The network for 'negative regulation of macromolecule metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPD3 Rpd3p 0.999
SIN3 Sin3p 0.996
GLC7 Glc7p 0.991
SIR2 Sir2p 0.989
SIR4 Sir4p 0.984
HHF1 Hhf1p 0.983
RAP1 Rap1p 0.955
CTK1 Ctk1p 0.951
SNF1 Snf1p 0.949
RTF1 Rtf1p 0.934
SET1 Set1p 0.930
SSE1 Sse1p 0.930
RIF1 Rif1p 0.928
SIN4 Sin4p 0.924
HMO1 Hmo1p 0.914
CCR4 Ccr4p 0.908
HDA1 Hda1p 0.902
RXT2 Rxt2p 0.902
GAL11 Gal11p 0.897
SIR3 Sir3p 0.885
PIL1 Pil1p 0.884
FKH2 Fkh2p 0.866
HOG1 Hog1p 0.863
AFT1 Aft1p 0.854
SIC1 Sic1p 0.847
SAS2 Sas2p 0.835
ORC1 Orc1p 0.832
CTI6 Cti6p 0.830
RNR4 Rnr4p 0.821
RPN4 Rpn4p 0.819
ADR1 Adr1p 0.818
ESF1 Esf1p 0.815
CYC8 Cyc8p 0.814
SDS3 Sds3p 0.809
SUM1 Sum1p 0.792
HTB1 Htb1p 0.782
IRE1 Ire1p 0.774
RLF2 Rlf2p 0.772
ARX1 Arx1p 0.766
ZDS2 Zds2p 0.753
CDC6 Cdc6p 0.745
DPB2 Dpb2p 0.743
ASF1 Asf1p 0.742
HTZ1 Htz1p 0.737
CTF18 Ctf18p 0.730
HTB2 Htb2p 0.730
CKA2 Cka2p 0.726
STE4 Ste4p 0.724
FKH1 Fkh1p 0.720
PPH21 Pph21p 0.719
MRC1 Mrc1p 0.717
GSY2 Gsy2p 0.712
NET1 Net1p 0.706
BDF1 Bdf1p 0.702
HDA2 Hda2p 0.699
HHT1 Hht1p 0.697
BOI2 Boi2p 0.690
UBP10 Ubp10p 0.684
HCM1 Hcm1p 0.684
RRM3 Rrm3p 0.668
STB3 Stb3p 0.664
RAD9 Rad9p 0.663
DEP1 Dep1p 0.660
PUB1 Pub1p 0.658
CDC20 Cdc20p 0.654
RSC2 Rsc2p 0.643
HAT2 Hat2p 0.643
PHO23 Pho23p 0.642
ORC2 Orc2p 0.640
HAS1 Has1p 0.631
PAF1 Paf1p 0.630
RAD51 Rad51p 0.630
HFI1 Hfi1p 0.629
DHH1 Dhh1p 0.628
POL2 Pol2p 0.623
NRG1 Nrg1p 0.619
HAT1 Hat1p 0.616
SPT16 Spt16p 0.613
ORC5 Orc5p 0.607
YTA7 Yta7p 0.606
SCH9 Sch9p 0.604
ROX3 Rox3p 0.594
UBP8 Ubp8p 0.589
RGR1 Rgr1p 0.589
SLX5 Slx5p 0.588
HHO1 Hho1p 0.587
RNR2 Rnr2p 0.582
SGV1 Sgv1p 0.578
PHO85 Pho85p 0.575
SSN3 Ssn3p 0.570
SPT8 Spt8p 0.567
MUM2 Mum2p 0.567
UME1 Ume1p 0.566
HSE1 Hse1p 0.563
IFH1 Ifh1p 0.562
NTO1 Nto1p 0.557
PGD1 Pgd1p 0.541
STN1 Stn1p 0.537
UME6 Ume6p 0.536
CHL1 Chl1p 0.535
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.894
vab-3 Protein VAB-3 0.689
snr-2 Protein SNR-2 0.640
glp-1 Protein GLP-1 0.615
nhr-67 Protein NHR-67 0.591
hlh-2 Protein HLH-2 0.581
let-502 Protein LET-502 0.578
lin-53 Protein LIN-53 0.575
egl-46 Protein EGL-46 0.565
egl-27 Protein EGL-27 0.553
atn-1 Protein ATN-1 0.546
mdf-2 Protein MDF-2 0.539
csn-4 Protein CSN-4 0.517
ten-1 Protein TEN-1 0.491
cacn-1 Protein CACN-1 0.478
pal-1 Protein PAL-1 0.467
hcp-3 Protein HCP-3 0.459
pha-4 Protein PHA-4 0.459
inx-3 Protein INX-3 0.455
zyg-9 Protein ZYG-9 0.442
his-16 Protein HIS-16 0.440
abi-1 Protein ABI-1 0.433
his-45 Protein HIS-45 0.428
elt-6 Protein ELT-6 0.428
CELE_C25A1.4 Protein C25A1.4 0.427
lmn-1 Protein LMN-1 0.409
nhr-2 Protein NHR-2 0.396
pqbp-1.1 Protein PQBP-1.1 0.387
atg-2 Protein ATG-2 0.385
egl-13 Protein EGL-13 0.372
his-5 Protein HIS-5 0.343
lin-35 Protein LIN-35 0.341
imb-2 Protein IMB-2 0.334
tbb-2 Protein TBB-2 0.332
zyg-1 Protein ZYG-1 0.325
his-48 Protein HIS-48 0.324
capg-1 Protein CAPG-1 0.322
npp-4 Protein NPP-4 0.316
CELE_C17E4.6 Protein C17E4.6 0.312
klp-19 Protein KLP-19 0.312
daf-14 Protein DAF-14 0.311
lin-66 Protein LIN-66 0.310
plk-3 Protein PLK-3 0.306
par-5 Protein PAR-5 0.306
his-1 Protein HIS-1 0.306
his-46 Protein HIS-46 0.303
npp-7 Protein NPP-7 0.301
rec-8 Protein REC-8 0.298
CELE_C23G10.8 Protein C23G10.8 0.297
CELE_C24H12.5 Protein C24H12.5 0.290
R11A8.7 Protein R11A8.7 0.287
cnd-1 Protein CND-1 0.284
inx-13 Protein INX-13 0.282
hum-5 Protein HUM-5 0.282
pry-1 Protein PRY-1 0.281
dve-1 Protein DVE-1 0.276
cam-1 Protein CAM-1 0.275
daf-3 Protein DAF-3 0.275
his-52 Protein HIS-52 0.269
cids-2 Protein CIDS-2 0.265
B0336.3 Protein B0336.3 0.262
nhr-25 Protein NHR-25 0.261
mes-3 Protein MES-3 0.261
hlh-11 Protein HLH-11 0.261
F49C12.9 Protein F49C12.9 0.260
CELE_T23B5.3 Protein T23B5.3 0.257
sdz-28 Protein SDZ-28 0.257
daf-4 Protein DAF-4 0.256
htz-1 Protein HTZ-1 0.255
mcm-7 Protein MCM-7 0.250
age-1 Protein AGE-1 0.238
CELE_F19F10.9 Protein F19F10.9 0.235
lin-15A Protein LIN-15A 0.234
his-3 Protein HIS-3 0.234
ptr-14 Protein PTR-14 0.232
his-42 Protein HIS-42 0.230
cfim-2 Protein CFIM-2 0.230
nap-1 Protein NAP-1 0.230
unc-62 Protein UNC-62 0.230
F59E12.9 Protein F59E12.9 0.229
daf-1 Protein DAF-1 0.228
lin-12 Protein LIN-12 0.227
his-47 Protein HIS-47 0.226
egl-8 Protein EGL-8 0.225
his-50 Protein HIS-50 0.224
air-2 Protein AIR-2 0.223
tbx-8 Protein TBX-8 0.222
sgo-1 Protein SGO-1 0.222
mat-3 Protein MAT-3 0.221
bet-1 Protein BET-1 0.221
gld-1 Protein GLD-1 0.220
csr-1 Protein CSR-1 0.216
F55F8.9 Protein F55F8.9 0.216
hlh-1 Protein HLH-1 0.216
F25H5.5 Protein F25H5.5 0.215
nol-5 Protein NOL-5 0.213
mcm-4 Protein MCM-4 0.211
ect-2 Protein ECT-2 0.210
unc-6 Protein UNC-6 0.210
ceh-27 Protein CEH-27 0.209
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.991
fgf3 fibroblast growth factor 3 0.869
gata6 GATA-binding protein 6 0.752
gli1 GLI-Kruppel family member 1 0.669
robo3 roundabout homolog 3 0.657
etv5b ets variant 5b 0.641
spry4 sprouty (Drosophila) homolog 4 0.641
six3b sine oculis homeobox homolog 3b 0.639
cdc25 cell division cycle 25 homolog 0.569
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.549
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.545
igf1rb insulin-like growth factor 1b receptor 0.542
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.526
ndr2 nodal-related 2 0.521
runx2b runt-related transcription factor 2b 0.495
dlx5a distal-less homeobox gene 5a 0.481
dlx3b distal-less homeobox gene 3b 0.467
egr1 early growth response 1 0.455
dlx2a distal-less homeobox gene 2a 0.435
gro1 groucho 1 0.433
zff9 zinc finger protein 9 0.426
smo smoothened homolog (Drosophila) 0.418
whsc1 Wolf-Hirschhorn syndrome candidate 1 0.416
foxi1 forkhead box I1 0.390
nap1l1 nucleosome assembly protein 1, like 1 0.390
dusp6 dual specificity phosphatase 6 0.387
fzd7a frizzled homolog 7a 0.384
chd chordin 0.381
tgfb3 transforming growth factor, beta 3 0.367
her6 hairy-related 6 0.364
tfap2a transcription factor AP-2 alpha 0.362
gpia glucose phosphate isomerase a 0.361
ncl nucleolin 0.358
boc brother of CDO 0.350
pax8 paired box gene 8 0.345
ascl1a achaete-scute complex-like 1a (Drosophila) 0.340
mab21l2 mab-21-like 2 0.339
sox11b SRY-box containing gene 11b 0.338
vsx1 visual system homeobox 1 homolog, chx10-like 0.331
notch1a notch homolog 1a 0.331
six3a sine oculis homeobox homolog 3a 0.321
clock clock 0.314
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.313
wnt1 wingless-type MMTV integration site family, member 1 0.310
tal1 T-cell acute lymphocytic leukemia 1 0.306
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.306
robo1 roundabout homolog 1 0.304
otpb orthopedia homolog b 0.302
lyz lysozyme 0.301
lhx1a LIM homeobox 1a 0.300
pou1f1 POU domain, class 1, transcription factor 1 0.291
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.283
rasl11b RAS-like, family 11, member B 0.281
nadl1.1 neural adhesion molecule L1.1 0.279
robo2 roundabout homolog 2 0.278
rx3 retinal homeobox gene 3 0.265
rab11fip4a RAB11 family interacting protein 4 (class II) a 0.263
klf4 Kruppel-like factor 4 0.262
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.262
frem3 Fras1 related extracellular matrix 3 0.262
kctd15a potassium channel tetramerisation domain containing 15a 0.262
tardbp TAR DNA binding protein 0.259
flot2a flotillin 2a 0.253
pea3 ETS-domain transcription factor pea3 0.249
mecom MDS1 and EVI1 complex locus 0.248
gata5 GATA-binding protein 5 0.247
zgc:101606 zgc:101606 0.244
flh floating head 0.233
ccnd1 cyclin D1 0.231
hoxb1b homeo box B1b 0.230
jag2 jagged 2 0.229
tbx6 T-box gene 6 0.226
slit3 slit (Drosophila) homolog 3 0.225
cdh1 cadherin 1, epithelial 0.224
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.219
irx4b iroquois homeobox protein 4b 0.216
pbx1a pre-B-cell leukemia transcription factor 1a 0.214
sema3aa semaphorin 3aa 0.214
otx1b orthodenticle homolog 1b 0.213
elk4 ELK4, ETS-domain protein 0.213
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.211
cry1a cryptochrome 1a 0.209
her11 hairy-related 11 0.208
rad21 RAD21 homolog (S. pombe) 0.207
sox19a SRY-box containing gene 19a 0.205
zic1 zic family member 1 (odd-paired homolog, Drosophila) 0.205
gata4 GATA-binding protein 4 0.203
smc4 structural maintenance of chromosomes 4 0.203
sox21a SRY-box containing gene 21a 0.203
tyr tyrosinase 0.202
sox4a SRY-box containing gene 4a 0.200
hmgb1a high-mobility group box 1a 0.198
diexf digestive organ expansion factor homolog 0.196
cdh23 cadherin-like 23 0.196
fzd5 frizzled homolog 5 0.193
wt1a wilms tumor 1a 0.193
sox11a SRY-box containing gene 11a 0.191
her1 hairy-related 1 0.188
zgc:77714 zgc:77714 0.186
bmp4 bone morphogenetic protein 4 0.186
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Junb jun B proto-oncogene 0.669
Dusp1 dual specificity phosphatase 1 0.643
Errfi1 ERBB receptor feedback inhibitor 1 0.587
Dbp D site of albumin promoter (albumin D-box) binding protein 0.580
Ifitm3 interferon induced transmembrane protein 3 0.553
Nfya nuclear transcription factor-Y alpha 0.550
Eif4h eukaryotic translation initiation factor 4H 0.547
Btg2 BTG family, member 2 0.532
Met met proto-oncogene 0.495
Jun Jun oncogene 0.459
Klf9 Kruppel-like factor 9 0.405
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.399
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.399
Fos FBJ osteosarcoma oncogene 0.397
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.384
Casp2 caspase 2 0.368
Foxi2 forkhead box I2 0.346
Ppp2cb protein phosphatase 2, catalytic subunit, beta isoform 0.336
Anxa5 annexin A5 0.329
Sfrs1 splicing factor, arginine/serine-rich 1 0.321
Dynll1 dynein light chain LC8-type 1 0.320
S100a10 S100 calcium binding protein A10 0.300
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.297
Tgfbr2 transforming growth factor, beta receptor II 0.284
Adra2b adrenergic, alpha-2B-, receptor 0.277
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.277
Nrg2 neuregulin 2 0.274
Irs1 insulin receptor substrate 1 0.274
Stip1 stress-induced phosphoprotein 1 0.269
Tcfe2a transcription factor E2a 0.269
Cd9 CD9 molecule 0.266
Rhob ras homolog gene family, member B 0.266
Iapp islet amyloid polypeptide 0.262
Rest RE1-silencing transcription factor 0.254
Klf4 Kruppel-like factor 4 (gut) 0.248
Arpc1b actin related protein 2/3 complex, subunit 1B 0.248
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.245
Asgr1 asialoglycoprotein receptor 1 0.243
Ier2 immediate early response 2 0.243
Mgp matrix Gla protein 0.239
Cdk2 cyclin dependent kinase 2 0.237
Stat6 signal transducer and activator of transcription 6 0.236
Jak1 Janus kinase 1 0.235
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.235
Nfia nuclear factor I/A 0.233
Thbd thrombomodulin 0.231
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.230
Anxa4 annexin A4 0.228
Kdm6b lysine (K)-specific demethylase 6B 0.228
Sgk1 serum/glucocorticoid regulated kinase 1 0.227
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.227
Arf6 ADP-ribosylation factor 6 0.219
Adora2a adenosine A2a receptor 0.218
Slc30a1 solute carrier family 30 (zinc transporter), member 1 0.216
Hes1 hairy and enhancer of split 1 (Drosophila) 0.215
Lbr lamin B receptor 0.213
Galr3 galanin receptor 3 0.210
Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 0.210
Smad2 SMAD family member 2 0.207
Rara retinoic acid receptor, alpha 0.207
Egr1 early growth response 1 0.206
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.206
Creb1 cAMP responsive element binding protein 1 0.205
Onecut1 one cut homeobox 1 0.202
Jak2 Janus kinase 2 0.201
Gja1 gap junction protein, alpha 1 0.199
Trim47 tripartite motif-containing 47 0.197
Dchs1 dachsous 1 (Drosophila) 0.196
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.191
Ambp alpha-1-microglobulin/bikunin precursor 0.191
Tcp11 t-complex protein 11 0.190
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.190
Cdk4 cyclin-dependent kinase 4 0.187
Smad7 SMAD family member 7 0.186
Myo1b myosin Ib 0.185
Lif leukemia inhibitory factor 0.184
Smad6 SMAD family member 6 0.184
Hoxb7 homeo box B7 0.184
Dcc deleted in colorectal carcinoma 0.182
Top2a topoisomerase (DNA) II alpha 0.182
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.181
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.181
Metap2 methionyl aminopeptidase 2 0.179
Flt1 FMS-related tyrosine kinase 1 0.179
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.179
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.178
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.177
Mbl1 mannose-binding lectin (protein A) 1 0.177
Il12b interleukin 12B 0.177
Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 0.177
Nrgn neurogranin 0.176
Tcf4 transcription factor 4 0.176
Bat1 HLA-B associated transcript 1 0.175
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.174
Alx1 ALX homeobox 1 0.174
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.173
Phlda1 pleckstrin homology-like domain, family A, member 1 0.173
F2 coagulation factor II (thrombin) 0.172
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.172
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.172