The network for 'negative regulation of dna recombination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of dna recombination

Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination.

Name Description Probability Func Analog Organism
RAD52 Rad52p 0.020
IRC8 Irc8p 0.015
RAD1 Rad1p 0.013
MSH3 Msh3p 0.013
SNT1 Snt1p 0.011
SRS2 Srs2p 0.011
RTF1 Rtf1p 0.011
RFA1 Rfa1p 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
prg-2 Protein PRG-2 0.109
pcaf-1 Protein PCAF-1 0.051
B0035.6 Protein B0035.6 0.047
acly-2 Protein ACLY-2 0.042
rad-54 Protein RAD-54 0.031
F31C3.3 Protein F31C3.3 0.029
qns-1 Protein QNS-1 0.023
K06A5.1 Protein K06A5.1 0.022
F55A12.5 Protein F55A12.5 0.022
M01A10.1 Protein M01A10.1 0.021
glp-1 Protein GLP-1 0.021
F22B3.4 Protein F22B3.4 0.019
msh-6 Protein MSH-6 0.018
glh-4 Protein GLH-4 0.018
F28C6.4 Protein F28C6.4 0.017
tag-315 Protein TAG-315 0.015
rme-2 Protein RME-2 0.015
B0001.2 Protein B0001.2 0.014
F33H2.2 Protein F33H2.2 0.013
T23G4.3 Protein T23G4.3 0.012
ani-2 Protein ANI-2 0.012
sep-1 Protein SEP-1 0.012
F46F11.6 Protein F46F11.6 0.012
xnd-1 Protein XND-1 0.012
meg-1 Protein MEG-1 0.012
mtm-1 Protein MTM-1 0.011
mrp-7 Protein MRP-7 0.011
CELE_C36A4.5 Protein C36A4.5 0.011
F25H5.5 Protein F25H5.5 0.011
R10H10.7 Protein R10H10.7 0.011
CELE_Y57A10A.13 Protein Y57A10A.13 0.011
ztf-15 Protein ZTF-15 0.011
age-1 Protein AGE-1 0.011
htp-3 Protein HTP-3 0.010
wrn-1 Protein WRN-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
piwil1 piwi-like 1 (Drosophila) 0.904
nanos3 nanos homolog 3 0.785
fancl Fanconi anemia, complementation group L 0.778
brca2 breast cancer 2, early onset 0.437
dnd dead end 0.364
blm Bloom syndrome 0.328
rnf17 ring finger protein 17 0.303
tbpl2 TATA box binding protein like 2 0.260
vasa vasa homolog 0.239
recql5 RecQ protein-like 5 0.195
tdrd1 tudor domain containing 1 0.191
otul OTU like protein 0.177
hspb11 heat shock protein, alpha-crystallin-related, b11 0.148
msh2 mutS homolog 2 (E. coli) 0.098
zgc:193933 zgc:193933 0.092
bmpr1bb bone morphogenetic protein receptor, type 1bb 0.084
henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) 0.080
syce2 synaptonemal complex central element protein 2 0.074
zorba Orb/CPEB-related RNA-binding protein 0.070
sycp3l synaptonemal complex protein 3 like 0.067
mre11a meiotic recombination 11 homolog A (S. cerevisiae) 0.065
mlh1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.065
lsm14b LSM14B, SCD6 homolog B (S. cerevisiae) 0.055
vtg1 vitellogenin 1 0.051
setdb2 SET domain, bifurcated 2 0.050
fas Fas (TNF receptor superfamily, member 6) 0.046
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.046
buc bucky ball 0.044
ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.043
amh anti-Mullerian hormone 0.037
inppl1a inositol polyphosphate phosphatase-like 1a 0.033
tdrd7 tudor domain containing 7 0.032
asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.030
hspb2 heat shock protein, alpha-crystallin-related, b2 0.030
zgc:92648 zgc:92648 0.030
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.029
htr1aa 5-hydroxytryptamine (serotonin) receptor 1A a 0.029
zgc:66313 zgc:66313 0.026
mybl2 myeloblastosis oncogene-like 2 0.024
eomesa eomesodermin homolog a 0.023
org oogenesis-related gene 0.023
cpa4 carboxypeptidase A4 0.022
timm13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.021
epo erythropoietin 0.021
si:ch211-1n9.7 si:ch211-1n9.7 0.021
dlst dihydrolipoamide S-succinyltransferase 0.020
zgc:103482 zgc:103482 0.020
scn1a sodium channel, voltage-gated, type I, alpha 0.020
cx45.6 connexin 45.6 0.020
epb41 erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) 0.020
pho phoenix 0.018
msh6 mutS homolog 6 (E. coli) 0.017
zgc:110434 zgc:110434 0.017
setd6 SET domain containing 6 0.017
npat nuclear protein, ataxia-telangiectasia locus 0.017
trmt2a trm2 tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.016
hist2h3ca1 histone 2, H3ca1 0.016
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.016
efna2 ephrin A2 0.016
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.016
LOC555504 novel protocadherin protein 0.015
slc30a2 solute carrier family 30 (zinc transporter), member 2 0.015
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.015
lrig1 leucine-rich repeats and immunoglobulin-like domains 1 0.015
slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.015
bmpr1ba bone morphogenetic protein receptor, type 1ba 0.014
efcab7 EF-hand calcium binding domain 7 0.014
mpv17 MpV17 transgene, murine homolog, glomerulosclerosis 0.014
olig4 oligodendrocyte transcription factor 4 0.014
map3k4 mitogen activated protein kinase kinase kinase 4 0.014
rplp1 ribosomal protein, large, P1 0.014
si:ch211-150a22.1 si:ch211-150a22.1 0.013
si:dkeyp-69b9.5 si:dkeyp-69b9.5 0.013
nup88 nucleoporin 88 0.013
zgc:136925 zgc:136925 0.013
haus3 HAUS augmin-like complex, subunit 3 0.013
cutl1 cut-like 1 (Drosophila) 0.013
zgc:64119 zgc:64119 0.013
pdcd4b programmed cell death 4b 0.013
senp6a SUMO1/sentrin specific peptidase 6a 0.013
src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.012
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.012
bnc2 basonuclin 2 0.012
med24 mediator complex subunit 24 0.012
exosc8 exosome component 8 0.012
zgc:112254 zgc:112254 0.012
rspo1 R-spondin homolog (Xenopus laevis) 0.012
hspb12 heat shock protein, alpha-crystallin-related, b12 0.012
tubgcp3 tubulin, gamma complex associated protein 3 0.012
si:dkey-109n11.1 si:dkey-109n11.1 0.012
zgc:113518 zgc:113518 0.012
hsf2 heat shock factor 2 0.012
adh5 alcohol dehydrogenase 5 0.011
zgc:110137 zgc:110137 0.011
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.011
zfhx3 zinc finger homeobox 3 0.011
rrad Ras-related associated with diabetes 0.011
wdr24 WD repeat domain 24 0.011
LOC572344 hypothetical protein LOC572344 0.011
cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
spn-E spindle E 0.489
piwi CG6122 gene product from transcript CG6122-RA 0.375
okr okra 0.034
CG4771 CG4771 gene product from transcript CG4771-RA 0.031
CG5524 CG5524 gene product from transcript CG5524-RA 0.023
lok loki 0.017
Brca2 Breast cancer 2, early onset homolog 0.016
Smc5 CG32438 gene product from transcript CG32438-RE 0.016
bam bag of marbles 0.013
armi armitage 0.013
stwl stonewall 0.012
orb oo18 RNA-binding protein 0.012
swa swallow 0.011
Nup160 Nucleoporin 160 0.010
zpg zero population growth 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
MSH6 mutS homolog 6 (E. coli) 0.856
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.665
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.388
EXO1 exonuclease 1 0.113
ZNF830 zinc finger protein 830 0.088
THOC5 THO complex 5 0.058
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.055
MSH3 mutS homolog 3 (E. coli) 0.042
PNKP polynucleotide kinase 3'-phosphatase 0.035
CLSPN claspin 0.027
RAD1 RAD1 homolog (S. pombe) 0.027
RPA1 replication protein A1, 70kDa 0.024
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.022
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.019
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.018
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.018
DTL denticleless homolog (Drosophila) 0.016
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.016
SLX4 SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) 0.013
NCOR2 nuclear receptor corepressor 2 0.013
PCDH9 protocadherin 9 0.013
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.011
NCAPG non-SMC condensin I complex, subunit G 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hist1h2bc histone cluster 1, H2bc 0.101
Card11 caspase recruitment domain family, member 11 0.099
Trp53 transformation related protein 53 0.093
Gli2 GLI-Kruppel family member GLI2 0.086
Terf1 telomeric repeat binding factor 1 0.081
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.076
Tcfcp2l1 transcription factor CP2-like 1 0.056
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.053
Pou5f1 POU domain, class 5, transcription factor 1 0.043
Xpa xeroderma pigmentosum, complementation group A 0.042
Pgrmc1 progesterone receptor membrane component 1 0.041
Brca2 breast cancer 2 0.035
Igh immunoglobulin heavy chain complex 0.035
Ahr aryl-hydrocarbon receptor 0.032
Wdr75 WD repeat domain 75 0.030
Stat5a signal transducer and activator of transcription 5A 0.030
Stk11 serine/threonine kinase 11 0.027
Chd1l chromodomain helicase DNA binding protein 1-like 0.027
Itfg1 integrin alpha FG-GAP repeat containing 1 0.026
Smad4 MAD homolog 4 (Drosophila) 0.023
Foxp2 forkhead box P2 0.023
Foxp1 forkhead box P1 0.023
Rc3h1 RING CCCH (C3H) domains 1 0.021
Eri2 exoribonuclease 2 0.021
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.020
Tcra T-cell receptor alpha chain 0.020
Men1 multiple endocrine neoplasia 1 0.019
Tmem30a transmembrane protein 30A 0.019
Exosc8 exosome component 8 0.019
Nvl nuclear VCP-like 0.019
Itm2b integral membrane protein 2B 0.018
Rttn rotatin 0.018
Tpp1 tripeptidyl peptidase I 0.018
Ttc7 tetratricopeptide repeat domain 7 0.017
Orc2 origin recognition complex, subunit 2 0.017
Lrrc40 leucine rich repeat containing 40 0.016
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.016
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.015
Dhfr dihydrofolate reductase 0.015
Dsn1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) 0.015
Tsn translin 0.014
Nptn neuroplastin 0.014
Dut deoxyuridine triphosphatase 0.014
She src homology 2 domain-containing transforming protein E 0.014
Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein 0.014
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.013
C78339 expressed sequence C78339 0.013
Tnf tumor necrosis factor 0.013
Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.013
Meox2 mesenchyme homeobox 2 0.013
Cpsf3 cleavage and polyadenylation specificity factor 3 0.012
Kdm1a lysine (K)-specific demethylase 1A 0.012
Zscan4b zinc finger and SCAN domain containing 4B 0.012
Bach2 BTB and CNC homology 2 0.012
Sox18 SRY-box containing gene 18 0.012
Il4 interleukin 4 0.012
Clcc1 chloride channel CLIC-like 1 0.012
Rnf103 ring finger protein 103 0.011
Msh2 mutS homolog 2 (E. coli) 0.011
Pms2 postmeiotic segregation increased 2 (S. cerevisiae) 0.011
Tm2d2 TM2 domain containing 2 0.010
Parn poly(A)-specific ribonuclease (deadenylation nuclease) 0.010
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism