The network for 'ketone catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ketone catabolic process

The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 1.000
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.912
SOD1 superoxide dismutase 1, soluble 0.842
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12 0.680
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.584
RAB35 RAB35, member RAS oncogene family 0.356
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 0.173
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.146
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.138
CCDC78 coiled-coil domain containing 78 0.134
AKR1C4 aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) 0.111
C1orf123 chromosome 1 open reading frame 123 0.094
RBBP7 retinoblastoma binding protein 7 0.088
PRDX2 peroxiredoxin 2 0.079
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 0.076
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 0.075
DIO1 deiodinase, iodothyronine, type I 0.072
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.061
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.053
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.052
PRDX5 peroxiredoxin 5 0.045
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.045
PRDX4 peroxiredoxin 4 0.040
EPHX2 epoxide hydrolase 2, cytoplasmic 0.039
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.037
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.037
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.036
PIR pirin (iron-binding nuclear protein) 0.035
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 0.035
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.034
HAL histidine ammonia-lyase 0.033
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.033
UROD uroporphyrinogen decarboxylase 0.031
SPP2 secreted phosphoprotein 2, 24kDa 0.030
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.030
ADH6 alcohol dehydrogenase 6 (class V) 0.030
KNG1 kininogen 1 0.029
FBXO7 F-box protein 7 0.027
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.026
FAS Fas (TNF receptor superfamily, member 6) 0.026
GSTA3 glutathione S-transferase alpha 3 0.026
FETUB fetuin B 0.025
HNF4A hepatocyte nuclear factor 4, alpha 0.025
G6PC glucose-6-phosphatase, catalytic subunit 0.024
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.024
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse) 0.024
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.024
FABP1 fatty acid binding protein 1, liver 0.023
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.023
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 0.022
CES1 carboxylesterase 1 0.022
PRDX6 peroxiredoxin 6 0.022
RDH16 retinol dehydrogenase 16 (all-trans) 0.022
APOC3 apolipoprotein C-III 0.022
HDAC1 histone deacetylase 1 0.021
CRP C-reactive protein, pentraxin-related 0.021
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.020
TFR2 transferrin receptor 2 0.020
AADAC arylacetamide deacetylase (esterase) 0.019
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 0.019
C8B complement component 8, beta polypeptide 0.019
NQO1 NAD(P)H dehydrogenase, quinone 1 0.019
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.019
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.018
FADD Fas (TNFRSF6)-associated via death domain 0.018
GSTT1 glutathione S-transferase theta 1 0.018
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 0.018
SEC14L2 SEC14-like 2 (S. cerevisiae) 0.018
ARG1 arginase, liver 0.018
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.018
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.017
F12 coagulation factor XII (Hageman factor) 0.017
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 0.016
DAD1 defender against cell death 1 0.016
ACAA1 acetyl-CoA acyltransferase 1 0.016
DEFB1 defensin, beta 1 0.016
FMO4 flavin containing monooxygenase 4 0.016
APOF apolipoprotein F 0.016
PIP prolactin-induced protein 0.016
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.016
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.015
OSGIN1 oxidative stress induced growth inhibitor 1 0.015
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 0.015
CRISP3 cysteine-rich secretory protein 3 0.015
PINK1 PTEN induced putative kinase 1 0.015
HGD homogentisate 1,2-dioxygenase 0.015
AKR1C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 0.015
PLG plasminogen 0.014
CBR1 carbonyl reductase 1 0.014
FRS2 fibroblast growth factor receptor substrate 2 0.014
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 0.013
C8G complement component 8, gamma polypeptide 0.013
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.013
ACO1 aconitase 1, soluble 0.013
C4BPA complement component 4 binding protein, alpha 0.013
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.013
PRODH proline dehydrogenase (oxidase) 1 0.013
CDA cytidine deaminase 0.013
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.013
MOSC1 MOCO sulphurase C-terminal domain containing 1 0.013
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Mus musculus
Name Description Probability Func Analog Organism
Apoa1bp apolipoprotein A-I binding protein 0.480
Surf1 surfeit gene 1 0.291
1810046J19Rik RIKEN cDNA 1810046J19 gene 0.232
Mosc2 MOCO sulphurase C-terminal domain containing 2 0.201
Ufc1 ubiquitin-fold modifier conjugating enzyme 1 0.181
Qdpr quinoid dihydropteridine reductase 0.156
Gsta4 glutathione S-transferase, alpha 4 0.141
Tbcb tubulin folding cofactor B 0.137
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.136
0610011F06Rik RIKEN cDNA 0610011F06 gene 0.131
Mrpl13 mitochondrial ribosomal protein L13 0.122
Ppa2 pyrophosphatase (inorganic) 2 0.120
Sirt3 sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) 0.111
Fam173a family with sequence similarity 173, member A 0.109
Eif3i eukaryotic translation initiation factor 3, subunit I 0.098
Higd2a HIG1 domain family, member 2A 0.095
Taldo1 transaldolase 1 0.092
Lamp1 lysosomal-associated membrane protein 1 0.090
Phpt1 phosphohistidine phosphatase 1 0.079
Fuca1 fucosidase, alpha-L- 1, tissue 0.069
Sil1 endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) 0.065
Bcap31 B-cell receptor-associated protein 31 0.063
Prdx1 peroxiredoxin 1 0.062
Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 0.060
BC004004 cDNA sequence BC004004 0.058
Rnh1 ribonuclease/angiogenin inhibitor 1 0.054
Pcbd2 pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.053
Carkd carbohydrate kinase domain containing 0.051
Cyb5 cytochrome b-5 0.048
Itm2c integral membrane protein 2C 0.048
BC031181 cDNA sequence BC031181 0.046
Cnpy2 canopy 2 homolog (zebrafish) 0.046
Bag1 BCL2-associated athanogene 1 0.045
Rnf181 ring finger protein 181 0.045
Ngrn neugrin, neurite outgrowth associated 0.043
Stk39 serine/threonine kinase 39, STE20/SPS1 homolog (yeast) 0.040
Clta clathrin, light polypeptide (Lca) 0.040
Mrps25 mitochondrial ribosomal protein S25 0.040
Gstk1 glutathione S-transferase kappa 1 0.039
Edf1 endothelial differentiation-related factor 1 0.038
Tmem205 transmembrane protein 205 0.038
Lepr leptin receptor 0.038
Romo1 reactive oxygen species modulator 1 0.038
Pebp1 phosphatidylethanolamine binding protein 1 0.038
Chmp2a chromatin modifying protein 2A 0.037
Ergic3 ERGIC and golgi 3 0.037
Glrx3 glutaredoxin 3 0.035
Slc12a1 solute carrier family 12, member 1 0.034
AI462493 expressed sequence AI462493 0.034
Arl6ip4 ADP-ribosylation factor-like 6 interacting protein 4 0.034
Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide 0.034
Agtr1a angiotensin II receptor, type 1a 0.034
Cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.032
Mrpl24 mitochondrial ribosomal protein L24 0.032
6720456B07Rik RIKEN cDNA 6720456B07 gene 0.030
Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 0.030
Tmem223 transmembrane protein 223 0.030
Cldn10 claudin 10 0.030
Cope coatomer protein complex, subunit epsilon 0.030
Gstp1 glutathione S-transferase, pi 1 0.030
Rexo2 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 0.029
Anapc13 anaphase promoting complex subunit 13 0.028
Hint1 histidine triad nucleotide binding protein 1 0.028
Cpsf3 cleavage and polyadenylation specificity factor 3 0.028
Ftl1 ferritin light chain 1 0.026
Arl3 ADP-ribosylation factor-like 3 0.026
Urod uroporphyrinogen decarboxylase 0.026
Prpf19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) 0.025
Cd81 CD81 antigen 0.025
Gsto1 glutathione S-transferase omega 1 0.025
Ppia peptidylprolyl isomerase A 0.025
Muted muted 0.025
Ift27 intraflagellar transport 27 homolog (Chlamydomonas) 0.025
Coq7 demethyl-Q 7 0.024
Pepd peptidase D 0.024
Ei24 etoposide induced 2.4 mRNA 0.024
Dcxr dicarbonyl L-xylulose reductase 0.024
Lcmt1 leucine carboxyl methyltransferase 1 0.024
0610007C21Rik RIKEN cDNA 0610007C21 gene 0.023
Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 0.023
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.023
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.023
Pnpo pyridoxine 5'-phosphate oxidase 0.023
Dhrs1 dehydrogenase/reductase (SDR family) member 1 0.022
Akr1a4 aldo-keto reductase family 1, member A4 (aldehyde reductase) 0.022
2810405K02Rik RIKEN cDNA 2810405K02 gene 0.022
Ccdc107 coiled-coil domain containing 107 0.022
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.022
Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.022
Lxn latexin 0.022
Atp6v1f ATPase, H+ transporting, lysosomal V1 subunit F 0.021
Mrps6 mitochondrial ribosomal protein S6 0.021
Idh3g isocitrate dehydrogenase 3 (NAD+), gamma 0.021
Trappc3 trafficking protein particle complex 3 0.020
Arpc1a actin related protein 2/3 complex, subunit 1A 0.019
Avpi1 arginine vasopressin-induced 1 0.019
Cbr1 carbonyl reductase 1 0.019
Fnta farnesyltransferase, CAAX box, alpha 0.019
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.019
Glod4 glyoxalase domain containing 4 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism