The network for 'cellular response to heat' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to heat

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.716
SSK2 Ssk2p 0.642
STI1 Sti1p 0.592
AHA1 Aha1p 0.527
HSP42 Hsp42p 0.522
BTN2 Btn2p 0.521
SSK1 Ssk1p 0.476
CPR6 Cpr6p 0.464
MOB1 Mob1p 0.456
HSP104 Hsp104p 0.423
SSA4 Ssa4p 0.405
NUP100 Nup100p 0.396
SSE1 Sse1p 0.349
YDJ1 Ydj1p 0.338
GLN3 Gln3p 0.248
STE5 Ste5p 0.247
STE11 Ste11p 0.233
RPD3 Rpd3p 0.219
SIN3 Sin3p 0.219
CTI6 Cti6p 0.201
MSN2 Msn2p 0.173
TPS1 Tps1p 0.171
SSE2 Sse2p 0.149
KIC1 Kic1p 0.148
NUP157 Nup157p 0.147
NUP170 Nup170p 0.145
OPY2 Opy2p 0.145
CLA4 Cla4p 0.144
SSA2 Ssa2p 0.143
GLE1 Gle1p 0.140
NUP145 Nup145p 0.134
RPB3 Rpb3p 0.129
RXT3 Rxt3p 0.118
NUP49 Nup49p 0.118
HSP26 Hsp26p 0.116
MBR1 Mbr1p 0.115
MIG1 Mig1p 0.114
BUR6 Bur6p 0.108
HSP31 Hsp31p 0.107
NUP120 Nup120p 0.105
HSC82 Hsc82p 0.103
FES1 Fes1p 0.101
DOT6 Dot6p 0.098
NUP116 Nup116p 0.095
STD1 Std1p 0.092
EBS1 Ebs1p 0.091
SIS1 Sis1p 0.091
PST1 Pst1p 0.089
HSF1 Hsf1p 0.087
MOT1 Mot1p 0.087
NBP2 Nbp2p 0.086
KAP95 Kap95p 0.086
YKR075C hypothetical protein 0.085
NRG1 Nrg1p 0.085
MSN5 Msn5p 0.084
HAL5 Hal5p 0.084
ASH1 Ash1p 0.083
PHM8 Phm8p 0.083
NUP53 Nup53p 0.081
RIA1 Ria1p 0.081
HXT3 Hxt3p 0.081
HSP10 Hsp10p 0.079
TPO2 Tpo2p 0.077
RXT2 Rxt2p 0.075
HCH1 Hch1p 0.074
UME1 Ume1p 0.074
YPL014W hypothetical protein 0.068
MOT3 Mot3p 0.067
SIN4 Sin4p 0.067
NAP1 Nap1p 0.066
RIM101 Rim101p 0.065
MKK2 Mkk2p 0.063
PTK2 Ptk2p 0.063
MSC1 Msc1p 0.063
CUP9 Cup9p 0.063
MMS22 Mms22p 0.062
CTK3 Ctk3p 0.061
POM152 Pom152p 0.061
GIS1 Gis1p 0.060
NUP82 Nup82p 0.058
UTP20 Utp20p 0.056
SSA3 Ssa3p 0.056
SHC1 Shc1p 0.054
GAL11 Gal11p 0.054
YRO2 Yro2p 0.053
NTO1 Nto1p 0.053
RCO1 Rco1p 0.052
SPT8 Spt8p 0.052
ASM4 Asm4p 0.052
CTT1 Ctt1p 0.051
ARP8 Arp8p 0.051
KAP120 Kap120p 0.050
SIR2 Sir2p 0.050
ICY1 Icy1p 0.050
YPR157W hypothetical protein 0.050
KIN3 Kin3p 0.050
SGF29 Sgf29p 0.047
VPS75 Vps75p 0.047
UME6 Ume6p 0.046
FLO9 Flo9p 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Hsp70Aa Heat-shock-protein-70Aa 0.998
Hsp70Ab Heat-shock-protein-70Ab 0.997
Hsp68 Heat shock protein 68 0.993
Mekk1 CG7717 gene product from transcript CG7717-RB 0.992
Hsp70Ba Heat-shock-protein-70Ba 0.711
Hsp70Bc Heat-shock-protein-70Bc 0.464
stv starvin 0.384
Hsp27 Heat shock protein 27 0.271
Trap1 CG3152 gene product from transcript CG3152-RA 0.243
Hsp26 Heat shock protein 26 0.240
Hsp70Bbb CG5834 gene product from transcript CG5834-RA 0.206
Ace Acetylcholine esterase 0.166
sec8 CG2095 gene product from transcript CG2095-RA 0.153
kat-60L1 katanin p60-like 1 0.142
sec6 CG5341 gene product from transcript CG5341-RA 0.124
rl rolled 0.121
Parg Poly(ADP-ribose) glycohydrolase 0.114
MTF-1 Metal response element-binding Transcription Factor-1 0.110
Hsp70Bb Heat-shock-protein-70Bb 0.110
RanBPM Ran-binding protein M 0.103
iav inactive 0.102
HisCl1 Histamine-gated chloride channel subunit 1 0.095
yuri yuri gagarin 0.088
cert ceramide transfer protein 0.086
Mpk2 CG5475 gene product from transcript CG5475-RB 0.085
Cat Catalase 0.084
DnaJ-1 DnaJ-like-1 0.083
Ric Ras which interacts with Calmodulin 0.083
lic licorne 0.081
Top2 Topoisomerase 2 0.078
NLaz Neural Lazarillo 0.077
scny scrawny 0.077
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.077
Parp Poly-(ADP-ribose) polymerase 0.073
CG17826 CG17826 gene product from transcript CG17826-RA 0.071
Dcp-1 Death caspase-1 0.069
chico CG5686 gene product from transcript CG5686-RB 0.061
CG12370 CG12370 gene product from transcript CG12370-RB 0.060
Vrp1 Verprolin 1 0.059
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.059
Hsc70-2 Heat shock protein cognate 2 0.057
spz spatzle 0.054
Gr39a Gustatory receptor 39a 0.053
Ilp6 Insulin-like peptide 6 0.052
EndoG Endonuclease G 0.046
mars CG17064 gene product from transcript CG17064-RB 0.045
CG1129 CG1129 gene product from transcript CG1129-RC 0.043
CG4836 CG4836 gene product from transcript CG4836-RC 0.042
CG42700 CG42700 gene product from transcript CG42700-RC 0.040
5-HT1A Serotonin receptor 1A 0.040
Cyp6g1 CG8453 gene product from transcript CG8453-RA 0.039
TotC Turandot C 0.039
Hsp23 Heat shock protein 23 0.037
Hsc70-1 Heat shock protein cognate 1 0.036
yellow-g CG5717 gene product from transcript CG5717-RA 0.034
CG6418 CG6418 gene product from transcript CG6418-RB 0.033
Vps16A Vacuolar protein sorting 16A 0.029
CG2469 CG2469 gene product from transcript CG2469-RB 0.029
Atu Another transcription unit 0.028
CG3759 CG3759 gene product from transcript CG3759-RB 0.028
SKIP Shal K[+] channel interacting protein 0.027
Atf-2 Activating transcription factor-2 0.027
eIF-4a Eukaryotic initiation factor 4a 0.027
CG18094 CG18094 gene product from transcript CG18094-RA 0.027
alpha-Est7 alpha-Esterase-7 0.027
CG11501 CG11501 gene product from transcript CG11501-RA 0.026
Rop Ras opposite 0.026
hts hu li tai shao 0.026
CG10164 CG10164 gene product from transcript CG10164-RB 0.026
CG3011 CG3011 gene product from transcript CG3011-RA 0.025
CG6486 CG6486 gene product from transcript CG6486-RA 0.025
Hr96 Hormone receptor-like in 96 0.025
mei-P26 CG12218 gene product from transcript CG12218-RA 0.024
Mt2 Methyltransferase 2 0.024
CG12680 CG12680 gene product from transcript CG12680-RB 0.024
TotA Turandot A 0.023
Jhe Juvenile hormone esterase 0.023
Sry-alpha Serendipity alpha 0.022
bdg bedraggled 0.022
CG3085 CG3085 gene product from transcript CG3085-RA 0.021
foxo forkhead box, sub-group O 0.021
DAAM Dishevelled Associated Activator of Morphogenesis 0.021
dalao CG7055 gene product from transcript CG7055-RA 0.021
Cwc25 CG2843 gene product from transcript CG2843-RA 0.021
CG14829 CG14829 gene product from transcript CG14829-RB 0.021
dnr1 defense repressor 1 0.020
Ilp2 Insulin-like peptide 2 0.020
CG8813 CG8813 gene product from transcript CG8813-RA 0.020
CG3638 CG3638 gene product from transcript CG3638-RE 0.019
twin CG31137 gene product from transcript CG31137-RB 0.019
GRHR Gonadotropin-releasing hormone receptor 0.019
Nup98 Nucleoporin 98 0.019
boss bride of sevenless 0.019
Spf45 CG17540 gene product from transcript CG17540-RB 0.019
CG11674 CG11674 gene product from transcript CG11674-RA 0.019
CG2118 CG2118 gene product from transcript CG2118-RB 0.019
CG8709 CG8709 gene product from transcript CG8709-RK 0.018
Hsp67Bb Heat shock gene 67Bb 0.018
capaR capa receptor 0.017
nero CG2245 gene product from transcript CG2245-RA 0.017
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Homo sapiens
Name Description Probability Func Analog Organism
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.964
FGFR2 fibroblast growth factor receptor 2 0.959
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.795
FGF1 fibroblast growth factor 1 (acidic) 0.716
HSPA1B heat shock 70kDa protein 1B 0.626
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.577
HSPA1A heat shock 70kDa protein 1A 0.498
NOSTRIN nitric oxide synthase trafficker 0.440
RBBP4 retinoblastoma binding protein 4 0.404
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.378
MAPK14 mitogen-activated protein kinase 14 0.372
FGFR1 fibroblast growth factor receptor 1 0.344
FKBP4 FK506 binding protein 4, 59kDa 0.298
HDAC1 histone deacetylase 1 0.296
HSPH1 heat shock 105kDa/110kDa protein 1 0.279
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.258
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.252
MAP2K4 mitogen-activated protein kinase kinase 4 0.238
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.237
HSPA8 heat shock 70kDa protein 8 0.226
ARRB2 arrestin, beta 2 0.208
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.182
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.166
SNTA1 syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component) 0.163
IL1R1 interleukin 1 receptor, type I 0.157
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.157
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.151
BAG3 BCL2-associated athanogene 3 0.132
PPP5C protein phosphatase 5, catalytic subunit 0.129
JUN jun proto-oncogene 0.107
HSPB1 heat shock 27kDa protein 1 0.106
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.096
NUP98 nucleoporin 98kDa 0.095
IRAK2 interleukin-1 receptor-associated kinase 2 0.094
FGF10 fibroblast growth factor 10 0.091
RBBP7 retinoblastoma binding protein 7 0.089
STIP1 stress-induced-phosphoprotein 1 0.089
CACYBP calcyclin binding protein 0.072
VCP valosin containing protein 0.066
DAPK1 death-associated protein kinase 1 0.064
NXF1 nuclear RNA export factor 1 0.057
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.053
TRAF6 TNF receptor-associated factor 6 0.052
HDAC2 histone deacetylase 2 0.049
NCOR1 nuclear receptor corepressor 1 0.048
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.047
CREBBP CREB binding protein 0.043
SQSTM1 sequestosome 1 0.042
SAP30 Sin3A-associated protein, 30kDa 0.041
XIAP X-linked inhibitor of apoptosis 0.039
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.039
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.037
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.037
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.033
PDCD6IP programmed cell death 6 interacting protein 0.031
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.031
CPNE6 copine VI (neuronal) 0.030
TOP1 topoisomerase (DNA) I 0.028
CDC37 cell division cycle 37 homolog (S. cerevisiae) 0.028
PELI3 pellino homolog 3 (Drosophila) 0.027
ATF2 activating transcription factor 2 0.024
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.023
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.023
CXCL11 chemokine (C-X-C motif) ligand 11 0.023
IL1RAP interleukin 1 receptor accessory protein 0.022
MAPK1 mitogen-activated protein kinase 1 0.021
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.021
TP53 tumor protein p53 0.020
SH3RF3 SH3 domain containing ring finger 3 0.020
UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast) 0.020
FHL2 four and a half LIM domains 2 0.020
BAG1 BCL2-associated athanogene 0.019
PKN1 protein kinase N1 0.019
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.019
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.019
PPID peptidylprolyl isomerase D 0.018
FGF7 fibroblast growth factor 7 0.017
IL1RN interleukin 1 receptor antagonist 0.016
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.016
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.015
HSPB8 heat shock 22kDa protein 8 0.015
DUSP1 dual specificity phosphatase 1 0.014
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.014
EED embryonic ectoderm development 0.014
ARRB1 arrestin, beta 1 0.014
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.013
C16orf70 chromosome 16 open reading frame 70 0.013
NQO1 NAD(P)H dehydrogenase, quinone 1 0.013
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.013
MYD88 myeloid differentiation primary response gene (88) 0.013
TRIM39 tripartite motif containing 39 0.012
SH3KBP1 SH3-domain kinase binding protein 1 0.012
EP300 E1A binding protein p300 0.012
IRAK3 interleukin-1 receptor-associated kinase 3 0.012
NCF2 neutrophil cytosolic factor 2 0.011
MTA3 metastasis associated 1 family, member 3 0.011
FLNB filamin B, beta 0.011
XPO7 exportin 7 0.011
SART3 squamous cell carcinoma antigen recognized by T cells 3 0.011
TOMM34 translocase of outer mitochondrial membrane 34 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Hspa8 heat shock protein 8 0.265
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.203
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.182
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.154
Hsph1 heat shock 105kDa/110kDa protein 1 0.123
Trp53 transformation related protein 53 0.089
Rac1 RAS-related C3 botulinum substrate 1 0.054
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.045
Pten phosphatase and tensin homolog 0.040
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.039
Atf2 activating transcription factor 2 0.029
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.022
Ahi1 Abelson helper integration site 1 0.016
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.016
Anxa1 annexin A1 0.015
Hdac1 histone deacetylase 1 0.015
Nphp1 nephronophthisis 1 (juvenile) homolog (human) 0.015
Cacybp calcyclin binding protein 0.015
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.014
Kit kit oncogene 0.014
Mknk2 MAP kinase-interacting serine/threonine kinase 2 0.013
Lif leukemia inhibitory factor 0.013
Lrpprc leucine-rich PPR-motif containing 0.013
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.013
Mb myoglobin 0.012
Hspa5 heat shock protein 5 0.011
Cldn16 claudin 16 0.011
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.011
Rgs12 regulator of G-protein signaling 12 0.010
Iqcb1 IQ calmodulin-binding motif containing 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.078
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.057
Hsph1 heat shock 105/110 protein 1 0.046
Stip1 stress-induced phosphoprotein 1 0.044
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.031
Hspd1 heat shock protein 1 (chaperonin) 0.029
Cxcl10 chemokine (C-X-C motif) ligand 10 0.028
Il1b interleukin 1 beta 0.026
Socs3 suppressor of cytokine signaling 3 0.025
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.019
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.018
Igsf6 immunoglobulin superfamily, member 6 0.018
Ccl2 chemokine (C-C motif) ligand 2 0.016
Fosl1 fos-like antigen 1 0.015
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.015
Ubb ubiquitin B 0.014
Ssb Sjogren syndrome antigen B 0.014
Galnt10 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) 0.014
Mapk1 mitogen activated protein kinase 1 0.014
Il6 interleukin 6 0.013
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.013
Ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.013
Hspb1 heat shock protein 1 0.012
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.012
St13 suppression of tumorigenicity 13 0.011
Ccl4 chemokine (C-C motif) ligand 4 0.011
Icam1 intercellular adhesion molecule 1 0.010
Cxcl2 chemokine (C-X-C motif) ligand 2 0.010