth factor receptor 3 0.449
Uba3 ubiquitin-like modifier activating enzyme 3 0.446
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 0.446
Klf7 Kruppel-like factor 7 (ubiquitous) 0.443
Stag2 stromal antigen 2 0.442
Lama5 laminin, alpha 5 0.431
Hmha1 histocompatibility (minor) HA-1 0.430
Ephb2 Eph receptor B2 0.426
Itga3 integrin alpha 3 0.425
Ifi47 interferon gamma inducible protein 47 0.424
Epb4.1l2 erythrocyte protein band 4.1-like 2 0.420
Lepr leptin receptor 0.420
Kcnk2 potassium channel, subfamily K, member 2 0.419
Tgtp2 T-cell specific GTPase 2 0.419
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.407
Nrbp2 nuclear receptor binding protein 2 0.405
Pnp2 purine-nucleoside phosphorylase 2 0.402
Adrb1 adrenergic receptor, beta 1 0.401
Bcr breakpoint cluster region 0.388
Irf1 interferon regulatory factor 1 0.387
Ctnnb1 catenin (cadherin associated protein), beta 1 0.386
Kl klotho 0.382
Dlg4 discs, large homolog 4 (Drosophila) 0.380
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.374
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.374
Pnpla2 patatin-like phospholipase domain containing 2 0.373
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.369
Efnb1 ephrin B1 0.368
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.363
Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 0.362
Nf2 neurofibromatosis 2 0.361
Sash3 SAM and SH3 domain containing 3 0.361
Rap1a RAS-related protein-1a 0.360
Lyst lysosomal trafficking regulator 0.360
Ret ret proto-oncogene 0.359
Arhgap1 Rho GTPase activating protein 1 0.357
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.354
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RHO1 Rho1p 0.892
GDI1 Gdi1p 0.874
YIP3 Yip3p 0.688
YPT52 Ypt52p 0.661
STE5 Ste5p 0.644
SEC13 Sec13p 0.602
MKK1 Mkk1p 0.549
SUI3 Sui3p 0.532
AVO1 Avo1p 0.478
YPT6 Ypt6p 0.414
STE4 Ste4p 0.385
VPS15 Vps15p 0.344
SEC2 Sec2p 0.324
YPT31 Ypt31p 0.309
ACK1 Ack1p 0.283
YPT1 Ypt1p 0.277
GIC2 Gic2p 0.269
SEC16 Sec16p 0.266
ROM2 Rom2p 0.241
YPT10 Ypt10p 0.240
SEC24 Sec24p 0.240
YPT53 Ypt53p 0.224
SEC4 Sec4p 0.209
TOM1 Tom1p 0.207
PKC1 Pkc1p 0.174
BEM3 Bem3p 0.170
FAR1 Far1p 0.163
KOG1 Kog1p 0.155
SED5 Sed5p 0.151
IRA1 Ira1p 0.151
PEP5 Pep5p 0.145
TRS65 Trs65p 0.143
BUD6 Bud6p 0.138
STT4 Stt4p 0.134
TRS31 Trs31p 0.132
YLR257W hypothetical protein 0.125
YHR127W hypothetical protein 0.119
BET3 Bet3p 0.115
CDC24 Cdc24p 0.105
VPS17 Vps17p 0.103
TOR1 Tor1p 0.102
STE2 Ste2p 0.100
FYV8 Fyv8p 0.099
TSC11 Tsc11p 0.098
PEA2 Pea2p 0.098
VTI1 Vti1p 0.097
TRX1 Trx1p 0.094
CCT4 Cct4p 0.093
NOP7 Nop7p 0.092
KES1 Kes1p 0.090
IOC3 Ioc3p 0.090
VPS41 Vps41p 0.087
NIP7 Nip7p 0.087
BUL1 Bul1p 0.080
SSK2 Ssk2p 0.078
ELP4 Elp4p 0.078
ATG20 Atg20p 0.077
MON1 Mon1p 0.076
HSV2 Hsv2p 0.073
APM3 Apm3p 0.073
AFG3 Afg3p 0.072
RFC1 Rfc1p 0.072
KAP114 Kap114p 0.072
PIS1 Pis1p 0.071
ATG14 Atg14p 0.071
CDC42 Cdc42p 0.071
HLJ1 Hlj1p 0.069
KEL1 Kel1p 0.069
NOG2 Nog2p 0.068
YMR258C hypothetical protein 0.068
STE20 Ste20p 0.068
YRB1 Yrb1p 0.067
YIP1 Yip1p 0.067
SMM1 Smm1p 0.067
RGD1 Rgd1p 0.066
SKM1 Skm1p 0.065
NSA2 Nsa2p 0.065
EXO84 Exo84p 0.063
RPM2 Rpm2p 0.062
SPA2 Spa2p 0.061
RER2 Rer2p 0.061
YIL055C hypothetical protein 0.060
HYP2 Hyp2p 0.060
MDS3 Mds3p 0.060
PRS2 Prs2p 0.059
VPS21 Vps21p 0.058
CLN3 Cln3p 0.057
YJR084W hypothetical protein 0.057
YPT7 Ypt7p 0.056
CHS1 Chs1p 0.056
APL4 Apl4p 0.055
YGL036W hypothetical protein 0.055
RPN14 Rpn14p 0.054
YML002W hypothetical protein 0.054
RRP9 Rrp9p 0.053
RRS1 Rrs1p 0.053
URA6 Ura6p 0.053
AKL1 Akl1p 0.053
NYV1 Nyv1p 0.052
YNL108C hypothetical protein 0.051