The network for 'cell cell signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cell signaling

Any process that mediates the transfer of information from one cell to another.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-9 Protein UNC-9 0.997
hif-1 Protein HIF-1 0.902
egl-30 Protein EGL-30 0.826
rig-6 Protein RIG-6 0.821
vab-3 Protein VAB-3 0.728
nhr-67 Protein NHR-67 0.706
goa-1 Protein GOA-1 0.702
dbl-1 Protein DBL-1 0.700
lin-11 Protein LIN-11 0.675
pdfr-1 Protein PDFR-1 0.661
unc-86 Protein UNC-86 0.642
unc-53 Protein UNC-53 0.630
unc-38 Protein UNC-38 0.601
C06G3.6 Protein C06G3.6 0.573
mrp-1 Protein MRP-1 0.545
CELE_C56A3.6 Protein C56A3.6 0.536
egl-36 Protein EGL-36 0.527
nlg-1 Protein NLG-1 0.523
gar-3 Protein GAR-3 0.504
glr-5 Protein GLR-5 0.456
unc-54 Protein UNC-54 0.433
pxf-1 Protein PXF-1 0.426
plc-1 Protein PLC-1 0.422
hlh-2 Protein HLH-2 0.407
pkg-1 Protein PKG-1 0.401
inx-12 Protein INX-12 0.386
inx-3 Protein INX-3 0.384
R13A5.9 Protein R13A5.9 0.383
unc-7 Protein UNC-7 0.371
egl-27 Protein EGL-27 0.368
ace-3 Protein ACE-3 0.368
let-756 Protein LET-756 0.361
let-23 Protein LET-23 0.355
slo-1 Protein SLO-1 0.349
unc-104 Protein UNC-104 0.347
F54E4.3 Protein F54E4.3 0.342
unc-6 Protein UNC-6 0.333
madd-4 Protein MADD-4 0.318
unc-79 Protein UNC-79 0.318
unc-73 Protein UNC-73 0.314
egl-3 Protein EGL-3 0.294
egl-5 Protein EGL-5 0.272
sng-1 Protein SNG-1 0.271
glp-1 Protein GLP-1 0.267
inx-13 Protein INX-13 0.266
sta-1 Protein STA-1 0.264
klc-2 Protein KLC-2 0.263
F49C12.9 Protein F49C12.9 0.261
egl-15 Protein EGL-15 0.256
num-1 Protein NUM-1 0.245
cyp-35C1 Protein CYP-35C1 0.245
dpff-1 Protein DPFF-1 0.241
C34F6.9 Protein C34F6.9 0.239
F55H12.3 Protein F55H12.3 0.237
spc-1 Protein SPC-1 0.235
egl-13 Protein EGL-13 0.221
plc-2 Protein PLC-2 0.220
faah-1 Protein FAAH-1 0.215
unc-26 Protein UNC-26 0.211
unc-103 Protein UNC-103 0.204
nhr-45 Protein NHR-45 0.201
unc-43 Protein UNC-43 0.199
ain-1 Protein AIN-1 0.198
pes-7 Protein PES-7 0.194
cyp-35A3 Protein CYP-35A3 0.193
glc-4 Protein GLC-4 0.193
glr-1 Protein GLR-1 0.189
C34D10.2 Protein C34D10.2 0.189
sem-5 Protein SEM-5 0.188
unc-47 Protein UNC-47 0.188
lev-8 Protein LEV-8 0.179
exc-5 Protein EXC-5 0.179
sto-5 Protein STO-5 0.178
fsn-1 Protein FSN-1 0.178
unc-60 Protein UNC-60 0.176
ttm-2 Protein TTM-2 0.174
CELE_Y37A1B.17 Protein Y37A1B.17 0.174
kcc-1 Protein KCC-1 0.171
Y43E12A.2 Protein Y43E12A.2 0.169
rsa-1 Protein RSA-1 0.168
stn-1 Protein STN-1 0.167
ser-2 Protein SER-2 0.166
prkl-1 Protein PRKL-1 0.163
acr-16 Protein ACR-16 0.160
polk-1 Protein POLK-1 0.160
CELE_W05H12.1 Protein W05H12.1 0.160
unc-10 Protein UNC-10 0.160
vpr-1 Protein VPR-1 0.157
gld-1 Protein GLD-1 0.155
cat-1 Protein CAT-1 0.155
zyg-8 Protein ZYG-8 0.153
hmr-1 Protein HMR-1 0.153
dat-1 Protein DAT-1 0.152
M01A8.2 Protein M01A8.2 0.152
ark-1 Protein ARK-1 0.152
F28E10.1 Protein F28E10.1 0.152
tag-303 Protein TAG-303 0.149
gdi-1 Protein GDI-1 0.149
cmd-1 Protein CMD-1 0.149
adt-2 Protein ADT-2 0.149
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Danio rerio
Name Description Probability Func Analog Organism
gli2a GLI-Kruppel family member GLI2a 0.895
wnt8b wingless-type MMTV integration site family, member 8b 0.880
pax8 paired box gene 8 0.625
pax6a paired box gene 6a 0.617
kal1a Kallmann syndrome 1a sequence 0.611
myod1 myogenic differentiation 1 0.507
wnt1 wingless-type MMTV integration site family, member 1 0.481
hnf1ba HNF1 homeobox Ba 0.471
efnb2a ephrin B2a 0.468
otpa orthopedia homolog a 0.432
lhx1a LIM homeobox 1a 0.427
rarab retinoic acid receptor, alpha b 0.393
gli1 GLI-Kruppel family member 1 0.383
ascl1a achaete-scute complex-like 1a (Drosophila) 0.377
myf5 myogenic factor 5 0.375
otpb orthopedia homolog b 0.373
phox2a paired-like homeobox 2a 0.372
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.348
nsfa N-ethylmaleimide-sensitive factor a 0.344
flh floating head 0.340
dld deltaD 0.322
gad2 glutamate decarboxylase 2 0.320
esr2a estrogen receptor 2a 0.318
tal1 T-cell acute lymphocytic leukemia 1 0.309
pou3f1 POU class 3 homeobox 1 0.307
notum3 notum 3 0.304
boc brother of CDO 0.302
atp1a3a ATPase, Na+/K+ transporting, alpha 3a polypeptide 0.296
dlc deltaC 0.289
dab1a disabled homolog 1a (Drosophila) 0.286
sox10 SRY-box containing gene 10 0.284
ptgs1 prostaglandin-endoperoxide synthase 1 0.274
foxa2 forkhead box A2 0.254
pax2a paired box gene 2a 0.253
slc1a2b solute carrier family 1 (glial high affinity glutamate transporter), member 2b 0.252
pax7a paired box gene 7a 0.247
alcamb activated leukocyte cell adhesion molecule b 0.242
nanos3 nanos homolog 3 0.239
raraa retinoic acid receptor, alpha a 0.238
vsx1 visual system homeobox 1 homolog, chx10-like 0.230
twist1a twist1a 0.227
ndrg4 N-myc downstream regulated gene 4 0.225
nlgn1 neuroligin 1 0.220
lepr leptin receptor 0.218
smad1 MAD homolog 1 (Drosophila) 0.215
ache acetylcholinesterase 0.212
egr1 early growth response 1 0.206
dharma dharma 0.204
dkk1b dickkopf 1b 0.202
tgfb3 transforming growth factor, beta 3 0.198
mib mind bomb 0.197
dcc deleted in colorectal carcinoma 0.195
col15a1b collagen, type XV, alpha 1b 0.187
wls wntless homolog (Drosophila) 0.184
osr1 odd-skipped related 1 (Drosophila) 0.180
jag2 jagged 2 0.178
bdnf brain-derived neurotrophic factor 0.178
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.170
sncgb synuclein, gamma b (breast cancer-specific protein 1) 0.168
gper G protein-coupled estrogen receptor 1 0.165
egr2b early growth response 2b 0.164
nrg2a neuregulin 2a 0.164
evx1 even-skipped homeobox 1 0.161
foxp2 forkhead box P2 0.159
gria3b glutamate receptor, ionotrophic, AMPA 3b 0.158
wnt5b wingless-type MMTV integration site family, member 5b 0.156
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.149
wnt3a wingless-type MMTV integration site family, member 3A 0.146
pcdh19 protocadherin 19 0.144
gja3 gap junction protein, alpha 3 0.141
pvalb7 parvalbumin 7 0.141
gfra1b gdnf family receptor alpha 1b 0.136
sec23a Sec23 homolog A (S. cerevisiae) 0.135
pcdh8 protocadherin 8 0.133
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.131
dusp6 dual specificity phosphatase 6 0.131
cyfip2 cytoplasmic FMR1 interacting protein 2 0.130
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.129
tfap2b transcription factor AP-2 beta 0.128
gria2a glutamate receptor, ionotropic, AMPA 2a 0.128
dmbx1a diencephalon/mesencephalon homeobox 1a 0.127
roraa RAR-related orphan receptor A, paralog a 0.127
snai1a snail homolog 1a (Drosophila) 0.126
si:dkey-228g21.4 si:dkey-228g21.4 0.124
acvr2a activin receptor IIa 0.122
ndr2 nodal-related 2 0.119
nrg1 neuregulin 1 0.119
tbx1 T-box 1 0.115
irx4a iroquois homeobox protein 4a 0.115
ncs1a neuronal calcium sensor 1a 0.115
etv2 ets variant gene 2 0.115
eng2a engrailed 2a 0.114
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.113
nf1a neurofibromin 1a 0.111
rapsn receptor-associated protein of the synapse, 43kD 0.109
lama2 laminin, alpha 2 0.106
bmp7a bone morphogenetic protein 7a 0.106
tshb thyroid stimulating hormone, beta subunit 0.105
gria1a glutamate receptor, ionotropic, AMPA 1a 0.105
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.104
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GRB2 growth factor receptor-bound protein 2 1.000
DLG4 discs, large homolog 4 (Drosophila) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.999
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.998
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.998
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.996
CREBBP CREB binding protein 0.993
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.988
EGFR epidermal growth factor receptor 0.979
KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4 0.961
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.960
FGFR1 fibroblast growth factor receptor 1 0.959
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.958
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.956
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.955
PSEN1 presenilin 1 0.948
DRD2 dopamine receptor D2 0.943
LRRK2 leucine-rich repeat kinase 2 0.940
PDX1 pancreatic and duodenal homeobox 1 0.939
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.937
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.918
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.906
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.903
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.897
CRHR1 corticotropin releasing hormone receptor 1 0.893
FGFR2 fibroblast growth factor receptor 2 0.879
ESR1 estrogen receptor 1 0.873
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.863
MAPK1 mitogen-activated protein kinase 1 0.851
SFN stratifin 0.842
GSK3B glycogen synthase kinase 3 beta 0.841
EPS15 epidermal growth factor receptor pathway substrate 15 0.838
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.832
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.832
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.829
SNAP25 synaptosomal-associated protein, 25kDa 0.814
ACTL6B actin-like 6B 0.807
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.791
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.782
JAG1 jagged 1 0.779
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.772
IGF1R insulin-like growth factor 1 receptor 0.751
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.751
FOXD3 forkhead box D3 0.746
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.743
CSNK1E casein kinase 1, epsilon 0.737
TEK TEK tyrosine kinase, endothelial 0.726
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.717
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 0.704
APP amyloid beta (A4) precursor protein 0.693
MYOD1 myogenic differentiation 1 0.692
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.690
SOX1 SRY (sex determining region Y)-box 1 0.685
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.678
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.674
KCNQ2 potassium voltage-gated channel, KQT-like subfamily, member 2 0.673
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.665
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.658
RAB1A RAB1A, member RAS oncogene family 0.642
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.637
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.637
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.636
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.629
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.628
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.628
SH3GL2 SH3-domain GRB2-like 2 0.617
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.617
PAX3 paired box 3 0.613
CABP1 calcium binding protein 1 0.588
SORBS3 sorbin and SH3 domain containing 3 0.586
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.581
FGF8 fibroblast growth factor 8 (androgen-induced) 0.580
KRT8 keratin 8 0.580
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.579
SSTR2 somatostatin receptor 2 0.569
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.569
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.563
FGF1 fibroblast growth factor 1 (acidic) 0.554
SMAD4 SMAD family member 4 0.553
CCR5 chemokine (C-C motif) receptor 5 0.552
HOXD12 homeobox D12 0.552
NEUROD2 neurogenic differentiation 2 0.552
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.551
EPS8 epidermal growth factor receptor pathway substrate 8 0.551
OCRL oculocerebrorenal syndrome of Lowe 0.543
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.542
SH3KBP1 SH3-domain kinase binding protein 1 0.541
ITSN1 intersectin 1 (SH3 domain protein) 0.534
TAL1 T-cell acute lymphocytic leukemia 1 0.532
SMAD2 SMAD family member 2 0.524
ORC2 origin recognition complex, subunit 2 0.519
LBX1 ladybird homeobox 1 0.517
SNAP23 synaptosomal-associated protein, 23kDa 0.517
DNM1 dynamin 1 0.511
PYY peptide YY 0.509
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.502
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.494
CAPNS1 calpain, small subunit 1 0.493
PRKCA protein kinase C, alpha 0.464
MAPT microtubule-associated protein tau 0.462
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.983
Gria2 glutamate receptor, ionotropic, AMPA 2 0.982
Syn1 synapsin I 0.974
Grm7 glutamate receptor, metabotropic 7 0.967
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.960
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.955
Epha5 EphA5 0.951
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.942
Dlg4 discs, large homolog 4 (Drosophila) 0.930
Amph amphiphysin 0.929
Unc5a unc-5 homolog A (C. elegans) 0.899
Nrxn3 neurexin 3 0.895
Syn2 synapsin II 0.888
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.866
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.866
Neurod2 neurogenic differentiation 2 0.863
Snap25 synaptosomal-associated protein 25 0.858
Kcnt1 potassium channel, subfamily T, member 1 0.847
Nfasc neurofascin 0.837
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.835
Rgs9 regulator of G-protein signaling 9 0.835
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.822
Myt1l myelin transcription factor 1-like 0.820
Gria1 glutamate receptor, ionotropic, AMPA 1 0.818
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.810
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.800
Syt4 synaptotagmin IV 0.792
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.791
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.778
Stx1b syntaxin 1B 0.771
Grik1 glutamate receptor, ionotropic, kainate 1 0.742
Avp arginine vasopressin 0.733
Hcrtr1 hypocretin (orexin) receptor 1 0.730
Prkcg protein kinase C, gamma 0.724
Ar androgen receptor 0.723
Hpca hippocalcin 0.702
Akr1c18 aldo-keto reductase family 1, member C18 0.685
Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.682
Adam2 ADAM metallopeptidase domain 2 0.677
Th tyrosine hydroxylase 0.674
Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 0.672
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.667
Acr acrosin 0.666
Nrcam neuronal cell adhesion molecule 0.661
Oprm1 opioid receptor, mu 1 0.657
Prkce protein kinase C, epsilon 0.652
Sstr2 somatostatin receptor 2 0.650
Pitx3 paired-like homeodomain 3 0.648
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.642
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.640
Mapk10 mitogen activated protein kinase 10 0.634
Nlgn3 neuroligin 3 0.634
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.632
Prkca protein kinase C, alpha 0.631
Fev FEV (ETS oncogene family) 0.631
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.630
Foxe3 forkhead box E3 0.629
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.626
Snap91 synaptosomal-associated protein 91 0.625
Ncan neurocan 0.619
Ddn dendrin 0.617
Lin7b lin-7 homolog b (C. elegans) 0.609
Gcm1 glial cells missing homolog 1 (Drosophila) 0.608
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.604
Vsnl1 visinin-like 1 0.603
Adra2a adrenergic, alpha-2A-, receptor 0.601
Camkv CaM kinase-like vesicle-associated 0.601
Hk1 hexokinase 1 0.600
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.599
Chrng cholinergic receptor, nicotinic, gamma 0.598
Ednrb endothelin receptor type B 0.593
Anxa2 annexin A2 0.592
Sh3gl2 SH3-domain GRB2-like 2 0.590
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.585
Begain brain-enriched guanylate kinase-associated 0.584
Il12b interleukin 12B 0.580
Accn1 amiloride-sensitive cation channel 1, neuronal 0.580
Kcnd3 potassium voltage-gated channel, Shal-related subfamily, member 3 0.579
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.578
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.577
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.576
Anxa1 annexin A1 0.574
Zg16 zymogen granule protein 16 0.573
Rgs8 regulator of G-protein signaling 8 0.572
Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.571
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.570
Kalrn kalirin, RhoGEF kinase 0.566
Dlgap2 discs, large (Drosophila) homolog-associated protein 2 0.564
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.564
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.561
Bsn bassoon 0.555
Tmod2 tropomodulin 2 0.548
Prss1 protease, serine, 1 (trypsin 1) 0.546
Rin1 Ras and Rab interactor 1 0.544
Syt1 synaptotagmin I 0.544
Vgf VGF nerve growth factor inducible 0.539
St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 0.530
Grid1 glutamate receptor, ionotropic, delta 1 0.530
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.529
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.529
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism