The network for 'transcription coupled nucleotide excision repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

transcription coupled nucleotide excision repair

The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 0.957
XAB2 XPA binding protein 2 0.784
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.773
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.261
THOC4 THO complex 4 0.181
STRN4 striatin, calmodulin binding protein 4 0.167
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.149
THOC5 THO complex 5 0.114
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.113
ISY1 ISY1 splicing factor homolog (S. cerevisiae) 0.078
SARNP SAP domain containing ribonucleoprotein 0.077
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 0.074
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 0.069
THOC1 THO complex 1 0.068
CHTOP chromatin target of PRMT1 0.059
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 0.049
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.026
THOC6 THO complex 6 homolog (Drosophila) 0.024
USP11 ubiquitin specific peptidase 11 0.022
RBM8A RNA binding motif protein 8A 0.019
TUBA1B tubulin, alpha 1b 0.018
XPA xeroderma pigmentosum, complementation group A 0.014
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.014
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.013
XPC xeroderma pigmentosum, complementation group C 0.013
ZMYND8 zinc finger, MYND-type containing 8 0.012
EIF4A3 eukaryotic translation initiation factor 4A3 0.012
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.011
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Srsf9 serine/arginine-rich splicing factor 9 0.674
Ssrp1 structure specific recognition protein 1 0.444
Snrnp40 small nuclear ribonucleoprotein 40 (U5) 0.323
Ewsr1 Ewing sarcoma breakpoint region 1 0.282
Rnps1 ribonucleic acid binding protein S1 0.247
Srrt serrate RNA effector molecule homolog (Arabidopsis) 0.247
Prmt1 protein arginine N-methyltransferase 1 0.230
Anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.201
Trim28 tripartite motif-containing 28 0.177
Hnrnpab heterogeneous nuclear ribonucleoprotein A/B 0.157
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.154
Ran RAN, member RAS oncogene family 0.126
Eftud2 elongation factor Tu GTP binding domain containing 2 0.115
Thoc4 THO complex 4 0.114
Tdg thymine DNA glycosylase 0.104
Ptma prothymosin alpha 0.093
Fbl fibrillarin 0.089
Gar1 GAR1 ribonucleoprotein homolog (yeast) 0.082
Pabpn1 poly(A) binding protein, nuclear 1 0.079
Nup93 nucleoporin 93 0.066
Impdh2 inosine 5'-phosphate dehydrogenase 2 0.053
Acin1 apoptotic chromatin condensation inducer 1 0.053
Banf1 barrier to autointegration factor 1 0.052
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.051
Ppp4c protein phosphatase 4, catalytic subunit 0.047
Srsf2 serine/arginine-rich splicing factor 2 0.047
Tuba1b tubulin, alpha 1B 0.043
1500001M20Rik RIKEN cDNA 1500001M20 gene 0.042
Rcc2 regulator of chromosome condensation 2 0.041
Ranbp1 RAN binding protein 1 0.040
Safb scaffold attachment factor B 0.039
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.039
Sf3b3 splicing factor 3b, subunit 3 0.038
U2af1 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 0.037
Set SET nuclear oncogene 0.035
Eif3g eukaryotic translation initiation factor 3, subunit G 0.035
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.035
Cct2 chaperonin containing Tcp1, subunit 2 (beta) 0.034
Hnrnpm heterogeneous nuclear ribonucleoprotein M 0.033
Refbp2 RNA and export factor binding protein 2 0.032
A430005L14Rik RIKEN cDNA A430005L14 gene 0.032
Senp3 SUMO/sentrin specific peptidase 3 0.032
Apex1 apurinic/apyrimidinic endonuclease 1 0.031
Gtf2f1 general transcription factor IIF, polypeptide 1 0.029
Eif4a3 eukaryotic translation initiation factor 4A3 0.029
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.029
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.029
Nup107 nucleoporin 107 0.027
Srsf4 serine/arginine-rich splicing factor 4 0.027
Ddx54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.026
Ncl nucleolin 0.026
Puf60 poly-U binding splicing factor 60 0.025
Ipo5 importin 5 0.024
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.024
Rbm14 RNA binding motif protein 14 0.023
Nup62 nucleoporin 62 0.023
Tbcb tubulin folding cofactor B 0.023
Cks1b CDC28 protein kinase 1b 0.023
Cdk2ap1 CDK2 (cyclin-dependent kinase 2)-associated protein 1 0.022
Cpsf1 cleavage and polyadenylation specific factor 1 0.022
Ctps cytidine 5'-triphosphate synthase 0.022
Nxt1 NTF2-related export protein 1 0.021
Tubb5 tubulin, beta 5 0.021
Ncbp1 nuclear cap binding protein subunit 1 0.021
Prpf8 pre-mRNA processing factor 8 0.021
Cdk4 cyclin-dependent kinase 4 0.020
Hn1 hematological and neurological expressed sequence 1 0.019
Cdca4 cell division cycle associated 4 0.018
Dtymk deoxythymidylate kinase 0.018
Taf5l TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor 0.018
Xab2 XPA binding protein 2 0.018
2700094K13Rik RIKEN cDNA 2700094K13 gene 0.017
Enoph1 enolase-phosphatase 1 0.017
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.017
Snrpa small nuclear ribonucleoprotein polypeptide A 0.017
U2af2 U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 0.016
Sltm SAFB-like, transcription modulator 0.016
Qrich1 glutamine-rich 1 0.016
Ppan peter pan homolog (Drosophila) 0.016
Odc1 ornithine decarboxylase, structural 1 0.016
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.016
H2afy H2A histone family, member Y 0.015
Ppp1r8 protein phosphatase 1, regulatory (inhibitor) subunit 8 0.015
2310036O22Rik RIKEN cDNA 2310036O22 gene 0.015
Eif3c eukaryotic translation initiation factor 3, subunit C 0.015
Brd2 bromodomain containing 2 0.015
Rbm10 RNA binding motif protein 10 0.015
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.014
Cherp calcium homeostasis endoplasmic reticulum protein 0.014
Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 0.014
Noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.014
Cox4nb COX4 neighbor 0.014
Siva1 SIVA1, apoptosis-inducing factor 0.014
Rbmxrt RNA binding motif protein, X chromosome retrogene 0.014
Dhx16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.014
Fam192a family with sequence similarity 192, member A 0.014
Pa2g4 proliferation-associated 2G4 0.014
Nxf1 nuclear RNA export factor 1 homolog (S. cerevisiae) 0.014
Gtf3c2 general transcription factor IIIC, polypeptide 2, beta 0.014
Pcbp1 poly(rC) binding protein 1 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RTF1 Rtf1p 0.838
CTR9 Ctr9p 0.820
HPR1 Hpr1p 0.538
SPT5 Spt5p 0.333
SPT16 Spt16p 0.242
GBP2 Gbp2p 0.241
RPB3 Rpb3p 0.234
PAF1 Paf1p 0.194
LEO1 Leo1p 0.102
DST1 Dst1p 0.090
MEX67 Mex67p 0.082
SSL1 Ssl1p 0.073
RPO21 Rpo21p 0.072
THO2 Tho2p 0.067
THP2 Thp2p 0.063
SUB1 Sub1p 0.058
SUS1 Sus1p 0.051
NRD1 Nrd1p 0.049
HOR2 Hor2p 0.042
SPT6 Spt6p 0.040
CKA1 Cka1p 0.039
TFA1 Tfa1p 0.035
PSY4 Psy4p 0.034
MSS116 Mss116p 0.031
YLR264C-A hypothetical protein 0.029
MPT5 Mpt5p 0.029
CKB1 Ckb1p 0.028
SRD1 Srd1p 0.028
LEU2 Leu2p 0.027
DED1 Ded1p 0.026
IML1 Iml1p 0.026
MMS1 Mms1p 0.026
HRB1 Hrb1p 0.026
BRN1 Brn1p 0.025
HXT3 Hxt3p 0.024
TEX1 Tex1p 0.024
UME1 Ume1p 0.023
YLR162W hypothetical protein 0.023
APN1 Apn1p 0.023
MOT2 Mot2p 0.023
ARP10 Arp10p 0.023
YOL038C-A hypothetical protein 0.023
TYE7 Tye7p 0.022
ECM30 Ecm30p 0.022
MER1 Mer1p 0.022
SWT1 Swt1p 0.021
URA3 Ura3p 0.021
SPT4 Spt4p 0.020
HST3 Hst3p 0.020
RAD7 Rad7p 0.020
MFT1 Mft1p 0.019
HDA2 Hda2p 0.019
CAB3 Cab3p 0.019
ARG8 Arg8p 0.019
HO Hop 0.018
YLR042C hypothetical protein 0.018
YAR068W hypothetical protein 0.018
SEM1 Sem1p 0.018
ATP6 Atp6p 0.018
OPI1 Opi1p 0.018
YIL151C hypothetical protein 0.017
SPL2 Spl2p 0.017
CUP1-1 Cup1-1p 0.017
SWC7 Swc7p 0.017
YBR013C hypothetical protein 0.017
THP3 Thp3p 0.016
YPR157W hypothetical protein 0.016
YIR035C hypothetical protein 0.016
YLR422W hypothetical protein 0.016
RAD18 Rad18p 0.016
HMO1 Hmo1p 0.016
FMT1 Fmt1p 0.016
APL5 Apl5p 0.015
STO1 Sto1p 0.015
AUA1 Aua1p 0.015
HPF1 Hpf1p 0.015
GYL1 Gyl1p 0.015
OPT2 Opt2p 0.015
BSC1 Bsc1p 0.015
SPE3 Spe3p 0.015
ZPS1 Zps1p 0.015
SWD3 Swd3p 0.015
CPD1 Cpd1p 0.014
RXT3 Rxt3p 0.014
TFG1 Tfg1p 0.014
ALT2 Alt2p 0.014
BAT2 Bat2p 0.014
MF(ALPHA)2 Mf(alpha)2p 0.014
YKR075C hypothetical protein 0.014
YOL013W-A hypothetical protein 0.014
CRP1 Crp1p 0.014
UPS3 Ups3p 0.014
YOL014W hypothetical protein 0.014
PCL9 Pcl9p 0.014
YNL234W hypothetical protein 0.013
ARO10 Aro10p 0.013
SCM4 Scm4p 0.013
CHA1 Cha1p 0.013
RPL41A Rpl41ap 0.013
YML003W hypothetical protein 0.013