The network for 'neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron.

Rattus norvegicus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.919
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.794
Nrxn1 neurexin 1 0.764
Lin7b lin-7 homolog b (C. elegans) 0.759
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.746
Pfn1 profilin 1 0.669
Atf3 activating transcription factor 3 0.658
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.652
Anxa2 annexin A2 0.645
Grm7 glutamate receptor, metabotropic 7 0.641
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.626
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.624
Sptan1 spectrin, alpha, non-erythrocytic 1 0.616
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.606
Ifitm3 interferon induced transmembrane protein 3 0.600
Calcrl calcitonin receptor-like 0.598
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.598
Itgb1 integrin, beta 1 0.595
Adrb1 adrenergic, beta-1-, receptor 0.584
Grm5 glutamate receptor, metabotropic 5 0.577
Apba1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.576
Dlg4 discs, large homolog 4 (Drosophila) 0.575
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.563
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.558
Tpm3 tropomyosin 3, gamma 0.555
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.555
Actb actin, beta 0.555
Adam17 ADAM metallopeptidase domain 17 0.552
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.547
Jak1 Janus kinase 1 0.544
Cd9 CD9 molecule 0.543
Acvr1 activin A receptor, type I 0.542
Pls3 plastin 3 (T-isoform) 0.541
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.536
Gria2 glutamate receptor, ionotropic, AMPA 2 0.526
Tgfbr2 transforming growth factor, beta receptor II 0.523
Acta2 smooth muscle alpha-actin 0.517
Dgkg diacylglycerol kinase, gamma 0.514
Dab2 disabled homolog 2 (Drosophila) 0.501
Nrxn3 neurexin 3 0.501
Ednrb endothelin receptor type B 0.497
Prkcg protein kinase C, gamma 0.493
Gnao1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.490
Map2 microtubule-associated protein 2 0.479
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.476
Ccl2 chemokine (C-C motif) ligand 2 0.472
Galr3 galanin receptor 3 0.453
Aqp4 aquaporin 4 0.452
Rab11a RAB11a, member RAS oncogene family 0.449
Sncb synuclein, beta 0.448
Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.440
Met met proto-oncogene 0.439
Foxd3 forkhead box D3 0.438
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.436
Lphn2 latrophilin 2 0.428
Jak2 Janus kinase 2 0.428
Nckap1 NCK-associated protein 1 0.428
Hoxa2 homeo box A2 0.427
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.426
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.425
Itgam integrin, alpha M 0.424
Kcnd2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.423
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.422
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.421
Nrcam neuronal cell adhesion molecule 0.421
Mprip myosin phosphatase Rho interacting protein 0.412
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.409
Rap1b RAP1B, member of RAS oncogene family 0.408
Syp synaptophysin 0.407
Astn1 astrotactin 1 0.404
Clic4 chloride intracellular channel 4 0.403
Gas7 growth arrest specific 7 0.403
Neurod2 neurogenic differentiation 2 0.403
Tacr3 tachykinin receptor 3 0.400
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.399
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.395
Apba3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.392
Map1a microtubule-associated protein 1A 0.392
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.390
Scn3a sodium channel, voltage-gated, type III, alpha 0.390
Prrx1 paired related homeobox 1 0.389
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.386
Camk4 calcium/calmodulin-dependent protein kinase IV 0.381
Lgals9 lectin, galactoside-binding, soluble, 9 0.378
Nell1 NEL-like 1 (chicken) 0.377
Wasl Wiskott-Aldrich syndrome-like 0.370
Ptprs protein tyrosine phosphatase, receptor type, S 0.366
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.363
Nefh neurofilament, heavy polypeptide 0.363
Nell2 NEL-like 2 (chicken) 0.363
Ier3 immediate early response 3 0.357
Ppap2b phosphatidic acid phosphatase type 2B 0.355
Cadm1 cell adhesion molecule 1 0.354
Robo1 roundabout homolog 1 (Drosophila) 0.353
Strn striatin, calmodulin binding protein 0.352
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.352
Tmod2 tropomodulin 2 0.351
Adcy6 adenylate cyclase 6 0.351
Tcf4 transcription factor 4 0.350
Sirpa signal-regulatory protein alpha 0.346
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.991
vab-3 Protein VAB-3 0.971
pha-4 Protein PHA-4 0.873
pry-1 Protein PRY-1 0.856
unc-73 Protein UNC-73 0.856
syg-1 Protein SYG-1 0.813
egl-46 Protein EGL-46 0.808
unc-9 Protein UNC-9 0.794
unc-53 Protein UNC-53 0.772
hbl-1 Protein HBL-1 0.726
T28F4.1 Protein T28F4.1 0.724
ceh-20 Protein CEH-20 0.718
sem-5 Protein SEM-5 0.692
nhr-67 Protein NHR-67 0.683
egl-44 Protein EGL-44 0.643
daf-11 Protein DAF-11 0.639
hlh-2 Protein HLH-2 0.637
ten-1 Protein TEN-1 0.594
sli-1 Protein SLI-1 0.587
unc-52 Protein UNC-52 0.576
egl-13 Protein EGL-13 0.563
rig-6 Protein RIG-6 0.561
ain-1 Protein AIN-1 0.558
unc-42 Protein UNC-42 0.556
C11E4.6 Protein C11E4.6 0.552
ida-1 Protein IDA-1 0.550
egl-8 Protein EGL-8 0.538
dnc-2 Protein DNC-2 0.531
sma-6 Protein SMA-6 0.529
cam-1 Protein CAM-1 0.501
nhr-34 Protein NHR-34 0.499
glp-1 Protein GLP-1 0.489
sax-3 Protein SAX-3 0.477
lin-11 Protein LIN-11 0.472
pxf-1 Protein PXF-1 0.451
sad-1 Protein SAD-1 0.450
elt-6 Protein ELT-6 0.446
osm-3 Protein OSM-3 0.445
sdz-28 Protein SDZ-28 0.444
C54E4.2 Protein C54E4.2 0.431
unc-62 Protein UNC-62 0.417
sup-12 Protein SUP-12 0.413
pal-1 Protein PAL-1 0.413
swah-1 Protein SWAH-1 0.411
epi-1 Protein EPI-1 0.405
hlh-1 Protein HLH-1 0.399
nhr-6 Protein NHR-6 0.396
fkh-2 Protein FKH-2 0.391
goa-1 Protein GOA-1 0.390
rsd-2 Protein RSD-2 0.388
mab-5 Protein MAB-5 0.380
let-60 Protein LET-60 0.373
gld-1 Protein GLD-1 0.367
K10D6.4 Protein K10D6.4 0.363
pan-1 Protein PAN-1 0.362
ceh-48 Protein CEH-48 0.356
let-607 Protein LET-607 0.355
pdfr-1 Protein PDFR-1 0.353
F33H2.3 Protein F33H2.3 0.351
dsh-1 Protein DSH-1 0.350
ace-3 Protein ACE-3 0.350
adr-1 Protein ADR-1 0.346
aap-1 Protein AAP-1 0.344
mpk-1 Protein MPK-1 0.344
egl-5 Protein EGL-5 0.342
cye-1 Protein CYE-1 0.340
sorb-1 Protein SORB-1 0.337
egl-15 Protein EGL-15 0.337
bar-1 Protein BAR-1 0.334
lin-23 Protein LIN-23 0.333
ttx-1 Protein TTX-1 0.325
wrk-1 Protein WRK-1 0.325
CELE_Y41E3.7 Protein Y41E3.7 0.325
cec-4 Protein CEC-4 0.325
ppfr-2 Protein PPFR-2 0.324
pkg-1 Protein PKG-1 0.321
lin-17 Protein LIN-17 0.319
unc-70 Protein UNC-70 0.319
lin-12 Protein LIN-12 0.319
let-2 Protein LET-2 0.318
T26A5.6 Protein T26A5.6 0.317
apb-1 Protein APB-1 0.310
T27A3.1 Protein T27A3.1 0.305
npp-1 Protein NPP-1 0.303
che-2 Protein CHE-2 0.302
hmp-1 Protein HMP-1 0.301
CELE_C23G10.8 Protein C23G10.8 0.299
hda-3 Protein HDA-3 0.297
F28E10.1 Protein F28E10.1 0.296
shn-1 Protein SHN-1 0.292
unc-6 Protein UNC-6 0.290
clh-5 Protein CLH-5 0.289
dpy-22 Protein DPY-22 0.288
pmk-1 Protein PMK-1 0.287
unc-104 Protein UNC-104 0.285
che-13 Protein CHE-13 0.285
vhp-1 Protein VHP-1 0.278
mig-2 Protein MIG-2 0.277
egl-27 Protein EGL-27 0.277
eor-1 Protein EOR-1 0.276
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Danio rerio
Name Description Probability Func Analog Organism
rx3 retinal homeobox gene 3 1.000
kdrl kinase insert domain receptor like 0.999
tbx1 T-box 1 0.999
fgf3 fibroblast growth factor 3 0.998
pax2a paired box gene 2a 0.997
lhx2b LIM homeobox 2b 0.997
sox2 SRY-box containing gene 2 0.995
otx2 orthodenticle homolog 2 0.994
pax6b paired box gene 6b 0.993
ndr2 nodal-related 2 0.993
foxi1 forkhead box I1 0.993
neurog1 neurogenin 1 0.991
dla deltaA 0.986
six3b sine oculis homeobox homolog 3b 0.984
isl1 islet1 0.983
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.981
fezf2 FEZ family zinc finger 2 0.977
pax6a paired box gene 6a 0.977
gbx2 gastrulation brain homeo box 2 0.972
alcamb activated leukocyte cell adhesion molecule b 0.972
wnt11r wingless-type MMTV integration site family, member 11, related 0.972
neurod neurogenic differentiation 0.971
fsta follistatin a 0.968
cdh2 cadherin 2, neuronal 0.967
otx1a orthodenticle homolog 1a 0.964
ptf1a pancreas specific transcription factor, 1a 0.963
crb2a crumbs homolog 2a 0.962
ttna titin a 0.961
tfap2a transcription factor AP-2 alpha 0.958
fli1a friend leukemia integration 1a 0.955
gli2a GLI-Kruppel family member GLI2a 0.954
stmn2b stathmin-like 2b 0.947
hoxd4a homeo box D4a 0.947
robo2 roundabout homolog 2 0.946
rarga retinoic acid receptor gamma a 0.945
six3a sine oculis homeobox homolog 3a 0.944
gli1 GLI-Kruppel family member 1 0.943
flh floating head 0.941
ift88 intraflagellar transport 88 homolog 0.939
otpb orthopedia homolog b 0.939
ptch2 patched 2 0.938
her4.2 hairy-related 4.2 0.938
sox1a SRY-box containing gene 1a 0.937
atoh7 atonal homolog 7 0.935
pcdh19 protocadherin 19 0.934
egr2b early growth response 2b 0.932
dlx2a distal-less homeobox gene 2a 0.932
traf4a tnf receptor-associated factor 4a 0.930
pou3f1 POU class 3 homeobox 1 0.929
epha4a eph receptor A4a 0.928
notch2 notch homolog 2 0.923
irx3a iroquois homeobox protein 3a 0.923
ncam1a neural cell adhesion molecule 1a 0.922
dmbx1a diencephalon/mesencephalon homeobox 1a 0.921
olfm2 olfactomedin 2 0.921
gdf6a growth differentiation factor 6a 0.920
kif17 kinesin family member 17 0.915
dlc deltaC 0.915
bhlhe22 basic helix-loop-helix family, member e22 0.914
dctn1a dynactin 1a 0.914
st8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.913
apc adenomatosis polyposis coli 0.906
dlx5a distal-less homeobox gene 5a 0.906
ankrd6 ankyrin repeat domain 6 0.905
otx1b orthodenticle homolog 1b 0.901
slc1a2b solute carrier family 1 (glial high affinity glutamate transporter), member 2b 0.900
sema3aa semaphorin 3aa 0.900
wnt11 wingless-type MMTV integration site family, member 11 0.897
fstl1b follistatin-like 1b 0.897
jag2 jagged 2 0.896
otx5 orthodenticle homolog 5 0.889
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.888
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.887
irx4b iroquois homeobox protein 4b 0.886
eomesa eomesodermin homolog a 0.886
neo1 neogenin 1 0.884
nes nestin 0.883
fn1 fibronectin 1 0.875
scn1lab sodium channel, voltage-gated, type I like, alpha b 0.873
boc brother of CDO 0.872
rx2 retinal homeobox gene 2 0.870
unc45b unc-45 homolog B (C. elegans) 0.869
eng2a engrailed 2a 0.869
slit3 slit (Drosophila) homolog 3 0.864
tp53 tumor protein p53 0.863
esrrga estrogen-related receptor gamma a 0.862
sox9a SRY-box containing gene 9a 0.861
myod1 myogenic differentiation 1 0.860
stmn2a stathmin-like 2a 0.858
fgfr4 fibroblast growth factor receptor 4 0.857
cntn2 contactin 2 0.855
shhb sonic hedgehog b 0.854
spry2 sprouty homolog 2 0.852
atoh1a atonal homolog 1a 0.845
sox17 SRY-box containing gene 17 0.843
tgfb3 transforming growth factor, beta 3 0.841
scn8aa sodium channel, voltage-gated, type VIII, alpha a 0.836
plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.836
prdm16 PR domain containing 16 0.834
drd2a dopamine receptor D2a 0.829
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
EGFR epidermal growth factor receptor 1.000
CREBBP CREB binding protein 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.999
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.999
QKI quaking homolog, KH domain RNA binding (mouse) 0.998
FYN FYN oncogene related to SRC, FGR, YES 0.998
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.998
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.998
ATXN1 ataxin 1 0.998
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.996
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.995
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.994
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.993
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.993
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.993
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.987
MAPT microtubule-associated protein tau 0.980
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.975
RB1 retinoblastoma 1 0.975
HDAC4 histone deacetylase 4 0.970
FN1 fibronectin 1 0.969
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.966
SMAD2 SMAD family member 2 0.964
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.963
GRB2 growth factor receptor-bound protein 2 0.957
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.954
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.954
LCK lymphocyte-specific protein tyrosine kinase 0.953
AR androgen receptor 0.947
NCOR1 nuclear receptor corepressor 1 0.946
SMN1 survival of motor neuron 1, telomeric 0.946
APC adenomatous polyposis coli 0.944
EP300 E1A binding protein p300 0.944
SFN stratifin 0.943
RUNX1 runt-related transcription factor 1 0.941
CFL1 cofilin 1 (non-muscle) 0.934
TUBB tubulin, beta 0.932
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.927
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.927
ATN1 atrophin 1 0.923
TP53 tumor protein p53 0.916
IGF1R insulin-like growth factor 1 receptor 0.912
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.907
JUN jun proto-oncogene 0.902
ACTB actin, beta 0.902
SMAD4 SMAD family member 4 0.900
FLNA filamin A, alpha 0.899
MAPK1 mitogen-activated protein kinase 1 0.886
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.882
TAL1 T-cell acute lymphocytic leukemia 1 0.881
GSK3B glycogen synthase kinase 3 beta 0.880
TUBB2C tubulin, beta 2C 0.877
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.875
YAP1 Yes-associated protein 1 0.872
APP amyloid beta (A4) precursor protein 0.872
ESR1 estrogen receptor 1 0.864
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.863
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.832
RARA retinoic acid receptor, alpha 0.827
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.820
STRN3 striatin, calmodulin binding protein 3 0.818
TUBA1A tubulin, alpha 1a 0.805
TUBB3 tubulin, beta 3 0.803
TRRAP transformation/transcription domain-associated protein 0.800
LRRK2 leucine-rich repeat kinase 2 0.797
PKM2 pyruvate kinase, muscle 0.795
PCGF2 polycomb group ring finger 2 0.793
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.786
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.775
FHL2 four and a half LIM domains 2 0.774
RXRA retinoid X receptor, alpha 0.774
SMAD3 SMAD family member 3 0.768
RPA1 replication protein A1, 70kDa 0.759
SPTBN1 spectrin, beta, non-erythrocytic 1 0.758
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.757
HDAC2 histone deacetylase 2 0.752
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.742
NCK1 NCK adaptor protein 1 0.740
TUBA1B tubulin, alpha 1b 0.737
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.736
MAPK8 mitogen-activated protein kinase 8 0.736
HSPG2 heparan sulfate proteoglycan 2 0.725
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.717
TUBA1C tubulin, alpha 1c 0.708
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.706
CBX5 chromobox homolog 5 0.695
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.695
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.694
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.691
TCF4 transcription factor 4 0.688
BMI1 BMI1 polycomb ring finger oncogene 0.683
MPRIP myosin phosphatase Rho interacting protein 0.683
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.680
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.678
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.672
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.671
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism