The network for 'positive regulation of protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RPN4 Rpn4p 0.053
CDC16 Cdc16p 0.026
RPT6 Rpt6p 0.025
UBC13 Ubc13p 0.023
NPL4 Npl4p 0.021
RAD23 Rad23p 0.020
UBP6 Ubp6p 0.018
AFT1 Aft1p 0.017
CDC23 Cdc23p 0.017
SPT16 Spt16p 0.014
ECO1 Eco1p 0.013
CKA1 Cka1p 0.013
NBL1 Nbl1p 0.012
BNR1 Bnr1p 0.012
RPN2 Rpn2p 0.011
ECM29 Ecm29p 0.011
RIM13 Rim13p 0.011
ATG9 Atg9p 0.011
CDC34 Cdc34p 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
ima-3 Protein IMA-3 0.038
uaf-1 Protein UAF-1 0.034
spk-1 Protein SPK-1 0.034
rnr-1 Protein RNR-1 0.034
daf-4 Protein DAF-4 0.033
mex-3 Protein MEX-3 0.031
rpt-1 Protein RPT-1 0.030
pcn-1 Protein PCN-1 0.028
klp-16 Protein KLP-16 0.028
egl-18 Protein EGL-18 0.027
cam-1 Protein CAM-1 0.027
daf-21 Protein DAF-21 0.021
rpn-7 Protein RPN-7 0.021
stam-1 Protein STAM-1 0.020
lin-25 Protein LIN-25 0.018
taf-5 Protein TAF-5 0.017
eor-2 Protein EOR-2 0.016
rpn-1 Protein RPN-1 0.016
bath-42 Protein BATH-42 0.016
unc-76 Protein UNC-76 0.015
axl-1 Protein AXL-1 0.014
pqn-65 Protein PQN-65 0.014
sel-10 Protein SEL-10 0.014
C05C10.5 Protein C05C10.5 0.014
CELE_C24H12.5 Protein C24H12.5 0.012
mex-5 Protein MEX-5 0.012
sma-3 Protein SMA-3 0.012
mom-2 Protein MOM-2 0.012
hcp-2 Protein HCP-2 0.012
ubxn-4 Protein UBXN-4 0.011
nhr-100 Protein NHR-100 0.011
madf-5 Protein MADF-5 0.011
imb-2 Protein IMB-2 0.011
pry-1 Protein PRY-1 0.011
Y47D3A.29 Protein Y47D3A.29 0.011
K02A6.3 Protein K02A6.3 0.010
bar-1 Protein BAR-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tws twins 0.349
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.333
hpo hippo 0.147
l(2)k14710 lethal (2) k14710 0.146
Mad Mothers against dpp 0.138
Top1 Topoisomerase 1 0.120
RYBP Ring and YY1 Binding Protein 0.086
SF2 CG6987 gene product from transcript CG6987-RA 0.085
corto CG2530 gene product from transcript CG2530-RA 0.085
Cul-5 Cullin-5 0.085
fz2 frizzled 2 0.079
dsh dishevelled 0.077
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.072
drk downstream of receptor kinase 0.067
Mov34 CG3416 gene product from transcript CG3416-RA 0.060
rl rolled 0.057
CSN4 COP9 complex homolog subunit 4 0.055
Cul-4 Cullin-4 0.052
Ras85D Ras oncogene at 85D 0.051
Atg1 Autophagy-specific gene 1 0.051
slmb supernumerary limbs 0.045
Cbl CG7037 gene product from transcript CG7037-RB 0.044
Rpn6 Proteasome p44.5 subunit 0.043
cdc16 CG6759 gene product from transcript CG6759-RA 0.042
CG33129 CG33129 gene product from transcript CG33129-RE 0.042
dlg1 discs large 1 0.042
CG13349 CG13349 gene product from transcript CG13349-RA 0.040
tan tantalus 0.040
Fcp1 CG12252 gene product from transcript CG12252-RA 0.040
smo smoothened 0.040
cdc23 CG2508 gene product from transcript CG2508-RA 0.040
pgant3 polypeptide GalNAc transferase 3 0.039
Uba1 Ubiquitin activating enzyme 1 0.039
TER94 CG2331 gene product from transcript CG2331-RA 0.037
CG12321 CG12321 gene product from transcript CG12321-RA 0.035
fry furry 0.034
tefu telomere fusion 0.032
CkIIalpha Casein kinase II alpha subunit 0.031
cav caravaggio 0.031
Su(H) Suppressor of Hairless 0.031
UbcD2 Ubiquitin conjugating enzyme 2 0.030
InR Insulin-like receptor 0.030
mats mob as tumor suppressor 0.030
CG31998 CG31998 gene product from transcript CG31998-RA 0.029
Sulf1 Sulfated 0.029
Cenp-C CG31258 gene product from transcript CG31258-RA 0.029
AGO1 Argonaute-1 0.029
dlt discs lost 0.028
wee CG4488 gene product from transcript CG4488-RA 0.028
CG4673 CG4673 gene product from transcript CG4673-RB 0.028
cutlet CG33122 gene product from transcript CG33122-RA 0.028
Sara Smad anchor for receptor activation 0.028
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.027
CG30382 CG30382 gene product from transcript CG30382-RB 0.027
Cul-2 Cullin-2 0.026
ago archipelago 0.026
CSN1b COP9 complex homolog subunit 1 b 0.026
aux auxillin 0.026
Sbf SET domain binding factor 0.025
Vps35 Vacuolar protein sorting 35 0.025
CG1109 CG1109 gene product from transcript CG1109-RA 0.025
Ube3a Ubiquitin protein ligase E3A 0.025
Mob4 CG3403 gene product from transcript CG3403-RA 0.024
Cas CAS/CSE1 segregation protein 0.024
shtd shattered 0.023
CG5384 CG5384 gene product from transcript CG5384-RA 0.023
Ras64B Ras oncogene at 64B 0.022
dco discs overgrown 0.022
Stam Signal transducing adaptor molecule 0.021
vps2 CG14542 gene product from transcript CG14542-RA 0.021
trpml transient receptor potential mucolipin 0.021
krz kurtz 0.021
wdb widerborst 0.021
sqz squeeze 0.020
Pros54 Proteasome 54kD subunit 0.020
sec15 CG7034 gene product from transcript CG7034-RA 0.020
Dcr-2 Dicer-2 0.020
CG5798 CG5798 gene product from transcript CG5798-RA 0.020
CG33523 CG33523 gene product from transcript CG33523-RD 0.020
Akt1 CG4006 gene product from transcript CG4006-RA 0.020
G9a CG2995 gene product from transcript CG2995-RA 0.019
Rpn3 Regulatory particle non-ATPase 3 0.019
Tbp-1 Tat-binding protein-1 0.018
Elongin-B Elongin B 0.018
zfh2 Zn finger homeodomain 2 0.018
Psf2 CG18013 gene product from transcript CG18013-RA 0.018
step steppke 0.018
tai taiman 0.018
Drp1 Dynamin related protein 1 0.018
dos daughter of sevenless 0.017
Orc1 Origin recognition complex subunit 1 0.017
sw short wing 0.017
E23 Early gene at 23 0.017
l(1)G0007 lethal (1) G0007 0.017
granny-smith granny smith 0.017
Clk Clock 0.017
cta concertina 0.017
myoglianin CG1838 gene product from transcript CG1838-RD 0.017
CG9866 CG9866 gene product from transcript CG9866-RA 0.017
Klp3A Kinesin-like protein at 3A 0.017
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Homo sapiens
Name Description Probability Func Analog Organism
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.993
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.992
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.982
SMAD1 SMAD family member 1 0.969
CSNK1E casein kinase 1, epsilon 0.959
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.958
SNX9 sorting nexin 9 0.958
CREBBP CREB binding protein 0.957
SMAD2 SMAD family member 2 0.940
SMAD4 SMAD family member 4 0.931
ADAM15 ADAM metallopeptidase domain 15 0.928
SKP1 S-phase kinase-associated protein 1 0.919
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.891
SMAD3 SMAD family member 3 0.887
CUL2 cullin 2 0.886
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.836
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.829
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.820
RNF11 ring finger protein 11 0.820
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.817
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.815
ANAPC4 anaphase promoting complex subunit 4 0.783
DNM1 dynamin 1 0.750
FASLG Fas ligand (TNF superfamily, member 6) 0.743
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.729
UBC ubiquitin C 0.722
RB1 retinoblastoma 1 0.712
IL1R1 interleukin 1 receptor, type I 0.702
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.677
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.588
TRAF2 TNF receptor-associated factor 2 0.532
FKBP1A FK506 binding protein 1A, 12kDa 0.515
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.500
TRAF1 TNF receptor-associated factor 1 0.499
VHL von Hippel-Lindau tumor suppressor 0.475
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.466
TADA3 transcriptional adaptor 3 0.464
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.462
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.461
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.459
AR androgen receptor 0.453
NCF1 neutrophil cytosolic factor 1 0.434
FBXW11 F-box and WD repeat domain containing 11 0.428
ANAPC7 anaphase promoting complex subunit 7 0.413
PRNP prion protein 0.410
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.408
AXIN1 axin 1 0.396
ANAPC11 anaphase promoting complex subunit 11 0.374
CUL5 cullin 5 0.358
SMN1 survival of motor neuron 1, telomeric 0.353
PSEN1 presenilin 1 0.348
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.344
DNM2 dynamin 2 0.343
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.337
PLK1 polo-like kinase 1 0.335
IGF2R insulin-like growth factor 2 receptor 0.328
EPAS1 endothelial PAS domain protein 1 0.318
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.316
SMAD7 SMAD family member 7 0.313
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.312
TRADD TNFRSF1A-associated via death domain 0.306
SMC6 structural maintenance of chromosomes 6 0.294
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.293
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.278
ZMYND11 zinc finger, MYND-type containing 11 0.276
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.271
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.259
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.257
BMP2 bone morphogenetic protein 2 0.257
CUL1 cullin 1 0.233
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.219
CUL4A cullin 4A 0.213
EPOR erythropoietin receptor 0.210
ANAPC1 anaphase promoting complex subunit 1 0.207
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.206
CDC23 cell division cycle 23 homolog (S. cerevisiae) 0.200
COPS6 COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) 0.199
TRAF5 TNF receptor-associated factor 5 0.198
NCF2 neutrophil cytosolic factor 2 0.195
APP amyloid beta (A4) precursor protein 0.194
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.194
SNX6 sorting nexin 6 0.193
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.190
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.187
ATXN3 ataxin 3 0.187
ZNF420 zinc finger protein 420 0.185
MPDZ multiple PDZ domain protein 0.185
LRP6 low density lipoprotein receptor-related protein 6 0.182
FBXL15 F-box and leucine-rich repeat protein 15 0.170
PIAS4 protein inhibitor of activated STAT, 4 0.167
TRAF3 TNF receptor-associated factor 3 0.163
PSEN2 presenilin 2 (Alzheimer disease 4) 0.159
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.157
TGFB1 transforming growth factor, beta 1 0.152
HP haptoglobin 0.150
SYNRG synergin, gamma 0.148
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.148
ANKRD28 ankyrin repeat domain 28 0.147
SORT1 sortilin 1 0.144
CYBA cytochrome b-245, alpha polypeptide 0.144
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.996
Hif1a hypoxia inducible factor 1, alpha subunit 0.829
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.723
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.656
Axin1 axin 1 0.652
Apc adenomatosis polyposis coli 0.646
Egfr epidermal growth factor receptor 0.580
Grb2 growth factor receptor bound protein 2 0.566
Gsk3b glycogen synthase kinase 3 beta 0.557
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.512
Smad6 MAD homolog 6 (Drosophila) 0.441
Smad7 MAD homolog 7 (Drosophila) 0.434
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.383
Vangl2 vang-like 2 (van gogh, Drosophila) 0.350
Tgfbr2 transforming growth factor, beta receptor II 0.305
Shc1 src homology 2 domain-containing transforming protein C1 0.290
Prnp prion protein 0.284
Fgfr2 fibroblast growth factor receptor 2 0.248
Rbl2 retinoblastoma-like 2 0.232
Fgfr3 fibroblast growth factor receptor 3 0.201
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.200
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.196
Jag1 jagged 1 0.184
Hprt hypoxanthine guanine phosphoribosyl transferase 0.183
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.183
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.180
Stat1 signal transducer and activator of transcription 1 0.178
Efnb2 ephrin B2 0.170
Fgfr1 fibroblast growth factor receptor 1 0.170
Vegfa vascular endothelial growth factor A 0.167
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.165
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.159
Cyld cylindromatosis (turban tumor syndrome) 0.156
Akt1 thymoma viral proto-oncogene 1 0.150
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.147
Arhgef7 Rho guanine nucleotide exchange factor (GEF7) 0.141
Smo smoothened homolog (Drosophila) 0.132
Atf4 activating transcription factor 4 0.131
Bmp4 bone morphogenetic protein 4 0.131
Acvr1 activin A receptor, type 1 0.128
Trim30d tripartite motif-containing 30D 0.125
Nf1 neurofibromatosis 1 0.124
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.123
Rnf111 ring finger 111 0.123
Hhex hematopoietically expressed homeobox 0.123
Rarg retinoic acid receptor, gamma 0.123
Tbx3 T-box 3 0.122
Trp53 transformation related protein 53 0.119
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.118
Psen1 presenilin 1 0.116
Meox2 mesenchyme homeobox 2 0.115
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.114
Tgfb2 transforming growth factor, beta 2 0.111
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.108
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.108
Tlr4 toll-like receptor 4 0.106
Rnf11 ring finger protein 11 0.105
Jag2 jagged 2 0.102
Pdpk1 3-phosphoinositide dependent protein kinase 1 0.102
Eda ectodysplasin-A 0.102
Il6 interleukin 6 0.099
Gclm glutamate-cysteine ligase, modifier subunit 0.099
Clstn1 calsyntenin 1 0.098
Notch1 Notch gene homolog 1 (Drosophila) 0.096
Ccnb2 cyclin B2 0.095
Ednrb endothelin receptor type B 0.093
Stat3 signal transducer and activator of transcription 3 0.090
Pkd1 polycystic kidney disease 1 homolog 0.089
Trim30a tripartite motif-containing 30A 0.089
Bhlhe40 basic helix-loop-helix family, member e40 0.087
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.086
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.086
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.085
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.081
Skil SKI-like 0.081
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.081
App amyloid beta (A4) precursor protein 0.077
Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.074
Ehmt2 euchromatic histone lysine N-methyltransferase 2 0.073
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.073
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.072
Prkce protein kinase C, epsilon 0.072
Adam17 a disintegrin and metallopeptidase domain 17 0.071
Sox4 SRY-box containing gene 4 0.071
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.070
Adam12 a disintegrin and metallopeptidase domain 12 (meltrin alpha) 0.070
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.068
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.067
Fcgr2b Fc receptor, IgG, low affinity IIb 0.067
Nr6a1 nuclear receptor subfamily 6, group A, member 1 0.067
Mitf microphthalmia-associated transcription factor 0.064
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.063
Ptch1 patched homolog 1 0.062
Rb1 retinoblastoma 1 0.062
Cops4 COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) 0.061
Pias2 protein inhibitor of activated STAT 2 0.061
Pick1 protein interacting with C kinase 1 0.060
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.060
Nudt3 nudix (nucleotide diphosphate linked moiety X)-type motif 3 0.059
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.059
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Rattus norvegicus
Name Description Probability Func Analog Organism