The network for 'positive regulation of hydrolase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MKK1 Mkk1p 0.329
GYL1 Gyl1p 0.293
DNM1 Dnm1p 0.251
STE11 Ste11p 0.220
SDS22 Sds22p 0.183
GCD6 Gcd6p 0.169
SUI3 Sui3p 0.169
STE20 Ste20p 0.149
RNY1 Rny1p 0.147
SHY1 Shy1p 0.142
MSH3 Msh3p 0.137
ROM2 Rom2p 0.137
RGA2 Rga2p 0.132
STI1 Sti1p 0.132
RHO1 Rho1p 0.130
CRN1 Crn1p 0.129
MSH2 Msh2p 0.128
BCK1 Bck1p 0.116
RAD52 Rad52p 0.110
PSP2 Psp2p 0.110
SEC27 Sec27p 0.102
HIS6 His6p 0.102
STE5 Ste5p 0.097
YME1 Yme1p 0.095
SCJ1 Scj1p 0.092
TSR1 Tsr1p 0.089
TSC11 Tsc11p 0.089
SLT2 Slt2p 0.086
SPA2 Spa2p 0.078
RAS2 Ras2p 0.074
IRA1 Ira1p 0.070
GCD11 Gcd11p 0.069
PTP2 Ptp2p 0.069
IRC5 Irc5p 0.068
VPS60 Vps60p 0.067
CCP1 Ccp1p 0.064
PKH2 Pkh2p 0.064
BST1 Bst1p 0.064
CHC1 Chc1p 0.062
BIK1 Bik1p 0.062
HSV2 Hsv2p 0.061
OCH1 Och1p 0.059
SEC13 Sec13p 0.059
FYV8 Fyv8p 0.059
BEM3 Bem3p 0.059
AHP1 Ahp1p 0.059
CDC24 Cdc24p 0.059
MSP1 Msp1p 0.058
URA6 Ura6p 0.057
MBF1 Mbf1p 0.056
BFR1 Bfr1p 0.056
PKC1 Pkc1p 0.054
PAN1 Pan1p 0.054
AKL1 Akl1p 0.052
RAD14 Rad14p 0.052
CLN3 Cln3p 0.052
MDS3 Mds3p 0.052
RPG1 Rpg1p 0.050
YGL036W hypothetical protein 0.050
CAK1 Cak1p 0.050
ENT1 Ent1p 0.049
YTA6 Yta6p 0.049
UBP5 Ubp5p 0.048
CHS1 Chs1p 0.048
YIP4 Yip4p 0.048
YPT53 Ypt53p 0.047
EXO1 Exo1p 0.047
REB1 Reb1p 0.047
CDC48 Cdc48p 0.046
UPS3 Ups3p 0.046
MON1 Mon1p 0.046
MPH1 Mph1p 0.046
NPL4 Npl4p 0.045
GGA1 Gga1p 0.045
KEL1 Kel1p 0.044
PAC11 Pac11p 0.044
CDC12 Cdc12p 0.044
POL3 Pol3p 0.042
ATG21 Atg21p 0.042
KIP2 Kip2p 0.042
SAC7 Sac7p 0.041
NEO1 Neo1p 0.041
MAS1 Mas1p 0.041
CDC50 Cdc50p 0.041
MSG5 Msg5p 0.040
VPS41 Vps41p 0.040
STE2 Ste2p 0.040
VPS9 Vps9p 0.040
YNR065C hypothetical protein 0.039
SLH1 Slh1p 0.039
TIF5 Tif5p 0.038
SSL2 Ssl2p 0.038
YLR257W hypothetical protein 0.038
PKH1 Pkh1p 0.038
ABP1 Abp1p 0.037
SIS1 Sis1p 0.036
QCR6 Qcr6p 0.036
PCL9 Pcl9p 0.036
SOK1 Sok1p 0.036
TUS1 Tus1p 0.036
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
mpk-1 Protein MPK-1 0.170
gei-4 Protein GEI-4 0.127
sem-5 Protein SEM-5 0.094
goa-1 Protein GOA-1 0.094
let-60 Protein LET-60 0.089
cyc-1 Protein CYC-1 0.086
pdi-3 Protein PDI-3 0.082
nck-1 Protein NCK-1 0.075
sli-1 Protein SLI-1 0.070
unc-26 Protein UNC-26 0.066
flh-2 Protein FLH-2 0.062
ant-1.1 Protein ANT-1.1 0.061
rig-6 Protein RIG-6 0.060
mbk-1 Protein MBK-1 0.060
bet-2 Protein BET-2 0.058
C11H1.3 Protein C11H1.3 0.055
cgef-2 Protein CGEF-2 0.052
nurf-1 Protein NURF-1 0.052
rhgf-2 Protein RHGF-2 0.049
sma-9 Protein SMA-9 0.047
lag-1 Protein LAG-1 0.046
ced-9 Protein CED-9 0.046
rps-5 Protein RPS-5 0.046
unc-71 Protein UNC-71 0.045
cks-1 Protein CKS-1 0.043
lin-45 Protein LIN-45 0.041
rbg-1 Protein RBG-1 0.041
npp-9 Protein NPP-9 0.041
rgl-1 Protein RGL-1 0.041
bar-1 Protein BAR-1 0.040
atg-11 Protein ATG-11 0.040
abl-1 Protein ABL-1 0.039
cin-4 Protein CIN-4 0.039
smp-1 Protein SMP-1 0.039
pek-1 Protein PEK-1 0.038
fhod-1 Protein FHOD-1 0.038
dars-1 Protein DARS-1 0.038
C07B5.4 Protein C07B5.4 0.037
afd-1 Protein AFD-1 0.036
rme-4 Protein RME-4 0.035
rla-0 Protein RLA-0 0.035
sur-2 Protein SUR-2 0.035
tag-343 Protein TAG-343 0.034
tmc-2 Protein TMC-2 0.034
cdc-48.2 Protein CDC-48.2 0.034
hsp-1 Protein HSP-1 0.033
lim-9 Protein LIM-9 0.033
egl-18 Protein EGL-18 0.033
mat-3 Protein MAT-3 0.032
ptp-4 Protein PTP-4 0.031
T28B11.1 Protein T28B11.1 0.031
lmp-2 Protein LMP-2 0.031
uaf-1 Protein UAF-1 0.031
CELE_Y60A3A.9 Protein Y60A3A.9 0.030
T21B6.3 Protein T21B6.3 0.030
mtm-3 Protein MTM-3 0.030
rab-5 Protein RAB-5 0.029
ostb-1 Protein OSTB-1 0.029
pde-4 Protein PDE-4 0.029
egl-13 Protein EGL-13 0.028
ess-2 Protein ESS-2 0.028
rpl-12 Protein RPL-12 0.028
CELE_K08E7.6 Protein K08E7.6 0.027
aha-1 Protein AHA-1 0.027
rpn-1 Protein RPN-1 0.027
W03G9.2 Protein W03G9.2 0.027
rsbp-1 Protein RSBP-1 0.027
sup-17 Protein SUP-17 0.027
rpm-1 Protein RPM-1 0.027
jnk-1 Protein JNK-1 0.027
let-268 Protein LET-268 0.027
gar-3 Protein GAR-3 0.027
egrh-1 Protein EGRH-1 0.027
C06G1.5 Protein C06G1.5 0.026
sad-1 Protein SAD-1 0.026
sma-1 Protein SMA-1 0.026
dpy-27 Protein DPY-27 0.026
plc-1 Protein PLC-1 0.026
mei-1 Protein MEI-1 0.026
F28B3.1 Protein F28B3.1 0.026
svh-2 Protein SVH-2 0.026
glb-6 Protein GLB-6 0.026
sta-1 Protein STA-1 0.025
T23B12.6 Protein T23B12.6 0.025
vrk-1 Protein VRK-1 0.025
snt-4 Protein SNT-4 0.025
rpt-1 Protein RPT-1 0.025
toca-1 Protein TOCA-1 0.025
Y77E11A.1 Protein Y77E11A.1 0.025
miro-1 Protein MIRO-1 0.025
dnj-25 Protein DNJ-25 0.025
ahcy-1 Protein AHCY-1 0.024
T20D3.11 Protein T20D3.11 0.024
cct-6 Protein CCT-6 0.024
K10C9.3 Protein K10C9.3 0.024
F07A11.2 Protein F07A11.2 0.024
daf-19 Protein DAF-19 0.023
gap-2 Protein GAP-2 0.023
rpn-6.1 Protein RPN-6.1 0.023
hmr-1 Protein HMR-1 0.023
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Danio rerio
Name Description Probability Func Analog Organism
sulf1 sulfatase 1 0.212
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.210
bida BH3 interacting domain death agonist 0.143
bmp7a bone morphogenetic protein 7a 0.141
wt1b wilms tumor 1b 0.119
desma desmin a 0.090
baxa bcl2-associated X protein, a 0.082
flot2a flotillin 2a 0.081
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.081
adrb2a adrenergic receptor, beta 2a 0.079
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.079
ahnak AHNAK nucleoprotein 0.079
tpm4 tropomyosin 4 0.078
sparc secreted acidic cysteine rich glycoprotein 0.077
tfe3b transcription factor binding to IGHM enhancer 3b 0.076
cx43 connexin 43 0.068
mcl1b myeloid cell leukemia sequence 1b 0.061
ccna2 cyclin A2 0.061
dzip1 DAZ interacting protein 1 0.060
hells helicase, lymphoid-specific 0.058
scinlb scinderin like b 0.057
nf1a neurofibromin 1a 0.056
rtcd1 RNA terminal phosphate cyclase domain 1 0.054
si:ch211-212m21.5 si:ch211-212m21.5 0.052
hmgb2b high-mobility group box 2b 0.050
mcm6 MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae) 0.050
dlx5a distal-less homeobox gene 5a 0.050
podxl podocalyxin-like 0.049
gata5 GATA-binding protein 5 0.046
fgfr3 fibroblast growth factor receptor 3 0.044
egr2b early growth response 2b 0.041
postn periostin, osteoblast specific factor 0.039
olfml3b olfactomedin-like 3b 0.039
ssrp1a structure specific recognition protein 1a 0.039
wif1 wnt inhibitory factor 1 0.038
sox7 SRY-box containing gene 7 0.038
unc5b unc-5 homolog B (C. elegans) 0.037
s100a10b S100 calcium binding protein A10b 0.036
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.036
plxnb2a plexin b2a 0.036
cnn2 calponin 2 0.036
bcl2 B-cell leukemia/lymphoma 2 0.036
mcl1a myeloid cell leukemia sequence 1a 0.036
zgc:92867 zgc:92867 0.035
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.034
hmgb3a high-mobility group box 3a 0.034
il8 interleukin 8 0.034
spry2 sprouty homolog 2 0.033
ptrfb polymerase I and transcript release factor b 0.033
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.033
evx1 even-skipped homeobox 1 0.033
ephb4b eph receptor B4b 0.032
appb amyloid beta (A4) precursor protein b 0.032
pitrm1 pitrilysin metalloproteinase 1 0.031
hmgb2a high-mobility group box 2a 0.031
msna moesin a 0.031
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.031
s100v2 S100 calcium binding protein V2 0.030
wls wntless homolog (Drosophila) 0.030
pole2 polymerase (DNA directed), epsilon 2 0.030
msh6 mutS homolog 6 (E. coli) 0.029
pdlim1 PDZ and LIM domain 1 (elfin) 0.029
bcl2l1 bcl2-like 1 0.029
vegfaa vascular endothelial growth factor Aa 0.028
nf1b neurofibromin 1b 0.028
adipoql adiponectin, C1Q and collagen domain containing, like 0.028
hspb1 heat shock protein, alpha-crystallin-related, 1 0.027
gsna gelsolin a 0.027
fes feline sarcoma oncogene 0.027
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.027
notch1a notch homolog 1a 0.027
mycbp2 MYC binding protein 2 0.026
vtg1 vitellogenin 1 0.026
mmp2 matrix metalloproteinase 2 0.026
psme2 proteasome activator subunit 2 0.026
yrk Yes-related kinase 0.026
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.026
ncapg2 non-SMC condensin II complex, subunit G2 0.026
perp PERP, TP53 apoptosis effector 0.026
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.025
hsp90a.2 heat shock protein 90-alpha 2 0.025
caspa caspase a 0.025
gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.024
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.024
pcna proliferating cell nuclear antigen 0.023
loxl2b lysyl oxidase-like 2b 0.023
cep70 centrosomal protein 70 0.023
foxn4 forkhead box N4 0.023
rhoab ras homolog gene family, member Ab 0.023
ihha Indian hedgehog homolog a 0.023
plxnd1 plexin D1 0.023
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.022
wnt11r wingless-type MMTV integration site family, member 11, related 0.022
icn ictacalcin 0.022
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.022
disp1 dispatched homolog 1 (Drosophila) 0.021
msh2 mutS homolog 2 (E. coli) 0.021
kdrl kinase insert domain receptor like 0.021
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.021
myca myelocytomatosis oncogene a 0.021
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.994
mbc myoblast city 0.620
puc puckered 0.609
pyd polychaetoid 0.604
flw flapwing 0.443
Ras85D Ras oncogene at 85D 0.417
XNP CG4548 gene product from transcript CG4548-RA 0.412
mys myospheroid 0.411
Pk61C Protein kinase 61C 0.384
Pak PAK-kinase 0.345
Rac1 CG2248 gene product from transcript CG2248-RA 0.340
garz gartenzwerg 0.333
Ced-12 CG5336 gene product from transcript CG5336-RA 0.315
kuz kuzbanian 0.312
LanA Laminin A 0.306
Abi Abelson interacting protein 0.281
jar jaguar 0.269
Pli Pellino 0.259
Git CG16728 gene product from transcript CG16728-RA 0.253
Smox Smad on X 0.252
Pten CG5671 gene product from transcript CG5671-RB 0.239
ninaC neither inactivation nor afterpotential C 0.229
dm diminutive 0.221
drpr draper 0.215
stg string 0.203
plexB plexin B 0.196
th thread 0.185
RnrL Ribonucleoside diphosphate reductase large subunit 0.173
jumu jumeau 0.173
nwk nervous wreck 0.172
cno canoe 0.169
rok Rho-kinase 0.167
Top3alpha Topoisomerase 3alpha 0.165
Pkn Protein kinase related to protein kinase N 0.161
rut rutabaga 0.157
CycA Cyclin A 0.156
kibra kibra ortholog 0.156
synj synaptojanin 0.155
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.153
Dab Disabled 0.151
r2d2 CG7138 gene product from transcript CG7138-RB 0.147
AGO2 Argonaute 2 0.141
pod1 CG4532 gene product from transcript CG4532-RF 0.140
rols rolling pebbles 0.139
N Notch 0.137
rhea CG6831 gene product from transcript CG6831-RA 0.134
stai stathmin 0.130
Rheb CG1081 gene product from transcript CG1081-RA 0.128
bnl branchless 0.128
Vha100-1 CG1709 gene product from transcript CG1709-RF 0.128
loco locomotion defects 0.128
trio CG18214 gene product from transcript CG18214-RA 0.127
mbt mushroom bodies tiny 0.126
Pros54 Proteasome 54kD subunit 0.124
px plexus 0.124
dnc dunce 0.123
cindr CIN85 and CD2AP orthologue 0.123
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.123
Fak56D Focal Adhesion Kinase 0.120
cuff cutoff 0.120
p120ctn Adherens junction protein p120 0.118
Cbl CG7037 gene product from transcript CG7037-RB 0.115
Sbf SET domain binding factor 0.115
Ephrin CG1862 gene product from transcript CG1862-RA 0.114
Tre1 trapped in endoderm-1 0.113
lea leak 0.111
Hem HEM-protein 0.111
nbs CG6754 gene product from transcript CG6754-RC 0.111
Galpha49B G protein alpha49B 0.110
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.110
htl heartless 0.110
Dcr-2 Dicer-2 0.109
Dredd Death related ced-3/Nedd2-like protein 0.108
ed echinoid 0.107
mei-41 meiotic 41 0.107
Mtl Mig-2-like 0.106
scb scab 0.102
Sin3A CG8815 gene product from transcript CG8815-RC 0.101
CG6719 CG6719 gene product from transcript CG6719-RA 0.101
Rm62 CG10279 gene product from transcript CG10279-RD 0.100
stumps CG31317 gene product from transcript CG31317-RC 0.100
rst roughest 0.099
trp transient receptor potential 0.098
rg rugose 0.095
CG6509 CG6509 gene product from transcript CG6509-RB 0.092
RASSF8 CG5053 gene product from transcript CG5053-RA 0.091
Rpt1 CG1341 gene product from transcript CG1341-RA 0.090
dik diskette 0.088
CG11347 CG11347 gene product from transcript CG11347-RE 0.086
Klp61F Kinesin-like protein at 61F 0.086
NaCP60E Na channel protein 60E 0.086
ran CG1404 gene product from transcript CG1404-RB 0.085
Prp31 CG6876 gene product from transcript CG6876-RA 0.085
rk rickets 0.083
Cip4 CG15015 gene product from transcript CG15015-RA 0.083
atl atlastin 0.081
car carnation 0.080
Myd88 CG2078 gene product from transcript CG2078-RA 0.079
Sema-2a CG4700 gene product from transcript CG4700-RC 0.078
rl rolled 0.077
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.997
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.996
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.996
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.995
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.992
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.990
GRB2 growth factor receptor-bound protein 2 0.988
FASLG Fas ligand (TNF superfamily, member 6) 0.985
BCAR1 breast cancer anti-estrogen resistance 1 0.984
ARRB1 arrestin, beta 1 0.982
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.980
FGFR2 fibroblast growth factor receptor 2 0.979
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.970
FAS Fas (TNF receptor superfamily, member 6) 0.970
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.956
SMAD4 SMAD family member 4 0.956
PTK2 PTK2 protein tyrosine kinase 2 0.927
FN1 fibronectin 1 0.927
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.920
SFN stratifin 0.912
BCL2 B-cell CLL/lymphoma 2 0.911
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.900
EGFR epidermal growth factor receptor 0.899
PTEN phosphatase and tensin homolog 0.897
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.882
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.873
FYN FYN oncogene related to SRC, FGR, YES 0.870
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.860
TSC2 tuberous sclerosis 2 0.857
PLCG1 phospholipase C, gamma 1 0.855
BAX BCL2-associated X protein 0.847
SKIL SKI-like oncogene 0.847
S100A6 S100 calcium binding protein A6 0.846
CFLAR CASP8 and FADD-like apoptosis regulator 0.836
MAPK14 mitogen-activated protein kinase 14 0.833
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.832
SMAD3 SMAD family member 3 0.826
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.813
PYCARD PYD and CARD domain containing 0.802
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.800
RIN3 Ras and Rab interactor 3 0.784
RHOA ras homolog gene family, member A 0.775
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.767
BBS10 Bardet-Biedl syndrome 10 0.759
BCL2L1 BCL2-like 1 0.746
SMN1 survival of motor neuron 1, telomeric 0.742
VEGFA vascular endothelial growth factor A 0.742
PSEN1 presenilin 1 0.736
NCK1 NCK adaptor protein 1 0.734
ARRB2 arrestin, beta 2 0.714
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.701
ABI1 abl-interactor 1 0.701
JUN jun proto-oncogene 0.694
S100A11 S100 calcium binding protein A11 0.694
NRP1 neuropilin 1 0.689
FMR1 fragile X mental retardation 1 0.688
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.681
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.680
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.680
BID BH3 interacting domain death agonist 0.672
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.660
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.658
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.657
FKBP4 FK506 binding protein 4, 59kDa 0.646
S100B S100 calcium binding protein B 0.638
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.635
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.629
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 0.628
FHL2 four and a half LIM domains 2 0.627
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.625
GAS7 growth arrest-specific 7 0.620
BAD BCL2-associated agonist of cell death 0.619
CCR5 chemokine (C-C motif) receptor 5 0.609
NCL nucleolin 0.606
RAD21 RAD21 homolog (S. pombe) 0.606
FGF1 fibroblast growth factor 1 (acidic) 0.604
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.599
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 0.590
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.584
EP300 E1A binding protein p300 0.583
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.582
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.574
MAPK1 mitogen-activated protein kinase 1 0.574
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.574
ENG endoglin 0.574
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.570
BMP2 bone morphogenetic protein 2 0.567
TRAF1 TNF receptor-associated factor 1 0.564
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.562
RACGAP1 Rac GTPase activating protein 1 0.559
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.554
RXRA retinoid X receptor, alpha 0.554
S100A1 S100 calcium binding protein A1 0.554
PLEC plectin 0.549
RARA retinoic acid receptor, alpha 0.549
TGFB1 transforming growth factor, beta 1 0.547
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 1.000
Trp53 transformation related protein 53 0.998
Bcl2 B-cell leukemia/lymphoma 2 0.964
Ctnnb1 catenin (cadherin associated protein), beta 1 0.929
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.926
Cd44 CD44 antigen 0.886
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.868
Tnf tumor necrosis factor 0.839
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.822
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.782
Ptprc protein tyrosine phosphatase, receptor type, C 0.771
Cbl Casitas B-lineage lymphoma 0.753
Nos3 nitric oxide synthase 3, endothelial cell 0.745
Vdr vitamin D receptor 0.736
Ccr1 chemokine (C-C motif) receptor 1 0.735
Il2rg interleukin 2 receptor, gamma chain 0.735
Bax BCL2-associated X protein 0.734
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.709
Il1r1 interleukin 1 receptor, type I 0.699
Hdac7 histone deacetylase 7 0.697
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.666
Egfr epidermal growth factor receptor 0.659
Tgfbr2 transforming growth factor, beta receptor II 0.651
Nf1 neurofibromatosis 1 0.643
Pycard PYD and CARD domain containing 0.632
Pnpla2 patatin-like phospholipase domain containing 2 0.626
Adam17 a disintegrin and metallopeptidase domain 17 0.621
Kl klotho 0.618
Ldlr low density lipoprotein receptor 0.609
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.595
Pten phosphatase and tensin homolog 0.587
Vav1 vav 1 oncogene 0.579
Igh immunoglobulin heavy chain complex 0.558
Mapk14 mitogen-activated protein kinase 14 0.542
Kit kit oncogene 0.528
Invs inversin 0.526
Rara retinoic acid receptor, alpha 0.520
Apc adenomatosis polyposis coli 0.515
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.510
Agtr1a angiotensin II receptor, type 1a 0.509
Ilk integrin linked kinase 0.507
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.503
Socs1 suppressor of cytokine signaling 1 0.488
Fbn1 fibrillin 1 0.481
Cd28 CD28 antigen 0.471
Rac1 RAS-related C3 botulinum substrate 1 0.470
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.469
Hdac4 histone deacetylase 4 0.462
Vegfa vascular endothelial growth factor A 0.461
Mef2a myocyte enhancer factor 2A 0.454
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.454
Hmha1 histocompatibility (minor) HA-1 0.451
Ltb lymphotoxin B 0.444
Efnb2 ephrin B2 0.442
Braf Braf transforming gene 0.441
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.440
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.439
Il10ra interleukin 10 receptor, alpha 0.432
Arrb2 arrestin, beta 2 0.430
Tgfbr1 transforming growth factor, beta receptor I 0.427
Drd2 dopamine receptor D2 0.409
Wt1 Wilms tumor 1 homolog 0.407
Lrp1 low density lipoprotein receptor-related protein 1 0.401
Numb numb gene homolog (Drosophila) 0.399
Eln elastin 0.397
Lox lysyl oxidase 0.393
Ncoa3 nuclear receptor coactivator 3 0.391
Casp1 caspase 1 0.390
Dnm1 dynamin 1 0.387
Tsc1 tuberous sclerosis 1 0.387
Trp73 transformation related protein 73 0.385
Lama5 laminin, alpha 5 0.370
Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 0.365
Wrn Werner syndrome homolog (human) 0.363
Psme2 proteasome (prosome, macropain) 28 subunit, beta 0.363
Jak2 Janus kinase 2 0.361
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.357
Mlf2 myeloid leukemia factor 2 0.348
Plxna1 plexin A1 0.346
Xiap X-linked inhibitor of apoptosis 0.341
Lyst lysosomal trafficking regulator 0.339
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.335
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.327
Rasgrp2 RAS, guanyl releasing protein 2 0.324
Adrb1 adrenergic receptor, beta 1 0.320
Scn5a sodium channel, voltage-gated, type V, alpha 0.317
Selp selectin, platelet 0.316
Hspd1 heat shock protein 1 (chaperonin) 0.315
Atp7a ATPase, Cu++ transporting, alpha polypeptide 0.310
Stat5a signal transducer and activator of transcription 5A 0.310
Cav1 caveolin 1, caveolae protein 0.310
Birc3 baculoviral IAP repeat-containing 3 0.308
Adrb3 adrenergic receptor, beta 3 0.308
Ikzf1 IKAROS family zinc finger 1 0.300
Irf1 interferon regulatory factor 1 0.300
Gbp5 guanylate binding protein 5 0.294
Fas Fas (TNF receptor superfamily member 6) 0.292
Cyld cylindromatosis (turban tumor syndrome) 0.289
Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.286
Ret ret proto-oncogene 0.284
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Rattus norvegicus
Name Description Probability Func Analog Organism
Jak1 Janus kinase 1 0.450
Alb albumin 0.299
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.252
Tmem176b transmembrane protein 176B 0.243
S100a8 S100 calcium binding protein A8 0.236
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.221
S100a9 S100 calcium binding protein A9 0.219
Pja2 praja 2, RING-H2 motif containing 0.212
Nckap1 NCK-associated protein 1 0.210
Homer1 homer homolog 1 (Drosophila) 0.205
Tgfb1 transforming growth factor, beta 1 0.203
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.191
Copb1 coatomer protein complex, subunit beta 1 0.176
Hk1 hexokinase 1 0.174
Prkcg protein kinase C, gamma 0.168
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.162
Gja1 gap junction protein, alpha 1 0.158
Dnm1l dynamin 1-like 0.157
Ccr5 chemokine (C-C motif) receptor 5 0.138
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.137
Clic4 chloride intracellular channel 4 0.137
Adora2a adenosine A2a receptor 0.136
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.132
Shank2 SH3 and multiple ankyrin repeat domains 2 0.132
Jak2 Janus kinase 2 0.129
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.128
Epas1 endothelial PAS domain protein 1 0.127
Pdcl phosducin-like 0.126
Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.125
Tgfbr2 transforming growth factor, beta receptor II 0.120
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.120
Tagln transgelin 0.118
H3f3b H3 histone, family 3B 0.114
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.112
Uqcrc1 ubiquinol-cytochrome c reductase core protein I 0.111
Tmed2 transmembrane emp24 domain trafficking protein 2 0.109
Copb2 coatomer protein complex, subunit beta 2 (beta prime) 0.106
Camk4 calcium/calmodulin-dependent protein kinase IV 0.106
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.105
Cfp complement factor properdin 0.105
Cd4 Cd4 molecule 0.102
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.101
Rnase4 ribonuclease, RNase A family 4 0.100
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.100
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.100
Gzmk granzyme K 0.098
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.094
RGD1564327 similar to integrin alpha 8 0.093
Cd247 Cd247 molecule 0.093
Psmd8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.092
Tek TEK tyrosine kinase, endothelial 0.092
Inpp5d inositol polyphosphate-5-phosphatase D 0.091
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.088
Nkg7 natural killer cell group 7 sequence 0.087
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.087
Rup2 urinary protein 2 0.087
Ap2b1 adaptor-related protein complex 2, beta 1 subunit 0.084
Anxa2 annexin A2 0.084
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.083
Hck hemopoietic cell kinase 0.082
Dhrs9 dehydrogenase/reductase (SDR family) member 9 0.082
Robo1 roundabout homolog 1 (Drosophila) 0.081
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.080
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.079
Hrh2 histamine receptor H 2 0.079
Plrg1 pleiotropic regulator 1, PRL1 homolog (Arabidopsis) 0.079
Adar adenosine deaminase, RNA-specific 0.078
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.078
Cald1 caldesmon 1 0.077
Casp3 caspase 3 0.076
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.076
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.075
Adcy5 adenylate cyclase 5 0.075
Vim vimentin 0.075
Vom1r93 vomeronasal 1 receptor 93 0.074
Hbe2 hemoglobin, epsilon 2 0.074
Gna15 guanine nucleotide binding protein, alpha 15 0.074
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.074
Sirpa signal-regulatory protein alpha 0.073
Fgfr2 fibroblast growth factor receptor 2 0.072
Impdh2 IMP (inosine monophosphate) dehydrogenase 2 0.071
Acvr1 activin A receptor, type I 0.071
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.071
Spp2 secreted phosphoprotein 2 0.071
Adrb2 adrenergic, beta-2-, receptor, surface 0.070
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.070
Fshb follicle stimulating hormone, beta polypeptide 0.069
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.069
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.068
Kitlg KIT ligand 0.068
Zfp260 zinc finger protein 260 0.068
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.068
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.067
Pklr pyruvate kinase, liver and RBC 0.067
Prkcb protein kinase C, beta 0.067
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.067
Fgfr1 Fibroblast growth factor receptor 1 0.066
Myo1b myosin Ib 0.066
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.066
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.066