The network for 'modification dependent protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

modification dependent protein catabolic process

The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC48 Cdc48p 1.000
RPT1 Rpt1p 0.999
RPT6 Rpt6p 0.995
PRE1 Pre1p 0.994
RAD23 Rad23p 0.992
RPT4 Rpt4p 0.991
RPN10 Rpn10p 0.989
RPN11 Rpn11p 0.980
KAR2 Kar2p 0.979
PRE10 Pre10p 0.967
RPT3 Rpt3p 0.959
SKP1 Skp1p 0.958
RPT2 Rpt2p 0.956
UFD4 Ufd4p 0.951
MAD2 Mad2p 0.948
FYV10 Fyv10p 0.944
HRD1 Hrd1p 0.943
MND2 Mnd2p 0.940
APC5 Apc5p 0.940
PPH21 Pph21p 0.939
RPT5 Rpt5p 0.938
RPN12 Rpn12p 0.928
RPN6 Rpn6p 0.920
PPH22 Pph22p 0.915
UFD2 Ufd2p 0.915
CDC23 Cdc23p 0.908
PRE2 Pre2p 0.905
PRE4 Pre4p 0.888
CDC53 Cdc53p 0.881
PRE5 Pre5p 0.870
ECM29 Ecm29p 0.866
DOC1 Doc1p 0.859
MUB1 Mub1p 0.853
HRT1 Hrt1p 0.838
VPS27 Vps27p 0.836
CDC16 Cdc16p 0.833
SCJ1 Scj1p 0.832
PMT1 Pmt1p 0.821
HRD3 Hrd3p 0.812
VID30 Vid30p 0.811
PRE9 Pre9p 0.809
PUP2 Pup2p 0.807
UMP1 Ump1p 0.801
PUP3 Pup3p 0.794
RPN3 Rpn3p 0.789
UBR1 Ubr1p 0.788
DSK2 Dsk2p 0.788
OTU1 Otu1p 0.783
PUP1 Pup1p 0.778
CDC20 Cdc20p 0.773
PRE7 Pre7p 0.772
SCL1 Scl1p 0.761
RPN7 Rpn7p 0.760
CDC26 Cdc26p 0.756
NOP6 Nop6p 0.755
UFD1 Ufd1p 0.755
UBP6 Ubp6p 0.753
PRE6 Pre6p 0.752
ELC1 Elc1p 0.748
NPL4 Npl4p 0.739
SWM1 Swm1p 0.737
APC2 Apc2p 0.729
VID28 Vid28p 0.725
CDC4 Cdc4p 0.706
VPS36 Vps36p 0.704
RPN9 Rpn9p 0.700
MET30 Met30p 0.694
RPN4 Rpn4p 0.694
CDC27 Cdc27p 0.683
GPB2 Gpb2p 0.681
RPN8 Rpn8p 0.668
DER1 Der1p 0.663
BRE5 Bre5p 0.650
DFM1 Dfm1p 0.619
APC1 Apc1p 0.614
UBC4 Ubc4p 0.595
RPN1 Rpn1p 0.589
CDC34 Cdc34p 0.576
APC9 Apc9p 0.575
CDC31 Cdc31p 0.566
BUB3 Bub3p 0.563
GPR1 Gpr1p 0.562
CTF13 Ctf13p 0.548
UBX3 Ubx3p 0.545
SGT2 Sgt2p 0.544
VPS60 Vps60p 0.541
RPN13 Rpn13p 0.529
CSE4 Cse4p 0.526
MCM21 Mcm21p 0.525
PRE3 Pre3p 0.517
RPN2 Rpn2p 0.503
YLR352W hypothetical protein 0.486
YMR258C hypothetical protein 0.485
DDI1 Ddi1p 0.482
BLM10 Blm10p 0.456
YDJ1 Ydj1p 0.443
RAD6 Rad6p 0.442
PRE8 Pre8p 0.439
RKR1 Rkr1p 0.424
VID24 Vid24p 0.422
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-7 Protein RPN-7 0.914
rpn-12 Protein RPN-12 0.905
rpt-3 Protein RPT-3 0.697
pas-4 Protein PAS-4 0.692
rpt-2 Protein RPT-2 0.652
pbs-2 Protein PBS-2 0.589
pas-2 Protein PAS-2 0.568
cul-1 Protein CUL-1 0.484
pas-6 Protein PAS-6 0.473
pbs-6 Protein PBS-6 0.457
rpn-2 Protein RPN-2 0.450
rpn-3 Protein RPN-3 0.415
imb-2 Protein IMB-2 0.403
pbs-7 Protein PBS-7 0.358
rpt-5 Protein RPT-5 0.353
pbs-4 Protein PBS-4 0.346
pbs-3 Protein PBS-3 0.321
npl-4.2 Protein NPL-4.2 0.312
rpn-9 Protein RPN-9 0.290
rnr-1 Protein RNR-1 0.283
app-1 Protein APP-1 0.276
rod-1 Protein ROD-1 0.272
tba-2 Protein TBA-2 0.262
par-5 Protein PAR-5 0.248
pbs-1 Protein PBS-1 0.237
egl-18 Protein EGL-18 0.232
pas-1 Protein PAS-1 0.227
rpt-4 Protein RPT-4 0.202
rfc-2 Protein RFC-2 0.193
pbs-5 Protein PBS-5 0.186
mig-5 Protein MIG-5 0.179
ima-2 Protein IMA-2 0.170
taf-5 Protein TAF-5 0.154
rpn-10 Protein RPN-10 0.153
mdf-2 Protein MDF-2 0.140
daf-21 Protein DAF-21 0.129
usp-14 Protein USP-14 0.125
rpn-5 Protein RPN-5 0.109
rpt-6 Protein RPT-6 0.109
bub-1 Protein BUB-1 0.108
pas-5 Protein PAS-5 0.107
ubc-25 Protein UBC-25 0.107
zen-4 Protein ZEN-4 0.104
E04D5.1 Protein E04D5.1 0.103
npl-4.1 Protein NPL-4.1 0.102
skr-1 Protein SKR-1 0.097
pcn-1 Protein PCN-1 0.096
pas-7 Protein PAS-7 0.096
F29G9.2 Protein F29G9.2 0.094
hsr-9 Protein HSR-9 0.093
stam-1 Protein STAM-1 0.088
dlc-1 Protein DLC-1 0.086
rpa-1 Protein RPA-1 0.086
trap-4 Protein TRAP-4 0.086
psr-1 Protein PSR-1 0.082
CELE_Y106G6H.6 Protein Y106G6H.6 0.082
rad-26 Protein RAD-26 0.078
pri-2 Protein PRI-2 0.077
pup-2 Protein PUP-2 0.075
CELE_C25A1.4 Protein C25A1.4 0.075
pas-3 Protein PAS-3 0.073
atx-3 Protein ATX-3 0.070
ubr-1 Protein UBR-1 0.063
pkc-3 Protein PKC-3 0.062
atg-13 Protein ATG-13 0.062
npp-22 Protein NPP-22 0.062
rpn-11 Protein RPN-11 0.061
ran-1 Protein RAN-1 0.060
T22F3.2 Protein T22F3.2 0.059
csn-3 Protein CSN-3 0.059
CELE_C24H12.5 Protein C24H12.5 0.059
klp-16 Protein KLP-16 0.058
htz-1 Protein HTZ-1 0.058
CELE_T10C6.6 Protein T10C6.6 0.057
K08E3.5 Protein K08E3.5 0.056
ZK507.6 Protein ZK507.6 0.056
hgrs-1 Protein HGRS-1 0.055
imp-2 Protein IMP-2 0.055
asb-1 Protein ASB-1 0.054
ubq-1 Protein UBQ-1 0.053
snr-2 Protein SNR-2 0.053
syx-17 Protein SYX-17 0.052
emo-1 Protein EMO-1 0.052
gei-11 Protein GEI-11 0.051
rpt-1 Protein RPT-1 0.051
F25B3.6 Protein F25B3.6 0.049
bli-1 Protein BLI-1 0.049
Y47D3A.29 Protein Y47D3A.29 0.049
trap-3 Protein TRAP-3 0.048
xbp-1 Protein XBP-1 0.048
syx-5 Protein SYX-5 0.048
cec-10 Protein CEC-10 0.047
his-42 Protein HIS-42 0.047
CELE_R102.5 Protein R102.5 0.047
F36D4.5 Protein F36D4.5 0.046
mcm-6 Protein MCM-6 0.046
ucr-2.3 Protein UCR-2.3 0.046
mdf-1 Protein MDF-1 0.045
R07G3.7 Protein R07G3.7 0.045
W08E12.7 Protein W08E12.7 0.044
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.965
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.963
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.927
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.892
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.856
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.850
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.845
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.783
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.749
hspa5 heat shock protein 5 0.743
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.739
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.728
vcp valosin containing protein 0.723
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.699
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.679
wnt4a wingless-type MMTV integration site family, member 4a 0.676
zgc:92775 zgc:92775 0.631
dynlrb1 dynein, light chain, roadblock-type 1 0.620
hyou1 hypoxia up-regulated 1 0.614
cdc20 cell division cycle 20 homolog 0.601
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.592
dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.582
max myc-associated factor X 0.559
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.550
ccnb1 cyclin B1 0.520
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.510
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.501
zgc:55671 zgc:55671 0.494
ck2b casein kinase 2 beta 0.493
zgc:86903 zgc:86903 0.473
ccne cyclin E 0.472
nasp nuclear autoantigenic sperm protein (histone-binding) 0.462
si:ch73-60e21.1 si:ch73-60e21.1 0.459
psma2 proteasome (prosome, macropain) subunit, alpha type, 2 0.441
ccnb2 cyclin B2 0.431
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.427
chuk conserved helix-loop-helix ubiquitous kinase 0.426
capn2b calpain 2, (m/II) large subunit b 0.424
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.420
baxa bcl2-associated X protein, a 0.419
hspa8 heat shock protein 8 0.418
orc1 origin recognition complex, subunit 1 0.403
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.398
rbpja recombination signal binding protein for immunoglobulin kappa J region a 0.393
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.385
plk1 polo-like kinase 1 (Drosophila) 0.372
chmp4b chromatin modifying protein 4B 0.363
zgc:56200 zgc:56200 0.362
ube2d1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.356
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.338
ccna2 cyclin A2 0.333
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.329
eif1b eukaryotic translation initiation factor 1B 0.323
axin1 axin 1 0.322
ihha Indian hedgehog homolog a 0.322
eif1axb eukaryotic translation initiation factor 1A, X-linked, b 0.319
gmnn geminin, DNA replication inhibitor 0.318
lancl1 LanC antibiotic synthetase component C-like 1 (bacterial) 0.317
aurkb aurora kinase B 0.314
zgc:111944 zgc:111944 0.314
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.311
kif23 kinesin family member 23 0.303
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.301
smek1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.300
bsdc1 BSD domain containing 1 0.299
dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.297
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.294
fbxw2 F-box and WD repeat domain containing 2 0.292
zgc:55448 zgc:55448 0.287
cct5 chaperonin containing TCP1, subunit 5 (epsilon) 0.282
tmed2 transmembrane emp24 domain trafficking protein 2 0.281
csnk1db casein kinase 1, delta b 0.278
si:ch211-244o22.2 si:ch211-244o22.2 0.278
zgc:153910 zgc:153910 0.276
psmd11a proteasome (prosome, macropain) 216S subunit, non-ATPase, 11a 0.274
sec23a Sec23 homolog A (S. cerevisiae) 0.272
smndc1 survival motor neuron domain containing 1 0.272
zgc:110116 zgc:110116 0.270
nexn nexilin (F actin binding protein) 0.267
tlk2 tousled-like kinase 2 0.267
bc2 putative breast adenocarcinoma marker 0.266
zgc:77817 zgc:77817 0.264
gps1 G protein pathway suppressor 1 0.263
si:ch211-69g19.2 si:ch211-69g19.2 0.261
ciapin1 cytokine induced apoptosis inhibitor 1 0.260
usp5 ubiquitin specific protease 5 0.258
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.255
hsbp1 heat shock factor binding protein 1 0.254
mapkapk2a mitogen-activated protein kinase-activated protein kinase 2a 0.252
cdt1 chromatin licensing and DNA replication factor 1 0.250
hspa4b heat shock protein 4b 0.249
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.248
pxn paxillin 0.246
akt2 v-akt murine thymoma viral oncogene homolog 2 0.246
tceb1b transcription elongation factor B (SIII), polypeptide 1b 0.244
zgc:110113 zgc:110113 0.241
abcf1 ATP-binding cassette, sub-family F (GCN20), member 1 0.240
atxn2l ataxin 2-like 0.238
rlf rearranged L-myc fusion 0.237
zgc:123326 zgc:123326 0.232
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Prosbeta2 Proteasome beta2 subunit 0.982
CycB Cyclin B 0.889
tefu telomere fusion 0.840
Rpt1 CG1341 gene product from transcript CG1341-RA 0.818
Mov34 CG3416 gene product from transcript CG3416-RA 0.781
Pros29 Proteasome 29kD subunit 0.780
Rpn9 CG10230 gene product from transcript CG10230-RB 0.769
Rpt4 CG3455 gene product from transcript CG3455-RA 0.769
skpA CG16983 gene product from transcript CG16983-RD 0.685
Prosbeta1 Proteasome beta1 subunit 0.655
Pros54 Proteasome 54kD subunit 0.650
CG13349 CG13349 gene product from transcript CG13349-RA 0.623
Ras85D Ras oncogene at 85D 0.608
Prosalpha5 Proteasome alpha5 subunit 0.597
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.586
Rpn7 CG5378 gene product from transcript CG5378-RA 0.571
Prosbeta3 Proteasome beta3 subunit 0.568
Rpt3 CG16916 gene product from transcript CG16916-RA 0.542
Tbp-1 Tat-binding protein-1 0.541
dco discs overgrown 0.504
polo CG12306 gene product from transcript CG12306-RA 0.494
Rpn3 Regulatory particle non-ATPase 3 0.472
Rpn1 CG7762 gene product from transcript CG7762-RA 0.463
ncd non-claret disjunctional 0.462
Fcp1 CG12252 gene product from transcript CG12252-RA 0.443
CG12321 CG12321 gene product from transcript CG12321-RA 0.418
Rpn12 CG4157 gene product from transcript CG4157-RA 0.413
Rpn11 CG18174 gene product from transcript CG18174-RA 0.398
Pros28.1 Proteasome 28kD subunit 1 0.397
Tak1 TGF-beta activated kinase 1 0.395
Cap-G CG34438 gene product from transcript CG34438-RF 0.392
Rpn2 CG11888 gene product from transcript CG11888-RA 0.385
Rpn5 CG1100 gene product from transcript CG1100-RA 0.377
brm brahma 0.374
lqf liquid facets 0.367
Pros26 Proteasome 26kD subunit 0.354
krz kurtz 0.349
UbcD2 Ubiquitin conjugating enzyme 2 0.348
Pros45 CG1489 gene product from transcript CG1489-RA 0.346
lsn larsen 0.334
lin19 lin-19-like 0.317
Rpn6 Proteasome p44.5 subunit 0.307
nej nejire 0.306
CG4673 CG4673 gene product from transcript CG4673-RB 0.302
Rab1 Rab-protein 1 0.300
Vps25 Vacuolar protein sorting 25 0.291
Dref DNA replication-related element factor 0.291
p53 CG33336 gene product from transcript CG33336-RB 0.272
Cul-3 Cullin-3 0.272
Rel Relish 0.266
Tip60 CG6121 gene product from transcript CG6121-RA 0.257
fzy fizzy 0.254
CG9135 CG9135 gene product from transcript CG9135-RB 0.250
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.244
cal1 chromosome alignment defect 1 0.234
Doa Darkener of apricot 0.216
endos endosulfine 0.209
wdb widerborst 0.203
slmb supernumerary limbs 0.198
Aos1 CG12276 gene product from transcript CG12276-RA 0.195
CycG Cyclin G 0.187
Spc105R Spc105-related 0.180
barr barren 0.178
Top1 Topoisomerase 1 0.165
CycB3 Cyclin B3 0.164
Akt1 CG4006 gene product from transcript CG4006-RA 0.162
ttv tout-velu 0.159
step steppke 0.157
Prosbeta7 Proteasome beta7 subunit 0.147
gwl greatwall 0.146
Su(var)2-10 Suppressor of variegation 2-10 0.146
dsh dishevelled 0.145
kis kismet 0.144
bel belle 0.144
CSN1b COP9 complex homolog subunit 1 b 0.140
CG4603 CG4603 gene product from transcript CG4603-RA 0.138
rap retina aberrant in pattern 0.137
Hsp83 Heat shock protein 83 0.135
Uba1 Ubiquitin activating enzyme 1 0.132
geminin CG3183 gene product from transcript CG3183-RA 0.131
CG2247 CG2247 gene product from transcript CG2247-RA 0.129
jub Ajuba LIM protein 0.129
CG17331 CG17331 gene product from transcript CG17331-RA 0.125
dp dumpy 0.125
CG11247 CG11247 gene product from transcript CG11247-RC 0.123
CG13625 CG13625 gene product from transcript CG13625-RA 0.123
smo smoothened 0.122
dhd deadhead 0.116
Csp Cysteine string protein 0.116
CG9772 CG9772 gene product from transcript CG9772-RB 0.115
cpa capping protein alpha 0.115
UbcD10 Ubiquitin conjugating enzyme 10 0.115
p47 CG11139 gene product from transcript CG11139-RA 0.114
ago archipelago 0.113
mats mob as tumor suppressor 0.111
CG9705 CG9705 gene product from transcript CG9705-RA 0.110
CG5555 CG5555 gene product from transcript CG5555-RA 0.110
Prosbeta5 Proteasome beta5 subunit 0.110
flfl falafel 0.108
jar jaguar 0.107
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
VCP valosin containing protein 1.000
RNF11 ring finger protein 11 1.000
XIAP X-linked inhibitor of apoptosis 1.000
TP53 tumor protein p53 1.000
CUL3 cullin 3 1.000
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 1.000
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 1.000
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
PTK2 PTK2 protein tyrosine kinase 2 0.999
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.999
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.999
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.999
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.999
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.998
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.998
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.998
SKP2 S-phase kinase-associated protein 2 (p45) 0.998
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.998
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.997
SKP1 S-phase kinase-associated protein 1 0.997
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.997
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.995
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.995
RB1 retinoblastoma 1 0.995
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.995
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.995
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.994
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.994
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.994
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.993
UBQLN1 ubiquilin 1 0.993
TRIM39 tripartite motif containing 39 0.993
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.992
HSPA8 heat shock 70kDa protein 8 0.991
CUL1 cullin 1 0.991
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.991
HDAC1 histone deacetylase 1 0.990
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.989
BIRC2 baculoviral IAP repeat containing 2 0.989
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.988
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.987
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.987
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.986
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.984
BTRC beta-transducin repeat containing 0.982
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.982
RNF111 ring finger protein 111 0.982
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.981
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.981
CDK2 cyclin-dependent kinase 2 0.980
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.978
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.976
ATXN3 ataxin 3 0.973
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.971
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.970
PLK1 polo-like kinase 1 0.968
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.965
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.963
UBE3A ubiquitin protein ligase E3A 0.962
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.960
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.959
RAD23B RAD23 homolog B (S. cerevisiae) 0.959
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.958
ANAPC4 anaphase promoting complex subunit 4 0.958
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.957
ADRM1 adhesion regulating molecule 1 0.954
ARIH2 ariadne homolog 2 (Drosophila) 0.953
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.951
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.949
FBXW11 F-box and WD repeat domain containing 11 0.947
CCNB1 cyclin B1 0.944
SMAD2 SMAD family member 2 0.943
TRAF6 TNF receptor-associated factor 6 0.942
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.940
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.939
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.939
PDCD6IP programmed cell death 6 interacting protein 0.938
ZNRF1 zinc and ring finger 1 0.935
ANAPC11 anaphase promoting complex subunit 11 0.932
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.929
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.922
CSNK1E casein kinase 1, epsilon 0.921
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.920
UFD1L ubiquitin fusion degradation 1 like (yeast) 0.917
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.916
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.915
TRIM43 tripartite motif containing 43 0.914
POMP proteasome maturation protein 0.912
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.910
SMAD4 SMAD family member 4 0.909
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.908
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.906
RNF126 ring finger protein 126 0.904
CCNA2 cyclin A2 0.903
BCAR1 breast cancer anti-estrogen resistance 1 0.900
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.899
ANAPC7 anaphase promoting complex subunit 7 0.898
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.896
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.997
Mdm2 transformed mouse 3T3 cell double minute 2 0.996
Axin1 axin 1 0.989
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.985
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.985
Per2 period homolog 2 (Drosophila) 0.982
Psen1 presenilin 1 0.982
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.975
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.959
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.958
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.949
Akt1 thymoma viral proto-oncogene 1 0.942
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.931
Cdk1 cyclin-dependent kinase 1 0.926
Ccnb1 cyclin B1 0.925
Gsk3b glycogen synthase kinase 3 beta 0.925
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.924
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.920
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.913
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.908
Ncstn nicastrin 0.901
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.896
Per1 period homolog 1 (Drosophila) 0.887
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.887
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.880
Ncoa3 nuclear receptor coactivator 3 0.852
Pten phosphatase and tensin homolog 0.851
Apc adenomatosis polyposis coli 0.850
Cry2 cryptochrome 2 (photolyase-like) 0.845
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.844
Clock circadian locomotor output cycles kaput 0.840
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.840
Rrm2 ribonucleotide reductase M2 0.824
Vcp valosin containing protein 0.815
Usp9x ubiquitin specific peptidase 9, X chromosome 0.770
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.763
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.755
Csnk1e casein kinase 1, epsilon 0.745
Rnf19a ring finger protein 19A 0.739
Skil SKI-like 0.733
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.731
Mdm4 transformed mouse 3T3 cell double minute 4 0.719
Rnf111 ring finger 111 0.714
Birc5 baculoviral IAP repeat-containing 5 0.710
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.709
Fgfr1 fibroblast growth factor receptor 1 0.704
App amyloid beta (A4) precursor protein 0.696
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.690
Anapc2 anaphase promoting complex subunit 2 0.684
Ldb3 LIM domain binding 3 0.667
Hif1a hypoxia inducible factor 1, alpha subunit 0.661
Cul4a cullin 4A 0.654
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.654
Dctn1 dynactin 1 0.633
Ranbp9 RAN binding protein 9 0.632
Add1 adducin 1 (alpha) 0.620
Kif22 kinesin family member 22 0.619
Hspa5 heat shock protein 5 0.612
Ccne1 cyclin E1 0.584
Cry1 cryptochrome 1 (photolyase-like) 0.584
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.582
Arrb2 arrestin, beta 2 0.572
Pomp proteasome maturation protein 0.563
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.554
Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.553
Csnk1g2 casein kinase 1, gamma 2 0.547
Ubxn1 UBX domain protein 1 0.533
Mlf2 myeloid leukemia factor 2 0.529
Aamp angio-associated migratory protein 0.527
Arrb1 arrestin, beta 1 0.522
Skp1a S-phase kinase-associated protein 1A 0.517
Mgea5 meningioma expressed antigen 5 (hyaluronidase) 0.501
Prc1 protein regulator of cytokinesis 1 0.498
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.496
Carm1 coactivator-associated arginine methyltransferase 1 0.495
Adrm1 adhesion regulating molecule 1 0.491
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.487
Bap1 Brca1 associated protein 1 0.487
Cyld cylindromatosis (turban tumor syndrome) 0.485
Tbx3 T-box 3 0.483
Lemd2 LEM domain containing 2 0.480
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.477
Pcna proliferating cell nuclear antigen 0.476
Ccnb2 cyclin B2 0.474
Rnf2 ring finger protein 2 0.469
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.463
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.458
Kif20a kinesin family member 20A 0.453
Dab1 disabled homolog 1 (Drosophila) 0.448
Prkce protein kinase C, epsilon 0.445
Ccna2 cyclin A2 0.443
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.440
Ski ski sarcoma viral oncogene homolog (avian) 0.433
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.432
Smad7 MAD homolog 7 (Drosophila) 0.424
Vhl von Hippel-Lindau tumor suppressor 0.422
Psme4 proteasome (prosome, macropain) activator subunit 4 0.419
Ctnnd1 catenin (cadherin associated protein), delta 1 0.419
Crb2 crumbs homolog 2 (Drosophila) 0.407
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.993
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.974
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.928
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.925
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.725
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.724
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.604
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.509
Psme2 proteasome (prosome, macropain) activator subunit 2 0.375
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.373
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.311
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.308
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.222
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.216
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.202
Acyp2 acylphosphatase 2, muscle type 0.174
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.171
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.166
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.159
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.156
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.145
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.131
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.124
Zfand5 zinc finger, AN1-type domain 5 0.113
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.107
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.106
Ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.100
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.099
Hsp90b1 heat shock protein 90, beta, member 1 0.094
Eef2 eukaryotic translation elongation factor 2 0.087
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.086
Pomp proteasome maturation protein 0.082
Pdia4 protein disulfide isomerase family A, member 4 0.081
Creld2 cysteine-rich with EGF-like domains 2 0.081
Manf mesencephalic astrocyte-derived neurotrophic factor 0.080
Csnk1d casein kinase 1, delta 0.077
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.072
Txnl1 thioredoxin-like 1 0.071
Nsfl1c NSFL1 (p97) cofactor (p47) 0.070
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.064
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.063
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.060
Cdk4 cyclin-dependent kinase 4 0.057
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.056
Phax phosphorylated adaptor for RNA export 0.056
Jtb jumping translocation breakpoint 0.054
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.053
Hspa5 heat shock protein 5 0.053
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.051
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.049
LOC100366237 prefoldin subunit 4-like 0.048
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.046
Taok1 TAO kinase 1 0.045
Rab5a RAB5A, member RAS oncogene family 0.042
Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.041
Pfn1 profilin 1 0.040
Txnrd1 thioredoxin reductase 1 0.039
Clic4 chloride intracellular channel 4 0.038
Ppm1a protein phosphatase 1A, magnesium dependent, alpha isoform 0.037
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.037
Ube2b ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae) 0.037
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.036
Foxm1 forkhead box M1 0.034
Kars lysyl-tRNA synthetase 0.033
Calr calreticulin 0.033
Tollip toll interacting protein 0.030
Dctn4 dynactin 4 0.030
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.030
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.029
Pdia3 protein disulfide isomerase family A, member 3 0.029
Ccnb1 cyclin B1 0.029
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.028
Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.028
Tiprl TIP41, TOR signaling pathway regulator-like (S. cerevisiae) 0.027
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.027
Rab11a RAB11a, member RAS oncogene family 0.026
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.026
Golph3 golgi phosphoprotein 3 (coat-protein) 0.026
Serinc1 serine incorporator 1 0.025
Cand1 cullin-associated and neddylation-dissociated 1 0.024
March5 membrane-associated ring finger (C3HC4) 5 0.024
Mgat2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 0.024
Azi2 5-azacytidine induced 2 0.024
Psmd5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.023
RGD1309102 similar to TRS85 homolog 0.023
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.023
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.023
Ubc ubiquitin C 0.023
Pex13 peroxisomal biogenesis factor 13 0.023
Rgs19 regulator of G-protein signaling 19 0.023
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.021
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.021
Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform 0.021
Ifi27l2b interferon, alpha-inducible protein 27 like 2B 0.020
Zfp364 zinc finger protein 364 0.020
Pdia6 protein disulfide isomerase family A, member 6 0.020
Top2a topoisomerase (DNA) II alpha 0.019
Psmb1 proteasome (prosome, macropain) subunit, beta type 1 0.019
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.019
Cops5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.019