The network for 'regulation of ras gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ras gtpase activity

Any process that modulates the activity of a GTPase of the Ras superfamily.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GYL1 Gyl1p 0.491
ROM2 Rom2p 0.278
STE11 Ste11p 0.236
MKK1 Mkk1p 0.222
BEM3 Bem3p 0.186
BET3 Bet3p 0.176
RHO1 Rho1p 0.153
MDS3 Mds3p 0.135
TRS65 Trs65p 0.104
PKC1 Pkc1p 0.102
STE5 Ste5p 0.100
GDI1 Gdi1p 0.099
CDC24 Cdc24p 0.098
FYV8 Fyv8p 0.082
CRM1 Crm1p 0.081
IRA1 Ira1p 0.078
ACK1 Ack1p 0.075
SEC3 Sec3p 0.067
TSC11 Tsc11p 0.066
SAC7 Sac7p 0.062
KEL1 Kel1p 0.058
KOG1 Kog1p 0.058
YIL055C hypothetical protein 0.055
SEC15 Sec15p 0.055
MNN9 Mnn9p 0.052
ATG20 Atg20p 0.050
TCO89 Tco89p 0.050
SLG1 Slg1p 0.048
TCA17 Tca17p 0.047
SLT2 Slt2p 0.046
SSK2 Ssk2p 0.045
SPA2 Spa2p 0.045
GIC2 Gic2p 0.042
RGD1 Rgd1p 0.040
YPT53 Ypt53p 0.039
GPB2 Gpb2p 0.039
GDS1 Gds1p 0.038
VPS15 Vps15p 0.037
SRP54 Srp54p 0.037
YDR186C hypothetical protein 0.033
PRS2 Prs2p 0.032
PTP2 Ptp2p 0.032
NVJ1 Nvj1p 0.032
FAA2 Faa2p 0.031
SEC2 Sec2p 0.031
SSK1 Ssk1p 0.030
VPS35 Vps35p 0.030
YOL087C hypothetical protein 0.030
BST1 Bst1p 0.030
FMS1 Fms1p 0.029
MON1 Mon1p 0.028
CHS1 Chs1p 0.028
FUS2 Fus2p 0.027
YPL066W hypothetical protein 0.026
TLG2 Tlg2p 0.026
KAP114 Kap114p 0.026
BEM2 Bem2p 0.026
TAO3 Tao3p 0.026
YLR264C-A hypothetical protein 0.025
TUS1 Tus1p 0.025
SRD1 Srd1p 0.024
AVO1 Avo1p 0.024
YIP3 Yip3p 0.024
CMK2 Cmk2p 0.024
SKM1 Skm1p 0.024
CDC12 Cdc12p 0.023
CSF1 Csf1p 0.023
TAM41 Tam41p 0.023
BIT61 Bit61p 0.023
SLH1 Slh1p 0.023
AKL1 Akl1p 0.023
HSV2 Hsv2p 0.023
BNI1 Bni1p 0.022
YLR162W hypothetical protein 0.022
URA3 Ura3p 0.022
SLM1 Slm1p 0.022
PPH21 Pph21p 0.022
TOM1 Tom1p 0.022
BPT1 Bpt1p 0.022
CDC25 Cdc25p 0.022
TRS85 Trs85p 0.022
LEU2 Leu2p 0.022
UBP5 Ubp5p 0.022
SSK22 Ssk22p 0.022
BEM4 Bem4p 0.021
ENT1 Ent1p 0.021
RGD2 Rgd2p 0.021
BUD8 Bud8p 0.021
BCK1 Bck1p 0.021
SPR6 Spr6p 0.021
YGR126W hypothetical protein 0.021
ARG8 Arg8p 0.021
YOL038C-A hypothetical protein 0.021
VPS41 Vps41p 0.020
CUP1-1 Cup1-1p 0.020
BUL1 Bul1p 0.020
HYP2 Hyp2p 0.020
ARP10 Arp10p 0.020
SEN54 Sen54p 0.020
MSB3 Msb3p 0.020
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
let-60 Protein LET-60 0.206
sup-17 Protein SUP-17 0.169
CELE_F47G4.4 Protein F47G4.4 0.144
sem-5 Protein SEM-5 0.136
C11E4.6 Protein C11E4.6 0.130
rgl-1 Protein RGL-1 0.126
rig-6 Protein RIG-6 0.126
zfp-3 Protein ZFP-3 0.118
snf-1 Protein SNF-1 0.107
zfp-1 Protein ZFP-1 0.105
R10E12.2 Protein R10E12.2 0.084
bet-2 Protein BET-2 0.072
abl-1 Protein ABL-1 0.071
unc-71 Protein UNC-71 0.068
mpk-1 Protein MPK-1 0.068
sym-4 Protein SYM-4 0.067
ptp-1 Protein PTP-1 0.062
CELE_W07A8.2 Protein W07A8.2 0.052
ajm-1 Protein AJM-1 0.042
T04F8.6 Protein T04F8.6 0.041
cdh-3 Protein CDH-3 0.041
afd-1 Protein AFD-1 0.039
zoo-1 Protein ZOO-1 0.039
par-3 Protein PAR-3 0.037
ddr-2 Protein DDR-2 0.036
gap-2 Protein GAP-2 0.034
plc-3 Protein PLC-3 0.033
mrck-1 Protein MRCK-1 0.033
Y55F3BR.8 Protein Y55F3BR.8 0.031
shn-1 Protein SHN-1 0.031
lag-1 Protein LAG-1 0.029
ape-1 Protein APE-1 0.029
R90.1 Protein R90.1 0.029
CELE_T10D4.6 Protein T10D4.6 0.029
lir-1 Protein LIR-1 0.028
smp-1 Protein SMP-1 0.027
sma-6 Protein SMA-6 0.027
unc-26 Protein UNC-26 0.027
itr-1 Protein ITR-1 0.026
gei-8 Protein GEI-8 0.026
rme-4 Protein RME-4 0.026
madf-5 Protein MADF-5 0.025
etr-1 Protein ETR-1 0.025
gar-3 Protein GAR-3 0.024
grk-1 Protein GRK-1 0.024
rab-5 Protein RAB-5 0.024
wdr-23 Protein WDR-23 0.024
magu-3 Protein MAGU-3 0.024
lin-48 Protein LIN-48 0.023
gei-4 Protein GEI-4 0.023
magi-1 Protein MAGI-1 0.023
unc-41 Protein UNC-41 0.022
CELE_F52E1.13 Protein F52E1.13 0.022
C06G1.5 Protein C06G1.5 0.022
rnp-8 Protein RNP-8 0.022
sma-9 Protein SMA-9 0.021
C41D11.4 Protein C41D11.4 0.021
R11A8.7 Protein R11A8.7 0.021
sax-3 Protein SAX-3 0.020
eor-1 Protein EOR-1 0.020
T23F2.2 Protein T23F2.2 0.020
CELE_F53C11.5 Protein F53C11.5 0.020
F22D3.2 Protein F22D3.2 0.020
nhr-45 Protein NHR-45 0.019
pak-1 Protein PAK-1 0.019
daf-19 Protein DAF-19 0.019
cgef-1 Protein CGEF-1 0.019
tat-1 Protein TAT-1 0.017
egl-18 Protein EGL-18 0.017
frm-8 Protein FRM-8 0.017
ina-1 Protein INA-1 0.017
pqn-39 Protein PQN-39 0.017
F16A11.1 Protein F16A11.1 0.017
lin-45 Protein LIN-45 0.017
frm-10 Protein FRM-10 0.017
CELE_R09F10.3 Protein R09F10.3 0.017
lfi-1 Protein LFI-1 0.016
D2085.5 Protein D2085.5 0.016
C27H2.2 Protein C27H2.2 0.016
sel-8 Protein SEL-8 0.016
mig-5 Protein MIG-5 0.016
unc-45 Protein UNC-45 0.016
cyld-1 Protein CYLD-1 0.016
rgs-7 Protein RGS-7 0.016
F07C6.4 Protein F07C6.4 0.016
fhod-1 Protein FHOD-1 0.016
cdh-9 Protein CDH-9 0.016
kin-25 Protein KIN-25 0.015
C53D5.1 Protein C53D5.1 0.015
egrh-1 Protein EGRH-1 0.015
stau-1 Protein STAU-1 0.015
git-1 Protein GIT-1 0.015
cah-6 Protein CAH-6 0.015
pry-1 Protein PRY-1 0.015
elt-6 Protein ELT-6 0.015
tag-303 Protein TAG-303 0.015
cam-1 Protein CAM-1 0.015
dpf-3 Protein DPF-3 0.015
nep-12 Protein NEP-12 0.015
mtm-3 Protein MTM-3 0.014
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.052
tpm4 tropomyosin 4 0.045
rtcd1 RNA terminal phosphate cyclase domain 1 0.042
plxnb2a plexin b2a 0.041
card9 caspase recruitment domain family, member 9 0.037
cnn2 calponin 2 0.032
adrb2a adrenergic receptor, beta 2a 0.029
anxa2a annexin A2a 0.029
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.029
pitx3 paired-like homeodomain transcription factor 3 0.026
pafah1b1a platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a 0.026
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.026
s100a10b S100 calcium binding protein A10b 0.025
vangl2 vang-like 2 (van gogh, Drosophila) 0.025
mat2a methionine adenosyltransferase II, alpha 0.025
abcf2 ATP-binding cassette, sub-family F (GCN20), member 2 0.025
si:dkey-228g21.4 si:dkey-228g21.4 0.024
cltca clathrin, heavy polypeptide a (Hc) 0.024
stmn2b stathmin-like 2b 0.023
kbp kif1-binding protein 0.023
mtp microsomal triglyceride transfer protein 0.023
scinlb scinderin like b 0.022
si:ch211-195h23.3 si:ch211-195h23.3 0.022
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.021
stau1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.021
gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a 0.021
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.021
casz1 castor zinc finger 1 0.021
fem1c fem-1 homolog c (C.elegans) 0.021
xpo4 exportin 4 0.021
aif1l allograft inflammatory factor 1-like 0.021
zbtb4 zinc finger and BTB domain containing 4 0.020
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.020
ahnak AHNAK nucleoprotein 0.020
pparg peroxisome proliferator activated receptor gamma 0.020
iqgap1 IQ motif containing GTPase activating protein 1 0.020
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.020
LOC565256 similar to Metabotropic glutamate receptor 3 precursor (mGluR3) 0.020
icn ictacalcin 0.020
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.020
sb:cb730 sb:cb730 0.020
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.019
foxa2 forkhead box A2 0.019
adrb2b adrenergic receptor, beta 2b 0.019
rps6ka3a ribosomal protein S6 kinase, polypeptide 3a 0.019
rxrbb retinoid x receptor, beta b 0.019
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.018
s100v2 S100 calcium binding protein V2 0.018
pvrl1b poliovirus receptor-related 1b 0.018
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.018
stau2 staufen, RNA binding protein, homolog 2 (Drosophila) 0.018
mycbp2 MYC binding protein 2 0.018
acvr1b activin A receptor, type IB 0.018
diaph2 diaphanous homolog 2 (Drosophila) 0.018
pob partial optokinetic response b 0.018
msna moesin a 0.018
dock1 dedicator of cytokinesis 1 0.018
ela2 elastase 2 0.018
m17 IL-6 subfamily cytokine M17 0.018
ankrd6 ankyrin repeat domain 6 0.018
zgc:85727 zgc:85727 0.018
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.018
tsc2 tuberous sclerosis 2 0.017
zeb1 zinc finger E-box binding homeobox 1 0.017
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.017
tm9sf2 transmembrane 9 superfamily member 2 0.017
huwe1 HECT, UBA and WWE domain containing 1 0.017
clic1 chloride intracellular channel 1 0.017
LOC565839 tumor necrosis factor alpha-induced protein 2-like 0.017
ints9 integrator complex subunit 9 0.017
eya2 eyes absent homolog 2 (Drosophila) 0.017
cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.017
akt2 v-akt murine thymoma viral oncogene homolog 2 0.017
optc opticin 0.017
il11ra interleukin 11 receptor, alpha 0.017
sri sorcin 0.017
ldb2a LIM-domain binding factor 2a 0.017
copeb core promoter element binding protein 0.017
phf21a PHD finger protein 21A 0.017
odc1 ornithine decarboxylase 1 0.017
zgc:112986 zgc:112986 0.017
zgc:56466 zgc:56466 0.017
atf3 activating transcription factor 3 0.016
slc12a10.2 solute carrier family 12 (sodium/potassium/chloride transporters), member 10.2 0.016
foxi2 forkhead box I2 0.016
bactin2 bactin2 0.016
gria4b glutamate receptor, ionotropic, AMPA 4b 0.016
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.016
slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.016
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.016
ssbp3a single stranded DNA binding protein 3a 0.016
nrarpa notch-regulated ankyrin repeat protein a 0.016
trpa1b transient receptor potential cation channel, subfamily A, member 1b 0.016
arpc1a actin related protein 2/3 complex, subunit 1A 0.016
zgc:153460 zgc:153460 0.016
hif1an hypoxia-inducible factor 1, alpha subunit inhibitor 0.016
zgc:100838 zgc:100838 0.016
march6 membrane-associated ring finger (C3HC4) 6 0.016
zgc:101724 zgc:101724 0.016
si:ch211-160j6.2 si:ch211-160j6.2 0.016
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
smo smoothened 0.817
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.814
pod1 CG4532 gene product from transcript CG4532-RF 0.742
Sos Son of sevenless 0.603
Rheb CG1081 gene product from transcript CG1081-RA 0.582
drk downstream of receptor kinase 0.517
trio CG18214 gene product from transcript CG18214-RA 0.391
rok Rho-kinase 0.278
dos daughter of sevenless 0.274
Pten CG5671 gene product from transcript CG5671-RB 0.262
CG6509 CG6509 gene product from transcript CG6509-RB 0.255
stai stathmin 0.228
Pkn Protein kinase related to protein kinase N 0.227
Fak56D Focal Adhesion Kinase 0.226
mbc myoblast city 0.181
synj synaptojanin 0.177
lgs legless 0.173
Stat92E Signal-transducer and activator of transcription protein at 92E 0.149
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.131
rl rolled 0.130
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.125
Apc APC-like 0.125
Arf79F ADP ribosylation factor 79F 0.122
puc puckered 0.121
ken ken and barbie 0.120
ttk tramtrack 0.119
htl heartless 0.111
Wnk CG7177 gene product from transcript CG7177-RA 0.107
flw flapwing 0.103
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.103
p120ctn Adherens junction protein p120 0.102
Hnf4 Hepatocyte nuclear factor 4 0.099
mbt mushroom bodies tiny 0.096
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.095
Ced-12 CG5336 gene product from transcript CG5336-RA 0.094
baz bazooka 0.092
siz schizo 0.088
Mad Mothers against dpp 0.087
Abi Abelson interacting protein 0.086
Pak3 CG14895 gene product from transcript CG14895-RA 0.085
aux auxillin 0.083
Su(H) Suppressor of Hairless 0.082
kuz kuzbanian 0.080
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.079
stg string 0.078
NaCP60E Na channel protein 60E 0.076
mask multiple ankyrin repeats single KH domain 0.075
rap retina aberrant in pattern 0.073
yrt yurt 0.071
CG11851 CG11851 gene product from transcript CG11851-RA 0.071
tutl turtle 0.068
Lar Leukocyte-antigen-related-like 0.066
neuroligin CG13772 gene product from transcript CG13772-RA 0.065
sima similar 0.064
mop myopic 0.064
CG8334 CG8334 gene product from transcript CG8334-RA 0.063
ths thisbe 0.061
Mtl Mig-2-like 0.061
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.060
CG4853 CG4853 gene product from transcript CG4853-RA 0.059
CG32772 CG32772 gene product from transcript CG32772-RC 0.059
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.058
Mer Merlin 0.057
Prp31 CG6876 gene product from transcript CG6876-RA 0.056
Rip11 Rab11 interacting protein 0.056
Drl-2 Derailed 2 0.056
Wnt5 Wnt oncogene analog 5 0.054
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.053
Ras64B Ras oncogene at 64B 0.053
ena enabled 0.052
CG7158 CG7158 gene product from transcript CG7158-RA 0.051
CG8155 CG8155 gene product from transcript CG8155-RA 0.051
Zasp66 Z band alternatively spliced PDZ-motif protein 66 0.051
CG10631 CG10631 gene product from transcript CG10631-RA 0.050
Akt1 CG4006 gene product from transcript CG4006-RA 0.050
pie pineapple eye 0.050
didum dilute class unconventional myosin 0.050
Rala Ras-related protein 0.049
l(2)k05819 lethal (2) k05819 0.048
Lnk CG17367 gene product from transcript CG17367-RC 0.048
alpha-Man-II alpha Mannosidase II 0.048
LIMK1 LIM-kinase1 0.048
Sin3A CG8815 gene product from transcript CG8815-RC 0.048
dm diminutive 0.047
CG4552 CG4552 gene product from transcript CG4552-RA 0.047
Vps16A Vacuolar protein sorting 16A 0.047
S6k RPS6-p70-protein kinase 0.047
Smox Smad on X 0.047
Ephrin CG1862 gene product from transcript CG1862-RA 0.047
cta concertina 0.046
Pk61C Protein kinase 61C 0.046
SCAR CG4636 gene product from transcript CG4636-RA 0.046
phl pole hole 0.046
plexB plexin B 0.045
vav CG7893 gene product from transcript CG7893-RB 0.045
cno canoe 0.045
rictor rapamycin-insensitive companion of Tor 0.045
gcl germ cell-less 0.045
CG11033 CG11033 gene product from transcript CG11033-RB 0.045
CG5798 CG5798 gene product from transcript CG5798-RA 0.044
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.999
EGFR epidermal growth factor receptor 0.999
PTK2 PTK2 protein tyrosine kinase 2 0.995
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.990
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.988
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.981
SH3KBP1 SH3-domain kinase binding protein 1 0.980
GRB7 growth factor receptor-bound protein 7 0.971
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.957
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.941
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.928
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.928
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.926
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.901
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.900
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.884
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.875
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.869
SFN stratifin 0.840
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.839
S100A6 S100 calcium binding protein A6 0.838
RHOA ras homolog gene family, member A 0.831
NCF2 neutrophil cytosolic factor 2 0.829
ADRBK1 adrenergic, beta, receptor kinase 1 0.737
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.736
JUN jun proto-oncogene 0.733
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.729
TRAF1 TNF receptor-associated factor 1 0.717
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.695
S100B S100 calcium binding protein B 0.692
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.689
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.672
SH3BP2 SH3-domain binding protein 2 0.654
IGF1R insulin-like growth factor 1 receptor 0.654
S100A8 S100 calcium binding protein A8 0.652
SOS1 son of sevenless homolog 1 (Drosophila) 0.625
TSC1 tuberous sclerosis 1 0.616
BCAR1 breast cancer anti-estrogen resistance 1 0.590
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.589
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.588
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.574
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.537
SH3RF1 SH3 domain containing ring finger 1 0.534
MARK3 MAP/microtubule affinity-regulating kinase 3 0.507
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.507
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.495
TSC2 tuberous sclerosis 2 0.479
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.472
ABI1 abl-interactor 1 0.460
FOS FBJ murine osteosarcoma viral oncogene homolog 0.441
S100A11 S100 calcium binding protein A11 0.435
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.408
ZMYND11 zinc finger, MYND-type containing 11 0.408
FMNL1 formin-like 1 0.408
MET met proto-oncogene (hepatocyte growth factor receptor) 0.398
CCR5 chemokine (C-C motif) receptor 5 0.395
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.388
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.384
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.375
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.372
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.368
RACGAP1 Rac GTPase activating protein 1 0.360
RHOC ras homolog gene family, member C 0.355
PKN3 protein kinase N3 0.348
HIPK2 homeodomain interacting protein kinase 2 0.333
FAM65A family with sequence similarity 65, member A 0.303
DOCK1 dedicator of cytokinesis 1 0.301
ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 0.300
GABARAPL1 GABA(A) receptor-associated protein like 1 0.297
TNF tumor necrosis factor 0.291
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.275
ANXA2 annexin A2 0.274
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.267
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.266
RPTOR regulatory associated protein of MTOR, complex 1 0.264
RALBP1 ralA binding protein 1 0.254
S100A9 S100 calcium binding protein A9 0.251
DSP desmoplakin 0.246
KIAA0930 KIAA0930 0.245
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.242
S100A4 S100 calcium binding protein A4 0.241
NCK1 NCK adaptor protein 1 0.240
CCL2 chemokine (C-C motif) ligand 2 0.239
TRAF5 TNF receptor-associated factor 5 0.234
GRB2 growth factor receptor-bound protein 2 0.230
AKT1S1 AKT1 substrate 1 (proline-rich) 0.220
KRT14 keratin 14 0.211
NCKAP1 NCK-associated protein 1 0.208
CSNK1G2 casein kinase 1, gamma 2 0.203
CAPG capping protein (actin filament), gelsolin-like 0.203
BBS10 Bardet-Biedl syndrome 10 0.201
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.199
EPHA7 EPH receptor A7 0.196
EFNA5 ephrin-A5 0.192
JUNB jun B proto-oncogene 0.188
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.187
RHEB Ras homolog enriched in brain 0.180
MPRIP myosin phosphatase Rho interacting protein 0.178
RND1 Rho family GTPase 1 0.175
ANK1 ankyrin 1, erythrocytic 0.172
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.000
Epha4 Eph receptor A4 0.999
Efnb2 ephrin B2 0.998
Ephb2 Eph receptor B2 0.997
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.989
Ret ret proto-oncogene 0.970
Ntf3 neurotrophin 3 0.955
Rac1 RAS-related C3 botulinum substrate 1 0.927
Sox10 SRY-box containing gene 10 0.926
Plcg1 phospholipase C, gamma 1 0.924
Braf Braf transforming gene 0.920
Adrb1 adrenergic receptor, beta 1 0.910
Plxnb1 plexin B1 0.909
Apc adenomatosis polyposis coli 0.906
Grb2 growth factor receptor bound protein 2 0.885
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.884
Lepr leptin receptor 0.864
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.859
Ephb3 Eph receptor B3 0.852
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.851
Shc1 src homology 2 domain-containing transforming protein C1 0.827
Cbl Casitas B-lineage lymphoma 0.823
Ccl2 chemokine (C-C motif) ligand 2 0.772
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.770
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.765
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.763
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.698
Kl klotho 0.696
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.693
Mapkap1 mitogen-activated protein kinase associated protein 1 0.690
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.689
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.677
Ly6h lymphocyte antigen 6 complex, locus H 0.667
Rtkn rhotekin 0.661
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.642
Eps15 epidermal growth factor receptor pathway substrate 15 0.621
Efna1 ephrin A1 0.616
Plxna1 plexin A1 0.607
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.594
Arrb2 arrestin, beta 2 0.590
Mtor mechanistic target of rapamycin (serine/threonine kinase) 0.588
Fos FBJ osteosarcoma oncogene 0.584
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.582
Vav3 vav 3 oncogene 0.572
Cd44 CD44 antigen 0.565
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.563
Git1 G protein-coupled receptor kinase-interactor 1 0.559
Tnks1bp1 tankyrase 1 binding protein 1 0.548
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.543
Hdac7 histone deacetylase 7 0.536
Vav2 vav 2 oncogene 0.535
Arhgef12 Rho guanine nucleotide exchange factor (GEF) 12 0.525
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.521
Spry4 sprouty homolog 4 (Drosophila) 0.496
Mmp15 matrix metallopeptidase 15 0.493
Adora2a adenosine A2a receptor 0.480
Pnpla2 patatin-like phospholipase domain containing 2 0.479
Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent 0.477
Spry2 sprouty homolog 2 (Drosophila) 0.471
Vav1 vav 1 oncogene 0.469
Prkcb protein kinase C, beta 0.467
Stxbp3a syntaxin binding protein 3A 0.466
Plxna3 plexin A3 0.462
Ltb lymphotoxin B 0.459
Nf2 neurofibromatosis 2 0.451
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.449
Pou3f3 POU domain, class 3, transcription factor 3 0.449
Ctnnb1 catenin (cadherin associated protein), beta 1 0.448
Jup junction plakoglobin 0.440
Arhgap21 Rho GTPase activating protein 21 0.433
Rasgrp1 RAS guanyl releasing protein 1 0.421
Cdh6 cadherin 6 0.418
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.409
Adrbk1 adrenergic receptor kinase, beta 1 0.399
Irf5 interferon regulatory factor 5 0.395
Fzd1 frizzled homolog 1 (Drosophila) 0.394
Sh3rf1 SH3 domain containing ring finger 1 0.385
Sh2d3c SH2 domain containing 3C 0.378
Prkce protein kinase C, epsilon 0.359
Grid1 glutamate receptor, ionotropic, delta 1 0.358
Adcy4 adenylate cyclase 4 0.358
Pparg peroxisome proliferator activated receptor gamma 0.354
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.353
Cttn cortactin 0.344
Nf1 neurofibromatosis 1 0.343
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.343
Sh3pxd2a SH3 and PX domains 2A 0.343
Mark4 MAP/microtubule affinity-regulating kinase 4 0.337
Ptk2 PTK2 protein tyrosine kinase 2 0.335
Src Rous sarcoma oncogene 0.332
Gli3 GLI-Kruppel family member GLI3 0.330
Dock1 dedicator of cytokinesis 1 0.328
Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.328
Rhob ras homolog gene family, member B 0.323
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.319
Elmo1 engulfment and cell motility 1, ced-12 homolog (C. elegans) 0.319
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.316
Pou3f2 POU domain, class 3, transcription factor 2 0.312
Kcnk2 potassium channel, subfamily K, member 2 0.310
Esrrb estrogen related receptor, beta 0.310
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Arpc3 actin related protein 2/3 complex, subunit 3 0.116
Nptn neuroplastin 0.103
Epas1 endothelial PAS domain protein 1 0.086
Dlg3 discs, large homolog 3 (Drosophila) 0.079
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.074
Anxa2 annexin A2 0.066
Smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.059
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.058
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.048
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.043
Sept10 septin 10 0.042
Exoc5 exocyst complex component 5 0.042
Zfp260 zinc finger protein 260 0.039
Pls3 plastin 3 (T-isoform) 0.037
Tek TEK tyrosine kinase, endothelial 0.037
Tle4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 0.036
Pja2 praja 2, RING-H2 motif containing 0.035
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.032
Klf6 Kruppel-like factor 6 0.031
Cyb5r4 cytochrome b5 reductase 4 0.030
Clcn2 chloride channel 2 0.030
Dync1h1 dynein cytoplasmic 1 heavy chain 1 0.029
Jak2 Janus kinase 2 0.029
Ptafr platelet-activating factor receptor 0.029
Pld2 phospholipase D2 0.028
Cyth1 cytohesin 1 0.027
Tgfbr2 transforming growth factor, beta receptor II 0.027
Fam108a1 family with sequence similarity 108, member A1 0.027
Bin2 bridging integrator 2 0.027
Map2 microtubule-associated protein 2 0.027
Picalm phosphatidylinositol binding clathrin assembly protein 0.027
Sdc3 syndecan 3 0.026
Capn2 calpain 2 0.026
Trappc6b trafficking protein particle complex 6B 0.026
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.026
Nckap1 NCK-associated protein 1 0.026
Rab1b RAB1B, member RAS oncogene family 0.026
Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.026
Ptprs protein tyrosine phosphatase, receptor type, S 0.026
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.025
Rap1b RAP1B, member of RAS oncogene family 0.025
Scamp1 secretory carrier membrane protein 1 0.025
Prkch protein kinase C, eta 0.025
Plxnd1 plexin D1 0.025
Klf4 Kruppel-like factor 4 (gut) 0.024
Gria2 glutamate receptor, ionotropic, AMPA 2 0.024
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.024
Hk1 hexokinase 1 0.024
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.023
LOC691920 similar to kinesin-like motor protein C20orf23 0.023
Gnai1 guanine nucleotide binding protein (G protein), alpha inhibiting 1 0.023
Pde2a phosphodiesterase 2A, cGMP-stimulated 0.023
Dok1 docking protein 1 0.023
Zfp36 zinc finger protein 36 0.023
Gpr116 G protein-coupled receptor 116 0.023
Utrn utrophin 0.022
Clcn7 chloride channel 7 0.022
Btg2 BTG family, member 2 0.022
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.021
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.021
Macf1 microtubule-actin crosslinking factor 1 0.021
Acvrl1 activin A receptor type II-like 1 0.021
Inpp5d inositol polyphosphate-5-phosphatase D 0.021
Akap1 A kinase (PRKA) anchor protein 1 0.021
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.021
S100a4 S100 calcium-binding protein A4 0.021
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.020
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.020
Dock9 dedicator of cytokinesis 9 0.020
Foxp1 forkhead box P1 0.020
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.020
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.020
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.020
Ntn1 netrin 1 0.020
Slit3 slit homolog 3 (Drosophila) 0.020
Itpr1 inositol 1,4,5-triphosphate receptor, type 1 0.020
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.020
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.019
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.019
Vsnl1 visinin-like 1 0.019
Lphn2 latrophilin 2 0.019
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.019
Add3 adducin 3 (gamma) 0.019
LOC313672 kazrin 0.019
Lzts2 leucine zipper, putative tumor suppressor 2 0.019
Adcy6 adenylate cyclase 6 0.018
Hivep2 human immunodeficiency virus type I enhancer binding protein 2 0.018
Unc13d unc-13 homolog D (C. elegans) 0.018
Pcnxl3 pecanex-like 3 (Drosophila) 0.018
Ppp1r13b protein phosphatase 1, regulatory (inhibitor) subunit 13B 0.018
Plcg1 phospholipase C, gamma 1 0.018
Sbf1 SET binding factor 1 0.018
Bcl6b B-cell CLL/lymphoma 6, member B (zinc finger protein) 0.018
Dapk3 death-associated protein kinase 3 0.018
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.018
Fgd5 FYVE, RhoGEF and PH domain containing 5 0.018
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.018
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.018
Sh2d3c SH2 domain containing 3C 0.017
G3bp2 GTPase activating protein (SH3 domain) binding protein 2 0.017