The network for 'protein modification process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

Rattus norvegicus
Name Description Probability Func Analog Organism
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
dsh-2 Protein DSH-2 0.630
dep-1 Protein DEP-1 0.590
egl-18 Protein EGL-18 0.577
sun-1 Protein SUN-1 0.549
atg-18 Protein ATG-18 0.491
mel-26 Protein MEL-26 0.491
lit-1 Protein LIT-1 0.453
CELE_Y52B11A.9 Protein Y52B11A.9 0.441
mat-3 Protein MAT-3 0.428
glp-1 Protein GLP-1 0.409
unc-9 Protein UNC-9 0.402
cam-1 Protein CAM-1 0.392
nud-2 Protein NUD-2 0.392
unc-83 Protein UNC-83 0.392
pdfr-1 Protein PDFR-1 0.391
ZK507.6 Protein ZK507.6 0.384
let-60 Protein LET-60 0.380
pup-2 Protein PUP-2 0.377
M01A8.2 Protein M01A8.2 0.372
D1081.8 Protein D1081.8 0.368
egl-8 Protein EGL-8 0.366
par-5 Protein PAR-5 0.365
pqn-59 Protein PQN-59 0.363
pkg-1 Protein PKG-1 0.362
klc-2 Protein KLC-2 0.362
vab-3 Protein VAB-3 0.361
sli-1 Protein SLI-1 0.359
kle-2 Protein KLE-2 0.353
spc-1 Protein SPC-1 0.351
sas-5 Protein SAS-5 0.340
sma-6 Protein SMA-6 0.335
ina-1 Protein INA-1 0.318
ceh-39 Protein CEH-39 0.315
klp-7 Protein KLP-7 0.315
lin-25 Protein LIN-25 0.314
nlg-1 Protein NLG-1 0.311
gyg-2 Protein GYG-2 0.304
R11A8.7 Protein R11A8.7 0.299
ida-1 Protein IDA-1 0.291
ifet-1 Protein IFET-1 0.286
pkc-3 Protein PKC-3 0.275
C05D10.4 Protein C05D10.4 0.273
zag-1 Protein ZAG-1 0.273
imb-2 Protein IMB-2 0.272
homt-1 Protein HOMT-1 0.272
skn-1 Protein SKN-1 0.267
unc-53 Protein UNC-53 0.266
tps-1 Protein TPS-1 0.266
clh-5 Protein CLH-5 0.264
sta-1 Protein STA-1 0.260
Y54E5A.7 Protein Y54E5A.7 0.258
sma-1 Protein SMA-1 0.258
pmk-1 Protein PMK-1 0.257
atn-1 Protein ATN-1 0.252
swsn-4 Protein SWSN-4 0.251
pcaf-1 Protein PCAF-1 0.249
hum-5 Protein HUM-5 0.249
B0336.3 Protein B0336.3 0.247
ceh-18 Protein CEH-18 0.246
cbd-1 Protein CBD-1 0.244
vps-53 Protein VPS-53 0.239
pde-2 Protein PDE-2 0.235
his-64 Protein HIS-64 0.234
mrck-1 Protein MRCK-1 0.234
csn-5 Protein CSN-5 0.233
cdk-9 Protein CDK-9 0.232
cids-2 Protein CIDS-2 0.232
mig-15 Protein MIG-15 0.232
mbk-2 Protein MBK-2 0.226
M03F8.3 Protein M03F8.3 0.225
klp-18 Protein KLP-18 0.224
let-70 Protein LET-70 0.223
his-1 Protein HIS-1 0.219
K03E6.7 Protein K03E6.7 0.218
dpy-10 Protein DPY-10 0.217
nhr-67 Protein NHR-67 0.217
C30C11.4 Protein C30C11.4 0.216
C16C8.4 Protein C16C8.4 0.216
tbb-1 Protein TBB-1 0.215
math-33 Protein MATH-33 0.213
T22C1.1 Protein T22C1.1 0.212
rsa-1 Protein RSA-1 0.209
rfc-4 Protein RFC-4 0.206
npp-23 Protein NPP-23 0.206
frm-7 Protein FRM-7 0.205
frm-2 Protein FRM-2 0.202
app-1 Protein APP-1 0.201
scc-1 Protein SCC-1 0.200
asd-1 Protein ASD-1 0.200
swsn-2.1 Protein SWSN-2.1 0.199
cfim-2 Protein CFIM-2 0.199
cki-2 Protein CKI-2 0.197
gei-11 Protein GEI-11 0.197
ptr-2 Protein PTR-2 0.196
hcp-3 Protein HCP-3 0.194
vrk-1 Protein VRK-1 0.193
CELE_C25A1.4 Protein C25A1.4 0.192
C05D2.10 Protein C05D2.10 0.191
gdi-1 Protein GDI-1 0.191
ubr-1 Protein UBR-1 0.189
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Danio rerio
Name Description Probability Func Analog Organism
tp53 tumor protein p53 0.856
efnb2a ephrin B2a 0.827
bmp2b bone morphogenetic protein 2b 0.767
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.744
bmp4 bone morphogenetic protein 4 0.720
dusp6 dual specificity phosphatase 6 0.712
myod1 myogenic differentiation 1 0.668
shha sonic hedgehog a 0.634
her6 hairy-related 6 0.625
wnt10a wingless-type MMTV integration site family, member 10a 0.572
fgf3 fibroblast growth factor 3 0.508
chd chordin 0.486
per3 period homolog 3 (Drosophila) 0.422
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.410
sall1a sal-like 1a (Drosophila) 0.380
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.380
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.347
foxi1 forkhead box I1 0.336
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.333
supt5h suppressor of Ty 5 homolog (S. cerevisiae) 0.330
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.327
ccnb1 cyclin B1 0.321
nrg2a neuregulin 2a 0.319
rbb4 retinoblastoma binding protein 4 0.314
smad1 MAD homolog 1 (Drosophila) 0.313
rarab retinoic acid receptor, alpha b 0.297
cops3 COP9 constitutive photomorphogenic homolog subunit 3 0.296
enc1 ectodermal-neural cortex (with BTB-like domain) 0.292
tgfb1a transforming growth factor, beta 1a 0.287
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.287
runx2a runt-related transcription factor 2a 0.287
kdrl kinase insert domain receptor like 0.286
notch1a notch homolog 1a 0.282
gro2 groucho 2 0.272
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.268
spry4 sprouty (Drosophila) homolog 4 0.266
gpr126 G protein-coupled receptor 126 0.256
prdm2b PR domain containing 2, with ZNF domain b 0.255
klf4 Kruppel-like factor 4 0.254
mapk6 mitogen-activated protein kinase 6 0.250
smarcb1a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a 0.250
mstnb myostatin b 0.249
ptk2.1 protein tyrosine kinase 2a 0.246
cdh1 cadherin 1, epithelial 0.244
zbtb16a zinc finger and BTB domain containing 16a 0.242
mapk3 mitogen-activated protein kinase 3 0.226
fgfr3 fibroblast growth factor receptor 3 0.218
sox32 SRY-box containing gene 32 0.217
sass6 spindle assembly 6 homolog (C. elegans) 0.206
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.202
cdc25 cell division cycle 25 homolog 0.202
setdb1b SET domain, bifurcated 1b 0.202
fgf17 fibroblast growth factor 17 0.198
celf1 cugbp, Elav-like family member 1 0.197
nrp2b neuropilin 2b 0.196
si:ch211-212m21.5 si:ch211-212m21.5 0.192
chek1 CHK1 checkpoint homolog (S. pombe) 0.191
foxo3b forkhead box O3b 0.191
irf6 interferon regulatory factor 6 0.190
park7 parkinson disease (autosomal recessive, early onset) 7 0.190
mmp9 matrix metalloproteinase 9 0.189
wnt3a wingless-type MMTV integration site family, member 3A 0.188
opn1sw1 opsin 1 (cone pigments), short-wave-sensitive 1 0.179
bhmt betaine-homocysteine methyltransferase 0.179
psen1 presenilin 1 0.179
appa amyloid beta (A4) precursor protein a 0.176
ccnd1 cyclin D1 0.176
btg2 B-cell translocation gene 2 0.175
aplp2 amyloid beta (A4) precursor-like protein 2 0.173
crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.171
zbtb4 zinc finger and BTB domain containing 4 0.166
tlr3 toll-like receptor 3 0.166
flh floating head 0.165
jag2 jagged 2 0.164
junb jun B proto-oncogene 0.163
ext1a exostoses (multiple) 1a 0.160
zgc:111944 zgc:111944 0.159
runx2b runt-related transcription factor 2b 0.158
col2a1a collagen type II, alpha-1a 0.158
kif23 kinesin family member 23 0.158
pcdh8 protocadherin 8 0.157
nasp nuclear autoantigenic sperm protein (histone-binding) 0.157
jup junction plakoglobin 0.156
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.155
nusap1 nucleolar and spindle associated protein 1 0.155
prkci protein kinase C, iota 0.154
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.154
gli1 GLI-Kruppel family member 1 0.154
tal1 T-cell acute lymphocytic leukemia 1 0.152
rtn1a reticulon 1a 0.152
arpp19a cAMP-regulated phosphoprotein 19a 0.152
osr1 odd-skipped related 1 (Drosophila) 0.151
wt1b wilms tumor 1b 0.150
socs3a suppressor of cytokine signaling 3a 0.149
eomesa eomesodermin homolog a 0.148
chrna4 cholinergic receptor, nicotinic, alpha 4 0.148
ptena phosphatase and tensin homolog A 0.148
gpib glucose phosphate isomerase b 0.147
waca WW domain containing adaptor with coiled-coil a 0.146
hmgn3 high mobility group nucleosomal binding domain 3 0.143
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.991
Atg1 Autophagy-specific gene 1 0.984
ebi CG4063 gene product from transcript CG4063-RA 0.968
Akt1 CG4006 gene product from transcript CG4006-RA 0.966
Su(H) Suppressor of Hairless 0.959
CycA Cyclin A 0.950
lwr lesswright 0.944
Pp1-87B Protein phosphatase 1 at 87B 0.943
rl rolled 0.934
gro groucho 0.930
slmb supernumerary limbs 0.921
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.921
rap retina aberrant in pattern 0.917
CkIIalpha Casein kinase II alpha subunit 0.915
Rho1 CG8416 gene product from transcript CG8416-RB 0.903
ago archipelago 0.898
rin rasputin 0.896
rok Rho-kinase 0.878
Rbf Retinoblastoma-family protein 0.859
Pak PAK-kinase 0.858
Smox Smad on X 0.858
put punt 0.855
rpr reaper 0.853
eIF-4E Eukaryotic initiation factor 4E 0.849
bsk basket 0.840
Ube3a Ubiquitin protein ligase E3A 0.836
par-1 CG8201 gene product from transcript CG8201-RA 0.828
Pp2B-14D Protein phosphatase 2B at 14D 0.816
CSN5 COP9 complex homolog subunit 5 0.812
pan pangolin 0.812
pygo pygopus 0.806
msn misshapen 0.804
numb CG3779 gene product from transcript CG3779-RB 0.796
unc-13 CG2999 gene product from transcript CG2999-RA 0.795
dsh dishevelled 0.795
fzy fizzy 0.781
BEAF-32 Boundary element-associated factor of 32kD 0.781
Dsp1 Dorsal switch protein 1 0.781
Cdc37 CG12019 gene product from transcript CG12019-RA 0.778
p53 CG33336 gene product from transcript CG33336-RB 0.771
lin19 lin-19-like 0.768
ph-p polyhomeotic proximal 0.764
Dab Disabled 0.758
Rac1 CG2248 gene product from transcript CG2248-RA 0.753
aop anterior open 0.751
CG13298 CG13298 gene product from transcript CG13298-RA 0.746
cindr CIN85 and CD2AP orthologue 0.743
Sema-1a CG18405 gene product from transcript CG18405-RD 0.739
Pten CG5671 gene product from transcript CG5671-RB 0.735
polo CG12306 gene product from transcript CG12306-RA 0.731
htl heartless 0.718
Ras85D Ras oncogene at 85D 0.717
Cdc42 CG12530 gene product from transcript CG12530-RA 0.715
fs(1)h female sterile (1) homeotic 0.713
gig gigas 0.713
kis kismet 0.711
dco discs overgrown 0.709
wg wingless 0.707
trx trithorax 0.702
vih vihar 0.699
fz frizzled 0.699
brat brain tumor 0.697
Myb Myb oncogene-like 0.696
okr okra 0.695
Tao-1 CG14217 gene product from transcript CG14217-RF 0.683
N Notch 0.683
sbr small bristles 0.666
Sara Smad anchor for receptor activation 0.662
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.662
sax saxophone 0.659
Rab5 Rab-protein 5 0.659
wds will die slowly 0.658
E(spl) Enhancer of split 0.650
Tsc1 CG6147 gene product from transcript CG6147-RA 0.649
park parkin 0.641
Imp IGF-II mRNA-binding protein 0.640
RYBP Ring and YY1 Binding Protein 0.639
yki yorkie 0.636
Klp10A CG1453 gene product from transcript CG1453-RA 0.636
klu klumpfuss 0.635
Dhc64C Dynein heavy chain 64C 0.634
woc without children 0.628
shot short stop 0.624
Wnk CG7177 gene product from transcript CG7177-RA 0.624
puc puckered 0.617
CG4400 CG4400 gene product from transcript CG4400-RA 0.617
Caki Calcium/calmodulin-dependent protein kinase 0.613
E(z) Enhancer of zeste 0.612
crol crooked legs 0.600
milt milton 0.599
rut rutabaga 0.593
Mgat1 UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I 0.588
Hsp83 Heat shock protein 83 0.588
pr-set7 CG3307 gene product from transcript CG3307-RC 0.587
Uch-L3 Ubiquitin C-terminal hydrolase 0.585
Nrx-IV Neurexin IV 0.584
CG5794 CG5794 gene product from transcript CG5794-RB 0.583
Mekk1 CG7717 gene product from transcript CG7717-RB 0.578
Top1 Topoisomerase 1 0.578
wls wntless 0.561
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism