The network for 'catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-12 Protein RPN-12 0.875
pas-4 Protein PAS-4 0.860
atp-2 Protein ATP-2 0.845
egl-18 Protein EGL-18 0.731
vab-3 Protein VAB-3 0.693
rpt-3 Protein RPT-3 0.670
pkg-1 Protein PKG-1 0.655
tpxl-1 Protein TPXL-1 0.628
sem-5 Protein SEM-5 0.628
egl-13 Protein EGL-13 0.612
dlc-1 Protein DLC-1 0.597
rnr-1 Protein RNR-1 0.570
atn-1 Protein ATN-1 0.560
hel-1 Protein HEL-1 0.555
app-1 Protein APP-1 0.553
vps-28 Protein VPS-28 0.544
unc-52 Protein UNC-52 0.528
rpt-2 Protein RPT-2 0.496
unc-54 Protein UNC-54 0.495
npl-4.2 Protein NPL-4.2 0.492
pqn-59 Protein PQN-59 0.486
unc-9 Protein UNC-9 0.481
pkc-3 Protein PKC-3 0.476
pcm-1 Protein PCM-1 0.476
rpa-1 Protein RPA-1 0.473
ucr-2.3 Protein UCR-2.3 0.470
tba-2 Protein TBA-2 0.469
sqt-1 Protein SQT-1 0.467
egl-36 Protein EGL-36 0.465
vab-1 Protein VAB-1 0.462
D1081.8 Protein D1081.8 0.455
pbs-5 Protein PBS-5 0.448
lin-37 Protein LIN-37 0.445
pmk-1 Protein PMK-1 0.444
lin-45 Protein LIN-45 0.443
zen-4 Protein ZEN-4 0.441
ced-9 Protein CED-9 0.427
CELE_Y57G11C.3 Protein Y57G11C.3 0.425
goa-1 Protein GOA-1 0.423
eat-6 Protein EAT-6 0.420
rpn-6.1 Protein RPN-6.1 0.419
zyx-1 Protein ZYX-1 0.417
col-157 Protein COL-157 0.415
idhb-1 Protein IDHB-1 0.400
let-60 Protein LET-60 0.400
col-49 Protein COL-49 0.398
nlg-1 Protein NLG-1 0.395
rab-1 Protein RAB-1 0.388
rol-8 Protein ROL-8 0.378
K10C8.1 Protein K10C8.1 0.377
unc-85 Protein UNC-85 0.377
lntl-1 Protein LNTL-1 0.371
fkb-6 Protein FKB-6 0.369
ZK688.3 Protein ZK688.3 0.367
wrt-6 Protein WRT-6 0.366
bec-1 Protein BEC-1 0.364
pbs-1 Protein PBS-1 0.363
alx-1 Protein ALX-1 0.363
unc-23 Protein UNC-23 0.361
F56C9.10 Protein F56C9.10 0.359
sli-1 Protein SLI-1 0.357
Y32F6B.1 Protein Y32F6B.1 0.355
cka-2 Protein CKA-2 0.355
T23F11.1 Protein T23F11.1 0.355
prx-5 Protein PRX-5 0.355
bmk-1 Protein BMK-1 0.355
elpc-4 Protein ELPC-4 0.354
ZK899.2 Protein ZK899.2 0.353
dpy-13 Protein DPY-13 0.353
rbg-2 Protein RBG-2 0.353
pri-2 Protein PRI-2 0.351
itr-1 Protein ITR-1 0.349
csr-1 Protein CSR-1 0.348
npp-19 Protein NPP-19 0.345
crt-1 Protein CRT-1 0.344
par-5 Protein PAR-5 0.344
CELE_Y39G10AR.15 Protein Y39G10AR.15 0.340
rab-6.1 Protein RAB-6.1 0.340
col-154 Protein COL-154 0.338
cki-2 Protein CKI-2 0.335
dim-1 Protein DIM-1 0.334
F22D3.2 Protein F22D3.2 0.332
pbs-6 Protein PBS-6 0.332
dpy-30 Protein DPY-30 0.330
mel-26 Protein MEL-26 0.330
bli-1 Protein BLI-1 0.327
egl-30 Protein EGL-30 0.323
spr-4 Protein SPR-4 0.321
CELE_F52E1.13 Protein F52E1.13 0.320
F26E4.3 Protein F26E4.3 0.320
rhgf-2 Protein RHGF-2 0.320
rpn-7 Protein RPN-7 0.317
col-119 Protein COL-119 0.315
inx-15 Protein INX-15 0.313
pgl-1 Protein PGL-1 0.312
rpt-5 Protein RPT-5 0.312
cye-1 Protein CYE-1 0.312
col-101 Protein COL-101 0.311
ifa-1 Protein IFA-1 0.310
rab-5 Protein RAB-5 0.310
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Danio rerio
Name Description Probability Func Analog Organism
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.715
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.369
pcna proliferating cell nuclear antigen 0.343
aldocb aldolase C, fructose-bisphosphate, b 0.311
hspa5 heat shock protein 5 0.228
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.203
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.199
actn2 actinin, alpha 2 0.194
prdm1a PR domain containing 1a, with ZNF domain 0.172
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.171
spsb4a splA/ryanodine receptor domain and SOCS box containing 4a 0.169
bmp4 bone morphogenetic protein 4 0.165
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.155
plxnb2a plexin b2a 0.155
ccnb1 cyclin B1 0.150
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.148
adipor2 adiponectin receptor 2 0.139
pou5f1 POU domain, class 5, transcription factor 1 0.131
hsp90a.2 heat shock protein 90-alpha 2 0.126
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.126
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.119
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.119
crabp2a cellular retinoic acid binding protein 2, a 0.109
sox9b SRY-box containing gene 9b 0.104
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.104
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.104
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.096
fstl1b follistatin-like 1b 0.094
tnni2a.4 troponin I, skeletal, fast 2a.4 0.092
LOC799612 prolactin 2 0.090
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.088
gdf6a growth differentiation factor 6a 0.088
gata5 GATA-binding protein 5 0.088
gro2 groucho 2 0.086
psma4 proteasome (prosome, macropain) subunit, alpha type, 4 0.086
dnm1l dynamin 1-like 0.086
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.085
itgb1b.2 integrin, beta 1b.2 0.084
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.082
chd chordin 0.082
nf1a neurofibromin 1a 0.081
smad2 MAD homolog 2 (Drosophila) 0.080
puf60b poly-U binding splicing factor b 0.078
ncor1 nuclear receptor co-repressor 1 0.078
smyhc1 slow myosin heavy chain 1 0.077
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.075
actn3a actinin alpha 3a 0.075
fabp11a fatty acid binding protein 11a 0.072
tbx1 T-box 1 0.072
ck2b casein kinase 2 beta 0.072
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.072
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.070
bc2 putative breast adenocarcinoma marker 0.070
hspd1 heat shock 60kD protein 1 (chaperonin) 0.066
fmr1 fragile X mental retardation 1 0.066
aurkb aurora kinase B 0.066
pkd2 polycystic kidney disease 2 0.065
ccnb2 cyclin B2 0.064
dhfr dihydrofolate reductase 0.064
fancl Fanconi anemia, complementation group L 0.064
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.064
itgb1b integrin, beta 1b 0.064
psmc1a proteasome (prosome, macropain) 26S subunit, ATPase, 1a 0.064
zgc:92775 zgc:92775 0.063
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.063
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.062
cand1 cullin-associated and neddylation-dissociated 1 0.059
hspa4a heat shock protein 4a 0.058
rae1 RAE1 RNA export 1 homolog (S. pombe) 0.058
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.057
rap1b RAS related protein 1b 0.056
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.055
desma desmin a 0.055
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.055
ache acetylcholinesterase 0.055
nadl1.2 neural adhesion molecule L1.2 0.053
fhla four and a half LIM domains a 0.053
mmp14b matrix metalloproteinase 14b (membrane-inserted) 0.053
ilk integrin linked kinase 0.052
wnt1 wingless-type MMTV integration site family, member 1 0.052
cdc25 cell division cycle 25 homolog 0.051
sass6 spindle assembly 6 homolog (C. elegans) 0.050
zgc:73142 zgc:73142 0.050
bmp2b bone morphogenetic protein 2b 0.050
ahcy S-adenosylhomocysteine hydrolase 0.049
zbtb4 zinc finger and BTB domain containing 4 0.049
sema3aa semaphorin 3aa 0.049
dnajb6b DnaJ (Hsp40) homolog, subfamily B, member 6b 0.049
ass1 argininosuccinate synthetase 1 0.049
myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle 0.048
rbm4.2 RNA binding motif protein 4.2 0.048
mtp microsomal triglyceride transfer protein 0.048
adipor1a adiponectin receptor 1a 0.048
zgc:101071 zgc:101071 0.048
hoxb3a homeo box B3a 0.048
gapdh glyceraldehyde-3-phosphate dehydrogenase 0.047
rp42-pen rp42 homolog (pending) and rp42 homolog 0.047
aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.047
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.047
nos2b nitric oxide synthase 2b, inducible 0.047
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.996
sax saxophone 0.988
EcR Ecdysone receptor 0.986
CG11347 CG11347 gene product from transcript CG11347-RE 0.952
shi shibire 0.948
Atg8a Autophagy-specific gene 8a 0.931
Rheb CG1081 gene product from transcript CG1081-RA 0.929
dco discs overgrown 0.915
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.888
Rpt1 CG1341 gene product from transcript CG1341-RA 0.882
mbc myoblast city 0.876
Tor Target of rapamycin 0.867
Atg18 Autophagy-specific gene 18 0.862
Dcr-2 Dicer-2 0.855
babo baboon 0.847
Atg1 Autophagy-specific gene 1 0.841
Stat92E Signal-transducer and activator of transcription protein at 92E 0.835
Syx7 Syntaxin 7 0.834
gig gigas 0.822
Rho1 CG8416 gene product from transcript CG8416-RB 0.816
p53 CG33336 gene product from transcript CG33336-RB 0.815
cpa capping protein alpha 0.814
TER94 CG2331 gene product from transcript CG2331-RA 0.813
Stam Signal transducing adaptor molecule 0.812
Su(H) Suppressor of Hairless 0.805
ben bendless 0.790
yki yorkie 0.783
CG7998 CG7998 gene product from transcript CG7998-RA 0.778
Nup154 Nucleoporin 154 0.774
rin rasputin 0.765
scny scrawny 0.764
Rpd3 CG7471 gene product from transcript CG7471-RA 0.763
Dhc64C Dynein heavy chain 64C 0.753
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.736
B52 CG10851 gene product from transcript CG10851-RB 0.726
Argk Arginine kinase 0.721
awd abnormal wing discs 0.718
loco locomotion defects 0.712
Axn Axin 0.711
Pvr PDGF- and VEGF-receptor related 0.707
Fmr1 CG6203 gene product from transcript CG6203-RC 0.706
N Notch 0.700
Rpn11 CG18174 gene product from transcript CG18174-RA 0.699
Smox Smad on X 0.697
mys myospheroid 0.696
Miro Mitochondrial Rho 0.685
lin19 lin-19-like 0.682
Ras85D Ras oncogene at 85D 0.668
tsr twinstar 0.667
myoglianin CG1838 gene product from transcript CG1838-RD 0.665
Akt1 CG4006 gene product from transcript CG4006-RA 0.660
Rpn2 CG11888 gene product from transcript CG11888-RA 0.657
ncd non-claret disjunctional 0.654
beta-Spec beta Spectrin 0.652
alpha-Spec alpha Spectrin 0.640
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.640
Aos1 CG12276 gene product from transcript CG12276-RA 0.638
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.633
Gug Grunge 0.632
par-1 CG8201 gene product from transcript CG8201-RA 0.630
RASSF8 CG5053 gene product from transcript CG5053-RA 0.624
Rac1 CG2248 gene product from transcript CG2248-RA 0.617
Fhos CG42610 gene product from transcript CG42610-RC 0.614
dm diminutive 0.609
if inflated 0.606
Gdh Glutamate dehydrogenase 0.592
Cat Catalase 0.589
Mad Mothers against dpp 0.572
Mnt CG13316 gene product from transcript CG13316-RD 0.569
Moe Moesin 0.565
wupA wings up A 0.563
CG1347 CG1347 gene product from transcript CG1347-RB 0.562
Pak PAK-kinase 0.550
jar jaguar 0.549
Sin3A CG8815 gene product from transcript CG8815-RC 0.546
CSN5 COP9 complex homolog subunit 5 0.535
dup double parked 0.534
nos nanos 0.531
rl rolled 0.530
RecQ4 CG7487 gene product from transcript CG7487-RA 0.529
ird1 immune response deficient 1 0.526
Nrt Neurotactin 0.524
gwl greatwall 0.522
drk downstream of receptor kinase 0.521
spas spastin 0.519
Snap Soluble NSF attachment protein 0.515
Vps16A Vacuolar protein sorting 16A 0.513
nej nejire 0.497
RagA CG11968 gene product from transcript CG11968-RA 0.497
Sir2 CG5216 gene product from transcript CG5216-RA 0.494
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.491
Prosbeta5 Proteasome beta5 subunit 0.486
Rab5 Rab-protein 5 0.481
Wnk CG7177 gene product from transcript CG7177-RA 0.479
CkIIalpha Casein kinase II alpha subunit 0.479
Atg6 Autophagy-specific gene 6 0.478
Dref DNA replication-related element factor 0.476
Ada2b CG9638 gene product from transcript CG9638-RA 0.475
msps mini spindles 0.473
key kenny 0.468
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.821
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.785
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.726
Hk1 hexokinase 1 0.720
Acaa2 acetyl-Coenzyme A acyltransferase 2 0.713
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.706
Ldha lactate dehydrogenase A 0.706
Pja2 praja 2, RING-H2 motif containing 0.697
Gstm1 glutathione S-transferase mu 1 0.645
Acadl acyl-Coenzyme A dehydrogenase, long-chain 0.641
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.635
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.629
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.580
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.578
Papola poly (A) polymerase alpha 0.533
Aldoa aldolase A, fructose-bisphosphate 0.531
Mgst2 microsomal glutathione S-transferase 2 0.524
Etfb electron-transfer-flavoprotein, beta polypeptide 0.523
Casp3 caspase 3 0.519
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.496
Txn1 thioredoxin 1 0.491
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.478
Anxa4 annexin A4 0.477
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.453
LOC494499 LOC494499 protein 0.451
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.448
Ephx1 epoxide hydrolase 1, microsomal 0.446
Gpx4 glutathione peroxidase 4 0.446
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.446
Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.444
Cttn cortactin 0.443
Akap1 A kinase (PRKA) anchor protein 1 0.441
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.441
Tpm3 tropomyosin 3, gamma 0.437
Aldh9a1 aldehyde dehydrogenase 9 family, member A1 0.426
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.416
G6pc glucose-6-phosphatase, catalytic subunit 0.399
Csnk1d casein kinase 1, delta 0.395
Lgals3 lectin, galactoside-binding, soluble, 3 0.393
Tpi1 triosephosphate isomerase 1 0.384
Ctbs chitobiase, di-N-acetyl- 0.379
Gipc1 GIPC PDZ domain containing family, member 1 0.379
Prkch protein kinase C, eta 0.377
LOC293989 cytochrome P450-like 0.376
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.376
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.374
Gstm5 glutathione S-transferase, mu 5 0.370
Morf4l2 mortality factor 4 like 2 0.363
Pdk2 pyruvate dehydrogenase kinase, isozyme 2 0.363
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.361
Taok1 TAO kinase 1 0.355
Gsta5 glutathione S-transferase Yc2 subunit 0.354
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.353
Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.352
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.350
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.348
Pfn1 profilin 1 0.347
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.342
Stxbp1 syntaxin binding protein 1 0.335
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.334
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.334
Lamp2 lysosomal-associated membrane protein 2 0.330
Litaf lipopolysaccharide-induced TNF factor 0.324
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.324
Ctsl1 cathepsin L1 0.320
Pkm2 pyruvate kinase, muscle 0.318
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.316
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.313
Adam7 ADAM metallopeptidase domain 7 0.311
Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 0.311
Apob apolipoprotein B 0.309
Ripk3 receptor-interacting serine-threonine kinase 3 0.309
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.308
Camk4 calcium/calmodulin-dependent protein kinase IV 0.307
Abp10 annexin V-binding protein ABP-10 0.306
LOC100134871 beta globin minor gene 0.305
Pbsn probasin 0.302
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.299
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.296
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.296
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.292
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.291
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.291
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.291
Acy1 aminoacylase 1 0.290
Gip gastric inhibitory polypeptide 0.287
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.287
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.285
Cox4i1 cytochrome c oxidase subunit IV isoform 1 0.284
Gcdh glutaryl-Coenzyme A dehydrogenase 0.283
Pdia4 protein disulfide isomerase family A, member 4 0.282
Anpep alanyl (membrane) aminopeptidase 0.278
Rhoa ras homolog gene family, member A 0.277
Psme2 proteasome (prosome, macropain) activator subunit 2 0.276
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.274
Gck glucokinase 0.273
Prdx5 peroxiredoxin 5 0.272
Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 0.272
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.272
Pebp1 phosphatidylethanolamine binding protein 1 0.272
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism