The network for 'negative regulation of gene silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of gene silencing

Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pcna proliferating cell nuclear antigen 0.036
nanos3 nanos homolog 3 0.031
buc bucky ball 0.028
otul OTU like protein 0.020
rrm1 ribonucleotide reductase M1 polypeptide 0.017
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.016
zgc:113210 zgc:113210 0.015
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.015
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.015
si:ch1073-351m12.1 si:ch1073-351m12.1 0.014
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.013
vasa vasa homolog 0.013
ppp1cbl protein phosphatase 1, catalytic subunit, beta isoform, like 0.012
piwil1 piwi-like 1 (Drosophila) 0.012
sybu syntabulin (syntaxin-interacting) 0.011
tdrd7 tudor domain containing 7 0.010
msh2 mutS homolog 2 (E. coli) 0.010
ca15b carbonic anhydrase XV b 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SP1 Sp1 transcription factor 0.090
SMAD4 SMAD family member 4 0.079
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.051
NCOR1 nuclear receptor corepressor 1 0.031
PBRM1 polybromo 1 0.030
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.030
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.028
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.026
MBD1 methyl-CpG binding domain protein 1 0.016
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.013
EP300 E1A binding protein p300 0.013
ARID1A AT rich interactive domain 1A (SWI-like) 0.012
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.011
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.011
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.011
BCOR BCL6 corepressor 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Sall4 sal-like 4 (Drosophila) 0.914
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.569
Arid1a AT rich interactive domain 1A (SWI-like) 0.562
Nanog Nanog homeobox 0.403
Hdac1 histone deacetylase 1 0.227
Tcfcp2l1 transcription factor CP2-like 1 0.217
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.142
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.085
Ap3b1 adaptor-related protein complex 3, beta 1 subunit 0.078
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.077
Ncor1 nuclear receptor co-repressor 1 0.066
Kdm5b lysine (K)-specific demethylase 5B 0.066
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.064
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.062
Sp1 trans-acting transcription factor 1 0.058
Pldn pallidin 0.058
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.056
Hist1h2bc histone cluster 1, H2bc 0.055
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.051
Sh3gl2 SH3-domain GRB2-like 2 0.049
Brd4 bromodomain containing 4 0.044
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.042
Rnf220 ring finger protein 220 0.040
Sap25 sin3 associated polypeptide 0.040
Cdk2 cyclin-dependent kinase 2 0.038
Ep300 E1A binding protein p300 0.035
Lig1 ligase I, DNA, ATP-dependent 0.032
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.032
Sox2 SRY-box containing gene 2 0.031
Baz2a bromodomain adjacent to zinc finger domain, 2A 0.030
Mta1 metastasis associated 1 0.029
Hdac2 histone deacetylase 2 0.029
Pld3 phospholipase D family, member 3 0.029
Ep400 E1A binding protein p400 0.027
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.027
Nr0b1 nuclear receptor subfamily 0, group B, member 1 0.027
Trp53 transformation related protein 53 0.026
Cdt1 chromatin licensing and DNA replication factor 1 0.026
Timeless timeless homolog (Drosophila) 0.026
Muted muted 0.025
Esrrb estrogen related receptor, beta 0.025
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.024
Kdm2b lysine (K)-specific demethylase 2B 0.024
Cnot6 CCR4-NOT transcription complex, subunit 6 0.023
Rcor1 REST corepressor 1 0.023
Pou2f1 POU domain, class 2, transcription factor 1 0.023
Bod1l biorientation of chromosomes in cell division 1-like 0.023
Blnk B-cell linker 0.022
Rad21 RAD21 homolog (S. pombe) 0.022
Gatad2a GATA zinc finger domain containing 2A 0.022
Gtf3c2 general transcription factor IIIC, polypeptide 2, beta 0.022
Ccna2 cyclin A2 0.022
Chd4 chromodomain helicase DNA binding protein 4 0.022
Actn4 actinin alpha 4 0.022
Sall3 sal-like 3 (Drosophila) 0.021
Pias1 protein inhibitor of activated STAT 1 0.021
Asxl1 additional sex combs like 1 (Drosophila) 0.021
Foxp1 forkhead box P1 0.021
Parp14 poly (ADP-ribose) polymerase family, member 14 0.021
Rrm1 ribonucleotide reductase M1 0.020
Sall1 sal-like 1 (Drosophila) 0.020
2210018M11Rik RIKEN cDNA 2210018M11 gene 0.020
Zfp42 zinc finger protein 42 0.020
Pml promyelocytic leukemia 0.020
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.020
Crebbp CREB binding protein 0.019
Arid3b AT rich interactive domain 3B (BRIGHT-like) 0.019
Nisch nischarin 0.019
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.019
Tcf3 transcription factor 3 0.019
Phf12 PHD finger protein 12 0.019
Dync1i1 dynein cytoplasmic 1 intermediate chain 1 0.019
Numa1 nuclear mitotic apparatus protein 1 0.018
Cabin1 calcineurin binding protein 1 0.018
Tnrc6a trinucleotide repeat containing 6a 0.018
Hcfc1 host cell factor C1 0.018
Tet1 tet oncogene 1 0.018
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.018
Myst2 MYST histone acetyltransferase 2 0.018
Pum2 pumilio 2 (Drosophila) 0.018
Smad4 MAD homolog 4 (Drosophila) 0.017
Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.017
Tcte2 t-complex-associated testis expressed 2 0.017
Nipbl Nipped-B homolog (Drosophila) 0.017
Dlgap4 discs, large homolog-associated protein 4 (Drosophila) 0.017
Rfc5 replication factor C (activator 1) 5 0.017
Yy1 YY1 transcription factor 0.017
Tk1 thymidine kinase 1 0.017
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.017
Ammecr1l AMME chromosomal region gene 1-like 0.017
Ccne1 cyclin E1 0.017
Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 0.017
Gabarap gamma-aminobutyric acid receptor associated protein 0.017
Sycp1 synaptonemal complex protein 1 0.017
Flot1 flotillin 1 0.016
Lyst lysosomal trafficking regulator 0.016
Prkd3 protein kinase D3 0.016
Actn3 actinin alpha 3 0.016
Maml1 mastermind like 1 (Drosophila) 0.016
Naa11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CTI6 Cti6p 0.831
SIN3 Sin3p 0.735
PHO23 Pho23p 0.616
RXT2 Rxt2p 0.536
UME1 Ume1p 0.482
RPD3 Rpd3p 0.431
RNR2 Rnr2p 0.406
SAP30 Sap30p 0.318
SDS3 Sds3p 0.284
NTO1 Nto1p 0.280
FKH2 Fkh2p 0.254
CDC6 Cdc6p 0.230
SUM1 Sum1p 0.215
MIG2 Mig2p 0.214
HHT1 Hht1p 0.197
HOS3 Hos3p 0.188
SIR2 Sir2p 0.175
SET3 Set3p 0.174
UME6 Ume6p 0.132
EAF3 Eaf3p 0.127
RCO1 Rco1p 0.122
AFT1 Aft1p 0.120
HHO1 Hho1p 0.120
ROX1 Rox1p 0.119
ASH1 Ash1p 0.113
SWI1 Swi1p 0.109
MIG1 Mig1p 0.100
HOS4 Hos4p 0.094
SLX8 Slx8p 0.088
ZAP1 Zap1p 0.086
SNT1 Snt1p 0.082
RAP1 Rap1p 0.081
MCM3 Mcm3p 0.079
DEF1 Def1p 0.077
MMS21 Mms21p 0.074
HXT3 Hxt3p 0.073
KIC1 Kic1p 0.071
YKR075C hypothetical protein 0.070
MIG3 Mig3p 0.068
YML082W hypothetical protein 0.068
AGP2 Agp2p 0.066
NRG1 Nrg1p 0.066
SLX5 Slx5p 0.065
SIR4 Sir4p 0.061
IRA2 Ira2p 0.059
HHF2 Hhf2p 0.058
SAN1 San1p 0.057
YLR455W hypothetical protein 0.053
RAD51 Rad51p 0.051
IXR1 Ixr1p 0.051
YGR126W hypothetical protein 0.048
YKU70 Yku70p 0.048
HOS2 Hos2p 0.048
YLR278C hypothetical protein 0.047
LYS5 Lys5p 0.046
HAL5 Hal5p 0.046
RXT3 Rxt3p 0.044
YOR390W hypothetical protein 0.044
OPI1 Opi1p 0.044
CAT8 Cat8p 0.041
STE7 Ste7p 0.040
SRP54 Srp54p 0.039
SIW14 Siw14p 0.039
RGT1 Rgt1p 0.038
HO Hop 0.038
HDA3 Hda3p 0.037
TYW1 Tyw1p 0.037
DOT6 Dot6p 0.036
STH1 Sth1p 0.036
HIR2 Hir2p 0.036
YMR259C hypothetical protein 0.036
SFL1 Sfl1p 0.035
MPT5 Mpt5p 0.034
TRA1 Tra1p 0.034
YDL156W hypothetical protein 0.034
YCL042W hypothetical protein 0.034
NDD1 Ndd1p 0.033
ATG15 Atg15p 0.033
DED1 Ded1p 0.033
HDA2 Hda2p 0.033
UBP8 Ubp8p 0.033
TBS1 Tbs1p 0.032
IFH1 Ifh1p 0.031
YKL187C hypothetical protein 0.031
HMO1 Hmo1p 0.030
MOT1 Mot1p 0.029
SNA4 Sna4p 0.029
RMA1 Rma1p 0.028
GAT2 Gat2p 0.028
GCR2 Gcr2p 0.028
ARP8 Arp8p 0.027
NFI1 Nfi1p 0.027
MET28 Met28p 0.027
GIC1 Gic1p 0.026
DEP1 Dep1p 0.026
IRC23 Irc23p 0.026
POG1 Pog1p 0.026
NUP1 Nup1p 0.026
HXT1 Hxt1p 0.025
RTF1 Rtf1p 0.025