The network for 'negative regulation of cytoskeleton organization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cytoskeleton organization

Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BBC1 Bbc1p 0.887
LSB1 Lsb1p 0.650
KAR9 Kar9p 0.462
ABP1 Abp1p 0.448
CAP2 Cap2p 0.391
MYO5 Myo5p 0.382
BMH1 Bmh1p 0.357
CDC14 Cdc14p 0.321
CLB3 Clb3p 0.211
BOI1 Boi1p 0.163
ASE1 Ase1p 0.154
DBF2 Dbf2p 0.131
SPA2 Spa2p 0.116
BMH2 Bmh2p 0.112
KIP2 Kip2p 0.105
SRV2 Srv2p 0.088
SAC6 Sac6p 0.086
ARC15 Arc15p 0.085
YPI1 Ypi1p 0.081
DYN1 Dyn1p 0.081
CDC6 Cdc6p 0.079
SHE1 She1p 0.077
ACM1 Acm1p 0.075
FPK1 Fpk1p 0.068
CLB1 Clb1p 0.067
RVS167 Rvs167p 0.067
GYL1 Gyl1p 0.066
CDC20 Cdc20p 0.065
COF1 Cof1p 0.050
BUD6 Bud6p 0.050
PIN3 Pin3p 0.048
ACK1 Ack1p 0.046
BUD3 Bud3p 0.045
NBL1 Nbl1p 0.045
KEL1 Kel1p 0.044
CAK1 Cak1p 0.044
CLB5 Clb5p 0.043
AIP1 Aip1p 0.043
SRO77 Sro77p 0.042
SPC29 Spc29p 0.042
TEF1 Tef1p 0.041
CAP1 Cap1p 0.040
TWF1 Twf1p 0.039
MPS1 Mps1p 0.038
KIN3 Kin3p 0.037
KIP1 Kip1p 0.036
VIK1 Vik1p 0.036
CLB6 Clb6p 0.036
YSC84 Ysc84p 0.035
BZZ1 Bzz1p 0.033
CDC28 Cdc28p 0.033
NDD1 Ndd1p 0.032
CIN8 Cin8p 0.032
ARC40 Arc40p 0.032
YMR315W hypothetical protein 0.029
ZDS1 Zds1p 0.029
YPL014W hypothetical protein 0.029
DAM1 Dam1p 0.028
BUD14 Bud14p 0.028
NUF2 Nuf2p 0.028
YIR014W hypothetical protein 0.027
YBR235W hypothetical protein 0.027
DBF20 Dbf20p 0.027
YGR016W hypothetical protein 0.026
NAP1 Nap1p 0.026
BNI1 Bni1p 0.026
FIR1 Fir1p 0.026
ARP10 Arp10p 0.026
YBR138C hypothetical protein 0.025
HSL1 Hsl1p 0.025
CSR2 Csr2p 0.025
SRD1 Srd1p 0.025
TSC11 Tsc11p 0.024
YLR264C-A hypothetical protein 0.024
CAM1 Cam1p 0.024
CLB4 Clb4p 0.024
CDC23 Cdc23p 0.024
PTI1 Pti1p 0.024
YMR086W hypothetical protein 0.023
STU2 Stu2p 0.023
YDR239C hypothetical protein 0.023
PKH3 Pkh3p 0.023
TIP1 Tip1p 0.023
FKS1 Fks1p 0.023
CIN1 Cin1p 0.022
VPS17 Vps17p 0.022
RCN1 Rcn1p 0.022
DYN3 Dyn3p 0.022
FAR1 Far1p 0.022
RHO1 Rho1p 0.022
CDC24 Cdc24p 0.021
YPK1 Ypk1p 0.021
YOL038C-A hypothetical protein 0.021
AVO1 Avo1p 0.021
VHS2 Vhs2p 0.021
YLR162W hypothetical protein 0.021
HOF1 Hof1p 0.020
IRC8 Irc8p 0.020
STB1 Stb1p 0.020
CIK1 Cik1p 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
egl egalitarian 0.879
dia diaphanous 0.876
exo84 CG6095 gene product from transcript CG6095-RA 0.849
CG32038 CG32038 gene product from transcript CG32038-RA 0.829
pbl pebble 0.715
Dap160 Dynamin associated protein 160 0.658
WASp CG1520 gene product from transcript CG1520-RA 0.626
trc tricornered 0.607
bru brunelleschi 0.502
Det Deterin 0.498
fwd four wheel drive 0.470
baz bazooka 0.466
Klp67A Kinesin-like protein at 67A 0.413
katanin-60 katanin 60 0.376
Arp66B Actin-related protein 66B 0.355
Grip128 CG9201 gene product from transcript CG9201-RB 0.326
asl asterless 0.272
chic chickadee 0.271
par-6 CG5884 gene product from transcript CG5884-RA 0.256
mars CG17064 gene product from transcript CG17064-RB 0.249
sec8 CG2095 gene product from transcript CG2095-RA 0.236
rok Rho-kinase 0.227
vib vibrator 0.221
Spc25 CG7242 gene product from transcript CG7242-RA 0.220
gwl greatwall 0.213
lkb1 CG9374 gene product from transcript CG9374-RJ 0.191
Lasp CG3849 gene product from transcript CG3849-RB 0.190
wun wunen 0.178
CG5741 CG5741 gene product from transcript CG5741-RC 0.165
CG10722 CG10722 gene product from transcript CG10722-RA 0.159
sti sticky 0.146
Mical Molecule interacting with CasL 0.145
flw flapwing 0.137
Rab11 Rab-protein 11 0.136
CG31224 CG31224 gene product from transcript CG31224-RA 0.134
sec6 CG5341 gene product from transcript CG5341-RA 0.129
borr borealin-related 0.127
sls sallimus 0.124
stai stathmin 0.122
Pink1 PTEN-induced putative kinase 1 0.122
chb chromosome bows 0.109
tef teflon 0.107
DAAM Dishevelled Associated Activator of Morphogenesis 0.106
tai taiman 0.104
Mlc2 Myosin light chain 2 0.099
CG8443 CG8443 gene product from transcript CG8443-RA 0.097
RhoGAP93B CG3421 gene product from transcript CG3421-RA 0.096
Ppcs Phosphopantothenoylcysteine synthetase 0.095
bond james bond 0.095
Arp14D Actin-related protein 14D 0.094
hang hangover 0.089
wupA wings up A 0.088
Poc1 Proteome of centrioles 1 0.088
Rab7 Rab-protein 7 0.085
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.081
hts hu li tai shao 0.080
aust australin 0.079
ana3 anastral spindle 3 0.079
pygo pygopus 0.078
scra scraps 0.076
ifc infertile crescent 0.075
Sra-1 specifically Rac1-associated protein 1 0.075
cher cheerio 0.075
Liprin-alpha CG11199 gene product from transcript CG11199-RB 0.075
CG11299 CG11299 gene product from transcript CG11299-RA 0.074
neb nebbish 0.072
ncd non-claret disjunctional 0.068
flr flare 0.067
jing CG9397 gene product from transcript CG9397-RI 0.066
wac wee Augmin 0.063
Grip71 CG10346 gene product from transcript CG10346-RA 0.062
Abl Abl tyrosine kinase 0.059
otk off-track 0.059
opa1-like optic atrophy 1-like 0.059
robo roundabout 0.057
zpg zero population growth 0.057
asp abnormal spindle 0.057
larp La related protein 0.056
Zasp66 Z band alternatively spliced PDZ-motif protein 66 0.056
nudE CG8104 gene product from transcript CG8104-RB 0.055
Caps Calcium activated protein for secretion 0.052
ari-2 ariadne 2 0.050
CG6051 CG6051 gene product from transcript CG6051-RB 0.050
fry furry 0.050
Cog7 CG31040 gene product from transcript CG31040-RA 0.049
Ank2 Ankyrin 2 0.049
Acsl Acyl-CoA synthetase long-chain 0.046
tay tay bridge 0.046
Zasp52 Z band alternatively spliced PDZ-motif protein 52 0.044
cpa capping protein alpha 0.044
fws four way stop 0.044
Gef26 CG9491 gene product from transcript CG9491-RB 0.044
CG10641 CG10641 gene product from transcript CG10641-RA 0.043
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.043
Bruce CG6303 gene product from transcript CG6303-RA 0.042
Vrp1 Verprolin 1 0.042
AGO1 Argonaute-1 0.041
Rae1 CG9862 gene product from transcript CG9862-RA 0.041
Mlc-c Myosin light chain cytoplasmic 0.041
CG8605 CG8605 gene product from transcript CG8605-RA 0.039
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Homo sapiens
Name Description Probability Func Analog Organism
BAIAP2 BAI1-associated protein 2 0.928
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.554
CORO1C coronin, actin binding protein, 1C 0.457
TPM4 tropomyosin 4 0.363
BIRC5 baculoviral IAP repeat containing 5 0.358
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.356
DAAM1 dishevelled associated activator of morphogenesis 1 0.347
NCF1 neutrophil cytosolic factor 1 0.317
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.304
NCOA1 nuclear receptor coactivator 1 0.289
PSEN2 presenilin 2 (Alzheimer disease 4) 0.278
MYH9 myosin, heavy chain 9, non-muscle 0.274
SQSTM1 sequestosome 1 0.248
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.247
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.241
IQGAP1 IQ motif containing GTPase activating protein 1 0.237
TRIM63 tripartite motif containing 63 0.219
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.213
AURKB aurora kinase B 0.211
TTN titin 0.196
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.194
RHOA ras homolog gene family, member A 0.174
KIF1B kinesin family member 1B 0.171
TEX11 testis expressed 11 0.152
STARD9 StAR-related lipid transfer (START) domain containing 9 0.143
ADRBK1 adrenergic, beta, receptor kinase 1 0.140
CP110 CP110 protein 0.138
DCAF7 DDB1 and CUL4 associated factor 7 0.133
PINK1 PTEN induced putative kinase 1 0.132
ITGB4 integrin, beta 4 0.130
MYPN myopalladin 0.130
CKS2 CDC28 protein kinase regulatory subunit 2 0.123
NEK6 NIMA (never in mitosis gene a)-related kinase 6 0.119
RIPK3 receptor-interacting serine-threonine kinase 3 0.113
CDK1 cyclin-dependent kinase 1 0.110
STIL SCL/TAL1 interrupting locus 0.108
FLNA filamin A, alpha 0.107
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.106
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.106
EPS8 epidermal growth factor receptor pathway substrate 8 0.105
PRKCA protein kinase C, alpha 0.100
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.100
CDK2 cyclin-dependent kinase 2 0.100
EXOC1 exocyst complex component 1 0.094
RHOC ras homolog gene family, member C 0.092
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.090
SUFU suppressor of fused homolog (Drosophila) 0.084
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.084
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.083
CDKN3 cyclin-dependent kinase inhibitor 3 0.083
CENPJ centromere protein J 0.082
SH3KBP1 SH3-domain kinase binding protein 1 0.082
AGTPBP1 ATP/GTP binding protein 1 0.078
ACTN1 actinin, alpha 1 0.077
AURKA aurora kinase A 0.075
EXOC2 exocyst complex component 2 0.073
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.071
C3orf15 chromosome 3 open reading frame 15 0.071
CCNA2 cyclin A2 0.071
MAPT microtubule-associated protein tau 0.070
ARL2 ADP-ribosylation factor-like 2 0.068
RAB6A RAB6A, member RAS oncogene family 0.066
SPTBN1 spectrin, beta, non-erythrocytic 1 0.065
GSK3B glycogen synthase kinase 3 beta 0.065
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.064
GLIS2 GLIS family zinc finger 2 0.062
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.062
OPTN optineurin 0.061
LMNA lamin A/C 0.060
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.059
TNNT1 troponin T type 1 (skeletal, slow) 0.058
ANKRD28 ankyrin repeat domain 28 0.057
GRB2 growth factor receptor-bound protein 2 0.056
SORBS3 sorbin and SH3 domain containing 3 0.055
CREBBP CREB binding protein 0.055
ZNF746 zinc finger protein 746 0.054
MYO9B myosin IXB 0.054
NCKIPSD NCK interacting protein with SH3 domain 0.053
CCDC85A coiled-coil domain containing 85A 0.053
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.052
FMNL1 formin-like 1 0.052
LMO2 LIM domain only 2 (rhombotin-like 1) 0.051
EXOC7 exocyst complex component 7 0.050
PTN pleiotrophin 0.050
SNCAIP synuclein, alpha interacting protein 0.048
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.047
ZYX zyxin 0.046
UBASH3B ubiquitin associated and SH3 domain containing B 0.045
FASLG Fas ligand (TNF superfamily, member 6) 0.044
CLTC clathrin, heavy chain (Hc) 0.044
VASP vasodilator-stimulated phosphoprotein 0.044
C16orf53 chromosome 16 open reading frame 53 0.043
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.043
APC adenomatous polyposis coli 0.043
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 0.043
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.043
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.043
CNN1 calponin 1, basic, smooth muscle 0.042
TUBA1A tubulin, alpha 1a 0.042
XPO1 exportin 1 (CRM1 homolog, yeast) 0.041
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Mus musculus
Name Description Probability Func Analog Organism
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.728
Ccnb1 cyclin B1 0.525
Arpc4 actin related protein 2/3 complex, subunit 4 0.517
Kif2c kinesin family member 2C 0.499
Akt1 thymoma viral proto-oncogene 1 0.470
Anln anillin, actin binding protein 0.468
Kif20a kinesin family member 20A 0.465
Capzb capping protein (actin filament) muscle Z-line, beta 0.461
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.391
Abi1 abl-interactor 1 0.386
Ccna2 cyclin A2 0.349
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.332
Cdk1 cyclin-dependent kinase 1 0.327
Prc1 protein regulator of cytokinesis 1 0.306
Flii flightless I homolog (Drosophila) 0.280
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.275
Msn moesin 0.271
Ccnb2 cyclin B2 0.260
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.256
Plk1 polo-like kinase 1 (Drosophila) 0.251
Dcx doublecortin 0.243
Rac1 RAS-related C3 botulinum substrate 1 0.239
Actb actin, beta 0.228
Birc5 baculoviral IAP repeat-containing 5 0.227
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.219
Wdr1 WD repeat domain 1 0.214
Racgap1 Rac GTPase-activating protein 1 0.213
Dbnl drebrin-like 0.186
Necap2 NECAP endocytosis associated 2 0.178
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.157
C330027C09Rik RIKEN cDNA C330027C09 gene 0.153
Ube2c ubiquitin-conjugating enzyme E2C 0.150
Gtse1 G two S phase expressed protein 1 0.150
Kif4 kinesin family member 4 0.149
Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.142
Ilk integrin linked kinase 0.137
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.136
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.136
Trim63 tripartite motif-containing 63 0.130
Ldb3 LIM domain binding 3 0.127
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.126
Capn1 calpain 1 0.125
Kif11 kinesin family member 11 0.122
Itga3 integrin alpha 3 0.122
Cdh23 cadherin 23 (otocadherin) 0.121
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.119
Rhoa ras homolog gene family, member A 0.118
Csrp1 cysteine and glycine-rich protein 1 0.118
Ckap2 cytoskeleton associated protein 2 0.116
Kif22 kinesin family member 22 0.113
Dclk1 doublecortin-like kinase 1 0.111
Lmnb1 lamin B1 0.109
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.108
Calm1 calmodulin 1 0.107
Gata3 GATA binding protein 3 0.106
Trim55 tripartite motif-containing 55 0.106
Pfn1 profilin 1 0.102
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.101
Tubb5 tubulin, beta 5 0.101
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.099
Cdkn3 cyclin-dependent kinase inhibitor 3 0.097
Kif23 kinesin family member 23 0.095
Aspm asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.087
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.085
Ctdsp2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.083
Robo2 roundabout homolog 2 (Drosophila) 0.082
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.082
Gnb1 guanine nucleotide binding protein (G protein), beta 1 0.082
Aurka aurora kinase A 0.081
Slit3 slit homolog 3 (Drosophila) 0.079
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.078
Vasp vasodilator-stimulated phosphoprotein 0.074
Lrrk2 leucine-rich repeat kinase 2 0.072
Anapc2 anaphase promoting complex subunit 2 0.069
Cdca8 cell division cycle associated 8 0.068
Nefm neurofilament, medium polypeptide 0.067
Cfl1 cofilin 1, non-muscle 0.065
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.064
Cttn cortactin 0.063
Ptp4a2 protein tyrosine phosphatase 4a2 0.063
Braf Braf transforming gene 0.062
Robo1 roundabout homolog 1 (Drosophila) 0.062
Foxm1 forkhead box M1 0.061
Lama5 laminin, alpha 5 0.061
Actn4 actinin alpha 4 0.059
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.058
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.058
Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.057
Dnm1 dynamin 1 0.056
Emx1 empty spiracles homolog 1 (Drosophila) 0.056
Bdnf brain derived neurotrophic factor 0.056
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.055
Coro1c coronin, actin binding protein 1C 0.055
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.055
Top2a topoisomerase (DNA) II alpha 0.055
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.055
Fam83d family with sequence similarity 83, member D 0.054
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.054
Ccdc99 coiled-coil domain containing 99 0.054
Arhgap1 Rho GTPase activating protein 1 0.054
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Rattus norvegicus
Name Description Probability Func Analog Organism