The network for 'cell surface receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.989
vab-3 Protein VAB-3 0.895
osm-5 Protein OSM-5 0.877
pha-4 Protein PHA-4 0.820
atn-1 Protein ATN-1 0.800
unc-62 Protein UNC-62 0.799
mig-2 Protein MIG-2 0.796
hlh-2 Protein HLH-2 0.793
let-60 Protein LET-60 0.746
pkg-1 Protein PKG-1 0.728
lag-1 Protein LAG-1 0.713
nhr-67 Protein NHR-67 0.692
che-3 Protein CHE-3 0.686
goa-1 Protein GOA-1 0.674
unc-52 Protein UNC-52 0.670
hmg-1.2 Protein HMG-1.2 0.664
egl-30 Protein EGL-30 0.664
brp-1 Protein BRP-1 0.650
eef-1A.1 Protein EEF-1A.1 0.607
mom-2 Protein MOM-2 0.607
unc-6 Protein UNC-6 0.588
cam-1 Protein CAM-1 0.583
lin-17 Protein LIN-17 0.545
apl-1 Protein APL-1 0.543
igcm-3 Protein IGCM-3 0.525
hlh-1 Protein HLH-1 0.503
daf-11 Protein DAF-11 0.503
pdfr-1 Protein PDFR-1 0.501
let-607 Protein LET-607 0.493
eat-4 Protein EAT-4 0.483
unc-37 Protein UNC-37 0.470
unc-7 Protein UNC-7 0.469
daf-7 Protein DAF-7 0.462
sma-6 Protein SMA-6 0.462
egl-13 Protein EGL-13 0.451
che-13 Protein CHE-13 0.444
egl-15 Protein EGL-15 0.430
egl-5 Protein EGL-5 0.429
magi-1 Protein MAGI-1 0.423
unc-9 Protein UNC-9 0.422
cst-2 Protein CST-2 0.419
vab-10 Protein VAB-10 0.419
syg-1 Protein SYG-1 0.408
ina-1 Protein INA-1 0.399
pry-1 Protein PRY-1 0.397
soc-2 Protein SOC-2 0.397
vab-1 Protein VAB-1 0.395
unc-120 Protein UNC-120 0.391
egl-8 Protein EGL-8 0.389
mod-1 Protein MOD-1 0.388
mig-5 Protein MIG-5 0.371
ceh-20 Protein CEH-20 0.361
cal-4 Protein CAL-4 0.358
flh-1 Protein FLH-1 0.356
che-2 Protein CHE-2 0.353
bar-1 Protein BAR-1 0.352
gsk-3 Protein GSK-3 0.349
pat-6 Protein PAT-6 0.347
plc-1 Protein PLC-1 0.339
lmn-1 Protein LMN-1 0.338
glr-4 Protein GLR-4 0.338
daf-2 Protein DAF-2 0.331
unc-79 Protein UNC-79 0.329
tag-297 Protein TAG-297 0.309
pat-3 Protein PAT-3 0.307
pxf-1 Protein PXF-1 0.307
cids-2 Protein CIDS-2 0.306
akt-1 Protein AKT-1 0.306
lin-25 Protein LIN-25 0.293
zyg-8 Protein ZYG-8 0.291
ima-3 Protein IMA-3 0.290
frm-7 Protein FRM-7 0.290
hlh-30 Protein HLH-30 0.282
par-5 Protein PAR-5 0.281
hmp-2 Protein HMP-2 0.278
daf-1 Protein DAF-1 0.275
T28F4.1 Protein T28F4.1 0.273
npp-7 Protein NPP-7 0.272
ceh-18 Protein CEH-18 0.271
zyg-9 Protein ZYG-9 0.269
lin-29 Protein LIN-29 0.268
dop-1 Protein DOP-1 0.267
nipi-3 Protein NIPI-3 0.267
gpb-1 Protein GPB-1 0.266
asd-1 Protein ASD-1 0.264
lin-11 Protein LIN-11 0.263
abts-3 Protein ABTS-3 0.261
tax-6 Protein TAX-6 0.261
osm-3 Protein OSM-3 0.261
aat-1 Protein AAT-1 0.260
F13H6.1 Protein F13H6.1 0.259
che-14 Protein CHE-14 0.258
cit-1.1 Protein CIT-1.1 0.258
unc-129 Protein UNC-129 0.257
cki-1 Protein CKI-1 0.257
tam-1 Protein TAM-1 0.254
sel-7 Protein SEL-7 0.252
ham-1 Protein HAM-1 0.250
sma-9 Protein SMA-9 0.250
rig-6 Protein RIG-6 0.249
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Danio rerio
Name Description Probability Func Analog Organism
chd chordin 1.000
gli1 GLI-Kruppel family member 1 0.999
ntla no tail a 0.997
cdh1 cadherin 1, epithelial 0.995
tbx1 T-box 1 0.993
bmp2b bone morphogenetic protein 2b 0.993
ndr2 nodal-related 2 0.993
shha sonic hedgehog a 0.991
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.982
ptch1 patched 1 0.980
ephb4b eph receptor B4b 0.978
twist1a twist1a 0.976
pitx3 paired-like homeodomain transcription factor 3 0.971
lef1 lymphocyte enhancer binding factor 1 0.970
fn1 fibronectin 1 0.969
dla deltaA 0.967
pcdh18b protocadherin 18b 0.963
fgf3 fibroblast growth factor 3 0.961
dusp6 dual specificity phosphatase 6 0.953
irx3a iroquois homeobox protein 3a 0.952
tyr tyrosinase 0.943
fgf8a fibroblast growth factor 8 a 0.938
il17rd interleukin 17 receptor D 0.935
alcamb activated leukocyte cell adhesion molecule b 0.934
notch1a notch homolog 1a 0.919
mib mind bomb 0.907
prdm1a PR domain containing 1a, with ZNF domain 0.895
fzd10 frizzled homolog 10 0.894
her6 hairy-related 6 0.892
tgfb3 transforming growth factor, beta 3 0.888
wnt5b wingless-type MMTV integration site family, member 5b 0.887
wnt4a wingless-type MMTV integration site family, member 4a 0.886
bmp2a bone morphogenetic protein 2a 0.881
wnt11r wingless-type MMTV integration site family, member 11, related 0.881
dld deltaD 0.873
ephb3a eph receptor B3a 0.872
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.868
snai1a snail homolog 1a (Drosophila) 0.867
smo smoothened homolog (Drosophila) 0.867
smad1 MAD homolog 1 (Drosophila) 0.864
wnt3 wingless-type MMTV integration site family, member 3 0.860
dcc deleted in colorectal carcinoma 0.859
gsc goosecoid 0.854
dlx5a distal-less homeobox gene 5a 0.849
lft2 lefty2 0.833
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.830
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.828
rspo1 R-spondin homolog (Xenopus laevis) 0.822
jun jun proto-oncogene 0.820
lft1 lefty1 0.819
tbx5a T-box 5a 0.818
tp53 tumor protein p53 0.815
btg2 B-cell translocation gene 2 0.808
snai1b snail homolog 1b (Drosophila) 0.807
s1pr2 sphingosine-1-phosphate receptor 2 0.805
crabp2a cellular retinoic acid binding protein 2, a 0.803
vegfc vascular endothelial growth factor c 0.803
twist2 twist2 0.800
runx2b runt-related transcription factor 2b 0.798
six3b sine oculis homeobox homolog 3b 0.795
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.794
flt4 fms-related tyrosine kinase 4 0.793
otx2 orthodenticle homolog 2 0.793
sox1a SRY-box containing gene 1a 0.787
rarab retinoic acid receptor, alpha b 0.784
nanos3 nanos homolog 3 0.781
pax8 paired box gene 8 0.780
gli2a GLI-Kruppel family member GLI2a 0.778
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.769
yrk Yes-related kinase 0.764
eve1 even-skipped-like1 0.764
tac1 tachykinin 1 0.760
egr1 early growth response 1 0.758
edn1 endothelin 1 0.755
kita kit receptor a 0.755
axin2 axin 2 (conductin, axil) 0.753
gro1 groucho 1 0.752
tbx16 T-box gene 16 0.750
tbx6 T-box gene 6 0.746
hoxd4a homeo box D4a 0.736
vegfaa vascular endothelial growth factor Aa 0.735
wnt2 wingless-type MMTV integration site family member 2 0.730
pou5f1 POU domain, class 5, transcription factor 1 0.730
ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase 0.729
fbn2b fibrillin 2b 0.729
ctsl1b cathepsin L, 1 b 0.728
her8a hairy-related 8a 0.727
pea3 ETS-domain transcription factor pea3 0.721
rarga retinoic acid receptor gamma a 0.720
nrp2b neuropilin 2b 0.719
wls wntless homolog (Drosophila) 0.715
dzip1 DAZ interacting protein 1 0.710
col5a1 procollagen, type V, alpha 1 0.710
csrp1a cysteine and glycine-rich protein 1a 0.708
LOC559201 similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3) 0.707
esr2a estrogen receptor 2a 0.703
adra2a adrenergic, alpha-2A-, receptor 0.702
sulf2 sulfatase 2 0.700
gdf6a growth differentiation factor 6a 0.697
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.696
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
STE4 Ste4p 0.961
STE12 Ste12p 0.888
STE2 Ste2p 0.835
CLA4 Cla4p 0.672
STE20 Ste20p 0.669
STE5 Ste5p 0.668
FUS3 Fus3p 0.528
APP1 App1p 0.511
PBS2 Pbs2p 0.475
BCK1 Bck1p 0.440
PRK1 Prk1p 0.432
CKA2 Cka2p 0.348
FAR1 Far1p 0.316
SSK2 Ssk2p 0.304
HOF1 Hof1p 0.275
STE7 Ste7p 0.266
SSK1 Ssk1p 0.244
MYO5 Myo5p 0.238
BOI2 Boi2p 0.184
ERP4 Erp4p 0.180
CKB2 Ckb2p 0.173
ERV25 Erv25p 0.166
ROM2 Rom2p 0.159
VRP1 Vrp1p 0.155
RIX1 Rix1p 0.153
CDC24 Cdc24p 0.152
KSS1 Kss1p 0.149
KDX1 Kdx1p 0.147
PKH2 Pkh2p 0.146
IZH4 Izh4p 0.131
RHO1 Rho1p 0.117
STP22 Stp22p 0.114
MRS6 Mrs6p 0.112
MF(ALPHA)1 Mf(alpha)1p 0.111
MSI1 Msi1p 0.110
END3 End3p 0.109
STE18 Ste18p 0.109
MDS3 Mds3p 0.108
BCK2 Bck2p 0.105
PAF1 Paf1p 0.104
YOL087C hypothetical protein 0.102
RSC8 Rsc8p 0.095
GIC2 Gic2p 0.088
SDS22 Sds22p 0.087
SLG1 Slg1p 0.087
PAN1 Pan1p 0.083
DID4 Did4p 0.083
MF(ALPHA)2 Mf(alpha)2p 0.083
AGA2 Aga2p 0.080
VPS4 Vps4p 0.079
ECM27 Ecm27p 0.078
RAS2 Ras2p 0.077
STE3 Ste3p 0.077
VPS36 Vps36p 0.077
DBF2 Dbf2p 0.076
GIS1 Gis1p 0.075
PSP2 Psp2p 0.074
SUP35 Sup35p 0.072
ARP2 Arp2p 0.072
NSR1 Nsr1p 0.071
PYK2 Pyk2p 0.070
YAP1801 hypothetical protein 0.069
SST2 Sst2p 0.068
YPT10 Ypt10p 0.068
STE50 Ste50p 0.068
ACT1 Act1p 0.065
SWI1 Swi1p 0.064
MFA1 Mfa1p 0.064
STI1 Sti1p 0.063
TPK2 Tpk2p 0.063
YPT1 Ypt1p 0.063
STE11 Ste11p 0.061
CDC34 Cdc34p 0.061
MSG5 Msg5p 0.058
VPS16 Vps16p 0.058
YGL036W hypothetical protein 0.057
ERP5 Erp5p 0.056
TFB4 Tfb4p 0.055
AIM3 Aim3p 0.054
GLO3 Glo3p 0.054
SIR2 Sir2p 0.053
PEP5 Pep5p 0.053
GIC1 Gic1p 0.052
VPS24 Vps24p 0.052
PPZ1 Ppz1p 0.052
NUP170 Nup170p 0.052
AQR1 Aqr1p 0.051
GPA1 Gpa1p 0.050
YNL024C hypothetical protein 0.049
DIA2 Dia2p 0.049
UGO1 Ugo1p 0.048
LHS1 Lhs1p 0.048
GSC2 Gsc2p 0.048
RSC2 Rsc2p 0.048
MFA2 Mfa2p 0.047
YCL042W hypothetical protein 0.047
PPQ1 Ppq1p 0.047
YBL086C hypothetical protein 0.047
GCS1 Gcs1p 0.046
MBR1 Mbr1p 0.046