The network for 'response to external stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to external stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.934
vab-3 Protein VAB-3 0.917
unc-9 Protein UNC-9 0.861
cam-1 Protein CAM-1 0.767
efn-2 Protein EFN-2 0.756
sma-6 Protein SMA-6 0.724
ima-3 Protein IMA-3 0.714
daf-11 Protein DAF-11 0.699
pkg-1 Protein PKG-1 0.667
hlh-2 Protein HLH-2 0.640
sli-1 Protein SLI-1 0.626
syg-1 Protein SYG-1 0.613
sem-5 Protein SEM-5 0.581
par-5 Protein PAR-5 0.573
ldb-1 Protein LDB-1 0.563
pdfr-1 Protein PDFR-1 0.561
pry-1 Protein PRY-1 0.556
lin-25 Protein LIN-25 0.556
ceh-20 Protein CEH-20 0.547
odr-3 Protein ODR-3 0.528
CELE_C17H12.8 Protein C17H12.8 0.527
gpb-1 Protein GPB-1 0.526
ncam-1 Protein NCAM-1 0.507
rol-6 Protein ROL-6 0.503
sax-3 Protein SAX-3 0.500
lrp-2 Protein LRP-2 0.491
sqt-1 Protein SQT-1 0.488
atat-2 Protein ATAT-2 0.481
clh-5 Protein CLH-5 0.473
unc-6 Protein UNC-6 0.454
unc-115 Protein UNC-115 0.444
plc-1 Protein PLC-1 0.440
dpy-13 Protein DPY-13 0.435
egl-27 Protein EGL-27 0.422
col-104 Protein COL-104 0.410
tbb-4 Protein TBB-4 0.407
che-1 Protein CHE-1 0.406
cnd-1 Protein CND-1 0.393
nhr-25 Protein NHR-25 0.393
tax-4 Protein TAX-4 0.391
hlh-1 Protein HLH-1 0.390
ilys-3 Protein ILYS-3 0.390
apl-1 Protein APL-1 0.387
unc-103 Protein UNC-103 0.384
scl-2 Protein SCL-2 0.381
che-2 Protein CHE-2 0.376
gfi-3 Protein GFI-3 0.370
atp-2 Protein ATP-2 0.369
che-3 Protein CHE-3 0.367
tax-6 Protein TAX-6 0.367
hmg-1.2 Protein HMG-1.2 0.366
flt-1 Protein FLT-1 0.365
CELE_F55G11.8 Protein F55G11.8 0.360
ahcy-1 Protein AHCY-1 0.352
rig-6 Protein RIG-6 0.351
hda-3 Protein HDA-3 0.349
atg-18 Protein ATG-18 0.346
glr-5 Protein GLR-5 0.343
ttyh-1 Protein TTYH-1 0.341
kle-2 Protein KLE-2 0.339
unc-104 Protein UNC-104 0.336
nhr-67 Protein NHR-67 0.334
T05G5.1 Protein T05G5.1 0.334
mep-1 Protein MEP-1 0.331
fkh-2 Protein FKH-2 0.320
dod-17 Protein DOD-17 0.317
glp-1 Protein GLP-1 0.315
eor-1 Protein EOR-1 0.314
osm-5 Protein OSM-5 0.313
daf-2 Protein DAF-2 0.309
ten-1 Protein TEN-1 0.305
ist-1 Protein IST-1 0.304
abl-1 Protein ABL-1 0.304
F28E10.1 Protein F28E10.1 0.304
mig-38 Protein MIG-38 0.303
D1007.5 Protein D1007.5 0.301
unc-32 Protein UNC-32 0.300
ida-1 Protein IDA-1 0.299
rpn-12 Protein RPN-12 0.297
col-146 Protein COL-146 0.297
ifg-1 Protein IFG-1 0.293
vav-1 Protein VAV-1 0.292
let-60 Protein LET-60 0.291
F47D12.6 Protein F47D12.6 0.291
gpa-14 Protein GPA-14 0.288
sqt-3 Protein SQT-3 0.284
olrn-1 Protein OLRN-1 0.283
C05D11.7 Protein C05D11.7 0.283
pxf-1 Protein PXF-1 0.282
K11G12.5 Protein K11G12.5 0.281
unc-7 Protein UNC-7 0.281
col-173 Protein COL-173 0.281
cst-1 Protein CST-1 0.281
cul-2 Protein CUL-2 0.279
pha-4 Protein PHA-4 0.278
ina-1 Protein INA-1 0.277
daf-25 Protein DAF-25 0.277
enu-3 Protein ENU-3 0.277
cki-1 Protein CKI-1 0.275
col-181 Protein COL-181 0.272
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Danio rerio
Name Description Probability Func Analog Organism
dlx5a distal-less homeobox gene 5a 0.988
gli2a GLI-Kruppel family member GLI2a 0.986
chd chordin 0.985
fgfr1a fibroblast growth factor receptor 1a 0.981
fgf3 fibroblast growth factor 3 0.981
her15.1 hairy and enhancer of split-related 15.1 0.977
shha sonic hedgehog a 0.977
otpa orthopedia homolog a 0.976
robo3 roundabout homolog 3 0.975
efnb2a ephrin B2a 0.969
gata5 GATA-binding protein 5 0.956
dlx2a distal-less homeobox gene 2a 0.945
ntla no tail a 0.945
tbx1 T-box 1 0.944
wnt10a wingless-type MMTV integration site family, member 10a 0.944
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.943
ndr2 nodal-related 2 0.937
egr1 early growth response 1 0.935
bdnf brain-derived neurotrophic factor 0.921
pitx3 paired-like homeodomain transcription factor 3 0.919
notch2 notch homolog 2 0.908
gli1 GLI-Kruppel family member 1 0.902
tp53 tumor protein p53 0.895
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.894
sox2 SRY-box containing gene 2 0.892
gro1 groucho 1 0.889
slit3 slit (Drosophila) homolog 3 0.888
cdh23 cadherin-like 23 0.886
pax2a paired box gene 2a 0.885
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.875
fgfr2 fibroblast growth factor receptor 2 0.874
wnt8b wingless-type MMTV integration site family, member 8b 0.872
igf1ra insulin-like growth factor 1a receptor 0.859
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.855
nos2a nitric oxide synthase 2a, inducible 0.848
glud1a glutamate dehydrogenase 1a 0.843
lamc1 laminin, gamma 1 0.823
angptl2 angiopoietin-like 2 0.820
col1a1a collagen, type I, alpha 1a 0.820
elavl3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) 0.817
alcama activated leukocyte cell adhesion molecule a 0.814
fn1 fibronectin 1 0.807
ext2 exostoses (multiple) 2 0.787
runx2b runt-related transcription factor 2b 0.786
rad21 RAD21 homolog (S. pombe) 0.785
nos1 nitric oxide synthase 1 (neuronal) 0.785
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.785
gad2 glutamate decarboxylase 2 0.771
itgb1b integrin, beta 1b 0.767
prnprs3 prion protein, related sequence 3 0.765
vasa vasa homolog 0.763
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.754
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.752
notch1a notch homolog 1a 0.751
smo smoothened homolog (Drosophila) 0.747
cd63 Cd63 antigen 0.744
dmd dystrophin 0.738
kal1b Kallmann syndrome 1b sequence 0.736
per3 period homolog 3 (Drosophila) 0.734
wnt1 wingless-type MMTV integration site family, member 1 0.730
nxph1 neurexophilin 1 0.723
sox9a SRY-box containing gene 9a 0.715
frem3 Fras1 related extracellular matrix 3 0.712
mnx1 motor neuron and pancreas homeobox 1 0.710
mycbp2 MYC binding protein 2 0.709
dag1 dystroglycan 1 0.708
plxnb2a plexin b2a 0.708
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.701
dharma dharma 0.696
gata2a GATA-binding protein 2a 0.690
plcg1 phospholipase C, gamma 1 0.690
rarga retinoic acid receptor gamma a 0.684
ihha Indian hedgehog homolog a 0.680
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.678
apoeb apolipoprotein Eb 0.678
atp1a3a ATPase, Na+/K+ transporting, alpha 3a polypeptide 0.675
dla deltaA 0.667
dusp6 dual specificity phosphatase 6 0.665
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.660
fabp7a fatty acid binding protein 7, brain, a 0.656
nrp2b neuropilin 2b 0.654
snai1a snail homolog 1a (Drosophila) 0.652
per2 period homolog 2 (Drosophila) 0.649
robo2 roundabout homolog 2 0.646
gbx2 gastrulation brain homeo box 2 0.644
tlr3 toll-like receptor 3 0.639
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.635
LOC567678 avidin-like 0.634
olig2 oligodendrocyte lineage transcription factor 2 0.634
ache acetylcholinesterase 0.628
col14a1 collagen, type XIV, alpha 1 0.627
dbh dopamine beta hydroxylase 0.627
pax8 paired box gene 8 0.626
traf4a tnf receptor-associated factor 4a 0.625
eng2a engrailed 2a 0.625
col1a2 collagen, type I, alpha 2 0.623
spry2 sprouty homolog 2 0.621
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.619
il6r interleukin 6 receptor 0.615
eno1 enolase 1, (alpha) 0.614
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ATG1 Atg1p 0.990
TOR1 Tor1p 0.969
MSN2 Msn2p 0.886
HSP82 Hsp82p 0.869
GAL11 Gal11p 0.837
GLN3 Gln3p 0.796
ATG21 Atg21p 0.787
KSP1 Ksp1p 0.728
RIM101 Rim101p 0.640
RTG3 Rtg3p 0.614
RPN4 Rpn4p 0.604
BMH2 Bmh2p 0.556
SNF4 Snf4p 0.532
YPT1 Ypt1p 0.524
ATG13 Atg13p 0.497
COG3 Cog3p 0.495
SIP1 Sip1p 0.489
HRK1 Hrk1p 0.472
GPR1 Gpr1p 0.471
ATG4 Atg4p 0.459
RVS167 Rvs167p 0.453
RIM15 Rim15p 0.451
VID24 Vid24p 0.450
OM45 Om45p 0.439
HSP33 Hsp33p 0.433
SLT2 Slt2p 0.427
MYO5 Myo5p 0.413
NUP170 Nup170p 0.410
VPS30 Vps30p 0.399
MKS1 Mks1p 0.396
PEP5 Pep5p 0.392
HSP32 Hsp32p 0.386
ISW1 Isw1p 0.386
ATG12 Atg12p 0.385
KGD1 Kgd1p 0.384
CLB3 Clb3p 0.380
CKA2 Cka2p 0.376
HSV2 Hsv2p 0.376
SOD1 Sod1p 0.372
CAT8 Cat8p 0.369
CCZ1 Ccz1p 0.368
STE2 Ste2p 0.362
ASP3-1 Asp3-1p 0.360
ATG3 Atg3p 0.347
NGR1 Ngr1p 0.347
VHS1 Vhs1p 0.338
GAL80 Gal80p 0.336
SMF2 Smf2p 0.335
NET1 Net1p 0.328
SNF5 Snf5p 0.327
KDX1 Kdx1p 0.316
DBF2 Dbf2p 0.314
DNF3 Dnf3p 0.309
GAL3 Gal3p 0.308
GLK1 Glk1p 0.304
GAT2 Gat2p 0.301
IZH4 Izh4p 0.301
AQY2 Aqy2p 0.299
ASP3-2 Asp3-2p 0.286
ATG14 Atg14p 0.283
ASP3-3 Asp3-3p 0.281
GAL4 Gal4p 0.278
SEC2 Sec2p 0.275
ENA5 Ena5p 0.274
ATG23 Atg23p 0.274
VPS36 Vps36p 0.273
SNX4 Snx4p 0.268
YOL087C hypothetical protein 0.268
FMP40 Fmp40p 0.267
STP2 Stp2p 0.262
ASP3-4 Asp3-4p 0.261
IML1 Iml1p 0.260
FIG4 Fig4p 0.256
SNF2 Snf2p 0.255
RLM1 Rlm1p 0.253
VAM6 Vam6p 0.252
PHO11 Pho11p 0.251
GSH1 Gsh1p 0.248
RRD1 Rrd1p 0.245
BDH2 Bdh2p 0.245
ARP7 Arp7p 0.240
CLB4 Clb4p 0.240
ITC1 Itc1p 0.233
ATG20 Atg20p 0.231
SWI1 Swi1p 0.228
MCK1 Mck1p 0.226
MET4 Met4p 0.226
YPK2 Ypk2p 0.226
SUM1 Sum1p 0.225
MON1 Mon1p 0.224
KAR2 Kar2p 0.223
GAL7 Gal7p 0.218
DGR2 Dgr2p 0.216
CIS1 Cis1p 0.216
RUD3 Rud3p 0.214
SSN3 Ssn3p 0.214
CHD1 Chd1p 0.213
VAC8 Vac8p 0.211
HOG1 Hog1p 0.211
GPA2 Gpa2p 0.208