The network for 'dna repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
POL30 Pol30p 1.000
RAD9 Rad9p 1.000
RAD1 Rad1p 1.000
RFA1 Rfa1p 1.000
RAD18 Rad18p 0.999
RAD53 Rad53p 0.999
SRS2 Srs2p 0.999
CTF4 Ctf4p 0.999
RAD5 Rad5p 0.999
RAD54 Rad54p 0.999
MSH6 Msh6p 0.998
RAD24 Rad24p 0.998
RAD50 Rad50p 0.997
RAD27 Rad27p 0.997
ELG1 Elg1p 0.997
REV3 Rev3p 0.997
RAD23 Rad23p 0.997
SMC6 Smc6p 0.996
HHF1 Hhf1p 0.995
MSH2 Msh2p 0.994
XRS2 Xrs2p 0.992
RAD14 Rad14p 0.990
YAF9 Yaf9p 0.990
DDC1 Ddc1p 0.988
EAF1 Eaf1p 0.987
RAD52 Rad52p 0.985
APN1 Apn1p 0.985
SMC5 Smc5p 0.984
EAF5 Eaf5p 0.984
RAD10 Rad10p 0.984
RAD57 Rad57p 0.983
MLH1 Mlh1p 0.983
SGS1 Sgs1p 0.980
POL31 Pol31p 0.980
POL12 Pol12p 0.979
RAD4 Rad4p 0.970
MUS81 Mus81p 0.970
DUN1 Dun1p 0.969
RAD16 Rad16p 0.968
ARP4 Arp4p 0.967
RAD17 Rad17p 0.967
SLD5 Sld5p 0.967
NSE3 Nse3p 0.967
CDC45 Cdc45p 0.957
ASF1 Asf1p 0.955
MRC1 Mrc1p 0.955
POL2 Pol2p 0.950
MRE11 Mre11p 0.946
SWC4 Swc4p 0.945
EPL1 Epl1p 0.942
RPN1 Rpn1p 0.939
RAD51 Rad51p 0.938
MMS21 Mms21p 0.936
RTF1 Rtf1p 0.928
PMS1 Pms1p 0.918
MEC3 Mec3p 0.916
DNL4 Dnl4p 0.914
MCM2 Mcm2p 0.911
ESA1 Esa1p 0.908
SHU1 Shu1p 0.907
PSF1 Psf1p 0.905
RTT107 Rtt107p 0.897
MCM4 Mcm4p 0.889
NTG2 Ntg2p 0.887
PSY3 Psy3p 0.881
RTT109 Rtt109p 0.874
MCM5 Mcm5p 0.870
POL3 Pol3p 0.861
MEC1 Mec1p 0.854
CSM3 Csm3p 0.847
HTB1 Htb1p 0.845
SPT16 Spt16p 0.843
RAD3 Rad3p 0.823
MCM6 Mcm6p 0.820
LIF1 Lif1p 0.818
RAD7 Rad7p 0.818
NPL6 Npl6p 0.818
RAD59 Rad59p 0.812
INO80 Ino80p 0.810
POL1 Pol1p 0.807
MCM3 Mcm3p 0.804
GIN4 Gin4p 0.802
RAD6 Rad6p 0.797
NTG1 Ntg1p 0.794
SWI3 Swi3p 0.790
RSC8 Rsc8p 0.788
POL32 Pol32p 0.783
POB3 Pob3p 0.782
HTA1 Hta1p 0.778
UBR1 Ubr1p 0.771
EAF7 Eaf7p 0.767
SSL1 Ssl1p 0.763
DMC1 Dmc1p 0.757
PIF1 Pif1p 0.738
SLX8 Slx8p 0.737
TOP3 Top3p 0.727
DEF1 Def1p 0.727
YAP1 Yap1p 0.721
MPH1 Mph1p 0.711
IRR1 Irr1p 0.706
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
his-16 Protein HIS-16 0.872
his-3 Protein HIS-3 0.847
his-1 Protein HIS-1 0.635
his-47 Protein HIS-47 0.598
his-42 Protein HIS-42 0.484
his-45 Protein HIS-45 0.442
F10C2.4 Protein F10C2.4 0.336
his-5 Protein HIS-5 0.298
hcp-4 Protein HCP-4 0.248
his-2 Protein HIS-2 0.226
his-39 Protein HIS-39 0.213
F52B5.3 Protein F52B5.3 0.208
his-9 Protein HIS-9 0.201
dcr-1 Protein DCR-1 0.199
npl-4.2 Protein NPL-4.2 0.179
his-7 Protein HIS-7 0.176
his-30 Protein HIS-30 0.175
his-51 Protein HIS-51 0.168
htz-1 Protein HTZ-1 0.167
knl-1 Protein KNL-1 0.159
gon-4 Protein GON-4 0.158
his-64 Protein HIS-64 0.153
tim-1 Protein TIM-1 0.152
brd-1 Protein BRD-1 0.145
mcm-5 Protein MCM-5 0.144
polq-1 Protein POLQ-1 0.144
cku-80 Protein CKU-80 0.143
his-50 Protein HIS-50 0.139
nasp-1 Protein NASP-1 0.131
his-48 Protein HIS-48 0.128
CELE_Y75B8A.25 Protein Y75B8A.25 0.128
C32E8.5 Protein C32E8.5 0.122
his-52 Protein HIS-52 0.119
ima-2 Protein IMA-2 0.117
ndc-80 Protein NDC-80 0.116
his-46 Protein HIS-46 0.113
his-38 Protein HIS-38 0.106
his-63 Protein HIS-63 0.105
his-61 Protein HIS-61 0.095
CELE_K08F4.1 Protein K08F4.1 0.094
his-31 Protein HIS-31 0.094
orc-5 Protein ORC-5 0.090
pme-3 Protein PME-3 0.089
his-29 Protein HIS-29 0.088
his-68 Protein HIS-68 0.087
aly-2 Protein ALY-2 0.081
his-26 Protein HIS-26 0.080
his-62 Protein HIS-62 0.079
pas-1 Protein PAS-1 0.078
CELE_C29A12.1 Protein C29A12.1 0.078
D1081.6 Protein D1081.6 0.077
mis-12 Protein MIS-12 0.074
spd-2 Protein SPD-2 0.073
pabp-2 Protein PABP-2 0.073
his-44 Protein HIS-44 0.071
his-4 Protein HIS-4 0.071
his-33 Protein HIS-33 0.070
F54E12.2 Protein F54E12.2 0.070
kle-2 Protein KLE-2 0.069
B0412.3 Protein B0412.3 0.067
Y55D9A.2 Protein Y55D9A.2 0.067
D2085.4 Protein D2085.4 0.066
msh-6 Protein MSH-6 0.065
F25H5.5 Protein F25H5.5 0.063
pme-1 Protein PME-1 0.063
mbtr-1 Protein MBTR-1 0.062
Y47D3A.29 Protein Y47D3A.29 0.062
CELE_Y41E3.11 Protein Y41E3.11 0.061
F33H2.5 Protein F33H2.5 0.060
F32E10.5 Protein F32E10.5 0.060
hcp-6 Protein HCP-6 0.058
dpf-3 Protein DPF-3 0.054
mac-1 Protein MAC-1 0.054
mcm-6 Protein MCM-6 0.054
his-6 Protein HIS-6 0.053
H14E04.2 Protein H14E04.2 0.053
C02F5.6 Protein C02F5.6 0.053
F10B5.8 Protein F10B5.8 0.052
his-14 Protein HIS-14 0.052
pcn-1 Protein PCN-1 0.052
icp-1 Protein ICP-1 0.051
dcn-1 Protein DCN-1 0.051
Y47D3A.28 Protein Y47D3A.28 0.051
hsr-9 Protein HSR-9 0.050
Y48G1C.1 Protein Y48G1C.1 0.050
prp-8 Protein PRP-8 0.049
mes-4 Protein MES-4 0.047
H21P03.2 Protein H21P03.2 0.047
CELE_C39E9.12 Protein C39E9.12 0.047
C50F2.3 Protein C50F2.3 0.047
snrp-200 Protein SNRP-200 0.046
npp-14 Protein NPP-14 0.046
Y110A7A.9 Protein Y110A7A.9 0.046
mcm-7 Protein MCM-7 0.046
crn-3 Protein CRN-3 0.045
moc-2 Protein MOC-2 0.045
mrp-7 Protein MRP-7 0.045
capg-2 Protein CAPG-2 0.045
T14B4.1 Protein T14B4.1 0.045
CELE_Y75B12B.1 Protein Y75B12B.1 0.045
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.248
pola2 polymerase (DNA directed), alpha 2 0.245
wdr76 WD repeat domain 76 0.089
chek1 CHK1 checkpoint homolog (S. pombe) 0.087
slbp stem-loop binding protein 0.061
ddb2 damage-specific DNA binding protein 2 0.060
nasp nuclear autoantigenic sperm protein (histone-binding) 0.058
fen1 flap structure-specific endonuclease 1 0.056
cry5 cryptochrome 5 0.052
pcna proliferating cell nuclear antigen 0.042
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.036
brca2 breast cancer 2, early onset 0.035
hat1 histone acetyltransferase 1 0.032
palb2 partner and localizer of BRCA2 0.032
si:dkey-258f14.5 si:dkey-258f14.5 0.029
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.027
zgc:101661 zgc:101661 0.023
fancl Fanconi anemia, complementation group L 0.023
hirip3 HIRA interacting protein 3 0.022
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.022
tef thyrotroph embryonic factor 0.021
dut dUTP pyrophosphatase 0.021
gins2 GINS complex subunit 2 0.020
suv39h1b suppressor of variegation 3-9 homolog 1b 0.018
ube2i ubiquitin-conjugating enzyme E2I 0.018
vcp valosin containing protein 0.018
xpc xeroderma pigmentosum, complementation group C 0.018
sass6 spindle assembly 6 homolog (C. elegans) 0.018
zgc:56197 zgc:56197 0.018
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.018
fanci Fanconi anemia, complementation group I 0.018
per2 period homolog 2 (Drosophila) 0.017
cdc45 CDC45 cell division cycle 45 homolog (S. cerevisiae) 0.016
blmh bleomycin hydrolase 0.016
rfc5 replication factor C (activator 1) 5 0.016
pola1 polymerase (DNA directed), alpha 1 0.016
mybl2 myeloblastosis oncogene-like 2 0.014
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.014
hells helicase, lymphoid-specific 0.013
cry-dash cryptochrome DASH 0.013
msh2 mutS homolog 2 (E. coli) 0.013
cdk2 cyclin-dependent kinase 2 0.013
hmgb2b high-mobility group box 2b 0.013
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.012
hoxa13a homeo box A13a 0.012
traip TRAF-interacting protein 0.012
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.012
eif4h eukaryotic translation initiation factor 4h 0.012
asf1bb ASF1 anti-silencing function 1 homolog Bb 0.011
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.011
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.011
paxip1 PAX interacting (with transcription-activation domain) protein 1 0.010
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.010
rap1a RAP1A, member of RAS oncogene family 0.010
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.010
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
mus205 mutagen-sensitive 205 0.999
rad50 CG6339 gene product from transcript CG6339-RD 0.999
hay haywire 0.997
okr okra 0.996
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.995
lok loki 0.986
Brca2 Breast cancer 2, early onset homolog 0.981
mus101 mutagen-sensitive 101 0.979
RpA-70 Replication Protein A 70 0.977
E(z) Enhancer of zeste 0.949
mus209 mutagen-sensitive 209 0.943
RecQ5 homolog of RecQ 0.937
Rev1 CG12189 gene product from transcript CG12189-RA 0.937
Mcm2 Minichromosome maintenance 2 0.929
mus201 mutagen-sensitive 201 0.887
Smc5 CG32438 gene product from transcript CG32438-RE 0.884
CG5524 CG5524 gene product from transcript CG5524-RA 0.877
mus210 mutagen-sensitive 210 0.870
Irbp Inverted repeat-binding protein 0.816
Ercc1 CG10215 gene product from transcript CG10215-RA 0.804
RfC4 Replication factor C subunit 4 0.794
mei-41 meiotic 41 0.724
CG9576 CG9576 gene product from transcript CG9576-RA 0.715
p53 CG33336 gene product from transcript CG33336-RB 0.682
Mcm3 Minichromosome maintenance 3 0.657
tefu telomere fusion 0.635
mus308 mutagen-sensitive 308 0.620
mus304 mutagen-sensitive 304 0.617
gro groucho 0.554
Mlh1 CG11482 gene product from transcript CG11482-RA 0.550
Mcm7 Minichromosome maintenance 7 0.539
RnrL Ribonucleoside diphosphate reductase large subunit 0.526
fzy fizzy 0.495
spn-B spindle B 0.493
Lig4 Ligase4 0.480
Rpn3 Regulatory particle non-ATPase 3 0.463
RPA2 Replication protein A2 0.395
mei-9 meiotic 9 0.390
Rpn1 CG7762 gene product from transcript CG7762-RA 0.373
Ssrp Structure specific recognition protein 0.367
skpA CG16983 gene product from transcript CG16983-RD 0.364
CG14814 CG14814 gene product from transcript CG14814-RA 0.360
DNApol-alpha73 DNA polymerase alpha 73kD 0.352
Rpn9 CG10230 gene product from transcript CG10230-RB 0.352
WRNexo WRN exonuclease 0.348
nbs CG6754 gene product from transcript CG6754-RC 0.338
mus301 mutagen-sensitive 301 0.335
Mcm5 Minichromosome maintenance 5 0.334
msps mini spindles 0.316
CG5003 CG5003 gene product from transcript CG5003-RA 0.310
mof males absent on the first 0.305
Fancd2 CG17269 gene product from transcript CG17269-RA 0.299
spn-E spindle E 0.291
stwl stonewall 0.282
RfC38 Replication factor C 38kD subunit 0.276
ik2 IkappaB kinase-like 2 0.275
CG5602 CG5602 gene product from transcript CG5602-RA 0.265
CG8142 CG8142 gene product from transcript CG8142-RA 0.264
CSN4 COP9 complex homolog subunit 4 0.263
Cks30A Cyclin-dependent kinase subunit 30A 0.256
CDC45L CG3658 gene product from transcript CG3658-RA 0.250
mre11 meiotic recombination 11 0.246
Tfb1 CG8151 gene product from transcript CG8151-RB 0.241
Psf1 CG9187 gene product from transcript CG9187-RA 0.240
CG13350 CG13350 gene product from transcript CG13350-RA 0.234
mus309 mutagen-sensitive 309 0.207
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.203
Jafrac1 thioredoxin peroxidase 1 0.200
l(2)dtl lethal-(2)-denticleless 0.198
Ku80 CG18801 gene product from transcript CG18801-RA 0.192
east enhanced adult sensory threshold 0.175
Cul-3 Cullin-3 0.173
D1 D1 chromosomal protein 0.172
ranshi CG9793 gene product from transcript CG9793-RA 0.169
ash2 absent, small, or homeotic discs 2 0.168
Pros54 Proteasome 54kD subunit 0.167
RfC3 Replication factor C subunit 3 0.166
Hus1-like CG2525 gene product from transcript CG2525-RA 0.164
dre4 CG1828 gene product from transcript CG1828-RB 0.162
CG2694 CG2694 gene product from transcript CG2694-RA 0.162
His2Av Histone H2A variant 0.156
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.155
RecQ4 CG7487 gene product from transcript CG7487-RA 0.151
CG5924 CG5924 gene product from transcript CG5924-RA 0.150
sle slender lobes 0.142
mad2 CG17498 gene product from transcript CG17498-RA 0.142
drosha CG8730 gene product from transcript CG8730-RA 0.141
BRWD3 CG31132 gene product from transcript CG31132-RA 0.140
HmgD High mobility group protein D 0.135
mus312 mutagen-sensitive 312 0.132
CkIIbeta Casein kinase II beta subunit 0.132
Bap55 Brahma associated protein 55kD 0.123
spn-A spindle A 0.123
CG14965 CG14965 gene product from transcript CG14965-RA 0.123
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.122
CG5931 CG5931 gene product from transcript CG5931-RA 0.122
Rpt1 CG1341 gene product from transcript CG1341-RA 0.119
CG4771 CG4771 gene product from transcript CG4771-RA 0.119
MED17 Mediator complex subunit 17 0.119
desat1 CG5887 gene product from transcript CG5887-RA 0.119
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 1.000
PCNA proliferating cell nuclear antigen 1.000
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 1.000
TP53 tumor protein p53 1.000
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.000
BLM Bloom syndrome, RecQ helicase-like 1.000
PARP1 poly (ADP-ribose) polymerase 1 1.000
H2AFX H2A histone family, member X 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 1.000
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 1.000
FANCA Fanconi anemia, complementation group A 1.000
FEN1 flap structure-specific endonuclease 1 0.999
MDC1 mediator of DNA-damage checkpoint 1 0.999
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.999
MSH6 mutS homolog 6 (E. coli) 0.999
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.998
NBN nibrin 0.998
RAD50 RAD50 homolog (S. cerevisiae) 0.997
RAD18 RAD18 homolog (S. cerevisiae) 0.997
RPA1 replication protein A1, 70kDa 0.996
BRCA2 breast cancer 2, early onset 0.996
DTL denticleless homolog (Drosophila) 0.995
HIST1H3D histone cluster 1, H3d 0.994
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.994
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.992
RAD51C RAD51 homolog C (S. cerevisiae) 0.990
HIST1H2BG histone cluster 1, H2bg 0.988
BARD1 BRCA1 associated RING domain 1 0.987
HIST1H2BD histone cluster 1, H2bd 0.987
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.982
RFC2 replication factor C (activator 1) 2, 40kDa 0.982
RAD1 RAD1 homolog (S. pombe) 0.980
FGFR2 fibroblast growth factor receptor 2 0.980
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.979
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.978
EXO1 exonuclease 1 0.978
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.974
C19orf39 chromosome 19 open reading frame 39 0.973
CREBBP CREB binding protein 0.972
RB1 retinoblastoma 1 0.972
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.970
RPA3 replication protein A3, 14kDa 0.967
HIST1H1C histone cluster 1, H1c 0.967
POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.965
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.959
MCM5 minichromosome maintenance complex component 5 0.958
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.958
WRN Werner syndrome, RecQ helicase-like 0.957
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.957
DDB1 damage-specific DNA binding protein 1, 127kDa 0.952
RAD23B RAD23 homolog B (S. cerevisiae) 0.951
HIST1H2AE histone cluster 1, H2ae 0.948
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.948
ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 0.942
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.938
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.936
MCM2 minichromosome maintenance complex component 2 0.936
SMC1A structural maintenance of chromosomes 1A 0.935
HIST1H2BF histone cluster 1, H2bf 0.930
HIST1H2AC histone cluster 1, H2ac 0.928
EP300 E1A binding protein p300 0.923
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.921
APTX aprataxin 0.911
RPA2 replication protein A2, 32kDa 0.908
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.908
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.906
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.900
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.899
MCM6 minichromosome maintenance complex component 6 0.899
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.892
PLK1 polo-like kinase 1 0.890
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.885
RFC4 replication factor C (activator 1) 4, 37kDa 0.885
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.882
UBC ubiquitin C 0.880
HIST2H2BE histone cluster 2, H2be 0.880
HDAC1 histone deacetylase 1 0.878
HIST1H2BI histone cluster 1, H2bi 0.876
PNKP polynucleotide kinase 3'-phosphatase 0.874
XPC xeroderma pigmentosum, complementation group C 0.874
POLH polymerase (DNA directed), eta 0.871
CHD4 chromodomain helicase DNA binding protein 4 0.868
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.854
HIST1H2BE histone cluster 1, H2be 0.854
MTA1 metastasis associated 1 0.849
RNF11 ring finger protein 11 0.845
ACTL6A actin-like 6A 0.840
CDK2 cyclin-dependent kinase 2 0.838
MCM4 minichromosome maintenance complex component 4 0.837
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.828
ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) 0.815
CDT1 chromatin licensing and DNA replication factor 1 0.809
DAXX death-domain associated protein 0.808
E2F1 E2F transcription factor 1 0.807
HIST1H2BH histone cluster 1, H2bh 0.802
FANCD2 Fanconi anemia, complementation group D2 0.799
CCNE1 cyclin E1 0.797
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.796
RAD51AP1 RAD51 associated protein 1 0.787
RAD51L3 RAD51-like 3 (S. cerevisiae) 0.780
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Brca1 breast cancer 1 1.000
Brca2 breast cancer 2 1.000
Msh2 mutS homolog 2 (E. coli) 0.999
Atm ataxia telangiectasia mutated homolog (human) 0.999
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.998
Cdt1 chromatin licensing and DNA replication factor 1 0.998
Rev1 REV1 homolog (S. cerevisiae) 0.996
Prim1 DNA primase, p49 subunit 0.994
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.973
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.973
Smc3 structural maintenace of chromosomes 3 0.971
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.969
Orc1 origin recognition complex, subunit 1 0.969
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.965
Timeless timeless homolog (Drosophila) 0.955
Trp53 transformation related protein 53 0.947
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.938
Hells helicase, lymphoid specific 0.930
Mdm4 transformed mouse 3T3 cell double minute 4 0.927
Gmnn geminin 0.926
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.925
E2f1 E2F transcription factor 1 0.925
Pou5f1 POU domain, class 5, transcription factor 1 0.921
Parp1 poly (ADP-ribose) polymerase family, member 1 0.912
Nbn nibrin 0.872
Terf1 telomeric repeat binding factor 1 0.863
Ssrp1 structure specific recognition protein 1 0.863
Dtl denticleless homolog (Drosophila) 0.861
Ewsr1 Ewing sarcoma breakpoint region 1 0.842
Mybl2 myeloblastosis oncogene-like 2 0.812
Cdca5 cell division cycle associated 5 0.803
Rad51 RAD51 homolog (S. cerevisiae) 0.797
Fancd2 Fanconi anemia, complementation group D2 0.770
Cdk4 cyclin-dependent kinase 4 0.763
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.754
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.751
Rfc1 replication factor C (activator 1) 1 0.738
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.736
Rttn rotatin 0.734
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.716
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.716
Pcna proliferating cell nuclear antigen 0.713
Mms22l MMS22-like, DNA repair protein 0.705
Trim28 tripartite motif-containing 28 0.686
Mlh1 mutL homolog 1 (E. coli) 0.684
Ep400 E1A binding protein p400 0.681
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.679
Skil SKI-like 0.679
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.665
Xpa xeroderma pigmentosum, complementation group A 0.662
Hdac1 histone deacetylase 1 0.654
Sgol1 shugoshin-like 1 (S. pombe) 0.647
Foxo3 forkhead box O3 0.642
Rfc2 replication factor C (activator 1) 2 0.631
Siva1 SIVA1, apoptosis-inducing factor 0.630
Pole polymerase (DNA directed), epsilon 0.620
Parp2 poly (ADP-ribose) polymerase family, member 2 0.610
H2afz H2A histone family, member Z 0.587
Supt16h suppressor of Ty 16 homolog (S. cerevisiae) 0.586
Anapc5 anaphase-promoting complex subunit 5 0.582
Rfc4 replication factor C (activator 1) 4 0.576
Rad54l RAD54 like (S. cerevisiae) 0.575
Hspa14 heat shock protein 14 0.565
Mcm10 minichromosome maintenance deficient 10 (S. cerevisiae) 0.554
Pnp2 purine-nucleoside phosphorylase 2 0.552
Wrn Werner syndrome homolog (human) 0.546
Cenpk centromere protein K 0.539
Arid1b AT rich interactive domain 1B (SWI-like) 0.524
Blm Bloom syndrome, RecQ helicase-like 0.521
Fen1 flap structure specific endonuclease 1 0.514
Smc2 structural maintenance of chromosomes 2 0.513
2700029M09Rik RIKEN cDNA 2700029M09 gene 0.512
Ncaph non-SMC condensin I complex, subunit H 0.508
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.507
Ctcf CCCTC-binding factor 0.501
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.498
Topbp1 topoisomerase (DNA) II binding protein 1 0.497
H2afx H2A histone family, member X 0.490
Ube2t ubiquitin-conjugating enzyme E2T (putative) 0.478
Kntc1 kinetochore associated 1 0.473
Hat1 histone aminotransferase 1 0.471
Smc1a structural maintenance of chromosomes 1A 0.469
Lig1 ligase I, DNA, ATP-dependent 0.466
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.466
Syce2 synaptonemal complex central element protein 2 0.454
Mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.451
Cdc45 cell division cycle 45 homolog (S. cerevisiae) 0.443
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.437
Ncapd3 non-SMC condensin II complex, subunit D3 0.432
Caprin2 caprin family member 2 0.427
Pfn1 profilin 1 0.421
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.418
Paip2 polyadenylate-binding protein-interacting protein 2 0.416
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.416
Pole2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.413
Mis18bp1 MIS18 binding protein 1 0.413
Tcfcp2l1 transcription factor CP2-like 1 0.412
Rpa1 replication protein A1 0.412
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.407
Hdac6 histone deacetylase 6 0.407
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Actb actin, beta 0.022
Actg1 actin, gamma 1 0.010