The network for 'phosphatidylinositol biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

phosphatidylinositol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GAA1 Gaa1p 0.972
LAS21 Las21p 0.911
GAB1 Gab1p 0.799
GPI17 Gpi17p 0.693
GWT1 Gwt1p 0.415
GPI16 Gpi16p 0.390
TGL1 Tgl1p 0.292
ALG6 Alg6p 0.258
GPI8 Gpi8p 0.243
OSH7 Osh7p 0.162
SLC1 Slc1p 0.152
MMF1 Mmf1p 0.139
ARV1 Arv1p 0.136
EMP24 Emp24p 0.131
MCD4 Mcd4p 0.121
CNE1 Cne1p 0.115
ACF2 Acf2p 0.106
GLO3 Glo3p 0.104
SPF1 Spf1p 0.101
ELO1 Elo1p 0.092
ERV29 Erv29p 0.089
SEC59 Sec59p 0.088
SPT14 Spt14p 0.083
YLR036C hypothetical protein 0.083
CHS7 Chs7p 0.080
PMT3 Pmt3p 0.078
YJR012C hypothetical protein 0.077
ERD2 Erd2p 0.075
ARF3 Arf3p 0.073
FIG4 Fig4p 0.070
MOB2 Mob2p 0.069
DIE2 Die2p 0.068
VPS1 Vps1p 0.066
PMT2 Pmt2p 0.061
YDR186C hypothetical protein 0.060
SNA3 Sna3p 0.059
PFA4 Pfa4p 0.059
GPI13 Gpi13p 0.058
AGE1 Age1p 0.058
CBK1 Cbk1p 0.056
GPI1 Gpi1p 0.055
CHA1 Cha1p 0.055
AXL2 Axl2p 0.054
SFB3 Sfb3p 0.054
YLR264C-A hypothetical protein 0.053
BET2 Bet2p 0.053
CDC1 Cdc1p 0.053
ADH4 Adh4p 0.052
YJR015W hypothetical protein 0.052
NEO1 Neo1p 0.052
MID1 Mid1p 0.051
MEC3 Mec3p 0.051
SRD1 Srd1p 0.051
KRE5 Kre5p 0.051
PFA5 Pfa5p 0.049
ARP10 Arp10p 0.049
BST1 Bst1p 0.049
YAE1 Yae1p 0.048
ERV25 Erv25p 0.047
GPI11 Gpi11p 0.046
GMH1 Gmh1p 0.046
ARG8 Arg8p 0.045
VPS74 Vps74p 0.045
LEU2 Leu2p 0.044
CHO1 Cho1p 0.044
RUD3 Rud3p 0.044
CNB1 Cnb1p 0.043
SSL1 Ssl1p 0.043
VPS15 Vps15p 0.043
SMP3 Smp3p 0.042
YOL038C-A hypothetical protein 0.041
MST27 Mst27p 0.040
LDB16 Ldb16p 0.040
YER186C hypothetical protein 0.039
JLP2 Jlp2p 0.039
DCR2 Dcr2p 0.039
TTI2 Tti2p 0.039
WAR1 War1p 0.039
CUP1-1 Cup1-1p 0.037
ARO10 Aro10p 0.037
SFT1 Sft1p 0.037
GPI2 Gpi2p 0.037
AVT4 Avt4p 0.037
YLR042C hypothetical protein 0.036
OPT2 Opt2p 0.036
SAP1 Sap1p 0.036
MER1 Mer1p 0.036
UTR4 Utr4p 0.035
VBA5 Vba5p 0.035
PGS1 Pgs1p 0.035
YLR162W hypothetical protein 0.034
SCM4 Scm4p 0.034
YMR122W-A hypothetical protein 0.034
CPR2 Cpr2p 0.034
AGP1 Agp1p 0.033
IZH4 Izh4p 0.033
TSC3 Tsc3p 0.033
FMT1 Fmt1p 0.033
UPS3 Ups3p 0.032
ARK1 Ark1p 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
disp1 dispatched homolog 1 (Drosophila) 0.046
satb2 SATB homeobox 2 0.029
pdgfab platelet derived growth factor alpha b 0.026
ift88 intraflagellar transport 88 homolog 0.025
jag1b jagged 1b 0.023
nkx2.3 NK2 transcription factor related 3 0.023
rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.018
chm choroideremia 0.018
foxa1 forkhead box A1 0.018
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.017
caprin2 caprin family member 2 0.015
nae1 nedd8 activating enzyme E1 subunit 1 0.015
fam20b family with sequence similarity 20, member B (H. sapiens) 0.013
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.013
ndrg1 N-myc downstream regulated gene 1 0.013
prickle2 prickle-like 2 (Drosophila) 0.012
npnt nephronectin 0.012
wnk1 WNK lysine deficient protein kinase 1 0.012
zgc:55413 zgc:55413 0.012
cul5a cullin 5a 0.012
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.012
tmprss4b transmembrane protease, serine 4b 0.011
hspb6 heat shock protein, alpha-crystallin-related, b6 0.011
efna2 ephrin A2 0.011
slc46a1 solute carrier family 46, member 1 0.010
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.010
atxn7l2a ataxin 7-like 2a 0.010
vamp4 vesicle-associated membrane protein 4 0.010
mitd1 MIT, microtubule interacting and transport, domain containing 1 0.010
tas2r200.1 taste receptor, type 2, member 200.1 0.010
crb2a crumbs homolog 2a 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.960
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.811
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.623
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.486
GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) 0.483
FGFR2 fibroblast growth factor receptor 2 0.469
FGFR1 fibroblast growth factor receptor 1 0.381
NOS1 nitric oxide synthase 1 (neuronal) 0.297
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.266
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.207
IRS1 insulin receptor substrate 1 0.187
PLCG1 phospholipase C, gamma 1 0.183
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 0.181
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.163
CMIP c-Maf-inducing protein 0.130
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.101
NRP1 neuropilin 1 0.067
FGF10 fibroblast growth factor 10 0.062
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.059
CD9 CD9 molecule 0.056
SPAG9 sperm associated antigen 9 0.051
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.047
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.047
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.045
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 0.044
CD81 CD81 molecule 0.044
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.037
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.035
CD63 CD63 molecule 0.034
SYK spleen tyrosine kinase 0.033
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.031
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.030
GAB1 GRB2-associated binding protein 1 0.030
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.029
TSPAN4 tetraspanin 4 0.028
PTPRB protein tyrosine phosphatase, receptor type, B 0.027
BLNK B-cell linker 0.024
HSPG2 heparan sulfate proteoglycan 2 0.024
SORBS1 sorbin and SH3 domain containing 1 0.023
THBS1 thrombospondin 1 0.022
ATMIN ATM interactor 0.022
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.022
PDGFA platelet-derived growth factor alpha polypeptide 0.022
LAT linker for activation of T cells 0.022
FGF2 fibroblast growth factor 2 (basic) 0.022
PDGFC platelet derived growth factor C 0.022
FGF1 fibroblast growth factor 1 (acidic) 0.021
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.021
GRB7 growth factor receptor-bound protein 7 0.020
VAV2 vav 2 guanine nucleotide exchange factor 0.020
VAV3 vav 3 guanine nucleotide exchange factor 0.019
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.019
FGF7 fibroblast growth factor 7 0.019
GAB2 GRB2-associated binding protein 2 0.019
UVRAG UV radiation resistance associated gene 0.019
PIGS phosphatidylinositol glycan anchor biosynthesis, class S 0.019
COL6A1 collagen, type VI, alpha 1 0.018
TLR3 toll-like receptor 3 0.018
SCAND1 SCAN domain containing 1 0.018
DLG5 discs, large homolog 5 (Drosophila) 0.018
CUTA cutA divalent cation tolerance homolog (E. coli) 0.018
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.017
IPO11 importin 11 0.017
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.017
C1D C1D nuclear receptor corepressor 0.016
HPS6 Hermansky-Pudlak syndrome 6 0.016
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.016
AXL AXL receptor tyrosine kinase 0.016
CHMP2B chromatin modifying protein 2B 0.016
ALAS1 aminolevulinate, delta-, synthase 1 0.016
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.016
GSS glutathione synthetase 0.015
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.015
SH3KBP1 SH3-domain kinase binding protein 1 0.015
SEP15 15 kDa selenoprotein 0.014
FIG4 FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) 0.014
FRS2 fibroblast growth factor receptor substrate 2 0.014
DSCAML1 Down syndrome cell adhesion molecule like 1 0.014
PFDN4 prefoldin subunit 4 0.014
PTK6 PTK6 protein tyrosine kinase 6 0.014
BAI1 brain-specific angiogenesis inhibitor 1 0.014
ARRDC3 arrestin domain containing 3 0.013
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.013
INSR insulin receptor 0.013
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 0.013
SORBS3 sorbin and SH3 domain containing 3 0.012
USP16 ubiquitin specific peptidase 16 0.012
INO80B INO80 complex subunit B 0.012
C1orf9 chromosome 1 open reading frame 9 0.012
COL5A1 collagen, type V, alpha 1 0.012
SLMO2 slowmo homolog 2 (Drosophila) 0.012
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.012
NOSTRIN nitric oxide synthase trafficker 0.012
G6PC3 glucose 6 phosphatase, catalytic, 3 0.012
CD99 CD99 molecule 0.012
NME3 non-metastatic cells 3, protein expressed in 0.012
BCAS2 breast carcinoma amplified sequence 2 0.012
ERRFI1 ERBB receptor feedback inhibitor 1 0.012
CD28 CD28 molecule 0.012
SNRNP27 small nuclear ribonucleoprotein 27kDa (U4/U6.U5) 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.949
Gab1 growth factor receptor bound protein 2-associated protein 1 0.491
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.444
Btk Bruton agammaglobulinemia tyrosine kinase 0.347
Dok1 docking protein 1 0.281
Cbl Casitas B-lineage lymphoma 0.242
Pten phosphatase and tensin homolog 0.223
Grb2 growth factor receptor bound protein 2 0.214
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.202
Mdm2 transformed mouse 3T3 cell double minute 2 0.183
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.174
Fyn Fyn proto-oncogene 0.140
Irs1 insulin receptor substrate 1 0.129
Ep300 E1A binding protein p300 0.116
Igh immunoglobulin heavy chain complex 0.109
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.105
Lig4 ligase IV, DNA, ATP-dependent 0.090
Cd40 CD40 antigen 0.079
Shc1 src homology 2 domain-containing transforming protein C1 0.075
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.068
Tgfbr1 transforming growth factor, beta receptor I 0.066
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.066
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.056
Tcrd T-cell receptor delta chain 0.053
Bcl6 B-cell leukemia/lymphoma 6 0.050
Notch2 Notch gene homolog 2 (Drosophila) 0.040
Parvg parvin, gamma 0.039
Nbn nibrin 0.037
Fcgr2b Fc receptor, IgG, low affinity IIb 0.032
Blnk B-cell linker 0.031
Gab2 growth factor receptor bound protein 2-associated protein 2 0.029
D15Ertd621e DNA segment, Chr 15, ERATO Doi 621, expressed 0.027
Ikzf1 IKAROS family zinc finger 1 0.027
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.026
Phlda3 pleckstrin homology-like domain, family A, member 3 0.026
Kifc3 kinesin family member C3 0.024
5730494N06Rik RIKEN cDNA 5730494N06 gene 0.023
Ptprc protein tyrosine phosphatase, receptor type, C 0.023
Kdelr1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.023
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.022
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.021
Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 0.021
B230308N11Rik RIKEN cDNA B230308N11 gene 0.020
Dok2 docking protein 2 0.020
Anapc7 anaphase promoting complex subunit 7 0.019
Pdpk1 3-phosphoinositide dependent protein kinase 1 0.019
Polr3k polymerase (RNA) III (DNA directed) polypeptide K 0.019
Slc33a1 solute carrier family 33 (acetyl-CoA transporter), member 1 0.019
Rc3h1 RING CCCH (C3H) domains 1 0.018
Brca2 breast cancer 2 0.018
Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 0.017
Fbxw7 F-box and WD-40 domain protein 7 0.017
Dynlt1b dynein light chain Tctex-type 1D 0.017
Aplp2 amyloid beta (A4) precursor-like protein 2 0.017
Met met proto-oncogene 0.017
St6galnac6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 0.016
Hook2 hook homolog 2 (Drosophila) 0.016
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.016
Dok3 docking protein 3 0.016
Pdgfc platelet-derived growth factor, C polypeptide 0.015
Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 0.015
Dnajb5 DnaJ (Hsp40) homolog, subfamily B, member 5 0.015
2310044H10Rik RIKEN cDNA 2310044H10 gene 0.015
Plcg1 phospholipase C, gamma 1 0.015
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.015
Zp2 zona pellucida glycoprotein 2 0.015
Ptgs2 prostaglandin-endoperoxide synthase 2 0.015
Prkce protein kinase C, epsilon 0.015
Slamf1 signaling lymphocytic activation molecule family member 1 0.015
9430031J16Rik RIKEN cDNA 9430031J16 gene 0.014
Gas6 growth arrest specific 6 0.014
Epas1 endothelial PAS domain protein 1 0.014
Etaa1 Ewing's tumor-associated antigen 1 0.014
Brca1 breast cancer 1 0.014
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.014
Kit kit oncogene 0.013
Atp11c ATPase, class VI, type 11C 0.013
Mapk3 mitogen-activated protein kinase 3 0.013
Sh3kbp1 SH3-domain kinase binding protein 1 0.013
Wrn Werner syndrome homolog (human) 0.013
Sorbs3 sorbin and SH3 domain containing 3 0.013
Gaa glucosidase, alpha, acid 0.013
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.013
Fbxo32 F-box protein 32 0.013
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.013
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.013
Cd22 CD22 antigen 0.012
Zfp148 zinc finger protein 148 0.012
Vegfb vascular endothelial growth factor B 0.012
Fnta farnesyltransferase, CAAX box, alpha 0.012
0610007C21Rik RIKEN cDNA 0610007C21 gene 0.012
Akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.012
Pde7a phosphodiesterase 7A 0.012
Man2c1 mannosidase, alpha, class 2C, member 1 0.012
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.012
Apln apelin 0.012
Atp5s ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s 0.012
Spry4 sprouty homolog 4 (Drosophila) 0.011
Acvr2a activin receptor IIA 0.011
Prf1 perforin 1 (pore forming protein) 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism