The network for 'protein targeting to mitochondrion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein targeting to mitochondrion

The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TIM23 Tim23p 1.000
TOM22 Tom22p 1.000
TOM40 Tom40p 1.000
TOM70 Tom70p 1.000
SSC1 Ssc1p 1.000
TIM44 Tim44p 1.000
MIA40 Mia40p 1.000
TOM20 Tom20p 1.000
TIM10 Tim10p 1.000
TIM17 Tim17p 1.000
TIM18 Tim18p 0.999
TIM50 Tim50p 0.999
SAM35 Sam35p 0.997
TIM9 Tim9p 0.997
PAM18 Pam18p 0.996
FCJ1 Fcj1p 0.993
SAM50 Sam50p 0.991
TIM54 Tim54p 0.989
PAM16 Pam16p 0.985
TIM13 Tim13p 0.974
TOM5 Tom5p 0.966
SSA1 Ssa1p 0.964
TIM22 Tim22p 0.958
MIM1 Mim1p 0.936
SSA2 Ssa2p 0.917
TIM8 Tim8p 0.912
STI1 Sti1p 0.873
TIM12 Tim12p 0.862
MGR2 Mgr2p 0.808
MAS2 Mas2p 0.780
ERV1 Erv1p 0.730
TIM21 Tim21p 0.726
SSA4 Ssa4p 0.689
MGE1 Mge1p 0.648
SSA3 Ssa3p 0.597
YDJ1 Ydj1p 0.582
TOM7 Tom7p 0.563
MAS1 Mas1p 0.457
YLR099W-A hypothetical protein 0.410
HSP60 Hsp60p 0.400
MDM10 Mdm10p 0.395
PAM17 Pam17p 0.388
ATP12 Atp12p 0.366
UPS1 Ups1p 0.364
SIS1 Sis1p 0.345
SAM37 Sam37p 0.314
YTA12 Yta12p 0.279
AHA1 Aha1p 0.262
MGR3 Mgr3p 0.247
KAR2 Kar2p 0.243
UGO1 Ugo1p 0.230
BTN2 Btn2p 0.227
MDJ1 Mdj1p 0.194
GRX5 Grx5p 0.193
CPR6 Cpr6p 0.190
DNM1 Dnm1p 0.185
ALO1 Alo1p 0.183
YLR253W hypothetical protein 0.158
YFH1 Yfh1p 0.154
CLU1 Clu1p 0.149
MDM35 Mdm35p 0.136
HDA2 Hda2p 0.133
ATG13 Atg13p 0.119
NTG1 Ntg1p 0.116
RDL2 Rdl2p 0.114
IMP1 Imp1p 0.110
CUE4 Cue4p 0.105
SSE1 Sse1p 0.103
ALT1 Alt1p 0.103
HSC82 Hsc82p 0.100
PHB1 Phb1p 0.097
GAL7 Gal7p 0.085
CUR1 Cur1p 0.084
ACP1 Acp1p 0.077
HSP104 Hsp104p 0.077
TOM6 Tom6p 0.077
SOM1 Som1p 0.077
RNR3 Rnr3p 0.075
IMP2 Imp2p 0.070
CPR3 Cpr3p 0.069
JEM1 Jem1p 0.063
FES1 Fes1p 0.061
FMP30 Fmp30p 0.061
COX2 Cox2p 0.058
ICP55 Icp55p 0.055
BFR1 Bfr1p 0.054
SOV1 Sov1p 0.054
AIM43 Aim43p 0.053
HSP78 Hsp78p 0.053
HCH1 Hch1p 0.052
YLR132C hypothetical protein 0.048
ZIM17 Zim17p 0.048
AIM36 Aim36p 0.047
YCL057C-A hypothetical protein 0.047
YAH1 Yah1p 0.046
MDM32 Mdm32p 0.046
ATG2 Atg2p 0.046
HXT3 Hxt3p 0.046
ALD6 Ald6p 0.045
YBL039W-B hypothetical protein 0.045
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
fkb-6 Protein FKB-6 0.351
cct-4 Protein CCT-4 0.299
hsp-1 Protein HSP-1 0.273
C30C11.4 Protein C30C11.4 0.259
cct-1 Protein CCT-1 0.258
eif-3.K Protein EIF-3.K 0.215
tomm-7 Protein TOMM-7 0.193
tin-9.1 Protein TIN-9.1 0.191
hsp-4 Protein HSP-4 0.190
cct-2 Protein CCT-2 0.170
mrps-33 Protein MRPS-33 0.169
ddp-1 Protein DDP-1 0.156
cdc-48.2 Protein CDC-48.2 0.140
cct-6 Protein CCT-6 0.138
cra-1 Protein CRA-1 0.135
tbb-2 Protein TBB-2 0.132
dnj-13 Protein DNJ-13 0.131
scpl-4 Protein SCPL-4 0.120
C34C12.8 Protein C34C12.8 0.112
ttll-12 Protein TTLL-12 0.095
mrps-14 Protein MRPS-14 0.089
rmo-1 Protein RMO-1 0.089
CELE_F45H11.5 Protein F45H11.5 0.086
dnj-21 Protein DNJ-21 0.083
sti-1 Protein STI-1 0.082
pbs-6 Protein PBS-6 0.077
C01A2.3 Protein C01A2.3 0.070
cct-5 Protein CCT-5 0.070
tin-13 Protein TIN-13 0.061
T06D8.5 Protein T06D8.5 0.059
F56D1.2 Protein F56D1.2 0.057
pdl-1 Protein PDL-1 0.057
CELE_Y105E8A.11 Protein Y105E8A.11 0.056
dnj-12 Protein DNJ-12 0.053
tomm-40 Protein TOMM-40 0.053
hap-1 Protein HAP-1 0.047
Y39A3CL.3 Protein Y39A3CL.3 0.046
R07E5.13 Protein R07E5.13 0.045
F35D11.5 Protein F35D11.5 0.044
hpo-22 Protein HPO-22 0.044
hint-1 Protein HINT-1 0.043
CELE_K08F4.2 Protein K08F4.2 0.042
CELE_Y116A8C.30 Protein Y116A8C.30 0.040
ztf-7 Protein ZTF-7 0.040
nol-5 Protein NOL-5 0.039
sax-7 Protein SAX-7 0.039
mrpl-49 Protein MRPL-49 0.036
prp-8 Protein PRP-8 0.035
fars-3 Protein FARS-3 0.034
Y22D7AL.10 Protein Y22D7AL.10 0.034
mrps-28 Protein MRPS-28 0.034
mrps-12 Protein MRPS-12 0.032
rpn-1 Protein RPN-1 0.032
mrps-21 Protein MRPS-21 0.031
F10G8.8 Protein F10G8.8 0.031
K05C4.2 Protein K05C4.2 0.028
tba-1 Protein TBA-1 0.028
glrx-5 Protein GLRX-5 0.028
moag-4 Protein MOAG-4 0.028
tag-210 Protein TAG-210 0.028
spk-1 Protein SPK-1 0.027
mrpl-12 Protein MRPL-12 0.026
F45G2.8 Protein F45G2.8 0.026
uba-1 Protein UBA-1 0.026
daf-21 Protein DAF-21 0.025
Y56A3A.19 Protein Y56A3A.19 0.024
F35G2.2 Protein F35G2.2 0.024
CELE_Y53F4B.14 Protein Y53F4B.14 0.024
mrpl-19 Protein MRPL-19 0.024
nuo-6 Protein NUO-6 0.023
F40G9.2 Protein F40G9.2 0.023
T09B4.9 Protein T09B4.9 0.023
F31D4.2 Protein F31D4.2 0.022
cyn-7 Protein CYN-7 0.022
tomm-22 Protein TOMM-22 0.021
H17B01.4 Protein H17B01.4 0.021
adr-1 Protein ADR-1 0.021
cct-7 Protein CCT-7 0.021
nduf-6 Protein NDUF-6 0.021
tin-10 Protein TIN-10 0.020
ostb-1 Protein OSTB-1 0.020
R90.1 Protein R90.1 0.020
mrpl-30 Protein MRPL-30 0.019
icd-1 Protein ICD-1 0.019
CELE_Y69A2AR.3 Protein Y69A2AR.3 0.019
T19A5.1 Protein T19A5.1 0.019
paa-1 Protein PAA-1 0.019
cyn-1 Protein CYN-1 0.019
metr-1 Protein METR-1 0.018
K10B2.4 Protein K10B2.4 0.018
C52E12.1 Protein C52E12.1 0.018
hsp-6 Protein HSP-6 0.018
clk-1 Protein CLK-1 0.018
qars-1 Protein QARS-1 0.018
T08A11.1 Protein T08A11.1 0.017
mrpl-32 Protein MRPL-32 0.017
F35D11.4 Protein F35D11.4 0.017
ima-3 Protein IMA-3 0.017
coq-8 Protein COQ-8 0.017
mrps-23 Protein MRPS-23 0.016
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
bor belphegor 0.030
CG8443 CG8443 gene product from transcript CG8443-RA 0.026
Drp1 Dynamin related protein 1 0.024
CG8531 CG8531 gene product from transcript CG8531-RA 0.020
CG6412 CG6412 gene product from transcript CG6412-RA 0.019
l(1)G0136 lethal (1) G0136 0.016
Hsp83 Heat shock protein 83 0.016
CG6878 CG6878 gene product from transcript CG6878-RA 0.015
CG7770 CG7770 gene product from transcript CG7770-RA 0.015
l(2)tid lethal (2) tumorous imaginal discs 0.014
Cctgamma CG8977 gene product from transcript CG8977-RC 0.013
CG5323 CG5323 gene product from transcript CG5323-RA 0.013
CG12736 CG12736 gene product from transcript CG12736-RA 0.013
Pbgs Porphobilinogen synthase 0.013
CG8728 CG8728 gene product from transcript CG8728-RA 0.012
Tcp-1eta CG8351 gene product from transcript CG8351-RA 0.012
mRpL30 mitochondrial ribosomal protein L30 0.011
milt milton 0.010
CG6565 CG6565 gene product from transcript CG6565-RA 0.010
CG7048 CG7048 gene product from transcript CG7048-RB 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.999
HSPA8 heat shock 70kDa protein 8 0.705
NUB1 negative regulator of ubiquitin-like proteins 1 0.462
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.443
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 0.418
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.387
PPID peptidylprolyl isomerase D 0.367
MARCH5 membrane-associated ring finger (C3HC4) 5 0.315
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.258
STIP1 stress-induced-phosphoprotein 1 0.242
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.201
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.198
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.126
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.126
BAX BCL2-associated X protein 0.116
MAPK8 mitogen-activated protein kinase 8 0.108
SKA3 spindle and kinetochore associated complex subunit 3 0.097
HSPH1 heat shock 105kDa/110kDa protein 1 0.090
TCP1 t-complex 1 0.086
PINK1 PTEN induced putative kinase 1 0.069
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.066
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 0.063
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.060
PPIF peptidylprolyl isomerase F 0.060
MRPL24 mitochondrial ribosomal protein L24 0.054
FKBP4 FK506 binding protein 4, 59kDa 0.054
HSPE1 heat shock 10kDa protein 1 (chaperonin 10) 0.052
MAP2K4 mitogen-activated protein kinase kinase 4 0.050
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.048
HSPA1A heat shock 70kDa protein 1A 0.047
BAK1 BCL2-antagonist/killer 1 0.045
MEOX2 mesenchyme homeobox 2 0.044
VDAC1 voltage-dependent anion channel 1 0.041
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.040
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.038
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.035
HSPA1B heat shock 70kDa protein 1B 0.034
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.033
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 0.031
PRDX5 peroxiredoxin 5 0.029
MRPS7 mitochondrial ribosomal protein S7 0.029
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 0.027
BCL2L1 BCL2-like 1 0.027
BAG2 BCL2-associated athanogene 2 0.027
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.027
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.025
BAG3 BCL2-associated athanogene 3 0.025
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.024
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast) 0.023
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.023
MRPL11 mitochondrial ribosomal protein L11 0.023
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 0.022
TUBA1A tubulin, alpha 1a 0.021
ARMC6 armadillo repeat containing 6 0.021
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.020
TUSC2 tumor suppressor candidate 2 0.020
C19orf70 chromosome 19 open reading frame 70 0.019
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.019
EIF5 eukaryotic translation initiation factor 5 0.019
MRPL28 mitochondrial ribosomal protein L28 0.019
BAG1 BCL2-associated athanogene 0.018
HCCS holocytochrome c synthase 0.018
PMVK phosphomevalonate kinase 0.018
CHCHD8 coiled-coil-helix-coiled-coil-helix domain containing 8 0.018
ROMO1 reactive oxygen species modulator 1 0.017
MRPL46 mitochondrial ribosomal protein L46 0.017
MRPS12 mitochondrial ribosomal protein S12 0.017
BAD BCL2-associated agonist of cell death 0.016
GFM2 G elongation factor, mitochondrial 2 0.016
PHB prohibitin 0.016
C1orf43 chromosome 1 open reading frame 43 0.016
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.016
DNM1L dynamin 1-like 0.015
TTC1 tetratricopeptide repeat domain 1 0.015
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) 0.015
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.014
KIF5B kinesin family member 5B 0.014
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 0.014
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 0.014
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.014
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 0.014
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.014
TXN2 thioredoxin 2 0.014
TUBB2B tubulin, beta 2B 0.014
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.013
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) 0.013
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.013
MRPL27 mitochondrial ribosomal protein L27 0.013
TP53BP2 tumor protein p53 binding protein, 2 0.013
NTPCR nucleoside-triphosphatase, cancer-related 0.013
LDHA lactate dehydrogenase A 0.013
ZNF593 zinc finger protein 593 0.013
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.013
BZW1 basic leucine zipper and W2 domains 1 0.013
GRSF1 G-rich RNA sequence binding factor 1 0.013
PEX19 peroxisomal biogenesis factor 19 0.012
CHUK conserved helix-loop-helix ubiquitous kinase 0.012
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.012
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.012
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.012
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Mus musculus
Name Description Probability Func Analog Organism
Hspd1 heat shock protein 1 (chaperonin) 0.998
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.995
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.989
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.986
Hspa9 heat shock protein 9 0.926
Hspa8 heat shock protein 8 0.915
Hsph1 heat shock 105kDa/110kDa protein 1 0.910
Rpgrip1l Rpgrip1-like 0.853
Iqcb1 IQ calmodulin-binding motif containing 1 0.783
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.720
Tomm70a translocase of outer mitochondrial membrane 70 homolog A (yeast) 0.516
Lrpprc leucine-rich PPR-motif containing 0.427
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.374
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.369
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.335
Hspe1 heat shock protein 1 (chaperonin 10) 0.323
Hspa5 heat shock protein 5 0.287
Ndufaf4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 0.261
Cacybp calcyclin binding protein 0.200
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.191
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.158
Timm8a1 translocase of inner mitochondrial membrane 8 homolog a1 (yeast) 0.135
Ahi1 Abelson helper integration site 1 0.114
Dnaja3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.097
Mrpl50 mitochondrial ribosomal protein L50 0.059
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.054
Immt inner membrane protein, mitochondrial 0.043
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.035
Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 0.034
Mks1 Meckel syndrome, type 1 0.033
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.033
Eprs glutamyl-prolyl-tRNA synthetase 0.031
Dld dihydrolipoamide dehydrogenase 0.030
Hsp90b1 heat shock protein 90, beta (Grp94), member 1 0.029
Mrps22 mitochondrial ribosomal protein S22 0.028
Dnm1l dynamin 1-like 0.026
1110002N22Rik RIKEN cDNA 1110002N22 gene 0.026
Stip1 stress-induced phosphoprotein 1 0.023
Hibch 3-hydroxyisobutyryl-Coenzyme A hydrolase 0.022
Cdc34 cell division cycle 34 homolog (S. cerevisiae) 0.022
Canx calnexin 0.022
1700021F05Rik RIKEN cDNA 1700021F05 gene 0.021
Ndufaf1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 0.021
Nol8 nucleolar protein 8 0.019
Rabep1 rabaptin, RAB GTPase binding effector protein 1 0.019
Ncl nucleolin 0.017
Cycs cytochrome c, somatic 0.017
Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.017
Hspa4 heat shock protein 4 0.017
Hccs holocytochrome c synthetase 0.016
Pdhx pyruvate dehydrogenase complex, component X 0.015
Eif3j eukaryotic translation initiation factor 3, subunit J 0.015
Ndufs1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 0.015
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.014
Fam136a family with sequence similarity 136, member A 0.014
Asna1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.014
Mat2a methionine adenosyltransferase II, alpha 0.014
Nap1l2 nucleosome assembly protein 1-like 2 0.013
Cct6a chaperonin containing Tcp1, subunit 6a (zeta) 0.013
Hspa4l heat shock protein 4 like 0.013
Gcsh glycine cleavage system protein H (aminomethyl carrier) 0.013
Bag2 BCL2-associated athanogene 2 0.013
Caprin1 cell cycle associated protein 1 0.013
Tmem70 transmembrane protein 70 0.013
Ahsa1 AHA1, activator of heat shock protein ATPase homolog 1 (yeast) 0.013
Rrp1 ribosomal RNA processing 1 homolog (S. cerevisiae) 0.013
Akt1 thymoma viral proto-oncogene 1 0.013
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.012
Tuba1a tubulin, alpha 1A 0.012
Nudt3 nudix (nucleotide diphosphate linked moiety X)-type motif 3 0.012
Afg3l2 AFG3(ATPase family gene 3)-like 2 (yeast) 0.011
Napb N-ethylmaleimide sensitive fusion protein attachment protein beta 0.011
Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 0.011
Serbp1 serpine1 mRNA binding protein 1 0.011
Opa1 optic atrophy 1 homolog (human) 0.010
Pex13 peroxisomal biogenesis factor 13 0.010
Sdhaf2 succinate dehydrogenase complex assembly factor 2 0.010
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.010
Mtch2 mitochondrial carrier homolog 2 (C. elegans) 0.010
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Hspd1 heat shock protein 1 (chaperonin) 0.101
Hsph1 heat shock 105/110 protein 1 0.076
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.033
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.030
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.028
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.028
Hspa8 heat shock protein 8 0.015
Stip1 stress-induced phosphoprotein 1 0.011