The network for 'nucleotide excision repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

nucleotide excision repair

A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD4 Rad4p 0.977
RAD7 Rad7p 0.946
RAD3 Rad3p 0.906
SPT16 Spt16p 0.875
RAD1 Rad1p 0.870
RTF1 Rtf1p 0.840
RFA1 Rfa1p 0.825
SSL1 Ssl1p 0.822
CTR9 Ctr9p 0.807
RAD52 Rad52p 0.788
TFB4 Tfb4p 0.749
RPB3 Rpb3p 0.746
RAD14 Rad14p 0.738
SUS1 Sus1p 0.694
TFB3 Tfb3p 0.691
RAD23 Rad23p 0.686
SAW1 Saw1p 0.646
TFB1 Tfb1p 0.542
SEM1 Sem1p 0.530
RAD5 Rad5p 0.506
HTB1 Htb1p 0.495
RAD16 Rad16p 0.483
MSH2 Msh2p 0.445
TFA1 Tfa1p 0.423
HTA1 Hta1p 0.419
MEC1 Mec1p 0.418
RAD26 Rad26p 0.404
RPO21 Rpo21p 0.372
HPR1 Hpr1p 0.372
RAD18 Rad18p 0.357
TFB5 Tfb5p 0.348
REV3 Rev3p 0.347
MSH6 Msh6p 0.336
RAD2 Rad2p 0.332
SWI1 Swi1p 0.330
RPN1 Rpn1p 0.323
MSH3 Msh3p 0.299
TFB2 Tfb2p 0.288
RAD9 Rad9p 0.264
HHF2 Hhf2p 0.250
POL32 Pol32p 0.249
SNF11 Snf11p 0.215
RAD10 Rad10p 0.200
PAF1 Paf1p 0.194
RFA2 Rfa2p 0.193
CDC21 Cdc21p 0.192
CCL1 Ccl1p 0.183
SSL2 Ssl2p 0.174
POL31 Pol31p 0.170
RAD53 Rad53p 0.170
CKB1 Ckb1p 0.157
HHT2 Hht2p 0.154
RPT3 Rpt3p 0.151
CDC9 Cdc9p 0.141
SGV1 Sgv1p 0.135
RAD27 Rad27p 0.132
LEO1 Leo1p 0.132
POL30 Pol30p 0.132
TFA2 Tfa2p 0.131
KIN28 Kin28p 0.125
RLF2 Rlf2p 0.125
YRA1 Yra1p 0.119
SWD3 Swd3p 0.112
RPT6 Rpt6p 0.107
SPT5 Spt5p 0.107
CDC31 Cdc31p 0.107
RPN10 Rpn10p 0.095
PSY4 Psy4p 0.092
ELC1 Elc1p 0.092
RPN2 Rpn2p 0.088
SNF5 Snf5p 0.088
APN1 Apn1p 0.086
NTG1 Ntg1p 0.084
BYE1 Bye1p 0.083
THO2 Tho2p 0.080
MFT1 Mft1p 0.080
RFC1 Rfc1p 0.079
RAD17 Rad17p 0.079
TEL1 Tel1p 0.077
CKB2 Ckb2p 0.076
MSI1 Msi1p 0.076
TFG1 Tfg1p 0.073
DNA2 Dna2p 0.067
MMS1 Mms1p 0.066
POB3 Pob3p 0.064
HDA2 Hda2p 0.063
HOR2 Hor2p 0.062
ALG14 Alg14p 0.061
MUS81 Mus81p 0.060
UME1 Ume1p 0.060
RSC8 Rsc8p 0.059
RNR1 Rnr1p 0.059
BRN1 Brn1p 0.057
THP2 Thp2p 0.055
MEX67 Mex67p 0.055
LIF1 Lif1p 0.054
RAD28 Rad28p 0.051
RAD24 Rad24p 0.050
ELF1 Elf1p 0.050
KEM1 Kem1p 0.049
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
his-42 Protein HIS-42 0.015
his-6 Protein HIS-6 0.011
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mus205 mutagen-sensitive 205 0.975
mus201 mutagen-sensitive 201 0.952
mei-9 meiotic 9 0.922
Brca2 Breast cancer 2, early onset homolog 0.870
spn-A spindle A 0.799
lok loki 0.788
hay haywire 0.595
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.590
spn-B spindle B 0.582
mus101 mutagen-sensitive 101 0.559
mus308 mutagen-sensitive 308 0.545
mei-41 meiotic 41 0.497
spn-E spindle E 0.486
CG5524 CG5524 gene product from transcript CG5524-RA 0.391
His2Av Histone H2A variant 0.372
okr okra 0.366
RecQ5 homolog of RecQ 0.320
MAGE CG10059 gene product from transcript CG10059-RA 0.314
RnrL Ribonucleoside diphosphate reductase large subunit 0.309
Rpt4 CG3455 gene product from transcript CG3455-RA 0.307
nbs CG6754 gene product from transcript CG6754-RC 0.293
rad50 CG6339 gene product from transcript CG6339-RD 0.285
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.259
Rpn9 CG10230 gene product from transcript CG10230-RB 0.222
Ercc1 CG10215 gene product from transcript CG10215-RA 0.199
Irbp Inverted repeat-binding protein 0.189
Mcm7 Minichromosome maintenance 7 0.172
Tbp-1 Tat-binding protein-1 0.161
mus301 mutagen-sensitive 301 0.136
pic piccolo 0.122
Smc5 CG32438 gene product from transcript CG32438-RE 0.119
mus209 mutagen-sensitive 209 0.113
RecQ4 CG7487 gene product from transcript CG7487-RA 0.097
mus304 mutagen-sensitive 304 0.080
mus312 mutagen-sensitive 312 0.077
mago mago nashi 0.069
Mcm3 Minichromosome maintenance 3 0.068
mus309 mutagen-sensitive 309 0.067
mre11 meiotic recombination 11 0.066
Rev1 CG12189 gene product from transcript CG12189-RA 0.060
CG15220 CG15220 gene product from transcript CG15220-RA 0.050
Rpt3 CG16916 gene product from transcript CG16916-RA 0.042
east enhanced adult sensory threshold 0.041
Rpt1 CG1341 gene product from transcript CG1341-RA 0.038
Pros29 Proteasome 29kD subunit 0.036
p53 CG33336 gene product from transcript CG33336-RB 0.035
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.035
Rassf Ras association family member 0.032
alph alphabet 0.031
Tctp Translationally controlled tumor protein 0.030
CG4771 CG4771 gene product from transcript CG4771-RA 0.030
Mnn1 Menin 1 0.029
Tip60 CG6121 gene product from transcript CG6121-RA 0.028
spn-D spindle D 0.028
debcl death executioner Bcl-2 homologue 0.027
Rpn11 CG18174 gene product from transcript CG18174-RA 0.027
egg eggless 0.026
Ge-1 CG6181 gene product from transcript CG6181-RA 0.026
RpA-70 Replication Protein A 70 0.023
Ku80 CG18801 gene product from transcript CG18801-RA 0.022
Pros28.1 Proteasome 28kD subunit 1 0.022
Rat1 CG10354 gene product from transcript CG10354-RA 0.021
flfl falafel 0.021
Prosbeta3 Proteasome beta3 subunit 0.020
CDC45L CG3658 gene product from transcript CG3658-RA 0.019
stwl stonewall 0.019
CG17331 CG17331 gene product from transcript CG17331-RA 0.019
CG5384 CG5384 gene product from transcript CG5384-RA 0.018
Rpn12 CG4157 gene product from transcript CG4157-RA 0.017
Art1 Arginine methyltransferase 1 0.016
Tpr2 Tetratricopeptide repeat protein 2 0.016
Bap55 Brahma associated protein 55kD 0.015
CG18271 CG18271 gene product from transcript CG18271-RB 0.015
me31B maternal expression at 31B 0.015
CG13779 CG13779 gene product from transcript CG13779-RA 0.015
lt light 0.014
Rpn1 CG7762 gene product from transcript CG7762-RA 0.014
snf sans fille 0.014
Art4 Arginine methyltransferase 4 0.013
Nipped-B CG17704 gene product from transcript CG17704-RI 0.013
CG9772 CG9772 gene product from transcript CG9772-RB 0.013
Jafrac1 thioredoxin peroxidase 1 0.012
Spf45 CG17540 gene product from transcript CG17540-RB 0.012
Pros26 Proteasome 26kD subunit 0.012
Smg6 CG6369 gene product from transcript CG6369-RA 0.011
tefu telomere fusion 0.011
Cct5 T-complex Chaperonin 5 0.011
msl-2 male-specific lethal 2 0.011
Prosalpha5 Proteasome alpha5 subunit 0.011
imd immune deficiency 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
RPA1 replication protein A1, 70kDa 1.000
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.999
H2AFX H2A histone family, member X 0.999
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.998
BRCA1 breast cancer 1, early onset 0.997
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.995
ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) 0.994
RPA3 replication protein A3, 14kDa 0.993
CDK7 cyclin-dependent kinase 7 0.992
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 0.989
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.988
MSH6 mutS homolog 6 (E. coli) 0.987
RAD50 RAD50 homolog (S. cerevisiae) 0.987
BLM Bloom syndrome, RecQ helicase-like 0.986
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.983
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.979
ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 0.968
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.968
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 0.961
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.955
PCNA proliferating cell nuclear antigen 0.955
MDC1 mediator of DNA-damage checkpoint 1 0.951
RAD23B RAD23 homolog B (S. cerevisiae) 0.943
FANCD2 Fanconi anemia, complementation group D2 0.938
RFC1 replication factor C (activator 1) 1, 145kDa 0.937
NBN nibrin 0.935
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.932
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.914
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.908
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.892
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.892
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 0.862
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.839
TP53 tumor protein p53 0.780
MSH3 mutS homolog 3 (E. coli) 0.779
CCNH cyclin H 0.779
THOC4 THO complex 4 0.755
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.745
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.725
APLF aprataxin and PNKP like factor 0.713
MUS81 MUS81 endonuclease homolog (S. cerevisiae) 0.677
XAB2 XPA binding protein 2 0.599
EXO1 exonuclease 1 0.569
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 0.545
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 0.536
XPC xeroderma pigmentosum, complementation group C 0.486
ERCC4 excision repair cross-complementing rodent repair deficiency, complementation group 4 0.479
SMC1A structural maintenance of chromosomes 1A 0.474
POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa 0.466
MNAT1 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) 0.459
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.455
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.448
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.416
ERCC1 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) 0.413
FANCG Fanconi anemia, complementation group G 0.410
WWOX WW domain containing oxidoreductase 0.410
RPA2 replication protein A2, 32kDa 0.363
WRN Werner syndrome, RecQ helicase-like 0.346
EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.305
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.286
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.280
THOC1 THO complex 1 0.279
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.278
ATM ataxia telangiectasia mutated 0.274
EP300 E1A binding protein p300 0.260
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.251
XPA xeroderma pigmentosum, complementation group A 0.249
THOC5 THO complex 5 0.243
RAD9A RAD9 homolog A (S. pombe) 0.242
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 0.240
BRCA2 breast cancer 2, early onset 0.239
PNKP polynucleotide kinase 3'-phosphatase 0.227
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.202
THOC2 THO complex 2 0.201
HUS1 HUS1 checkpoint homolog (S. pombe) 0.191
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.189
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.176
C20orf94 chromosome 20 open reading frame 94 0.146
DDB2 damage-specific DNA binding protein 2, 48kDa 0.146
RFC2 replication factor C (activator 1) 2, 40kDa 0.144
RAD18 RAD18 homolog (S. cerevisiae) 0.143
LIG1 ligase I, DNA, ATP-dependent 0.143
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.141
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 0.117
ATR ataxia telangiectasia and Rad3 related 0.109
CHTOP chromatin target of PRMT1 0.101
KDM4A lysine (K)-specific demethylase 4A 0.101
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.096
PARP1 poly (ADP-ribose) polymerase 1 0.095
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.092
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.092
TERF2 telomeric repeat binding factor 2 0.083
RBBP5 retinoblastoma binding protein 5 0.077
TP53BP1 tumor protein p53 binding protein 1 0.077
HIST1H4A histone cluster 1, H4a 0.077
CCDC101 coiled-coil domain containing 101 0.068
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.067
KRT5 keratin 5 0.067
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.066
ERCC2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.064
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Mus musculus
Name Description Probability Func Analog Organism
Msh2 mutS homolog 2 (E. coli) 0.859
Trp53 transformation related protein 53 0.746
Timeless timeless homolog (Drosophila) 0.586
Mdm2 transformed mouse 3T3 cell double minute 2 0.527
Dnajc9 DnaJ (Hsp40) homolog, subfamily C, member 9 0.460
Atm ataxia telangiectasia mutated homolog (human) 0.437
Mdm4 transformed mouse 3T3 cell double minute 4 0.410
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.310
Xpa xeroderma pigmentosum, complementation group A 0.218
Tomm70a translocase of outer mitochondrial membrane 70 homolog A (yeast) 0.208
Rb1 retinoblastoma 1 0.175
Nf1 neurofibromatosis 1 0.124
Parp1 poly (ADP-ribose) polymerase family, member 1 0.111
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.096
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.092
Brca1 breast cancer 1 0.087
Anp32e acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.085
Hmgb1 high mobility group box 1 0.082
Foxo3 forkhead box O3 0.080
Eftud2 elongation factor Tu GTP binding domain containing 2 0.075
Ormdl1 ORM1-like 1 (S. cerevisiae) 0.071
Ewsr1 Ewing sarcoma breakpoint region 1 0.070
Nup85 nucleoporin 85 0.070
Dsg4 desmoglein 4 0.068
Ncl nucleolin 0.065
Lsm3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.062
Lsm2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.060
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.059
E2f1 E2F transcription factor 1 0.059
Rnf7 ring finger protein 7 0.058
Prmt1 protein arginine N-methyltransferase 1 0.054
Xpc xeroderma pigmentosum, complementation group C 0.052
Prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.051
Trim28 tripartite motif-containing 28 0.048
Actr6 ARP6 actin-related protein 6 homolog (yeast) 0.046
Hdac2 histone deacetylase 2 0.046
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.045
Wwox WW domain-containing oxidoreductase 0.044
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.044
Srsf9 serine/arginine-rich splicing factor 9 0.043
Dtymk deoxythymidylate kinase 0.043
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.043
Cry1 cryptochrome 1 (photolyase-like) 0.041
Tbcb tubulin folding cofactor B 0.040
Siva1 SIVA1, apoptosis-inducing factor 0.039
Srsf4 serine/arginine-rich splicing factor 4 0.039
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.039
Stk11 serine/threonine kinase 11 0.038
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.038
Tsc1 tuberous sclerosis 1 0.037
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.037
Nup188 nucleoporin 188 0.036
Rrm1 ribonucleotide reductase M1 0.036
Pole polymerase (DNA directed), epsilon 0.035
Hist1h2bm histone cluster 1, H2bm 0.033
Ints9 integrator complex subunit 9 0.033
Rttn rotatin 0.032
Rev1 REV1 homolog (S. cerevisiae) 0.032
Mapk14 mitogen-activated protein kinase 14 0.032
Wrn Werner syndrome homolog (human) 0.032
Snrnp40 small nuclear ribonucleoprotein 40 (U5) 0.031
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.030
Nup133 nucleoporin 133 0.030
Ptch1 patched homolog 1 0.029
2700029M09Rik RIKEN cDNA 2700029M09 gene 0.029
Tipin timeless interacting protein 0.029
Smarcd1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.029
2500003M10Rik RIKEN cDNA 2500003M10 gene 0.029
Gtf2h2 general transcription factor II H, polypeptide 2 0.028
Dut deoxyuridine triphosphatase 0.028
Rfc1 replication factor C (activator 1) 1 0.028
Nbn nibrin 0.027
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.027
Rnf8 ring finger protein 8 0.026
Terf1 telomeric repeat binding factor 1 0.025
Eif1ax eukaryotic translation initiation factor 1A, X-linked 0.025
Ssrp1 structure specific recognition protein 1 0.025
Psmg2 proteasome (prosome, macropain) assembly chaperone 2 0.025
Pten phosphatase and tensin homolog 0.024
Gins4 GINS complex subunit 4 (Sld5 homolog) 0.024
Smn1 survival motor neuron 1 0.024
E130303B06Rik RIKEN cDNA E130303B06 gene 0.024
Rpgrip1l Rpgrip1-like 0.024
Mlh1 mutL homolog 1 (E. coli) 0.024
Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.023
Gtl3 gene trap locus 3 0.023
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.023
Fancd2 Fanconi anemia, complementation group D2 0.023
Sae1 SUMO1 activating enzyme subunit 1 0.023
Bmi1 Bmi1 polycomb ring finger oncogene 0.023
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.023
Zfp444 zinc finger protein 444 0.023
Gmnn geminin 0.022
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.022
AI314976 expressed sequence AI314976 0.022
Ep300 E1A binding protein p300 0.022
Cdc123 cell division cycle 123 homolog (S. cerevisiae) 0.021
Mybl2 myeloblastosis oncogene-like 2 0.021
Huwe1 HECT, UBA and WWE domain containing 1 0.021
Nup107 nucleoporin 107 0.021
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Rattus norvegicus
Name Description Probability Func Analog Organism