The network for 'positive regulation of macromolecule biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of macromolecule biosynthetic process

Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
YAP1 Yap1p 0.982
SIN3 Sin3p 0.972
LSM1 Lsm1p 0.970
RTF1 Rtf1p 0.970
URE2 Ure2p 0.945
GAL11 Gal11p 0.930
ADA2 Ada2p 0.924
SPT15 Spt15p 0.924
SNF6 Snf6p 0.918
RIM101 Rim101p 0.915
GLN3 Gln3p 0.913
SWI6 Swi6p 0.890
RPD3 Rpd3p 0.866
CTR9 Ctr9p 0.854
CTK3 Ctk3p 0.819
MKS1 Mks1p 0.813
CCR4 Ccr4p 0.806
MCM1 Mcm1p 0.803
RGR1 Rgr1p 0.802
SWI1 Swi1p 0.784
RXT2 Rxt2p 0.778
GCN5 Gcn5p 0.774
CHD1 Chd1p 0.773
SRB4 Srb4p 0.769
SSN3 Ssn3p 0.769
HOG1 Hog1p 0.768
CYC8 Cyc8p 0.766
FKH1 Fkh1p 0.762
CTI6 Cti6p 0.751
MKK2 Mkk2p 0.751
ESA1 Esa1p 0.749
SNF5 Snf5p 0.742
YTA7 Yta7p 0.741
HSP78 Hsp78p 0.729
MSN2 Msn2p 0.720
RSP5 Rsp5p 0.719
CTK1 Ctk1p 0.716
YAK1 Yak1p 0.712
FKH2 Fkh2p 0.707
SSN2 Ssn2p 0.698
ARG81 Arg81p 0.686
MED6 Med6p 0.683
CGI121 Cgi121p 0.676
HST1 Hst1p 0.673
PGD1 Pgd1p 0.670
LEU3 Leu3p 0.667
CAF40 Caf40p 0.663
SNF2 Snf2p 0.655
SDS3 Sds3p 0.654
HMO1 Hmo1p 0.638
MFT1 Mft1p 0.635
RAS2 Ras2p 0.629
HHT1 Hht1p 0.606
RAP1 Rap1p 0.605
HAP5 Hap5p 0.600
RTG3 Rtg3p 0.599
FLO8 Flo8p 0.598
CPR1 Cpr1p 0.598
SIN4 Sin4p 0.587
UTP7 Utp7p 0.583
MSN4 Msn4p 0.580
MED2 Med2p 0.574
HAP4 Hap4p 0.573
SNF1 Snf1p 0.570
SUB2 Sub2p 0.568
NUT2 Nut2p 0.566
HTA2 Hta2p 0.559
CAT8 Cat8p 0.547
KSS1 Kss1p 0.543
SET3 Set3p 0.536
DOT6 Dot6p 0.529
CKS1 Cks1p 0.529
UBP3 Ubp3p 0.525
CDC36 Cdc36p 0.524
NUP100 Nup100p 0.522
RAM2 Ram2p 0.517
KDX1 Kdx1p 0.514
STE12 Ste12p 0.513
ROM2 Rom2p 0.512
SPT8 Spt8p 0.510
WHI3 Whi3p 0.509
PSH1 Psh1p 0.504
CDC39 Cdc39p 0.494
MED1 Med1p 0.492
CDC43 Cdc43p 0.490
GAL80 Gal80p 0.483
RSC58 Rsc58p 0.481
PHO23 Pho23p 0.478
ATG1 Atg1p 0.477
NRG1 Nrg1p 0.477
SPT5 Spt5p 0.476
AEP1 Aep1p 0.474
MED8 Med8p 0.474
SFL1 Sfl1p 0.473
SRB5 Srb5p 0.469
PCC1 Pcc1p 0.468
MSN1 Msn1p 0.467
GAL4 Gal4p 0.463
ROX3 Rox3p 0.463
VID24 Vid24p 0.459
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.999
pha-4 Protein PHA-4 0.999
elt-6 Protein ELT-6 0.987
vab-3 Protein VAB-3 0.973
unc-42 Protein UNC-42 0.939
rad-26 Protein RAD-26 0.878
nhr-49 Protein NHR-49 0.872
pbrm-1 Protein PBRM-1 0.843
eya-1 Protein EYA-1 0.842
skp-1 Protein SKP-1 0.840
nhr-67 Protein NHR-67 0.833
zip-7 Protein ZIP-7 0.810
fkh-2 Protein FKH-2 0.782
mab-5 Protein MAB-5 0.767
ten-1 Protein TEN-1 0.739
mat-3 Protein MAT-3 0.734
lin-17 Protein LIN-17 0.704
cam-1 Protein CAM-1 0.700
hbl-1 Protein HBL-1 0.692
sma-6 Protein SMA-6 0.690
bar-1 Protein BAR-1 0.674
his-64 Protein HIS-64 0.650
his-1 Protein HIS-1 0.645
egl-46 Protein EGL-46 0.625
unc-62 Protein UNC-62 0.617
hlh-2 Protein HLH-2 0.591
hnd-1 Protein HND-1 0.585
pry-1 Protein PRY-1 0.554
lin-11 Protein LIN-11 0.554
daf-1 Protein DAF-1 0.547
tbx-8 Protein TBX-8 0.529
ced-9 Protein CED-9 0.519
glp-1 Protein GLP-1 0.506
unc-43 Protein UNC-43 0.497
his-5 Protein HIS-5 0.495
F12F6.1 Protein F12F6.1 0.493
cnd-1 Protein CND-1 0.491
ceh-27 Protein CEH-27 0.485
zyg-1 Protein ZYG-1 0.480
mig-15 Protein MIG-15 0.469
unc-73 Protein UNC-73 0.458
cfim-2 Protein CFIM-2 0.450
pop-1 Protein POP-1 0.445
unc-40 Protein UNC-40 0.437
npp-2 Protein NPP-2 0.432
tax-4 Protein TAX-4 0.424
let-60 Protein LET-60 0.423
K10D6.4 Protein K10D6.4 0.421
kin-10 Protein KIN-10 0.420
gei-4 Protein GEI-4 0.418
sax-3 Protein SAX-3 0.413
unc-37 Protein UNC-37 0.400
lsy-22 Protein LSY-22 0.397
pax-3 Protein PAX-3 0.397
ain-1 Protein AIN-1 0.382
mep-1 Protein MEP-1 0.381
sas-4 Protein SAS-4 0.380
flh-2 Protein FLH-2 0.379
Y47D3A.29 Protein Y47D3A.29 0.378
lin-35 Protein LIN-35 0.369
set-1 Protein SET-1 0.365
hmg-4 Protein HMG-4 0.364
F33H2.5 Protein F33H2.5 0.361
dlk-1 Protein DLK-1 0.338
mix-1 Protein MIX-1 0.335
soc-2 Protein SOC-2 0.328
lntl-1 Protein LNTL-1 0.322
mab-31 Protein MAB-31 0.320
lmn-1 Protein LMN-1 0.316
plx-2 Protein PLX-2 0.314
nhr-34 Protein NHR-34 0.306
mdf-2 Protein MDF-2 0.306
his-46 Protein HIS-46 0.305
lag-1 Protein LAG-1 0.302
nhr-25 Protein NHR-25 0.295
icd-1 Protein ICD-1 0.292
his-31 Protein HIS-31 0.291
sas-5 Protein SAS-5 0.289
hrp-1 Protein HRP-1 0.288
peb-1 Protein PEB-1 0.286
prp-21 Protein PRP-21 0.282
eef-1A.1 Protein EEF-1A.1 0.280
daf-3 Protein DAF-3 0.278
F53F10.2 Protein F53F10.2 0.271
rps-2 Protein RPS-2 0.271
fox-1 Protein FOX-1 0.271
CELE_ZK337.2 Protein ZK337.2 0.270
saeg-1 Protein SAEG-1 0.267
dpf-3 Protein DPF-3 0.267
hif-1 Protein HIF-1 0.267
ceh-22 Protein CEH-22 0.267
ceh-20 Protein CEH-20 0.264
ztf-2 Protein ZTF-2 0.262
chk-1 Protein CHK-1 0.260
T28F4.1 Protein T28F4.1 0.259
odd-2 Protein ODD-2 0.257
daf-14 Protein DAF-14 0.256
panl-2 Protein PANL-2 0.253
F46H5.7 Protein F46H5.7 0.252
nhr-6 Protein NHR-6 0.246
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.952
tp53 tumor protein p53 0.943
ndr2 nodal-related 2 0.937
notch1a notch homolog 1a 0.914
crabp2a cellular retinoic acid binding protein 2, a 0.881
gata3 GATA-binding protein 3 0.879
pitx3 paired-like homeodomain transcription factor 3 0.868
isl1 islet1 0.864
fgf8a fibroblast growth factor 8 a 0.754
eya1 eyes absent homolog 1 0.727
mef2d myocyte enhancer factor 2d 0.663
kita kit receptor a 0.660
flh floating head 0.655
six4b sine oculis homeobox homolog 4b 0.638
eomesa eomesodermin homolog a 0.634
fgf4 fibroblast growth factor 4 0.634
fn1 fibronectin 1 0.624
pitx2 paired-like homeodomain transcription factor 2 0.621
klf4 Kruppel-like factor 4 0.597
egr1 early growth response 1 0.583
hoxa2b homeo box A2b 0.539
tbx20 T-box 20 0.536
evx1 even-skipped homeobox 1 0.529
kdrl kinase insert domain receptor like 0.526
gli1 GLI-Kruppel family member 1 0.512
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.483
ascl1a achaete-scute complex-like 1a (Drosophila) 0.469
myf5 myogenic factor 5 0.445
irx7 iroquois homeobox protein 7 0.443
runx2b runt-related transcription factor 2b 0.441
osr1 odd-skipped related 1 (Drosophila) 0.441
irx4b iroquois homeobox protein 4b 0.440
zic4 zic family member 4 0.439
hnf1ba HNF1 homeobox Ba 0.435
notch3 notch homolog 3 0.429
otpa orthopedia homolog a 0.426
jag2 jagged 2 0.413
mab21l2 mab-21-like 2 0.410
wnt3a wingless-type MMTV integration site family, member 3A 0.395
wnt4a wingless-type MMTV integration site family, member 4a 0.388
tshb thyroid stimulating hormone, beta subunit 0.386
nkx3.2 NK3 homeobox 2 0.385
atoh1a atonal homolog 1a 0.384
foxi1 forkhead box I1 0.383
nkx2.2a NK2 transcription factor related 2a 0.379
pax7a paired box gene 7a 0.376
tfap2a transcription factor AP-2 alpha 0.375
hoxc4a homeo box C4a 0.373
nkx2.5 NK2 transcription factor related 5 0.369
bmp2b bone morphogenetic protein 2b 0.367
dlx2a distal-less homeobox gene 2a 0.359
tfap2b transcription factor AP-2 beta 0.356
chd chordin 0.354
lft1 lefty1 0.347
prox1 prospero-related homeobox gene 1 0.341
fzd8a frizzled homolog 8a 0.337
pax8 paired box gene 8 0.332
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.331
sox19a SRY-box containing gene 19a 0.331
sox1a SRY-box containing gene 1a 0.318
tll1 tolloid-like 1 0.312
ripk2 receptor-interacting serine-threonine kinase 2 0.308
myog myogenin 0.299
dlc deltaC 0.291
sall4 sal-like 4 (Drosophila) 0.283
col2a1a collagen type II, alpha-1a 0.276
foxj1a forkhead box J1a 0.275
ptf1a pancreas specific transcription factor, 1a 0.269
myf6 myogenic factor 6 0.268
twist3 twist3 0.267
wt1a wilms tumor 1a 0.265
gbx2 gastrulation brain homeo box 2 0.259
fgfr4 fibroblast growth factor receptor 4 0.258
cdh1 cadherin 1, epithelial 0.257
lhx1a LIM homeobox 1a 0.246
lhx1b LIM homeobox 1b 0.242
oprk1 opioid receptor, kappa 1 0.241
dla deltaA 0.235
tbx16 T-box gene 16 0.234
hoxb1b homeo box B1b 0.227
barhl2 BarH-like 2 0.226
hoxb5a homeo box B5a 0.221
foxd3 forkhead box D3 0.218
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.217
hmx3 homeo box (H6 family) 3 0.217
gdnf glial cell derived neurotrophic factor 0.215
acvr2b activin receptor IIb 0.212
rx2 retinal homeobox gene 2 0.210
fgfr3 fibroblast growth factor receptor 3 0.205
barx1 BarH-like homeobox 1 0.197
pcdh18b protocadherin 18b 0.193
pdlim7 PDZ and LIM domain 7 0.191
dlx5a distal-less homeobox gene 5a 0.187
gh1 growth hormone 1 0.186
atoh1b atonal homolog 1b 0.186
junbl jun B proto-oncogene, like 0.185
foxp2 forkhead box P2 0.185
hoxd13a homeo box D13a 0.184
zic5 zic family member 5 (odd-paired homolog, Drosophila) 0.183
tal1 T-cell acute lymphocytic leukemia 1 0.182
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Egfr Epidermal growth factor receptor 0.999
wg wingless 0.995
brm brahma 0.983
Pp2B-14D Protein phosphatase 2B at 14D 0.981
Ubx Ultrabithorax 0.978
ush u-shaped 0.974
gro groucho 0.970
phl pole hole 0.969
Med Medea 0.968
eyg eyegone 0.967
Akt1 CG4006 gene product from transcript CG4006-RA 0.963
exd extradenticle 0.961
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.958
EcR Ecdysone receptor 0.955
ci cubitus interruptus 0.952
sd scalloped 0.947
Su(H) Suppressor of Hairless 0.946
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.946
dm diminutive 0.940
CG4699 CG4699 gene product from transcript CG4699-RJ 0.926
kis kismet 0.921
dsx doublesex 0.918
psq pipsqueak 0.905
klu klumpfuss 0.902
trx trithorax 0.900
dom domino 0.899
e(y)3 enhancer of yellow 3 0.899
E(spl) Enhancer of split 0.899
Snr1 Snf5-related 1 0.894
Ras85D Ras oncogene at 85D 0.892
Smox Smad on X 0.890
shn schnurri 0.886
bowl brother of odd with entrails limited 0.885
Moe Moesin 0.873
gsb gooseberry 0.872
mor moira 0.862
ebi CG4063 gene product from transcript CG4063-RA 0.849
ss spineless 0.849
amos absent MD neurons and olfactory sensilla 0.847
pan pangolin 0.842
aop anterior open 0.840
Gug Grunge 0.840
Fmr1 CG6203 gene product from transcript CG6203-RC 0.831
B-H2 BarH2 0.830
emc extra macrochaetae 0.828
Cp190 Centrosomal protein 190kD 0.827
cnc cap-n-collar 0.825
ecd ecdysoneless 0.822
Pc Polycomb 0.821
Src42A Src oncogene at 42A 0.820
CG11347 CG11347 gene product from transcript CG11347-RE 0.819
nmo nemo 0.815
bs blistered 0.814
G-salpha60A G protein salpha 60A 0.809
ara araucan 0.802
CkIIalpha Casein kinase II alpha subunit 0.789
kay kayak 0.786
InR Insulin-like receptor 0.784
Antp Antennapedia 0.769
fz frizzled 0.768
hep hemipterous 0.763
Bre1 CG10542 gene product from transcript CG10542-RA 0.758
pdm2 POU domain protein 2 0.749
BRWD3 CG31132 gene product from transcript CG31132-RA 0.748
dac dachshund 0.745
pb proboscipedia 0.745
heph hephaestus 0.742
tin tinman 0.740
Abd-B Abdominal B 0.739
ewg erect wing 0.737
Ser Serrate 0.734
Optix CG18455 gene product from transcript CG18455-RA 0.731
dco discs overgrown 0.729
sens senseless 0.728
sbb scribbler 0.723
Doc2 Dorsocross2 0.717
rk rickets 0.716
drk downstream of receptor kinase 0.714
CDC45L CG3658 gene product from transcript CG3658-RA 0.710
ftz-f1 ftz transcription factor 1 0.710
Snoo Sno oncogene 0.708
shot short stop 0.707
hkb huckebein 0.706
smt3 CG4494 gene product from transcript CG4494-RA 0.703
tral trailer hitch 0.702
HLHm7 E(spl) region transcript m7 0.701
Pka-C1 cAMP-dependent protein kinase 1 0.699
tll tailless 0.689
hth homothorax 0.686
cg combgap 0.680
CG32685 CG32685 gene product from transcript CG32685-RC 0.679
sna snail 0.677
odd odd skipped 0.673
esc extra sexcombs 0.670
otu ovarian tumor 0.667
Rbf Retinoblastoma-family protein 0.666
abd-A abdominal A 0.665
rho rhomboid 0.663
18w 18 wheeler 0.662
stwl stonewall 0.660
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.708
Ccl4 chemokine (C-C motif) ligand 4 0.635
Ddr1 discoidin domain receptor tyrosine kinase 1 0.607
Tgfbr2 transforming growth factor, beta receptor II 0.599
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.598
Crebbp CREB binding protein 0.593
Tcfe2a transcription factor E2a 0.590
Junb jun B proto-oncogene 0.585
Zfp36 zinc finger protein 36 0.579
Ncl nucleolin 0.564
Klf6 Kruppel-like factor 6 0.550
Jak2 Janus kinase 2 0.547
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.518
Ccl3 chemokine (C-C motif) ligand 3 0.516
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.493
Egr3 early growth response 3 0.493
Aqp2 aquaporin 2 (collecting duct) 0.493
Prf1 perforin 1 (pore forming protein) 0.479
Rara retinoic acid receptor, alpha 0.474
Met met proto-oncogene 0.445
Tcf4 transcription factor 4 0.436
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.418
Slc12a1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 0.404
Mapk1 mitogen activated protein kinase 1 0.393
C5ar1 complement component 5a receptor 1 0.390
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.380
Dusp1 dual specificity phosphatase 1 0.368
Adam17 ADAM metallopeptidase domain 17 0.364
A4galt alpha 1,4-galactosyltransferase 0.363
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.361
Fgfr1 Fibroblast growth factor receptor 1 0.355
Lig3 ligase III, DNA, ATP-dependent 0.350
Adrb1 adrenergic, beta-1-, receptor 0.346
Tcp11 t-complex protein 11 0.334
Nr1d1 nuclear receptor subfamily 1, group D, member 1 0.332
Iapp islet amyloid polypeptide 0.332
Trim28 tripartite motif-containing 28 0.331
Smad1 SMAD family member 1 0.331
Fos FBJ osteosarcoma oncogene 0.329
Gata6 GATA binding protein 6 0.326
LOC684996 similar to chromosome 7 open reading frame 11 0.322
Foxa3 forkhead box A3 0.321
Atxn1 ataxin 1 0.318
Gja5 gap junction protein, alpha 5 0.318
Lin7c lin-7 homolog C (C. elegans) 0.316
Klf13 Kruppel-like factor 13 0.316
Col12a1 collagen, type XII, alpha 1 0.315
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.311
Errfi1 ERBB receptor feedback inhibitor 1 0.306
Cd40lg CD40 ligand 0.305
Jak1 Janus kinase 1 0.304
Runx1 runt-related transcription factor 1 0.301
Hand2 heart and neural crest derivatives expressed 2 0.301
Dlx5 distal-less homeobox 5 0.301
Acvr1 activin A receptor, type I 0.294
Mprip myosin phosphatase Rho interacting protein 0.289
Nkg7 natural killer cell group 7 sequence 0.289
Mef2d myocyte enhancer factor 2D 0.283
Fgf10 fibroblast growth factor 10 0.283
Prrx1 paired related homeobox 1 0.283
Il2rg interleukin 2 receptor, gamma 0.282
Clps colipase, pancreatic 0.279
Myc myelocytomatosis oncogene 0.275
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.274
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.273
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.273
Il2ra interleukin 2 receptor, alpha 0.270
Syt10 synaptotagmin X 0.267
Tas2r13 taste receptor, type 2, member 13 0.266
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.265
Phf12 PHD finger protein 12 0.265
Irs1 insulin receptor substrate 1 0.265
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.259
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.257
Fut4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.256
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.252
Nfib nuclear factor I/B 0.248
Ciita class II, major histocompatibility complex, transactivator 0.248
Olr1500 olfactory receptor 1500 0.246
Ncr1 natural cytotoxicity triggering receptor 1 0.246
Myd88 myeloid differentiation primary response gene 88 0.243
Rbl2 retinoblastoma-like 2 0.243
RGD1561143 similar to cell surface receptor FDFACT 0.242
Plcg2 phospholipase C, gamma 2 0.242
Nrp1 neuropilin 1 0.240
Jtb jumping translocation breakpoint 0.240
Nfat5 nuclear factor of activated T-cells 5 0.237
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.236
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.235
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.234
Hmgb1 high mobility group box 1 0.233
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.232
Foxe3 forkhead box E3 0.230
Hnrpd heterogeneous nuclear ribonucleoprotein D 0.230
Gata4 GATA binding protein 4 0.229
Map3k1 mitogen activated protein kinase kinase kinase 1 0.229
Lphn2 latrophilin 2 0.225
Fgfr2 fibroblast growth factor receptor 2 0.223
Ctdsp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 0.223
Ptprs protein tyrosine phosphatase, receptor type, S 0.220