The network for 'negative regulation of nitrogen compound metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of nitrogen compound metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
HHT1 Hht1p 0.998
RPD3 Rpd3p 0.998
SIN3 Sin3p 0.988
SIR2 Sir2p 0.980
SET1 Set1p 0.967
RLF2 Rlf2p 0.964
HHF1 Hhf1p 0.950
RPN4 Rpn4p 0.946
GLN3 Gln3p 0.943
RIF1 Rif1p 0.938
CTK1 Ctk1p 0.932
PHO23 Pho23p 0.931
ASF1 Asf1p 0.922
SIN4 Sin4p 0.908
SDS3 Sds3p 0.908
RAP1 Rap1p 0.896
HAT1 Hat1p 0.891
RCO1 Rco1p 0.880
SNF1 Snf1p 0.875
DIA2 Dia2p 0.850
GAL11 Gal11p 0.850
SIR4 Sir4p 0.848
SAS2 Sas2p 0.835
SRP1 Srp1p 0.827
CTF18 Ctf18p 0.826
RXT2 Rxt2p 0.820
RAD9 Rad9p 0.818
BDF1 Bdf1p 0.807
ORC5 Orc5p 0.805
NRG1 Nrg1p 0.790
MED2 Med2p 0.777
YCS4 Ycs4p 0.765
ORC2 Orc2p 0.752
HDA1 Hda1p 0.748
SIR3 Sir3p 0.746
FKH2 Fkh2p 0.742
YAK1 Yak1p 0.740
HRK1 Hrk1p 0.734
CCR4 Ccr4p 0.726
ISW2 Isw2p 0.725
GLC7 Glc7p 0.725
SNT1 Snt1p 0.717
SNF5 Snf5p 0.714
UME6 Ume6p 0.710
SWD1 Swd1p 0.693
RRS1 Rrs1p 0.692
GCR2 Gcr2p 0.687
HTB1 Htb1p 0.682
RIM101 Rim101p 0.680
CTI6 Cti6p 0.674
RNR4 Rnr4p 0.668
DEP1 Dep1p 0.663
NUT1 Nut1p 0.660
HMO1 Hmo1p 0.657
HHO1 Hho1p 0.631
PGD1 Pgd1p 0.630
CDC45 Cdc45p 0.624
SSN3 Ssn3p 0.623
HIR1 Hir1p 0.615
VID22 Vid22p 0.609
ADA2 Ada2p 0.608
MOT1 Mot1p 0.608
PHO4 Pho4p 0.595
IES3 Ies3p 0.592
MCM7 Mcm7p 0.587
CYC8 Cyc8p 0.583
SPT8 Spt8p 0.580
SSN8 Ssn8p 0.569
POL30 Pol30p 0.569
PAF1 Paf1p 0.563
HCM1 Hcm1p 0.562
HDA2 Hda2p 0.556
SPT16 Spt16p 0.553
DBP10 Dbp10p 0.552
MCM2 Mcm2p 0.545
ADR1 Adr1p 0.541
MET4 Met4p 0.540
HDA3 Hda3p 0.534
DOT6 Dot6p 0.529
RNR2 Rnr2p 0.528
SAS4 Sas4p 0.526
ORC3 Orc3p 0.526
KAP95 Kap95p 0.523
RIM20 Rim20p 0.521
SPT10 Spt10p 0.519
SSA2 Ssa2p 0.503
TOR1 Tor1p 0.502
MRC1 Mrc1p 0.488
LGE1 Lge1p 0.483
CDC14 Cdc14p 0.481
SUM1 Sum1p 0.481
YLR419W hypothetical protein 0.476
CKA2 Cka2p 0.469
GDS1 Gds1p 0.465
BOP3 Bop3p 0.463
NTO1 Nto1p 0.457
SRM1 Srm1p 0.453
UME1 Ume1p 0.450
NUP133 Nup133p 0.447
IFH1 Ifh1p 0.445
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.906
pha-4 Protein PHA-4 0.638
his-16 Protein HIS-16 0.462
elt-6 Protein ELT-6 0.395
zip-7 Protein ZIP-7 0.374
his-46 Protein HIS-46 0.324
nhr-67 Protein NHR-67 0.278
daf-1 Protein DAF-1 0.247
egl-13 Protein EGL-13 0.246
let-502 Protein LET-502 0.241
rad-26 Protein RAD-26 0.235
mes-4 Protein MES-4 0.234
his-1 Protein HIS-1 0.225
eya-1 Protein EYA-1 0.221
his-61 Protein HIS-61 0.205
egl-46 Protein EGL-46 0.194
his-3 Protein HIS-3 0.187
klp-19 Protein KLP-19 0.180
mep-1 Protein MEP-1 0.179
npp-22 Protein NPP-22 0.179
hcp-3 Protein HCP-3 0.172
lin-53 Protein LIN-53 0.168
ran-1 Protein RAN-1 0.167
prp-8 Protein PRP-8 0.164
mix-1 Protein MIX-1 0.162
his-5 Protein HIS-5 0.162
his-64 Protein HIS-64 0.151
inx-3 Protein INX-3 0.151
ceh-32 Protein CEH-32 0.147
T28C6.7 Protein T28C6.7 0.136
his-31 Protein HIS-31 0.134
C33A11.1 Protein C33A11.1 0.133
his-48 Protein HIS-48 0.132
jmjd-2 Protein JMJD-2 0.131
his-42 Protein HIS-42 0.131
attf-2 Protein ATTF-2 0.129
hda-1 Protein HDA-1 0.128
unc-62 Protein UNC-62 0.123
his-62 Protein HIS-62 0.122
daf-14 Protein DAF-14 0.121
ztf-2 Protein ZTF-2 0.120
tbx-8 Protein TBX-8 0.117
hlh-11 Protein HLH-11 0.114
patr-1 Protein PATR-1 0.108
ceh-27 Protein CEH-27 0.105
mca-1 Protein MCA-1 0.100
rsp-1 Protein RSP-1 0.100
mig-38 Protein MIG-38 0.099
his-51 Protein HIS-51 0.098
ras-1 Protein RAS-1 0.098
sur-2 Protein SUR-2 0.096
F39B2.1 Protein F39B2.1 0.096
nrde-3 Protein NRDE-3 0.096
spt-5 Protein SPT-5 0.096
glp-1 Protein GLP-1 0.096
sacy-1 Protein SACY-1 0.096
lin-11 Protein LIN-11 0.095
pbrm-1 Protein PBRM-1 0.095
exc-7 Protein EXC-7 0.095
atg-2 Protein ATG-2 0.095
nhr-25 Protein NHR-25 0.094
his-39 Protein HIS-39 0.093
CELE_C24H12.5 Protein C24H12.5 0.093
his-47 Protein HIS-47 0.091
hda-3 Protein HDA-3 0.091
pry-1 Protein PRY-1 0.090
hlh-2 Protein HLH-2 0.089
mab-5 Protein MAB-5 0.088
pop-1 Protein POP-1 0.088
irx-1 Protein IRX-1 0.088
dcr-1 Protein DCR-1 0.087
bar-1 Protein BAR-1 0.086
his-52 Protein HIS-52 0.085
his-68 Protein HIS-68 0.085
rpt-2 Protein RPT-2 0.085
F25H5.5 Protein F25H5.5 0.084
mcm-5 Protein MCM-5 0.083
sas-6 Protein SAS-6 0.081
nhr-2 Protein NHR-2 0.081
F40F4.7 Protein F40F4.7 0.080
plc-1 Protein PLC-1 0.080
CELE_C25A1.4 Protein C25A1.4 0.080
prpf-4 Protein PRPF-4 0.080
cnd-1 Protein CND-1 0.079
zyg-9 Protein ZYG-9 0.079
cam-1 Protein CAM-1 0.079
dbl-1 Protein DBL-1 0.079
lin-12 Protein LIN-12 0.079
lin-35 Protein LIN-35 0.078
zyg-1 Protein ZYG-1 0.078
rnp-5 Protein RNP-5 0.078
skp-1 Protein SKP-1 0.078
prp-3 Protein PRP-3 0.077
flh-2 Protein FLH-2 0.077
his-38 Protein HIS-38 0.076
cfim-2 Protein CFIM-2 0.075
Y87G2A.1 Protein Y87G2A.1 0.075
fkb-6 Protein FKB-6 0.075
rsp-2 Protein RSP-2 0.074
sox-2 Protein SOX-2 0.074
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Danio rerio
Name Description Probability Func Analog Organism
gata6 GATA-binding protein 6 0.740
ndr2 nodal-related 2 0.583
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.563
bmp2b bone morphogenetic protein 2b 0.557
gli1 GLI-Kruppel family member 1 0.551
twist3 twist3 0.486
chd chordin 0.474
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.472
sox9b SRY-box containing gene 9b 0.457
tbx6 T-box gene 6 0.403
esr2a estrogen receptor 2a 0.392
foxi1 forkhead box I1 0.386
snai1b snail homolog 1b (Drosophila) 0.363
pax8 paired box gene 8 0.328
pkd2 polycystic kidney disease 2 0.309
tfap2a transcription factor AP-2 alpha 0.299
prox1 prospero-related homeobox gene 1 0.292
atoh7 atonal homolog 7 0.290
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.289
foxa3 forkhead box A3 0.278
otx2 orthodenticle homolog 2 0.272
mab21l2 mab-21-like 2 0.269
per2 period homolog 2 (Drosophila) 0.269
meis2.1 myeloid ecotropic viral integration site 2.1 0.261
pou5f1 POU domain, class 5, transcription factor 1 0.251
lhx5 LIM homeobox 5 0.247
fli1a friend leukemia integration 1a 0.246
her7 hairy and enhancer of split related-7 0.238
wt1a wilms tumor 1a 0.236
pcna proliferating cell nuclear antigen 0.235
grem2 gremlin 2, cysteine knot superfamily 0.227
tp53 tumor protein p53 0.227
isl1 islet1 0.221
fgf3 fibroblast growth factor 3 0.219
fzd7a frizzled homolog 7a 0.204
notch1b notch homolog 1b 0.203
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.200
ripply1 ripply1 0.197
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.195
hmx1 H6 homeo box 1 0.191
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.183
mef2d myocyte enhancer factor 2d 0.181
socs3a suppressor of cytokine signaling 3a 0.181
pbx1a pre-B-cell leukemia transcription factor 1a 0.180
pax6a paired box gene 6a 0.180
fgf8a fibroblast growth factor 8 a 0.177
spaw southpaw 0.177
tbx2a T-box gene 2a 0.175
otx1b orthodenticle homolog 1b 0.171
alcama activated leukocyte cell adhesion molecule a 0.170
evx1 even-skipped homeobox 1 0.170
hand2 heart and neural crest derivatives expressed transcript 2 0.169
six1b sine oculis homeobox homolog 1b 0.168
jag2 jagged 2 0.167
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.166
dlx1a distal-less homeobox gene 1a 0.162
eomesa eomesodermin homolog a 0.161
sox32 SRY-box containing gene 32 0.160
tfe3b transcription factor binding to IGHM enhancer 3b 0.156
hoxc4a homeo box C4a 0.156
hoxb1b homeo box B1b 0.155
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.154
nadl1.1 neural adhesion molecule L1.1 0.154
fgf19 fibroblast growth factor 19 0.152
dct dopachrome tautomerase 0.152
adrb2a adrenergic receptor, beta 2a 0.151
dlc deltaC 0.151
irx3b iroquois homeobox protein 3b 0.150
sox19a SRY-box containing gene 19a 0.149
rx2 retinal homeobox gene 2 0.148
msxe muscle segment homeobox E 0.146
her1 hairy-related 1 0.146
gro2 groucho 2 0.145
pax6b paired box gene 6b 0.143
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.143
hp1bp3 heterochromatin protein 1, binding protein 3 0.142
gata4 GATA-binding protein 4 0.141
osr2 odd-skipped related 2 (Drosophila) 0.141
vcana versican a 0.140
crestin crestin 0.140
setdb1a SET domain, bifurcated 1a 0.140
dlx2a distal-less homeobox gene 2a 0.138
ascl1a achaete-scute complex-like 1a (Drosophila) 0.138
vent ventral expressed homeobox 0.137
tal1 T-cell acute lymphocytic leukemia 1 0.136
ptch1 patched 1 0.135
ntla no tail a 0.134
gcm2 glial cells missing homolog 2 (Drosophila) 0.134
rarab retinoic acid receptor, alpha b 0.134
junb jun B proto-oncogene 0.133
ddx39b DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b 0.132
notch1a notch homolog 1a 0.130
traf4a tnf receptor-associated factor 4a 0.129
ef1a elongation factor 1-alpha 0.128
msxc muscle segment homeobox C 0.127
robo3 roundabout homolog 3 0.127
gbx1 gastrulation brain homeobox 1 0.126
pou3f3b POU class 3 homeobox 3b 0.125
meis3 myeloid ecotropic viral integration site 3 0.123
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.123
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Drosophila melanogaster
Name Description Probability Func Analog Organism
kay kayak 0.998
Ubx Ultrabithorax 0.997
Mad Mothers against dpp 0.996
Snr1 Snf5-related 1 0.996
CtBP C-terminal Binding Protein 0.993
ato atonal 0.993
p53 CG33336 gene product from transcript CG33336-RB 0.993
hep hemipterous 0.992
trx trithorax 0.992
E(spl) Enhancer of split 0.991
Iswi Imitation SWI 0.977
Pp1-87B Protein phosphatase 1 at 87B 0.976
smt3 CG4494 gene product from transcript CG4494-RA 0.976
wts warts 0.976
Rpd3 CG7471 gene product from transcript CG7471-RA 0.973
Scm Sex comb on midleg 0.968
ci cubitus interruptus 0.961
ash1 absent, small, or homeotic discs 1 0.960
phyl phyllopod 0.956
Socs36E Suppressor of cytokine signaling at 36E 0.952
dco discs overgrown 0.948
slp1 sloppy paired 1 0.948
nmo nemo 0.946
Pc Polycomb 0.945
lwr lesswright 0.938
Sir2 CG5216 gene product from transcript CG5216-RA 0.937
gpp grappa 0.935
mor moira 0.933
gro groucho 0.932
BEAF-32 Boundary element-associated factor of 32kD 0.927
Pka-C1 cAMP-dependent protein kinase 1 0.927
ara araucan 0.927
Sce Sex combs extra 0.922
eyg eyegone 0.922
barr barren 0.917
ss spineless 0.912
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.911
dac dachshund 0.911
pb proboscipedia 0.908
sog short gastrulation 0.908
rho rhomboid 0.903
InR Insulin-like receptor 0.900
pros prospero 0.895
pan pangolin 0.887
esc extra sexcombs 0.887
dally division abnormally delayed 0.885
Su(H) Suppressor of Hairless 0.885
Su(var)205 Suppressor of variegation 205 0.881
Pcl Polycomblike 0.881
Hel25E Helicase at 25E 0.879
par-1 CG8201 gene product from transcript CG8201-RA 0.875
gsb gooseberry 0.866
Dsp1 Dorsal switch protein 1 0.861
tsh teashirt 0.861
pr-set7 CG3307 gene product from transcript CG3307-RC 0.858
nub nubbin 0.854
dsh dishevelled 0.854
Doc2 Dorsocross2 0.853
N Notch 0.850
CTCF CG8591 gene product from transcript CG8591-RA 0.845
HLHmdelta E(spl) region transcript mdelta 0.832
aop anterior open 0.827
Rga Regena 0.826
MED6 Mediator complex subunit 6 0.825
ems empty spiracles 0.825
crm cramped 0.822
Trl Trithorax-like 0.816
kn knot 0.795
Src42A Src oncogene at 42A 0.793
nab CG33545 gene product from transcript CG33545-RC 0.788
Jra Jun-related antigen 0.786
osa CG7467 gene product from transcript CG7467-RD 0.785
spen split ends 0.783
kibra kibra ortholog 0.781
Med Medea 0.781
slou slouch 0.776
sna snail 0.771
dpp decapentaplegic 0.771
bcd bicoid 0.771
Acf1 ATP-dependent chromatin assembly factor large subunit 0.768
BRWD3 CG31132 gene product from transcript CG31132-RA 0.767
al aristaless 0.766
Optix CG18455 gene product from transcript CG18455-RA 0.753
ush u-shaped 0.745
slmb supernumerary limbs 0.744
mam mastermind 0.729
Trf2 TATA box binding protein-related factor 2 0.721
E(var)3-9 Enhancer of variegation 3-9 0.721
Tip60 CG6121 gene product from transcript CG6121-RA 0.713
Pten CG5671 gene product from transcript CG5671-RB 0.712
eya eyes absent 0.707
Rho1 CG8416 gene product from transcript CG8416-RB 0.706
Kr-h1 Kruppel homolog 1 0.702
vas vasa 0.698
CycB Cyclin B 0.695
Kr Kruppel 0.694
enok enoki mushroom 0.691
Ced-12 CG5336 gene product from transcript CG5336-RA 0.689
G9a CG2995 gene product from transcript CG2995-RA 0.686
tin tinman 0.684
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dusp1 dual specificity phosphatase 1 0.815
Jun Jun oncogene 0.724
Il8rb interleukin 8 receptor, beta 0.699
Id1 inhibitor of DNA binding 1 0.596
Tgfbr2 transforming growth factor, beta receptor II 0.581
Tcfe2a transcription factor E2a 0.556
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.546
Junb jun B proto-oncogene 0.542
Nfib nuclear factor I/B 0.541
Fos FBJ osteosarcoma oncogene 0.528
Dbp D site of albumin promoter (albumin D-box) binding protein 0.517
Hoxc4 homeo box C4 0.483
Klf4 Kruppel-like factor 4 (gut) 0.467
Dchs1 dachsous 1 (Drosophila) 0.456
Arf6 ADP-ribosylation factor 6 0.432
Creb1 cAMP responsive element binding protein 1 0.424
Ier2 immediate early response 2 0.415
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.406
Dusp6 dual specificity phosphatase 6 0.393
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.382
Rhob ras homolog gene family, member B 0.366
Hnrnpr heterogeneous nuclear ribonucleoprotein R 0.360
Shh sonic hedgehog 0.348
Anxa2 annexin A2 0.348
Trim28 tripartite motif-containing 28 0.345
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.345
Prss3 protease, serine, 3 0.343
Flt1 FMS-related tyrosine kinase 1 0.332
Nfia nuclear factor I/A 0.326
Smad3 SMAD family member 3 0.325
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.318
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.314
Btg2 BTG family, member 2 0.311
Cyss cystatin S 0.308
Gabbr1 gamma-aminobutyric acid (GABA) B receptor 1 0.307
Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.306
S100a8 S100 calcium binding protein A8 0.304
Casp2 caspase 2 0.302
Zfp36 zinc finger protein 36 0.299
Smad7 SMAD family member 7 0.296
Egr1 early growth response 1 0.295
Tmpo thymopoietin 0.295
Pde4b phosphodiesterase 4B, cAMP specific 0.284
Synpo synaptopodin 0.283
Hdac2 histone deacetylase 2 0.282
S100a9 S100 calcium binding protein A9 0.281
Dab2 disabled homolog 2 (Drosophila) 0.278
Ptma prothymosin alpha 0.274
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.274
Sfrs1 splicing factor, arginine/serine-rich 1 0.273
Wbp11 WW domain binding protein 11 0.267
Syt2 synaptotagmin II 0.255
Kcnt1 potassium channel, subfamily T, member 1 0.254
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.250
Lif leukemia inhibitory factor 0.250
Sfrs2 splicing factor, arginine/serine-rich 2 0.247
Klf2 Kruppel-like factor 2 (lung) 0.246
Set SET nuclear oncogene 0.244
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.243
Igfbp5 insulin-like growth factor binding protein 5 0.242
Vim vimentin 0.242
Cd9 CD9 molecule 0.239
Fyn FYN oncogene related to SRC, FGR, YES 0.237
Mgp matrix Gla protein 0.236
Galr2 galanin receptor 2 0.236
Pcna proliferating cell nuclear antigen 0.234
Sgk1 serum/glucocorticoid regulated kinase 1 0.234
Prrx1 paired related homeobox 1 0.230
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.228
Lnpep leucyl/cystinyl aminopeptidase 0.228
Purb purine rich element binding protein B 0.227
Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 0.227
Stip1 stress-induced phosphoprotein 1 0.225
Vom2r27 vomeronasal 2 receptor, 27 0.224
Hand2 heart and neural crest derivatives expressed 2 0.221
Foxd1 forkhead box D1 0.219
Trim47 tripartite motif-containing 47 0.218
Myc myelocytomatosis oncogene 0.218
Cd247 Cd247 molecule 0.217
Zranb2 zinc finger, RAN-binding domain containing 2 0.216
Calm2 calmodulin 2 0.213
Dynll1 dynein light chain LC8-type 1 0.212
Grk1 G protein-coupled receptor kinase 1 0.211
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.210
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.210
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.208
Sdc3 syndecan 3 0.208
Rorb RAR-related orphan receptor B 0.207
Met met proto-oncogene 0.206
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.203
Crebbp CREB binding protein 0.202
Arl9 ADP-ribosylation factor-like 9 0.202
Anxa1 annexin A1 0.201
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.201
Socs3 suppressor of cytokine signaling 3 0.199
Hmgb1 high mobility group box 1 0.198
Fabp1 fatty acid binding protein 1, liver 0.198
Sox18 SRY (sex determining region Y)-box 18 0.197
Thbd thrombomodulin 0.196
Hfe hemochromatosis 0.195