The network for 'error prone translesion synthesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

error prone translesion synthesis

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

Name Description Probability Func Analog Organism
RAD5 Rad5p 0.887
RAD9 Rad9p 0.799
POL2 Pol2p 0.796
REV1 Rev1p 0.681
REV7 Rev7p 0.580
RAD24 Rad24p 0.248
REV3 Rev3p 0.246
RAD17 Rad17p 0.213
POL3 Pol3p 0.132
RAD18 Rad18p 0.108
MGS1 Mgs1p 0.089
RAD30 Rad30p 0.077
DPB2 Dpb2p 0.068
ORC6 Orc6p 0.066
DPB3 Dpb3p 0.065
CDC9 Cdc9p 0.064
DLS1 Dls1p 0.057
SRD1 Srd1p 0.057
RFC2 Rfc2p 0.048
CUP1-1 Cup1-1p 0.047
YLR264C-A hypothetical protein 0.046
LEU2 Leu2p 0.046
PSF1 Psf1p 0.046
YOL038C-A hypothetical protein 0.040
ARP10 Arp10p 0.039
SWC7 Swc7p 0.039
YLR162W hypothetical protein 0.038
MER1 Mer1p 0.038
UBC13 Ubc13p 0.038
ORC4 Orc4p 0.034
YPR157W hypothetical protein 0.032
ARG8 Arg8p 0.032
YIR035C hypothetical protein 0.031
HXT3 Hxt3p 0.030
PIF1 Pif1p 0.030
YLR042C hypothetical protein 0.030
ATP6 Atp6p 0.029
YAR068W hypothetical protein 0.029
SPL2 Spl2p 0.029
HO Hop 0.028
EST2 Est2p 0.027
CRP1 Crp1p 0.027
AUA1 Aua1p 0.026
PRS2 Prs2p 0.024
YIL151C hypothetical protein 0.024
MCM10 Mcm10p 0.024
ZPS1 Zps1p 0.024
YGR126W hypothetical protein 0.024
YBR013C hypothetical protein 0.024
APN1 Apn1p 0.023
HPF1 Hpf1p 0.022
FMT1 Fmt1p 0.022
YOL013W-A hypothetical protein 0.022
SAS4 Sas4p 0.022
BSC1 Bsc1p 0.021
CHA1 Cha1p 0.021
CUP1-2 Cup1-2p 0.020
SCM4 Scm4p 0.020
DPB4 Dpb4p 0.020
IZH4 Izh4p 0.020
MF(ALPHA)2 Mf(alpha)2p 0.020
OPT2 Opt2p 0.020
TYE7 Tye7p 0.020
MET8 Met8p 0.019
CPD1 Cpd1p 0.019
YPR096C hypothetical protein 0.019
URA3 Ura3p 0.019
YKR075C hypothetical protein 0.018
LIF1 Lif1p 0.018
SMC6 Smc6p 0.018
YLR040C hypothetical protein 0.017
DIC1 Dic1p 0.017
RAD1 Rad1p 0.017
ZRT1 Zrt1p 0.016
NRG2 Nrg2p 0.016
SFT1 Sft1p 0.016
CUE4 Cue4p 0.016
YJL181W hypothetical protein 0.016
COS12 Cos12p 0.016
YGR035C hypothetical protein 0.016
YAL037C-A hypothetical protein 0.016
HLR1 Hlr1p 0.016
ALT2 Alt2p 0.016
YLR126C hypothetical protein 0.016
WSS1 Wss1p 0.015
TSC3 Tsc3p 0.015
PMS1 Pms1p 0.015
YAL064W hypothetical protein 0.015
YAR066W hypothetical protein 0.015
SSP1 Ssp1p 0.015
YAR029W hypothetical protein 0.015
MRC1 Mrc1p 0.015
YML003W hypothetical protein 0.015
YGL006W-A hypothetical protein 0.015
YCR102C hypothetical protein 0.015
DUR1,2 Dur1,2p 0.015
RNP1 Rnp1p 0.015
YJL160C hypothetical protein 0.015
BIO4 Bio4p 0.015
MSH3 Msh3p 0.014
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Clk4 CDC like kinase 4 0.043
Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 0.014
Timeless timeless homolog (Drosophila) 0.011
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism