The network for 'positive regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
YAP1 Yap1p 0.998
RPD3 Rpd3p 0.988
RTF1 Rtf1p 0.982
PBS2 Pbs2p 0.980
SIN3 Sin3p 0.972
GLN3 Gln3p 0.970
LSM1 Lsm1p 0.969
GCN5 Gcn5p 0.942
BMH1 Bmh1p 0.935
MET4 Met4p 0.933
GAL11 Gal11p 0.919
SNF2 Snf2p 0.913
MSN2 Msn2p 0.909
SPT15 Spt15p 0.897
CKA2 Cka2p 0.890
RSP5 Rsp5p 0.880
SSN3 Ssn3p 0.877
CDC28 Cdc28p 0.875
STE20 Ste20p 0.873
SPT16 Spt16p 0.868
SNF1 Snf1p 0.858
CTI6 Cti6p 0.853
SPT8 Spt8p 0.850
RPT6 Rpt6p 0.847
ADA2 Ada2p 0.813
RPT3 Rpt3p 0.807
DNM1 Dnm1p 0.794
SNF5 Snf5p 0.792
FKH2 Fkh2p 0.773
SNF6 Snf6p 0.771
RPN4 Rpn4p 0.769
MOT2 Mot2p 0.759
CLB5 Clb5p 0.751
CHD1 Chd1p 0.722
ATG1 Atg1p 0.721
PPH21 Pph21p 0.720
CTK3 Ctk3p 0.717
POP2 Pop2p 0.710
MED1 Med1p 0.706
TAF14 Taf14p 0.699
ROX3 Rox3p 0.697
CDC7 Cdc7p 0.696
YAK1 Yak1p 0.691
CLA4 Cla4p 0.691
HST1 Hst1p 0.689
RGR1 Rgr1p 0.688
TOR1 Tor1p 0.686
RTG3 Rtg3p 0.678
SET2 Set2p 0.676
RAD23 Rad23p 0.674
HMO1 Hmo1p 0.673
SET3 Set3p 0.672
MIG1 Mig1p 0.670
INO2 Ino2p 0.665
MUS81 Mus81p 0.661
SDS3 Sds3p 0.655
STE7 Ste7p 0.654
CYC8 Cyc8p 0.654
UBP6 Ubp6p 0.642
UBP3 Ubp3p 0.639
ARP9 Arp9p 0.636
PAT1 Pat1p 0.636
MED6 Med6p 0.636
HSL1 Hsl1p 0.607
SRB4 Srb4p 0.603
PAF1 Paf1p 0.596
MSS4 Mss4p 0.594
MKS1 Mks1p 0.593
CSR2 Csr2p 0.589
SNF4 Snf4p 0.584
STE11 Ste11p 0.583
YFH1 Yfh1p 0.575
MYO5 Myo5p 0.568
NNK1 Nnk1p 0.567
KSP1 Ksp1p 0.558
CTK1 Ctk1p 0.557
TPS1 Tps1p 0.555
KSS1 Kss1p 0.552
FKH1 Fkh1p 0.550
PCC1 Pcc1p 0.548
SSN8 Ssn8p 0.547
STB5 Stb5p 0.544
AFT1 Aft1p 0.538
RCK1 Rck1p 0.530
CTR9 Ctr9p 0.530
MET30 Met30p 0.528
GAL4 Gal4p 0.526
IXR1 Ixr1p 0.522
SWI6 Swi6p 0.516
RXT2 Rxt2p 0.512
PUB1 Pub1p 0.508
PHO85 Pho85p 0.508
SMC3 Smc3p 0.503
DOA4 Doa4p 0.498
STB4 Stb4p 0.492
HAP5 Hap5p 0.489
YKE2 Yke2p 0.489
CSE2 Cse2p 0.488
RLM1 Rlm1p 0.488
MSG5 Msg5p 0.486
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
pha-4 Protein PHA-4 0.996
elt-6 Protein ELT-6 0.982
egl-18 Protein EGL-18 0.957
cam-1 Protein CAM-1 0.930
nhr-67 Protein NHR-67 0.920
rps-2 Protein RPS-2 0.913
nhr-49 Protein NHR-49 0.876
egl-13 Protein EGL-13 0.862
mat-3 Protein MAT-3 0.845
eya-1 Protein EYA-1 0.840
egl-46 Protein EGL-46 0.818
vab-3 Protein VAB-3 0.770
hlh-2 Protein HLH-2 0.759
zip-7 Protein ZIP-7 0.755
sas-5 Protein SAS-5 0.696
T09B4.5 Protein T09B4.5 0.681
cnd-1 Protein CND-1 0.677
hlh-1 Protein HLH-1 0.661
unc-42 Protein UNC-42 0.647
lin-36 Protein LIN-36 0.642
unc-37 Protein UNC-37 0.634
fkh-2 Protein FKH-2 0.630
unc-40 Protein UNC-40 0.624
glp-1 Protein GLP-1 0.601
skp-1 Protein SKP-1 0.600
pry-1 Protein PRY-1 0.581
soc-2 Protein SOC-2 0.581
nhr-34 Protein NHR-34 0.559
mig-5 Protein MIG-5 0.555
daf-1 Protein DAF-1 0.533
his-64 Protein HIS-64 0.529
his-5 Protein HIS-5 0.513
mcm-7 Protein MCM-7 0.507
ldb-1 Protein LDB-1 0.497
pal-1 Protein PAL-1 0.493
unc-73 Protein UNC-73 0.465
ceh-34 Protein CEH-34 0.464
ten-1 Protein TEN-1 0.462
zyg-9 Protein ZYG-9 0.461
aap-1 Protein AAP-1 0.456
cdl-1 Protein CDL-1 0.453
madf-5 Protein MADF-5 0.450
CELE_C25A1.4 Protein C25A1.4 0.449
tct-1 Protein TCT-1 0.441
Y48E1A.1 Protein Y48E1A.1 0.432
lin-12 Protein LIN-12 0.427
hbl-1 Protein HBL-1 0.426
CELE_C17E4.6 Protein C17E4.6 0.418
pch-2 Protein PCH-2 0.412
sel-5 Protein SEL-5 0.412
lin-11 Protein LIN-11 0.395
flh-2 Protein FLH-2 0.392
his-1 Protein HIS-1 0.390
R11A8.7 Protein R11A8.7 0.382
epn-1 Protein EPN-1 0.379
apl-1 Protein APL-1 0.379
uaf-1 Protein UAF-1 0.377
bra-2 Protein BRA-2 0.376
atg-2 Protein ATG-2 0.371
mix-1 Protein MIX-1 0.368
alg-2 Protein ALG-2 0.365
daf-14 Protein DAF-14 0.359
F33H1.4 Protein F33H1.4 0.358
unc-84 Protein UNC-84 0.357
frm-7 Protein FRM-7 0.355
DH11.5 Protein DH11.5 0.353
D1081.8 Protein D1081.8 0.346
abl-1 Protein ABL-1 0.345
sdz-28 Protein SDZ-28 0.344
F18A1.6 Protein F18A1.6 0.338
saeg-1 Protein SAEG-1 0.336
chd-7 Protein CHD-7 0.335
aak-2 Protein AAK-2 0.335
npp-2 Protein NPP-2 0.333
ajm-1 Protein AJM-1 0.333
hda-3 Protein HDA-3 0.322
flt-1 Protein FLT-1 0.321
Y47D3A.29 Protein Y47D3A.29 0.320
rnp-4 Protein RNP-4 0.319
inx-3 Protein INX-3 0.319
rpn-3 Protein RPN-3 0.315
cdk-1 Protein CDK-1 0.313
rad-51 Protein RAD-51 0.310
lin-1 Protein LIN-1 0.309
dre-1 Protein DRE-1 0.309
lsy-2 Protein LSY-2 0.307
nhr-6 Protein NHR-6 0.307
mep-1 Protein MEP-1 0.307
lin-66 Protein LIN-66 0.303
his-46 Protein HIS-46 0.298
gla-3 Protein GLA-3 0.296
unc-62 Protein UNC-62 0.294
lntl-1 Protein LNTL-1 0.291
zif-1 Protein ZIF-1 0.289
F28C1.1 Protein F28C1.1 0.289
icd-1 Protein ICD-1 0.289
ucr-2.3 Protein UCR-2.3 0.285
ceh-27 Protein CEH-27 0.283
Y17G7B.20 Protein Y17G7B.20 0.281
hrp-1 Protein HRP-1 0.281
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Danio rerio
Name Description Probability Func Analog Organism
tp53 tumor protein p53 0.968
dlx3b distal-less homeobox gene 3b 0.951
notch1a notch homolog 1a 0.941
dlx2a distal-less homeobox gene 2a 0.913
gata3 GATA-binding protein 3 0.909
nkx2.2a NK2 transcription factor related 2a 0.879
gli1 GLI-Kruppel family member 1 0.878
flh floating head 0.872
prdm1a PR domain containing 1a, with ZNF domain 0.868
evx1 even-skipped homeobox 1 0.855
her7 hairy and enhancer of split related-7 0.846
pitx2 paired-like homeodomain transcription factor 2 0.832
wu:fv91b12 wu:fv91b12 0.829
runx2b runt-related transcription factor 2b 0.827
myf5 myogenic factor 5 0.804
dlc deltaC 0.803
otpa orthopedia homolog a 0.795
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.793
shha sonic hedgehog a 0.792
runx2a runt-related transcription factor 2a 0.791
foxi1 forkhead box I1 0.789
spry4 sprouty (Drosophila) homolog 4 0.772
bmp4 bone morphogenetic protein 4 0.760
ndr2 nodal-related 2 0.753
otpb orthopedia homolog b 0.739
wnt1 wingless-type MMTV integration site family, member 1 0.735
nanos3 nanos homolog 3 0.702
lhx1a LIM homeobox 1a 0.700
dlx5a distal-less homeobox gene 5a 0.685
sox9a SRY-box containing gene 9a 0.684
myod1 myogenic differentiation 1 0.682
bmp2b bone morphogenetic protein 2b 0.680
egr2b early growth response 2b 0.669
pax7a paired box gene 7a 0.651
gata6 GATA-binding protein 6 0.648
neo1 neogenin 1 0.647
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.643
fezf2 FEZ family zinc finger 2 0.641
fgfr3 fibroblast growth factor receptor 3 0.623
foxa2 forkhead box A2 0.603
pcna proliferating cell nuclear antigen 0.599
pax8 paired box gene 8 0.594
tbx2a T-box gene 2a 0.589
tpm4 tropomyosin 4 0.570
hnf1ba HNF1 homeobox Ba 0.563
pax2a paired box gene 2a 0.560
fzd5 frizzled homolog 5 0.553
oep one-eyed pinhead 0.548
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.544
wnt10a wingless-type MMTV integration site family, member 10a 0.541
kdrl kinase insert domain receptor like 0.511
col2a1a collagen type II, alpha-1a 0.510
raraa retinoic acid receptor, alpha a 0.504
tfap2a transcription factor AP-2 alpha 0.498
egr1 early growth response 1 0.497
smad9 MAD homolog 9 (Drosophila) 0.493
emx3 empty spiracles homeobox 3 0.485
sox19b SRY-box containing gene 19b 0.479
tal1 T-cell acute lymphocytic leukemia 1 0.478
pax6b paired box gene 6b 0.477
oprm1 opioid receptor, mu 1 0.463
jag2 jagged 2 0.462
gata4 GATA-binding protein 4 0.462
ascl1a achaete-scute complex-like 1a (Drosophila) 0.461
twist3 twist3 0.448
pea3 ETS-domain transcription factor pea3 0.439
rad21 RAD21 homolog (S. pombe) 0.437
mab21l2 mab-21-like 2 0.429
bmp2a bone morphogenetic protein 2a 0.418
tgfb3 transforming growth factor, beta 3 0.409
cx43 connexin 43 0.404
mstnb myostatin b 0.401
foxd3 forkhead box D3 0.398
fgf17 fibroblast growth factor 17 0.398
csnk1a1 casein kinase 1, alpha 1 0.394
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.378
sox4b SRY-box containing gene 4b 0.378
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.372
hoxd10a homeo box D10a 0.369
eomesa eomesodermin homolog a 0.369
rasl11b RAS-like, family 11, member B 0.362
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.362
foxh1 forkhead box H1 0.360
junb jun B proto-oncogene 0.359
nrg2a neuregulin 2a 0.358
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.354
fn1 fibronectin 1 0.347
sulf1 sulfatase 1 0.344
her1 hairy-related 1 0.341
znf503 zinc finger protein 503 0.329
lhx5 LIM homeobox 5 0.317
wnt3a wingless-type MMTV integration site family, member 3A 0.316
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.315
hoxb1b homeo box B1b 0.313
rarga retinoic acid receptor gamma a 0.313
barhl2 BarH-like 2 0.310
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.306
eng2a engrailed 2a 0.303
fzd10 frizzled homolog 10 0.301
myog myogenin 0.297
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Akt1 CG4006 gene product from transcript CG4006-RA 1.000
Ras85D Ras oncogene at 85D 1.000
Su(H) Suppressor of Hairless 0.998
wg wingless 0.997
Mad Mothers against dpp 0.996
Fmr1 CG6203 gene product from transcript CG6203-RC 0.994
sd scalloped 0.993
hep hemipterous 0.992
phl pole hole 0.992
nmo nemo 0.992
Egfr Epidermal growth factor receptor 0.989
tws twins 0.989
dco discs overgrown 0.988
slmb supernumerary limbs 0.988
bcd bicoid 0.987
lola longitudinals lacking 0.985
sgg shaggy 0.984
eyg eyegone 0.982
foxo forkhead box, sub-group O 0.980
gro groucho 0.980
mam mastermind 0.979
Rac1 CG2248 gene product from transcript CG2248-RA 0.975
InR Insulin-like receptor 0.973
Ubx Ultrabithorax 0.972
Dll Distal-less 0.971
dsh dishevelled 0.968
eya eyes absent 0.964
put punt 0.960
G-oalpha47A G protein oalpha 47A 0.960
EcR Ecdysone receptor 0.957
rl rolled 0.953
yki yorkie 0.949
lwr lesswright 0.946
TER94 CG2331 gene product from transcript CG2331-RA 0.945
ci cubitus interruptus 0.944
Tao-1 CG14217 gene product from transcript CG14217-RF 0.942
CycE Cyclin E 0.941
aop anterior open 0.937
E(spl) Enhancer of split 0.937
CkIIalpha Casein kinase II alpha subunit 0.933
ftz-f1 ftz transcription factor 1 0.932
cnc cap-n-collar 0.929
wts warts 0.925
RYBP Ring and YY1 Binding Protein 0.925
Pc Polycomb 0.924
Rheb CG1081 gene product from transcript CG1081-RA 0.924
ash2 absent, small, or homeotic discs 2 0.923
dm diminutive 0.917
Src42A Src oncogene at 42A 0.916
drk downstream of receptor kinase 0.910
Sara Smad anchor for receptor activation 0.902
ac achaete 0.900
HLHm7 E(spl) region transcript m7 0.899
ovo CG6824 gene product from transcript CG6824-RE 0.895
bs blistered 0.890
robo roundabout 0.889
brm brahma 0.889
tkv thickveins 0.888
p120ctn Adherens junction protein p120 0.886
jub Ajuba LIM protein 0.886
psq pipsqueak 0.882
nej nejire 0.880
Ser Serrate 0.879
pb proboscipedia 0.879
ago archipelago 0.876
shi shibire 0.874
MED15 Mediator complex subunit 15 0.873
pan pangolin 0.873
vg vestigial 0.872
kay kayak 0.870
sna snail 0.868
os outstretched 0.866
CTCF CG8591 gene product from transcript CG8591-RA 0.866
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.865
Bre1 CG10542 gene product from transcript CG10542-RA 0.858
Cdc42 CG12530 gene product from transcript CG12530-RA 0.858
eIF-4E Eukaryotic initiation factor 4E 0.858
Atg1 Autophagy-specific gene 1 0.854
RpII215 RNA polymerase II 215kD subunit 0.851
smt3 CG4494 gene product from transcript CG4494-RA 0.846
Sos Son of sevenless 0.844
kis kismet 0.844
nkd naked cuticle 0.841
chico CG5686 gene product from transcript CG5686-RB 0.839
wls wntless 0.838
bsk basket 0.833
Mnt CG13316 gene product from transcript CG13316-RD 0.830
ss spineless 0.825
rk rickets 0.824
hbs hibris 0.822
Rbf Retinoblastoma-family protein 0.821
eff effete 0.820
klu klumpfuss 0.818
toy twin of eyeless 0.817
Pp2B-14D Protein phosphatase 2B at 14D 0.809
osa CG7467 gene product from transcript CG7467-RD 0.807
Gap1 GTPase-activating protein 1 0.803
shot short stop 0.800
Cp190 Centrosomal protein 190kD 0.797
dock dreadlocks 0.790
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism