The network for 'regulation of signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CLA4 Cla4p 0.949
FAR1 Far1p 0.785
VPS64 Vps64p 0.696
SHO1 Sho1p 0.686
STE20 Ste20p 0.653
PPH21 Pph21p 0.651
CRZ1 Crz1p 0.650
CDC55 Cdc55p 0.624
FAR11 Far11p 0.622
TPK2 Tpk2p 0.600
RRI1 Rri1p 0.585
HOG1 Hog1p 0.576
PBS2 Pbs2p 0.567
ERP4 Erp4p 0.565
ROM2 Rom2p 0.525
CDC34 Cdc34p 0.507
SSK2 Ssk2p 0.429
PTC1 Ptc1p 0.400
TPK1 Tpk1p 0.399
BOI1 Boi1p 0.370
STE4 Ste4p 0.364
RHO1 Rho1p 0.350
CDC24 Cdc24p 0.346
AKL1 Akl1p 0.345
YOL087C hypothetical protein 0.344
STE5 Ste5p 0.336
MON1 Mon1p 0.326
NBP2 Nbp2p 0.324
BEM1 Bem1p 0.316
MSG5 Msg5p 0.309
PRB1 Prb1p 0.298
ENA5 Ena5p 0.297
STI1 Sti1p 0.285
KSS1 Kss1p 0.277
GSC2 Gsc2p 0.268
KOG1 Kog1p 0.266
GYL1 Gyl1p 0.266
ZDS1 Zds1p 0.258
PPH22 Pph22p 0.254
MSN2 Msn2p 0.252
SLA2 Sla2p 0.246
PMT2 Pmt2p 0.242
CCR4 Ccr4p 0.240
STE7 Ste7p 0.240
STE50 Ste50p 0.238
SLT2 Slt2p 0.235
MKK1 Mkk1p 0.234
TOR1 Tor1p 0.234
RUD3 Rud3p 0.231
FUS3 Fus3p 0.223
SOK1 Sok1p 0.222
PRK1 Prk1p 0.218
YGL036W hypothetical protein 0.214
HSP60 Hsp60p 0.212
TSC11 Tsc11p 0.212
GCN20 Gcn20p 0.210
PIK1 Pik1p 0.208
SSK22 Ssk22p 0.206
ICE2 Ice2p 0.205
BNI1 Bni1p 0.197
PCI8 Pci8p 0.197
HST1 Hst1p 0.192
AHP1 Ahp1p 0.192
MKT1 Mkt1p 0.190
VPS36 Vps36p 0.184
PPZ1 Ppz1p 0.182
RPT3 Rpt3p 0.177
STE2 Ste2p 0.177
ERP2 Erp2p 0.175
YAK1 Yak1p 0.173
FAR3 Far3p 0.172
STE11 Ste11p 0.172
PKC1 Pkc1p 0.170
ULA1 Ula1p 0.166
TPS1 Tps1p 0.165
SSN8 Ssn8p 0.162
ADR1 Adr1p 0.154
SRO7 Sro7p 0.152
MYO5 Myo5p 0.151
SPA2 Spa2p 0.150
HOS4 Hos4p 0.146
SEC7 Sec7p 0.143
PEP5 Pep5p 0.142
IME2 Ime2p 0.142
IZH4 Izh4p 0.142
ARC35 Arc35p 0.142
SLM2 Slm2p 0.141
VPS41 Vps41p 0.140
BCK2 Bck2p 0.139
VPS20 Vps20p 0.139
CHC1 Chc1p 0.137
KSP1 Ksp1p 0.131
MDS3 Mds3p 0.131
SNF8 Snf8p 0.130
UBC4 Ubc4p 0.130
STE12 Ste12p 0.128
MKK2 Mkk2p 0.128
CNB1 Cnb1p 0.128
SET3 Set3p 0.128
UBP2 Ubp2p 0.128
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.928
egl-18 Protein EGL-18 0.868
atn-1 Protein ATN-1 0.748
mig-5 Protein MIG-5 0.744
par-5 Protein PAR-5 0.715
bar-1 Protein BAR-1 0.636
goa-1 Protein GOA-1 0.579
K10D6.4 Protein K10D6.4 0.576
mpz-2 Protein MPZ-2 0.515
imb-2 Protein IMB-2 0.493
npp-7 Protein NPP-7 0.493
lin-25 Protein LIN-25 0.458
akt-1 Protein AKT-1 0.449
mec-2 Protein MEC-2 0.439
unc-108 Protein UNC-108 0.420
egl-30 Protein EGL-30 0.403
eor-2 Protein EOR-2 0.388
sma-6 Protein SMA-6 0.388
unc-62 Protein UNC-62 0.381
ida-1 Protein IDA-1 0.378
lin-45 Protein LIN-45 0.372
eps-8 Protein EPS-8 0.371
daf-11 Protein DAF-11 0.370
plc-1 Protein PLC-1 0.347
daf-6 Protein DAF-6 0.340
sem-5 Protein SEM-5 0.340
let-60 Protein LET-60 0.334
shn-1 Protein SHN-1 0.333
lin-36 Protein LIN-36 0.322
pha-4 Protein PHA-4 0.317
egl-8 Protein EGL-8 0.317
pxf-1 Protein PXF-1 0.312
osm-5 Protein OSM-5 0.298
elt-6 Protein ELT-6 0.293
pry-1 Protein PRY-1 0.291
ZK686.3 Protein ZK686.3 0.287
pmk-1 Protein PMK-1 0.285
etr-1 Protein ETR-1 0.281
nhr-67 Protein NHR-67 0.273
gld-1 Protein GLD-1 0.265
abl-1 Protein ABL-1 0.265
hda-3 Protein HDA-3 0.262
che-3 Protein CHE-3 0.262
lag-1 Protein LAG-1 0.256
trim-9 Protein TRIM-9 0.253
imp-2 Protein IMP-2 0.251
daf-14 Protein DAF-14 0.246
ptr-14 Protein PTR-14 0.240
lin-17 Protein LIN-17 0.238
T04C9.1 Protein T04C9.1 0.233
scd-1 Protein SCD-1 0.231
mei-2 Protein MEI-2 0.231
jnk-1 Protein JNK-1 0.226
csn-5 Protein CSN-5 0.221
CELE_F47G4.4 Protein F47G4.4 0.220
mes-3 Protein MES-3 0.213
inx-13 Protein INX-13 0.212
CELE_C12D8.1 Protein C12D8.1 0.206
nhr-34 Protein NHR-34 0.203
sax-7 Protein SAX-7 0.203
egl-27 Protein EGL-27 0.200
pmp-3 Protein PMP-3 0.200
lit-1 Protein LIT-1 0.200
eef-1A.1 Protein EEF-1A.1 0.197
npp-22 Protein NPP-22 0.195
jmjd-1.2 Protein JMJD-1.2 0.193
sax-3 Protein SAX-3 0.193
daf-21 Protein DAF-21 0.190
unc-40 Protein UNC-40 0.190
nhr-6 Protein NHR-6 0.190
unc-7 Protein UNC-7 0.189
faah-1 Protein FAAH-1 0.184
vav-1 Protein VAV-1 0.183
arf-3 Protein ARF-3 0.177
grk-2 Protein GRK-2 0.177
ztf-4 Protein ZTF-4 0.176
Y48G1A.2 Protein Y48G1A.2 0.175
unc-104 Protein UNC-104 0.173
pal-1 Protein PAL-1 0.169
mat-3 Protein MAT-3 0.168
klp-7 Protein KLP-7 0.168
rgl-1 Protein RGL-1 0.168
zfp-3 Protein ZFP-3 0.167
uig-1 Protein UIG-1 0.165
let-607 Protein LET-607 0.164
che-2 Protein CHE-2 0.164
dpy-31 Protein DPY-31 0.163
irx-1 Protein IRX-1 0.162
pkg-1 Protein PKG-1 0.161
ceh-44 Protein CEH-44 0.160
evl-14 Protein EVL-14 0.160
abts-1 Protein ABTS-1 0.159
atg-2 Protein ATG-2 0.159
hgrs-1 Protein HGRS-1 0.157
ykt-6 Protein YKT-6 0.156
unc-32 Protein UNC-32 0.156
T11G6.4 Protein T11G6.4 0.153
msp-78 Protein MSP-78 0.150
R90.1 Protein R90.1 0.148
csnk-1 Protein CSNK-1 0.148
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.999
tbx1 T-box 1 0.997
ntla no tail a 0.997
shha sonic hedgehog a 0.987
fgf8a fibroblast growth factor 8 a 0.984
wnt5b wingless-type MMTV integration site family, member 5b 0.983
gli2a GLI-Kruppel family member GLI2a 0.977
notch1a notch homolog 1a 0.959
bmp2b bone morphogenetic protein 2b 0.940
sox2 SRY-box containing gene 2 0.932
wnt11 wingless-type MMTV integration site family, member 11 0.929
gli1 GLI-Kruppel family member 1 0.929
fgf3 fibroblast growth factor 3 0.923
acvr1l activin A receptor, type I like 0.913
tp53 tumor protein p53 0.910
flt4 fms-related tyrosine kinase 4 0.910
dld deltaD 0.902
rarab retinoic acid receptor, alpha b 0.888
flh floating head 0.884
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.875
dusp6 dual specificity phosphatase 6 0.865
frem3 Fras1 related extracellular matrix 3 0.850
ptch1 patched 1 0.837
kdrl kinase insert domain receptor like 0.836
epb4.1l4 erythrocyte protein band 4.1-like 4 0.827
lft1 lefty1 0.822
tie1 endothelium-specific receptor tyrosine kinase 1 0.812
pkd2 polycystic kidney disease 2 0.804
nrp2b neuropilin 2b 0.802
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.801
tal1 T-cell acute lymphocytic leukemia 1 0.789
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.787
yap1 Yes-associated protein 1 0.779
pou5f1 POU domain, class 5, transcription factor 1 0.766
dcc deleted in colorectal carcinoma 0.752
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.750
brd4 bromodomain containing 4 0.735
rest RE1-silencing transcription factor 0.723
etv5b ets variant 5b 0.717
igf1rb insulin-like growth factor 1b receptor 0.714
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.703
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.692
efnb2a ephrin B2a 0.690
furina furin (paired basic amino acid cleaving enzyme) a 0.686
rag1 recombination activating gene 1 0.684
nrp1a neuropilin 1a 0.678
lhx2b LIM homeobox 2b 0.677
gro2 groucho 2 0.669
bmp4 bone morphogenetic protein 4 0.667
plcg1 phospholipase C, gamma 1 0.663
lef1 lymphocyte enhancer binding factor 1 0.660
gdf6a growth differentiation factor 6a 0.660
khdrbs1a KH domain containing, RNA binding, signal transduction associated 1a 0.659
gata3 GATA-binding protein 3 0.652
sox9b SRY-box containing gene 9b 0.643
ext2 exostoses (multiple) 2 0.639
tbx16 T-box gene 16 0.635
fzd10 frizzled homolog 10 0.635
foxi1 forkhead box I1 0.634
tyr tyrosinase 0.630
sox9a SRY-box containing gene 9a 0.625
evx1 even-skipped homeobox 1 0.621
wu:fv91b12 wu:fv91b12 0.615
pcdh18b protocadherin 18b 0.610
hoxd4a homeo box D4a 0.605
dkk1b dickkopf 1b 0.604
bmp2a bone morphogenetic protein 2a 0.603
smad5 MAD homolog 5 (Drosophila) 0.601
robo3 roundabout homolog 3 0.597
fzd5 frizzled homolog 5 0.594
bbc3 BCL2 binding component 3 0.589
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.585
lhx1a LIM homeobox 1a 0.583
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.582
ptprk protein tyrosine phosphatase, receptor type, K 0.582
six3b sine oculis homeobox homolog 3b 0.582
cdh5 cadherin 5 0.580
tp53bp2 tumor protein p53 binding protein, 2 0.575
runx2b runt-related transcription factor 2b 0.575
twist3 twist3 0.567
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.566
nanos3 nanos homolog 3 0.564
wnt11r wingless-type MMTV integration site family, member 11, related 0.562
fgfr1b fibroblast growth factor receptor 1b 0.559
zbtb4 zinc finger and BTB domain containing 4 0.557
esr2a estrogen receptor 2a 0.556
spry4 sprouty (Drosophila) homolog 4 0.548
smo smoothened homolog (Drosophila) 0.546
vegfc vascular endothelial growth factor c 0.540
pitx3 paired-like homeodomain transcription factor 3 0.537
cmyb transcription factor cmyb 0.535
pdlim3b PDZ and LIM domain 3b 0.534
oep one-eyed pinhead 0.534
cdh2 cadherin 2, neuronal 0.533
sox32 SRY-box containing gene 32 0.530
sox19a SRY-box containing gene 19a 0.530
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.530
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.518
lmna lamin A 0.510
ntn1b netrin 1b 0.503
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Cd14 CD14 molecule 0.808
Itgam integrin, alpha M 0.796
Fgfr2 fibroblast growth factor receptor 2 0.739
Dlg4 discs, large homolog 4 (Drosophila) 0.710
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.709
Lepr leptin receptor 0.648
Hoxa1 homeo box A1 0.647
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.622
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.622
Ptafr platelet-activating factor receptor 0.604
Utrn utrophin 0.579
Jak2 Janus kinase 2 0.575
Prkch protein kinase C, eta 0.571
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.570
Met met proto-oncogene 0.565
Ncr1 natural cytotoxicity triggering receptor 1 0.564
Gzmb granzyme B 0.561
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.558
Folh1 folate hydrolase 1 0.554
Fgfr1 Fibroblast growth factor receptor 1 0.540
Icam1 intercellular adhesion molecule 1 0.521
Calcrl calcitonin receptor-like 0.515
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.508
Epn2 epsin 2 0.503
Bcl2 B-cell CLL/lymphoma 2 0.502
Runx1 runt-related transcription factor 1 0.501
Tgfbr2 transforming growth factor, beta receptor II 0.495
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.487
RGD1564327 similar to integrin alpha 8 0.481
Rara retinoic acid receptor, alpha 0.475
Myh9 myosin, heavy chain 9, non-muscle 0.472
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.471
Cugbp2 CUG triplet repeat, RNA binding protein 2 0.469
Flt1 FMS-related tyrosine kinase 1 0.463
Ccl2 chemokine (C-C motif) ligand 2 0.463
Fgf7 fibroblast growth factor 7 0.457
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.453
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.447
Il1r1 interleukin 1 receptor, type I 0.446
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.439
Agtr1a angiotensin II receptor, type 1a 0.434
Rhag Rh-associated glycoprotein 0.429
Adora2a adenosine A2a receptor 0.427
Syt8 synaptotagmin VIII 0.426
Grin2d glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.426
Adarb2 adenosine deaminase, RNA-specific, B2 0.417
Cd8a CD8a molecule 0.411
Dchs1 dachsous 1 (Drosophila) 0.404
Jak1 Janus kinase 1 0.401
Vav1 vav 1 guanine nucleotide exchange factor 0.401
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.400
Nrxn3 neurexin 3 0.399
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.398
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.397
Sirpa signal-regulatory protein alpha 0.393
Oprm1 opioid receptor, mu 1 0.393
Gfra2 GDNF family receptor alpha 2 0.387
Homer1 homer homolog 1 (Drosophila) 0.387
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.380
Adam2 ADAM metallopeptidase domain 2 0.380
Dlg3 discs, large homolog 3 (Drosophila) 0.379
Ucp3 uncoupling protein 3 (mitochondrial, proton carrier) 0.377
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.376
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.375
Ddr1 discoidin domain receptor tyrosine kinase 1 0.374
Pld2 phospholipase D2 0.371
Lgals5 lectin, galactose binding, soluble 5 0.371
Tpc1808 tropic 1808 0.371
Sgk1 serum/glucocorticoid regulated kinase 1 0.367
Nrxn1 neurexin 1 0.367
Snrk SNF related kinase 0.365
Pnlip pancreatic lipase 0.364
Neurog3 neurogenin 3 0.354
Creb1 cAMP responsive element binding protein 1 0.354
Dlg1 discs, large homolog 1 (Drosophila) 0.352
Ciita class II, major histocompatibility complex, transactivator 0.349
Myo1b myosin Ib 0.349
Cmklr1 chemokine-like receptor 1 0.349
P2ry2 purinergic receptor P2Y, G-protein coupled, 2 0.347
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.346
Slc9a1 solute carrier family 9 (sodium/hydrogen exchanger), member 1 0.343
Lphn2 latrophilin 2 0.342
Gdnf glial cell derived neurotrophic factor 0.342
Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 0.341
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.341
Pdgfb platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.340
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.340
Shox2 short stature homeobox 2 0.339
Gria1 glutamate receptor, ionotropic, AMPA 1 0.337
S1pr2 sphingosine-1-phosphate receptor 2 0.335
Cxcl10 chemokine (C-X-C motif) ligand 10 0.333
Il10ra interleukin 10 receptor, alpha 0.332
Unc5a unc-5 homolog A (C. elegans) 0.331
Glt25d1 glycosyltransferase 25 domain containing 1 0.331
Fosl1 fos-like antigen 1 0.329
Acmsd aminocarboxymuconate semialdehyde decarboxylase 0.329
Robo1 roundabout homolog 1 (Drosophila) 0.327
Kitlg KIT ligand 0.326
Lnpep leucyl/cystinyl aminopeptidase 0.326
Il9r interleukin 9 receptor 0.324