The network for 'negative regulation of cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell fate specification

Any process that restricts, stops or prevents a cell from adopting a specific cell fate.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
hmx4 H6 family homeobox 4 0.632
notch2 notch homolog 2 0.495
pcdh8 protocadherin 8 0.494
bmp2b bone morphogenetic protein 2b 0.493
dkk1b dickkopf 1b 0.442
hoxa11a homeo box A11a 0.437
mespa mesoderm posterior a 0.370
chd chordin 0.285
otx1a orthodenticle homolog 1a 0.169
bmp4 bone morphogenetic protein 4 0.161
foxa3 forkhead box A3 0.154
neo1 neogenin 1 0.153
msxc muscle segment homeobox C 0.153
pea3 ETS-domain transcription factor pea3 0.114
foxi1 forkhead box I1 0.112
sfrp1a secreted frizzled-related protein 1a 0.108
twist3 twist3 0.105
gbx2 gastrulation brain homeo box 2 0.102
notch3 notch homolog 3 0.095
pnx posterior neuron-specific homeobox 0.088
foxd5 forkhead box D5 0.088
six4b sine oculis homeobox homolog 4b 0.086
col14a1 collagen, type XIV, alpha 1 0.085
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.082
nkx2.5 NK2 transcription factor related 5 0.080
gli1 GLI-Kruppel family member 1 0.078
sptb spectrin, beta, erythrocytic 0.077
tbx16 T-box gene 16 0.077
her5 hairy-related 5 0.072
tbx18 T-box 18 0.070
fgf3 fibroblast growth factor 3 0.069
stm starmaker 0.068
tll1 tolloid-like 1 0.068
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.063
frem3 Fras1 related extracellular matrix 3 0.063
wnt4a wingless-type MMTV integration site family, member 4a 0.061
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.060
tbx6 T-box gene 6 0.054
nrg2a neuregulin 2a 0.053
mespb mesoderm posterior b 0.053
wnt5b wingless-type MMTV integration site family, member 5b 0.052
dusp6 dual specificity phosphatase 6 0.050
msxb muscle segment homeobox B 0.048
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.047
boc brother of CDO 0.047
fgfr4 fibroblast growth factor receptor 4 0.046
fgf8b fibroblast growth factor 8 b 0.046
flh floating head 0.046
notch1b notch homolog 1b 0.046
vsx2 visual system homeobox 2 0.043
egr2b early growth response 2b 0.042
dspa desmoplakin a 0.042
ef1 ETS-related factor1 0.042
fzd7a frizzled homolog 7a 0.042
hoxd13a homeo box D13a 0.042
waca WW domain containing adaptor with coiled-coil a 0.041
jag1b jagged 1b 0.041
lhx1b LIM homeobox 1b 0.041
igf3 insulin-like growth factor 3 0.040
ntn1b netrin 1b 0.040
gata4 GATA-binding protein 4 0.039
wnt11r wingless-type MMTV integration site family, member 11, related 0.039
ptgs2a prostaglandin-endoperoxide synthase 2a 0.039
hmx2 H6 family homeobox 2 0.038
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.038
pitx3 paired-like homeodomain transcription factor 3 0.038
snai1b snail homolog 1b (Drosophila) 0.037
fgfr2 fibroblast growth factor receptor 2 0.036
uts2a urotensin 2, alpha 0.036
plagl2 pleiomorphic adenoma gene-like 2 0.036
atoh1a atonal homolog 1a 0.036
tbx20 T-box 20 0.036
lft1 lefty1 0.036
col5a2l collagen, type V, alpha 2-like 0.035
hoxd11a homeo box D11a 0.035
pcdh18a protocadherin 18a 0.033
etv5b ets variant 5b 0.032
zfand5a zinc finger, AN1-type domain 5a 0.032
sox17 SRY-box containing gene 17 0.032
wnt8b wingless-type MMTV integration site family, member 8b 0.031
lama5 laminin, alpha 5 0.029
tp63 tumor protein p63 0.029
nkd1 naked cuticle homolog 1 (Drosophila) 0.029
met met proto-oncogene (hepatocyte growth factor receptor) 0.029
vent ventral expressed homeobox 0.029
ptch1 patched 1 0.028
ext1a exostoses (multiple) 1a 0.028
rasl11b RAS-like, family 11, member B 0.028
hoxb5a homeo box B5a 0.027
jag1a jagged 1a 0.027
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.027
zgc:193933 zgc:193933 0.027
slc8a4b solute carrier family 8 (sodium/calcium exchanger), member 4b 0.027
sox32 SRY-box containing gene 32 0.026
twist1b twist1b 0.026
smad1 MAD homolog 1 (Drosophila) 0.026
ndr2 nodal-related 2 0.026
wif1 wnt inhibitory factor 1 0.024
pcdh10b protocadherin 10b 0.024
bmp7a bone morphogenetic protein 7a 0.024
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dpp decapentaplegic 0.861
hh hedgehog 0.684
wg wingless 0.591
InR Insulin-like receptor 0.543
N Notch 0.471
H Hairless 0.449
eve even skipped 0.329
sli slit 0.323
Egfr Epidermal growth factor receptor 0.263
sty sprouty 0.225
argos CG4531 gene product from transcript CG4531-RA 0.221
tld tolloid 0.219
Ubx Ultrabithorax 0.204
pb proboscipedia 0.185
kirre kin of irre 0.172
en engrailed 0.154
aop anterior open 0.152
ci cubitus interruptus 0.146
hbs hibris 0.134
dsx doublesex 0.125
Ser Serrate 0.123
pan pangolin 0.107
btl breathless 0.100
klar klarsicht 0.085
rho rhomboid 0.085
foxo forkhead box, sub-group O 0.084
brk brinker 0.084
dally division abnormally delayed 0.069
bab1 bric a brac 1 0.066
nej nejire 0.066
zfh1 Zn finger homeodomain 1 0.061
ftz fushi tarazu 0.060
sog short gastrulation 0.055
trk trunk 0.055
bin biniou 0.054
tin tinman 0.054
Parp Poly-(ADP-ribose) polymerase 0.054
crb crumbs 0.053
pnt pointed 0.051
emc extra macrochaetae 0.049
slp2 sloppy paired 2 0.049
twi twist 0.048
Traf4 TNF-receptor-associated factor 4 0.046
bnl branchless 0.046
kni knirps 0.046
slou slouch 0.045
tsg twisted gastrulation 0.044
rn rotund 0.041
Eip93F CG18389 gene product from transcript CG18389-RB 0.040
lbe ladybird early 0.039
run runt 0.038
rk rickets 0.037
os outstretched 0.037
Doc2 Dorsocross2 0.037
ptc patched 0.036
rols rolling pebbles 0.036
ara araucan 0.035
ro rough 0.034
vg vestigial 0.034
sca scabrous 0.034
sd scalloped 0.034
htl heartless 0.034
Kr Kruppel 0.033
byn brachyenteron 0.032
tkv thickveins 0.031
tll tailless 0.030
Dsor1 Downstream of raf1 0.030
Mad Mothers against dpp 0.027
CG8290 CG8290 gene product from transcript CG8290-RA 0.026
bab2 CG9102 gene product from transcript CG9102-RA 0.026
Hr38 Hormone receptor-like in 38 0.026
abd-A abdominal A 0.026
Toll-6 CG7250 gene product from transcript CG7250-RA 0.024
ed echinoid 0.024
srw shrew 0.024
Akt1 CG4006 gene product from transcript CG4006-RA 0.024
ru roughoid 0.023
disco disconnected 0.022
amos absent MD neurons and olfactory sensilla 0.021
gt giant 0.021
sns sticks and stones 0.020
Dad Daughters against dpp 0.019
Rac2 CG8556 gene product from transcript CG8556-RA 0.018
wb wing blister 0.018
jar jaguar 0.018
tsl torso-like 0.018
gsb gooseberry 0.018
luna CG33473 gene product from transcript CG33473-RB 0.017
rg rugose 0.017
in inturned 0.017
sha shavenoid 0.016
elav embryonic lethal abnormal vision 0.016
sens senseless 0.016
rib ribbon 0.016
Ras85D Ras oncogene at 85D 0.016
robo3 CG5423 gene product from transcript CG5423-RA 0.016
nub nubbin 0.016
B-H1 BarH1 0.015
Peb Protein ejaculatory bulb 0.015
Notum CG13076 gene product from transcript CG13076-RB 0.015
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Homo sapiens
Name Description Probability Func Analog Organism
CSNK1E casein kinase 1, epsilon 0.996
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.986
AR androgen receptor 0.980
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.978
BMPR1A bone morphogenetic protein receptor, type IA 0.969
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.939
FZD1 frizzled homolog 1 (Drosophila) 0.880
SMAD1 SMAD family member 1 0.868
CTNNBIP1 catenin, beta interacting protein 1 0.860
APC adenomatous polyposis coli 0.827
DAXX death-domain associated protein 0.804
NOG noggin 0.786
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.751
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.735
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.704
AXIN1 axin 1 0.667
CEP164 centrosomal protein 164kDa 0.609
ZFYVE9 zinc finger, FYVE domain containing 9 0.582
LRP6 low density lipoprotein receptor-related protein 6 0.500
PSEN1 presenilin 1 0.481
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.406
BMP2 bone morphogenetic protein 2 0.355
CDK11B cyclin-dependent kinase 11B 0.352
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.329
TWIST2 twist homolog 2 (Drosophila) 0.317
WNT5A wingless-type MMTV integration site family, member 5A 0.316
CTNND1 catenin (cadherin-associated protein), delta 1 0.310
ZNF512B zinc finger protein 512B 0.288
FGF2 fibroblast growth factor 2 (basic) 0.272
BMP7 bone morphogenetic protein 7 0.267
MYST2 MYST histone acetyltransferase 2 0.264
FSTL1 follistatin-like 1 0.254
GLIS2 GLIS family zinc finger 2 0.247
CREBBP CREB binding protein 0.224
NCOA2 nuclear receptor coactivator 2 0.214
TCF4 transcription factor 4 0.192
ELF5 E74-like factor 5 (ets domain transcription factor) 0.153
WT1 Wilms tumor 1 0.152
FZD8 frizzled homolog 8 (Drosophila) 0.148
FOXD3 forkhead box D3 0.143
ERG v-ets erythroblastosis virus E26 oncogene homolog (avian) 0.136
JUP junction plakoglobin 0.134
MCC mutated in colorectal cancers 0.134
NDP Norrie disease (pseudoglioma) 0.126
WNT3A wingless-type MMTV integration site family, member 3A 0.122
FOXO1 forkhead box O1 0.122
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.119
PITX1 paired-like homeodomain 1 0.118
PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide 0.113
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.108
RBPMS RNA binding protein with multiple splicing 0.103
DSG2 desmoglein 2 0.094
FRS2 fibroblast growth factor receptor substrate 2 0.094
SFRP1 secreted frizzled-related protein 1 0.089
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.076
SIX1 SIX homeobox 1 0.076
DSP desmoplakin 0.070
FOS FBJ murine osteosarcoma viral oncogene homolog 0.067
NOSTRIN nitric oxide synthase trafficker 0.066
MXRA5 matrix-remodelling associated 5 0.065
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.064
LRRK2 leucine-rich repeat kinase 2 0.063
BAHD1 bromo adjacent homology domain containing 1 0.062
CDH5 cadherin 5, type 2 (vascular endothelium) 0.062
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.061
C9orf100 chromosome 9 open reading frame 100 0.061
EMD emerin 0.061
FOXF2 forkhead box F2 0.061
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.054
JUN jun proto-oncogene 0.051
HIC1 hypermethylated in cancer 1 0.051
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.049
PKP4 plakophilin 4 0.047
FERMT2 fermitin family member 2 0.042
FOXA1 forkhead box A1 0.041
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.041
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.040
MSX1 msh homeobox 1 0.040
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.039
BMP4 bone morphogenetic protein 4 0.039
WDYHV1 WDYHV motif containing 1 0.038
SP100 SP100 nuclear antigen 0.037
CCNK cyclin K 0.036
EHF ets homologous factor 0.035
JAG1 jagged 1 0.034
PTPRJ protein tyrosine phosphatase, receptor type, J 0.034
FLNB filamin B, beta 0.034
NKD2 naked cuticle homolog 2 (Drosophila) 0.033
BMPR1B bone morphogenetic protein receptor, type IB 0.032
MDFI MyoD family inhibitor 0.032
EZR ezrin 0.031
SNIP1 Smad nuclear interacting protein 1 0.030
GATA5 GATA binding protein 5 0.030
INHBB inhibin, beta B 0.030
HOXB9 homeobox B9 0.029
TWIST1 twist homolog 1 (Drosophila) 0.029
PLCG1 phospholipase C, gamma 1 0.028
HOXC8 homeobox C8 0.028
GAS1 growth arrest-specific 1 0.027
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.027
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Fgfr1 fibroblast growth factor receptor 1 0.999
Prrx1 paired related homeobox 1 0.999
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Pax3 paired box gene 3 0.999
Sox9 SRY-box containing gene 9 0.999
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.997
Bmp4 bone morphogenetic protein 4 0.997
Hand1 heart and neural crest derivatives expressed transcript 1 0.996
Meox2 mesenchyme homeobox 2 0.995
Alx4 aristaless-like homeobox 4 0.995
Msx1 homeobox, msh-like 1 0.994
Foxc1 forkhead box C1 0.989
Gli2 GLI-Kruppel family member GLI2 0.988
Otx2 orthodenticle homolog 2 (Drosophila) 0.987
Tcfap2a transcription factor AP-2, alpha 0.982
Foxc2 forkhead box C2 0.981
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.974
Bmp7 bone morphogenetic protein 7 0.970
Ctnnb1 catenin (cadherin associated protein), beta 1 0.967
Fgfr3 fibroblast growth factor receptor 3 0.966
Smo smoothened homolog (Drosophila) 0.962
Fgf8 fibroblast growth factor 8 0.959
Eya1 eyes absent 1 homolog (Drosophila) 0.957
Hand2 heart and neural crest derivatives expressed transcript 2 0.945
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.941
Sox11 SRY-box containing gene 11 0.929
Pitx2 paired-like homeodomain transcription factor 2 0.909
Pax6 paired box gene 6 0.902
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.899
Tgfb2 transforming growth factor, beta 2 0.884
Sox2 SRY-box containing gene 2 0.883
Hoxd13 homeobox D13 0.873
Wnt3a wingless-related MMTV integration site 3A 0.866
Rarg retinoic acid receptor, gamma 0.838
Ptch1 patched homolog 1 0.819
Vangl1 vang-like 1 (van gogh, Drosophila) 0.805
Isl1 ISL1 transcription factor, LIM/homeodomain 0.788
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.787
Hes1 hairy and enhancer of split 1 (Drosophila) 0.769
Gbx2 gastrulation brain homeobox 2 0.764
Nkx2-1 NK2 homeobox 1 0.739
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.739
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.692
Prrx2 paired related homeobox 2 0.689
Gsc goosecoid homeobox 0.679
Dlx5 distal-less homeobox 5 0.668
Foxg1 forkhead box G1 0.667
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.665
Lrp6 low density lipoprotein receptor-related protein 6 0.655
Pbx1 pre B-cell leukemia transcription factor 1 0.652
Hoxa13 homeobox A13 0.650
Msx2 homeobox, msh-like 2 0.649
Tbx1 T-box 1 0.637
Sox4 SRY-box containing gene 4 0.606
Lmx1b LIM homeobox transcription factor 1 beta 0.595
Pitx1 paired-like homeodomain transcription factor 1 0.591
Fgf10 fibroblast growth factor 10 0.585
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.584
Cdh23 cadherin 23 (otocadherin) 0.563
Pou4f3 POU domain, class 4, transcription factor 3 0.550
Tbx15 T-box 15 0.548
Eda ectodysplasin-A 0.524
Hhex hematopoietically expressed homeobox 0.507
Tcf15 transcription factor 15 0.493
Hoxa3 homeobox A3 0.481
Runx2 runt related transcription factor 2 0.478
Smad6 MAD homolog 6 (Drosophila) 0.460
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.457
Alx1 ALX homeobox 1 0.454
Rxra retinoid X receptor alpha 0.446
Gata4 GATA binding protein 4 0.425
Hoxa2 homeobox A2 0.422
Nodal nodal 0.399
Acvr1 activin A receptor, type 1 0.395
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.395
Crebbp CREB binding protein 0.389
Nf1 neurofibromatosis 1 0.388
Dll1 delta-like 1 (Drosophila) 0.380
Alx3 aristaless-like homeobox 3 0.368
Ednra endothelin receptor type A 0.367
Nkx3-2 NK3 homeobox 2 0.360
She src homology 2 domain-containing transforming protein E 0.357
Chd7 chromodomain helicase DNA binding protein 7 0.354
Rarb retinoic acid receptor, beta 0.352
Psen1 presenilin 1 0.341
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.341
Wnt5a wingless-related MMTV integration site 5A 0.334
Pou5f1 POU domain, class 5, transcription factor 1 0.332
Rara retinoic acid receptor, alpha 0.314
Smad7 MAD homolog 7 (Drosophila) 0.314
Emx2 empty spiracles homolog 2 (Drosophila) 0.308
Notch3 Notch gene homolog 3 (Drosophila) 0.302
Hoxa5 homeobox A5 0.276
Emx1 empty spiracles homolog 1 (Drosophila) 0.268
Lef1 lymphoid enhancer binding factor 1 0.263
Zeb1 zinc finger E-box binding homeobox 1 0.263
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism