The network for 'protein targeting to vacuole' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein targeting to vacuole

The process of directing proteins towards the vacuole, usually using signals contained within the protein.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VPS28 Vps28p 0.999
COG6 Cog6p 0.997
VPS21 Vps21p 0.996
ATG9 Atg9p 0.988
VPS36 Vps36p 0.986
ATG7 Atg7p 0.985
APL5 Apl5p 0.981
ATG3 Atg3p 0.979
SNX4 Snx4p 0.979
VPS41 Vps41p 0.979
COG8 Cog8p 0.972
SRN2 Srn2p 0.972
VPS35 Vps35p 0.958
MON1 Mon1p 0.941
COG3 Cog3p 0.939
COG7 Cog7p 0.934
YPT6 Ypt6p 0.925
ATG12 Atg12p 0.900
ATG4 Atg4p 0.892
YPT52 Ypt52p 0.888
LSB3 Lsb3p 0.882
VAM6 Vam6p 0.878
VPS17 Vps17p 0.876
TLG2 Tlg2p 0.873
APL6 Apl6p 0.847
VPS3 Vps3p 0.847
ATG14 Atg14p 0.846
ATG11 Atg11p 0.843
VPS16 Vps16p 0.835
SEC4 Sec4p 0.818
COG5 Cog5p 0.781
VPS45 Vps45p 0.737
ATG20 Atg20p 0.734
VTI1 Vti1p 0.720
ATG16 Atg16p 0.686
ATG23 Atg23p 0.685
PEP1 Pep1p 0.679
YPT7 Ypt7p 0.655
ATG13 Atg13p 0.648
TRS85 Trs85p 0.645
PEP5 Pep5p 0.634
ATG21 Atg21p 0.628
HSV2 Hsv2p 0.627
PEP3 Pep3p 0.621
VAM7 Vam7p 0.610
APM3 Apm3p 0.601
BRO1 Bro1p 0.582
VPS52 Vps52p 0.581
COG4 Cog4p 0.574
ATG29 Atg29p 0.567
VPS20 Vps20p 0.564
GDI1 Gdi1p 0.558
ATG5 Atg5p 0.528
ATG1 Atg1p 0.518
BSD2 Bsd2p 0.508
APS3 Aps3p 0.493
VAM3 Vam3p 0.484
COG1 Cog1p 0.481
MON2 Mon2p 0.476
IST1 Ist1p 0.465
ATG10 Atg10p 0.450
ASI1 Asi1p 0.421
ATG18 Atg18p 0.421
ATG26 Atg26p 0.356
SYS1 Sys1p 0.355
ATG8 Atg8p 0.345
VPS9 Vps9p 0.343
SNF8 Snf8p 0.342
YPT53 Ypt53p 0.328
COG2 Cog2p 0.325
DID4 Did4p 0.322
CCZ1 Ccz1p 0.287
VPS34 Vps34p 0.278
YPT10 Ypt10p 0.278
VPS4 Vps4p 0.276
GYL1 Gyl1p 0.265
MVP1 Mvp1p 0.262
FAR7 Far7p 0.258
VPS30 Vps30p 0.256
PEP8 Pep8p 0.246
ECM21 Ecm21p 0.240
VPS33 Vps33p 0.228
COT1 Cot1p 0.218
RIM21 Rim21p 0.216
PHO84 Pho84p 0.207
ATG19 Atg19p 0.205
EMP47 Emp47p 0.204
BPT1 Bpt1p 0.200
VPS38 Vps38p 0.197
CIS1 Cis1p 0.192
VPS5 Vps5p 0.184
TRE1 Tre1p 0.181
RGP1 Rgp1p 0.164
ARL3 Arl3p 0.164
SLG1 Slg1p 0.163
VPS74 Vps74p 0.159
BZZ1 Bzz1p 0.158
KTR4 Ktr4p 0.153
VPS8 Vps8p 0.148
VPS53 Vps53p 0.144
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rab5aa RAB5A, member RAS oncogene family, a 0.228
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.171
cltca clathrin, heavy polypeptide a (Hc) 0.131
inha inhibin, alpha 0.115
rab7 RAB7, member RAS oncogene family 0.106
paqr8 progestin and adipoQ receptor family member VIII 0.102
zgc:77849 zgc:77849 0.084
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.082
vps26bl vacuolar protein sorting 26 homolog B, like 0.077
cyp17a1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.062
zgc:73134 zgc:73134 0.055
fshr follicle stimulating hormone receptor 0.053
arpc5a actin related protein 2/3 complex, subunit 5A 0.046
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.045
igf3 insulin-like growth factor 3 0.042
atp6v1f ATPase, H+ transporting, V1 subunit F 0.041
hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.041
zgc:152984 zgc:152984 0.038
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.036
paqr7b progestin and adipoQ receptor family member VII, b 0.035
sec24c SEC24 family, member C (S. cerevisiae) 0.034
ndfip1 Nedd4 family interacting protein 1 0.034
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.031
clcn7 chloride channel 7 0.029
mtmr6 myotubularin related protein 6 0.027
sdf4 stromal cell derived factor 4 0.027
aktip akt interacting protein 0.027
gabarapa GABA(A) receptor-associated protein a 0.027
wdr16 WD repeat domain 16 0.027
apeh acylpeptide hydrolase 0.026
jak1 Janus kinase 1 0.026
pfn2 profilin 2 0.025
syap1 synapse associated protein 1 0.025
brap BRCA1 associated protein 0.024
igf2r insulin-like growth factor 2 receptor 0.024
capza1a capping protein (actin filament) muscle Z-line, alpha 1a 0.024
rab5c RAB5C, member RAS oncogene family 0.024
si:ch211-260p9.1 si:ch211-260p9.1 0.024
zgc:175140 zgc:175140 0.024
lhb luteinizing hormone, beta polypeptide 0.024
inhbab inhibin, beta Ab 0.023
ctsd cathepsin D 0.023
arpc5b actin related protein 2/3 complex, subunit 5B 0.023
wipi1 WD repeat domain, phosphoinositide interacting 1 0.023
zgc:64161 zgc:64161 0.023
sbf1 SET binding factor 1 0.022
zgc:56010 zgc:56010 0.022
wwp2 WW domain containing E3 ubiquitin protein ligase 2 0.022
tdrd1 tudor domain containing 1 0.022
gdf9 growth differentiation factor 9 0.021
arih2 ariadne homolog 2 (Drosophila) 0.021
scamp2 secretory carrier membrane protein 2 0.020
rab2a RAB2A, member RAS oncogene family 0.020
nedd1 neural precursor cell expressed, developmentally down-regulated 1 0.020
zgc:152900 zgc:152900 0.020
atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.020
tm9sf2 transmembrane 9 superfamily member 2 0.020
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.019
mxd4 MAX dimerization protein 4 0.019
LOC100333215 dystonin-like 0.019
zgc:63831 zgc:63831 0.019
kop askopos 0.019
tbc1d16 TBC1 domain family, member 16 0.019
ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 0.018
h1fx H1 histone family, member X 0.018
macf1 microtubule-actin crosslinking factor 1 0.018
zgc:55573 zgc:55573 0.018
ndrg1 N-myc downstream regulated gene 1 0.018
kdm5ba lysine (K)-specific demethylase 5Ba 0.018
atf4b2 activating transcription factor 4b2 0.017
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.017
LOC555482 tachykinin receptor 3-like 0.017
plekha3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.017
im:7150937 im:7150937 0.017
bsdc1 BSD domain containing 1 0.016
cldnc claudin c 0.016
dusp7 dual specificity phosphatase 7 0.016
tmem9b TMEM9 domain family, member B 0.016
abca1a ATP-binding cassette, sub-family A (ABC1), member 1A 0.016
tbc1d15 TBC1 domain family, member 15 0.016
gdi2 GDP dissociation inhibitor 2 0.015
rab5ab RAB5A, member RAS oncogene family, b 0.015
dazap2 DAZ associated protein 2 0.015
si:ch211-184m19.1 si:ch211-184m19.1 0.015
cyba cytochrome b-245, alpha polypeptide 0.015
taf1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.015
tax1bp1b Tax1 (human T-cell leukemia virus type I) binding protein 1b 0.014
tsc22d2 TSC22 domain family 2 and TSC22 domain family, member 2 0.014
mospd1 motile sperm domain containing 1 0.014
cldna claudin a 0.014
glb1 galactosidase, beta 1 0.014
cldn2 claudin 2 0.014
spns1 spinster homolog 1 (Drosophila) 0.014
zgc:112430 zgc:112430 0.014
rps6ka1 ribosomal protein S6 kinase a, polypeptide 1 0.014
gtpbp1 GTP binding protein 1 0.014
snn stannin 0.014
hnf1bb HNF1 homeobox Bb 0.014
phf20b PHD finger protein 20, b 0.014
klhl11 kelch-like 11 (Drosophila) 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.870
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.824
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.757
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.420
ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae) 0.347
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.319
GABARAP GABA(A) receptor-associated protein 0.300
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.217
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.156
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.127
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.122
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) 0.113
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.088
EEA1 early endosome antigen 1 0.079
LRRK2 leucine-rich repeat kinase 2 0.076
PDCD6IP programmed cell death 6 interacting protein 0.063
DNM2 dynamin 2 0.061
SORT1 sortilin 1 0.056
RNF11 ring finger protein 11 0.055
ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae) 0.052
SYNRG synergin, gamma 0.043
SQSTM1 sequestosome 1 0.042
IGF2R insulin-like growth factor 2 receptor 0.041
ELL elongation factor RNA polymerase II 0.039
ANKRD13A ankyrin repeat domain 13A 0.035
ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae) 0.034
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.033
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.030
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.024
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.024
ZFYVE9 zinc finger, FYVE domain containing 9 0.023
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.021
NBR1 neighbor of BRCA1 gene 1 0.021
RAB22A RAB22A, member RAS oncogene family 0.020
FBXL15 F-box and leucine-rich repeat protein 15 0.020
CHMP4B chromatin modifying protein 4B 0.019
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.018
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.018
COG7 component of oligomeric golgi complex 7 0.017
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) 0.017
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.017
TSG101 tumor susceptibility gene 101 0.016
STAMBP STAM binding protein 0.016
RHOA ras homolog gene family, member A 0.016
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.016
ATG13 ATG13 autophagy related 13 homolog (S. cerevisiae) 0.016
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.016
WASL Wiskott-Aldrich syndrome-like 0.015
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.015
RAB6A RAB6A, member RAS oncogene family 0.015
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.015
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.014
TOM1 target of myb1 (chicken) 0.014
SMAD4 SMAD family member 4 0.013
ROD1 ROD1 regulator of differentiation 1 (S. pombe) 0.013
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.013
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.013
OCRL oculocerebrorenal syndrome of Lowe 0.013
KIAA1033 KIAA1033 0.012
ATG10 ATG10 autophagy related 10 homolog (S. cerevisiae) 0.012
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 0.012
TGFBR1 transforming growth factor, beta receptor 1 0.012
ZRANB1 zinc finger, RAN-binding domain containing 1 0.011
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.010
CAPRIN2 caprin family member 2 0.010
COG1 component of oligomeric golgi complex 1 0.010
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Atg12 autophagy-related 12 (yeast) 0.692
Amhr2 anti-Mullerian hormone type 2 receptor 0.348
Ctnnb1 catenin (cadherin associated protein), beta 1 0.296
Stx7 syntaxin 7 0.294
Ndfip1 Nedd4 family interacting protein 1 0.294
Grb10 growth factor receptor bound protein 10 0.254
Gsk3b glycogen synthase kinase 3 beta 0.248
Axin1 axin 1 0.217
8430410K20Rik RIKEN cDNA 8430410K20 gene 0.176
Ghr growth hormone receptor 0.162
Lrrk2 leucine-rich repeat kinase 2 0.126
Chmp1b chromatin modifying protein 1B 0.126
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.121
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.120
Lyst lysosomal trafficking regulator 0.093
Rnf103 ring finger protein 103 0.090
Rab1 RAB1, member RAS oncogene family 0.088
Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 0.083
Ar androgen receptor 0.078
Kit kit oncogene 0.076
Rab27a RAB27A, member RAS oncogene family 0.075
Klhl9 kelch-like 9 (Drosophila) 0.069
Rnf11 ring finger protein 11 0.069
Esr1 estrogen receptor 1 (alpha) 0.068
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.066
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.061
Sec23a SEC23A (S. cerevisiae) 0.061
Stam2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.057
Ap3d1 adaptor-related protein complex 3, delta 1 subunit 0.056
Lrp6 low density lipoprotein receptor-related protein 6 0.054
Hps1 Hermansky-Pudlak syndrome 1 homolog (human) 0.053
Pldn pallidin 0.053
Rragc Ras-related GTP binding C 0.047
Wls wntless homolog (Drosophila) 0.047
Clock circadian locomotor output cycles kaput 0.045
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.045
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.045
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.044
Stxbp3a syntaxin binding protein 3A 0.044
Rab33b RAB33B, member of RAS oncogene family 0.042
Apoe apolipoprotein E 0.042
Lrp5 low density lipoprotein receptor-related protein 5 0.042
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.041
Hps6 Hermansky-Pudlak syndrome 6 0.041
Hps5 Hermansky-Pudlak syndrome 5 homolog (human) 0.041
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.040
Rab18 RAB18, member RAS oncogene family 0.040
Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 0.039
Mtmr6 myotubularin related protein 6 0.039
Psen1 presenilin 1 0.039
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.038
Pdcl phosducin-like 0.037
Rbbp9 retinoblastoma binding protein 9 0.036
Hps4 Hermansky-Pudlak syndrome 4 homolog (human) 0.036
Mesdc2 mesoderm development candidate 2 0.036
Chm choroidermia 0.036
Copa coatomer protein complex subunit alpha 0.036
Cno cappuccino 0.035
Atg5 autophagy-related 5 (yeast) 0.035
Mitf microphthalmia-associated transcription factor 0.035
Bglap bone gamma carboxyglutamate protein 0.034
Inha inhibin alpha 0.033
3110043O21Rik RIKEN cDNA 3110043O21 gene 0.033
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.033
C78339 expressed sequence C78339 0.033
Rab11a RAB11a, member RAS oncogene family 0.032
Apc adenomatosis polyposis coli 0.032
Cltc clathrin, heavy polypeptide (Hc) 0.032
Sdcbp syndecan binding protein 0.031
Mobkl3 MOB1, Mps One Binder kinase activator-like 3 (yeast) 0.031
Stx12 syntaxin 12 0.030
Arl1 ADP-ribosylation factor-like 1 0.030
Pofut1 protein O-fucosyltransferase 1 0.029
Fundc1 FUN14 domain containing 1 0.028
Dync1i2 dynein cytoplasmic 1 intermediate chain 2 0.028
Arhgap5 Rho GTPase activating protein 5 0.028
Dock7 dedicator of cytokinesis 7 0.028
Armcx3 armadillo repeat containing, X-linked 3 0.027
Crtc3 CREB regulated transcription coactivator 3 0.027
Syap1 synapse associated protein 1 0.027
Dstn destrin 0.027
Htt huntingtin 0.027
Hdlbp high density lipoprotein (HDL) binding protein 0.027
Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 0.027
Prrg2 proline-rich Gla (G-carboxyglutamic acid) polypeptide 2 0.026
Pls3 plastin 3 (T-isoform) 0.026
Gnrh1 gonadotropin releasing hormone 1 0.026
Fpgt fucose-1-phosphate guanylyltransferase 0.026
Ropn1 ropporin, rhophilin associated protein 1 0.025
Kiss1r KISS1 receptor 0.025
Sept7 septin 7 0.025
Cttn cortactin 0.025
Lysmd3 LysM, putative peptidoglycan-binding, domain containing 3 0.025
Samd4b sterile alpha motif domain containing 4B 0.025
Atg7 autophagy-related 7 (yeast) 0.025
Mzf1 myeloid zinc finger 1 0.025
Bglap2 bone gamma-carboxyglutamate protein 2 0.024
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) 0.024
Nxt2 nuclear transport factor 2-like export factor 2 0.024
Arpc2 actin related protein 2/3 complex, subunit 2 0.024
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Rattus norvegicus
Name Description Probability Func Analog Organism