The network for 'regulation of response to extracellular stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of response to extracellular stimulus

Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ATG13 Atg13p 0.361
TRA1 Tra1p 0.361
KSP1 Ksp1p 0.250
MIG1 Mig1p 0.222
ATG9 Atg9p 0.213
NET1 Net1p 0.204
PCL8 Pcl8p 0.172
HRK1 Hrk1p 0.171
YKR015C hypothetical protein 0.168
SEC2 Sec2p 0.132
TPK1 Tpk1p 0.125
SLG1 Slg1p 0.124
BOI1 Boi1p 0.122
KOG1 Kog1p 0.112
VID24 Vid24p 0.109
KIN2 Kin2p 0.095
FPK1 Fpk1p 0.080
VHS1 Vhs1p 0.078
KCC4 Kcc4p 0.077
IOC4 Ioc4p 0.076
YKR075C hypothetical protein 0.075
MIG3 Mig3p 0.074
SNT1 Snt1p 0.071
ATG4 Atg4p 0.063
NTO1 Nto1p 0.063
RPD3 Rpd3p 0.062
TEC1 Tec1p 0.060
SSK1 Ssk1p 0.059
GAT2 Gat2p 0.057
HXT3 Hxt3p 0.054
REG1 Reg1p 0.054
CKA1 Cka1p 0.053
MDS3 Mds3p 0.053
GLN3 Gln3p 0.053
PHO81 Pho81p 0.051
CDC15 Cdc15p 0.049
EAF1 Eaf1p 0.048
PCL2 Pcl2p 0.047
SKS1 Sks1p 0.047
SAP185 Sap185p 0.047
FOB1 Fob1p 0.045
TOF2 Tof2p 0.042
CRZ1 Crz1p 0.042
YNL234W hypothetical protein 0.042
HMS1 Hms1p 0.041
MIG2 Mig2p 0.041
EAF3 Eaf3p 0.041
STD1 Std1p 0.041
HHO1 Hho1p 0.041
PPH3 Pph3p 0.041
DOT6 Dot6p 0.041
MHP1 Mhp1p 0.041
DSS4 Dss4p 0.040
SNF4 Snf4p 0.040
CLB3 Clb3p 0.039
ESA1 Esa1p 0.039
SSK2 Ssk2p 0.038
YHR009C hypothetical protein 0.038
POG1 Pog1p 0.038
YMR102C hypothetical protein 0.037
YPL260W hypothetical protein 0.037
YLR177W hypothetical protein 0.037
SEF1 Sef1p 0.037
MON1 Mon1p 0.036
PRR2 Prr2p 0.035
BMH1 Bmh1p 0.035
TGL4 Tgl4p 0.035
TRK1 Trk1p 0.034
YAK1 Yak1p 0.032
GIS4 Gis4p 0.032
CSR2 Csr2p 0.032
SAS5 Sas5p 0.031
UBP9 Ubp9p 0.031
ICY2 Icy2p 0.030
ISR1 Isr1p 0.029
MET4 Met4p 0.029
ROX1 Rox1p 0.029
YPT32 Ypt32p 0.029
ATG1 Atg1p 0.029
PRS2 Prs2p 0.029
STP1 Stp1p 0.029
KIN82 Kin82p 0.028
AVO1 Avo1p 0.028
TOM1 Tom1p 0.027
YPT35 Ypt35p 0.027
RGS2 Rgs2p 0.027
SFL1 Sfl1p 0.026
HXT1 Hxt1p 0.025
RPI1 Rpi1p 0.025
CAT8 Cat8p 0.025
YPL014W hypothetical protein 0.025
YRO2 Yro2p 0.024
VAC7 Vac7p 0.024
EAF5 Eaf5p 0.023
TYE7 Tye7p 0.023
HRR25 Hrr25p 0.023
SNF1 Snf1p 0.023
ICY1 Icy1p 0.023
MKS1 Mks1p 0.023
USO1 Uso1p 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
foxa3 forkhead box A3 0.716
LOC100332193 growth hormone secretagogue receptor type 1-like 0.406
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.398
sst1.1 somatostatin 1, tandem duplicate 1 0.266
inka1a induced in neural crest by AP2, 1a 0.259
zbtb4 zinc finger and BTB domain containing 4 0.200
gro2 groucho 2 0.173
sox9b SRY-box containing gene 9b 0.165
trim13 tripartite motif-containing 13 0.149
ift88 intraflagellar transport 88 homolog 0.128
dusp4 dual specificity phosphatase 4 0.116
mapk3 mitogen-activated protein kinase 3 0.107
ntla no tail a 0.105
fgf3 fibroblast growth factor 3 0.104
stmn4 stathmin-like 4 0.103
gata3 GATA-binding protein 3 0.093
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.085
gata6 GATA-binding protein 6 0.075
ptk2.1 protein tyrosine kinase 2a 0.075
ptprk protein tyrosine phosphatase, receptor type, K 0.073
frzb frizzled-related protein 0.070
ptpra protein tyrosine phosphatase, receptor type, A 0.066
nos2a nitric oxide synthase 2a, inducible 0.065
piwil2 piwi-like 2 (Drosophila) 0.063
xbp1 X-box binding protein 1 0.063
her1 hairy-related 1 0.063
foxp2 forkhead box P2 0.062
kif17 kinesin family member 17 0.060
igf1rb insulin-like growth factor 1b receptor 0.057
aldh2a aldehyde dehydrogenase 2 family (mitochondrial)a 0.056
adrb2b adrenergic receptor, beta 2b 0.056
rhoaa ras homolog gene family, member Aa 0.056
oprd1b opioid receptor, delta 1b 0.056
stk11 serine/threonine kinase 11 0.054
pias4a protein inhibitor of activated STAT, 4a 0.054
odc1 ornithine decarboxylase 1 0.054
foxa1 forkhead box A1 0.052
pld1a phospholipase D1a 0.052
dag1 dystroglycan 1 0.051
faf2 Fas associated factor family member 2 0.050
pbx1a pre-B-cell leukemia transcription factor 1a 0.050
ep300b E1A binding protein p300 b 0.050
fzd5 frizzled homolog 5 0.050
cldni claudin i 0.050
ralgapa1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.049
mapk4 mitogen-activated protein kinase 4 0.048
igf1 insulin-like growth factor 1 0.047
npy4r neuropeptide Y receptor Y4 0.047
grnb granulin b 0.046
cdh1 cadherin 1, epithelial 0.046
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.046
mnx1 motor neuron and pancreas homeobox 1 0.046
bbs2 Bardet-Biedl syndrome 2 0.046
nlgn4a neuroligin 4a 0.046
si:dkey-108d22.4 si:dkey-108d22.4 0.045
dlg1 discs, large (Drosophila) homolog 1 0.045
cecr1a cat eye syndrome chromosome region, candidate 1a 0.045
brd2a bromodomain-containing 2a 0.045
mpp6b membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6) 0.044
prkcea protein kinase C, epsilon a 0.044
zgc:101598 zgc:101598 0.043
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.043
ldb1a LIM-domain binding factor 1a 0.043
ints6 integrator complex subunit 6 0.043
esr2b estrogen receptor 2b 0.042
ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.042
ncoa2 nuclear receptor coactivator 2 0.042
foxa2 forkhead box A2 0.041
zgc:101761 zgc:101761 0.041
gro1 groucho 1 0.041
ntm neurotrimin 0.041
igf2a insulin-like growth factor 2a 0.041
c11orf2 c11orf2 homolog (H. sapiens) 0.041
xgb x globin 0.040
pmch pro-melanin concentrating hormone 0.040
zgc:92745 zgc:92745 0.040
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.040
per2 period homolog 2 (Drosophila) 0.040
crsp7 cofactor required for Sp1 transcriptional activation, subunit 7 0.039
snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.039
zgc:175214 zgc:175214 0.038
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.038
ispd isoprenoid synthase domain containing 0.037
npc1 Niemann-Pick disease, type C1 0.037
ndr1 nodal-related 1 0.037
btbd2 BTB (POZ) domain containing 2 0.037
mxi1 max interacting protein 0.037
hlxb9la homeo box HB9 like a 0.037
krt5 keratin 5 0.036
hnf1ba HNF1 homeobox Ba 0.036
cry3 cryptochrome 3 0.036
siah2l seven in absentia homolog 2 (Drosophila)-like 0.035
tp63 tumor protein p63 0.035
foxl1 forkhead box L1 0.035
krt4 keratin 4 0.035
bida BH3 interacting domain death agonist 0.035
zgc:73134 zgc:73134 0.034
zgc:172101 zgc:172101 0.034
wwp2 WW domain containing E3 ubiquitin protein ligase 2 0.034
angptl1 angiopoietin-like 1 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
rpr reaper 0.933
Ras85D Ras oncogene at 85D 0.668
Rel Relish 0.447
foxo forkhead box, sub-group O 0.422
p53 CG33336 gene product from transcript CG33336-RB 0.349
th thread 0.315
Akt1 CG4006 gene product from transcript CG4006-RA 0.257
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.223
Atg13 Autophagy-specific gene 13 0.203
Atg1 Autophagy-specific gene 1 0.193
grim CG4345 gene product from transcript CG4345-RA 0.183
drk downstream of receptor kinase 0.145
gek genghis khan 0.137
Thor CG8846 gene product from transcript CG8846-RA 0.125
Rab7 Rab-protein 7 0.110
rl rolled 0.108
Kr Kruppel 0.107
Lk6 CG17342 gene product from transcript CG17342-RA 0.099
nos nanos 0.098
AGO2 Argonaute 2 0.095
BG4 CG12297 gene product from transcript CG12297-RA 0.090
byn brachyenteron 0.088
Krn Keren 0.086
spo spook 0.085
RASSF8 CG5053 gene product from transcript CG5053-RA 0.081
Atg18 Autophagy-specific gene 18 0.080
drpr draper 0.078
Atg8a Autophagy-specific gene 8a 0.077
dm diminutive 0.075
imd immune deficiency 0.075
shd shade 0.065
Rheb CG1081 gene product from transcript CG1081-RA 0.063
debcl death executioner Bcl-2 homologue 0.062
Mio Mlx interactor 0.057
RagA CG11968 gene product from transcript CG11968-RA 0.056
hppy happyhour 0.056
Hdac3 Histone deacetylase 3 0.055
CG32486 CG32486 gene product from transcript CG32486-RD 0.055
Syx7 Syntaxin 7 0.055
csw corkscrew 0.054
car carnation 0.048
Rab14 Rab-protein 14 0.048
Klp31E CG5300 gene product from transcript CG5300-RD 0.047
pr-set7 CG3307 gene product from transcript CG3307-RC 0.046
Ilp2 Insulin-like peptide 2 0.045
sro shroud 0.043
Traf4 TNF-receptor-associated factor 4 0.037
Dsor1 Downstream of raf1 0.037
edl ETS-domain lacking 0.036
bsk basket 0.036
puc puckered 0.035
dib disembodied 0.035
wts warts 0.035
Ice CG7788 gene product from transcript CG7788-RA 0.034
rempA reduced mechanoreceptor potential A 0.034
Pten CG5671 gene product from transcript CG5671-RB 0.034
CG18754 CG18754 gene product from transcript CG18754-RB 0.033
BEAF-32 Boundary element-associated factor of 32kD 0.032
Trh Tryptophan hydroxylase 0.031
melt melted 0.031
Ark Apaf-1-related-killer 0.030
klu klumpfuss 0.029
CG7220 CG7220 gene product from transcript CG7220-RD 0.029
npf neuropeptide F 0.028
flfl falafel 0.028
pnt pointed 0.027
Jra Jun-related antigen 0.027
Dcp-1 Death caspase-1 0.027
nudE CG8104 gene product from transcript CG8104-RB 0.026
skl sickle 0.026
CdsA CDP diglyceride synthetase 0.026
Pi4KIIalpha CG2929 gene product from transcript CG2929-RC 0.025
CG32581 CG32581 gene product from transcript CG32581-RB 0.025
Xbp1 X box binding protein-1 0.022
mtt mangetout 0.022
cer crammer 0.021
tefu telomere fusion 0.021
Ptp61F Protein tyrosine phosphatase 61F 0.021
Nc Nedd2-like caspase 0.020
Hmgcr HMG Coenzyme A reductase 0.020
CG8974 CG8974 gene product from transcript CG8974-RD 0.020
Sox14 Sox box protein 14 0.020
Su(z)2 Suppressor of zeste 2 0.020
X11L CG5675 gene product from transcript CG5675-RB 0.019
Syx17 Syntaxin 17 0.019
GLaz Glial Lazarillo 0.019
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.019
Rab1 Rab-protein 1 0.019
Atg2 Autophagy-specific gene 2 0.018
yata CG1973 gene product from transcript CG1973-RA 0.018
CG9801 CG9801 gene product from transcript CG9801-RC 0.018
Src42A Src oncogene at 42A 0.018
lok loki 0.018
sNPF short neuropeptide F precursor 0.018
eve even skipped 0.017
CG30344 CG30344 gene product from transcript CG30344-RA 0.017
CG16721 CG16721 gene product from transcript CG16721-RA 0.017
Eip74EF Ecdysone-induced protein 74EF 0.017
hug hugin 0.017
fs(1)M3 female sterile (1) M3 0.017
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Homo sapiens
Name Description Probability Func Analog Organism
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.266
MAP2K1 mitogen-activated protein kinase kinase 1 0.059
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.056
SQSTM1 sequestosome 1 0.040
GFM1 G elongation factor, mitochondrial 1 0.039
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.038
MAPK8 mitogen-activated protein kinase 8 0.036
CREBBP CREB binding protein 0.033
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.032
IRS2 insulin receptor substrate 2 0.031
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.024
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.023
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.022
RRAGA Ras-related GTP binding A 0.021
NCOA1 nuclear receptor coactivator 1 0.019
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.019
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.018
BBS2 Bardet-Biedl syndrome 2 0.018
SESN2 sestrin 2 0.017
GABARAP GABA(A) receptor-associated protein 0.015
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.015
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.015
AR androgen receptor 0.014
TRIM63 tripartite motif containing 63 0.014
MAPK1 mitogen-activated protein kinase 1 0.013
NCOR1 nuclear receptor corepressor 1 0.013
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.013
SIRT1 sirtuin 1 0.013
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.012
RHEB Ras homolog enriched in brain 0.012
OCRL oculocerebrorenal syndrome of Lowe 0.012
ACACA acetyl-CoA carboxylase alpha 0.012
SH3GL2 SH3-domain GRB2-like 2 0.012
CREB1 cAMP responsive element binding protein 1 0.012
SCHIP1 schwannomin interacting protein 1 0.011
ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 0.011
MAP2K2 mitogen-activated protein kinase kinase 2 0.011
PDCD6 programmed cell death 6 0.011
RUSC2 RUN and SH3 domain containing 2 0.011
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.011
GOLGA2 golgin A2 0.011
BBS1 Bardet-Biedl syndrome 1 0.010
COASY CoA synthase 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.017
Shank2 SH3 and multiple ankyrin repeat domains 2 0.011
Zfp706 zinc finger protein 706 0.011
Fkbp4 FK506 binding protein 4 0.011
Hpca hippocalcin 0.011
Chst10 carbohydrate sulfotransferase 10 0.010