The network for 'cellular macromolecule catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
POP2 Pop2p 0.999
CDC48 Cdc48p 0.998
DHH1 Dhh1p 0.983
RAD23 Rad23p 0.980
RPT6 Rpt6p 0.945
RRP6 Rrp6p 0.943
RPN10 Rpn10p 0.938
KAR2 Kar2p 0.932
NPL3 Npl3p 0.911
CAF40 Caf40p 0.902
SKI2 Ski2p 0.901
RPN12 Rpn12p 0.897
KEM1 Kem1p 0.893
RPT1 Rpt1p 0.887
RPT2 Rpt2p 0.881
BRE5 Bre5p 0.875
PRE2 Pre2p 0.872
RAD52 Rad52p 0.872
PUP1 Pup1p 0.858
PRE1 Pre1p 0.848
SKI7 Ski7p 0.846
PPH21 Pph21p 0.843
MOT2 Mot2p 0.842
PAP2 Pap2p 0.835
RPN3 Rpn3p 0.834
BCK1 Bck1p 0.833
YBP2 Ybp2p 0.819
PPH22 Pph22p 0.817
UBP6 Ubp6p 0.816
PRE10 Pre10p 0.808
FYV10 Fyv10p 0.808
RPT3 Rpt3p 0.797
CDC16 Cdc16p 0.788
RPN11 Rpn11p 0.776
HRD1 Hrd1p 0.773
SCJ1 Scj1p 0.769
UBP15 Ubp15p 0.766
SKI6 Ski6p 0.764
CTF4 Ctf4p 0.763
ECM29 Ecm29p 0.757
DOC1 Doc1p 0.752
UBR1 Ubr1p 0.744
NPL4 Npl4p 0.735
CDC23 Cdc23p 0.735
UBX3 Ubx3p 0.732
RSP5 Rsp5p 0.730
CSL4 Csl4p 0.728
CDC28 Cdc28p 0.710
RPN8 Rpn8p 0.702
PRE7 Pre7p 0.702
MAD2 Mad2p 0.698
AIR1 Air1p 0.698
PUP2 Pup2p 0.693
MCM21 Mcm21p 0.692
HRD3 Hrd3p 0.688
ELC1 Elc1p 0.685
UFD1 Ufd1p 0.684
PAT1 Pat1p 0.684
SWE1 Swe1p 0.678
RPT4 Rpt4p 0.671
LSM1 Lsm1p 0.671
VPS36 Vps36p 0.666
VPS60 Vps60p 0.664
RRP4 Rrp4p 0.664
PRE6 Pre6p 0.647
RRP46 Rrp46p 0.640
SGV1 Sgv1p 0.640
SSE2 Sse2p 0.637
OTU1 Otu1p 0.635
APC2 Apc2p 0.609
SEC7 Sec7p 0.608
CTF13 Ctf13p 0.605
CDC27 Cdc27p 0.603
UBC13 Ubc13p 0.598
DSK2 Dsk2p 0.595
DCP2 Dcp2p 0.587
MTR3 Mtr3p 0.583
WBP1 Wbp1p 0.582
PRE3 Pre3p 0.579
APC9 Apc9p 0.573
HRT1 Hrt1p 0.561
RRP43 Rrp43p 0.554
PRE4 Pre4p 0.553
DFM1 Dfm1p 0.546
MDM30 Mdm30p 0.537
SMC6 Smc6p 0.535
TIF4631 Tif4631p 0.535
RPN6 Rpn6p 0.530
YJL163C hypothetical protein 0.528
RPO21 Rpo21p 0.528
CCR4 Ccr4p 0.526
PRE9 Pre9p 0.525
RMD5 Rmd5p 0.522
SKP1 Skp1p 0.516
PRE5 Pre5p 0.507
SEM1 Sem1p 0.507
CDC53 Cdc53p 0.506
CDC26 Cdc26p 0.506
RPT5 Rpt5p 0.504
DOA4 Doa4p 0.504
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpn-12 Protein RPN-12 0.212
rpn-7 Protein RPN-7 0.194
pas-4 Protein PAS-4 0.177
rpt-2 Protein RPT-2 0.151
taf-5 Protein TAF-5 0.127
pbs-6 Protein PBS-6 0.114
atx-3 Protein ATX-3 0.111
tba-2 Protein TBA-2 0.104
imb-2 Protein IMB-2 0.101
stam-1 Protein STAM-1 0.100
rpn-6.1 Protein RPN-6.1 0.097
rad-51 Protein RAD-51 0.093
snr-2 Protein SNR-2 0.085
rpt-3 Protein RPT-3 0.082
CELE_K08F4.1 Protein K08F4.1 0.079
larp-5 Protein LARP-5 0.073
rpt-5 Protein RPT-5 0.072
pbs-1 Protein PBS-1 0.071
cul-1 Protein CUL-1 0.070
cdl-1 Protein CDL-1 0.069
pbs-5 Protein PBS-5 0.068
mig-5 Protein MIG-5 0.067
pas-6 Protein PAS-6 0.065
dpy-30 Protein DPY-30 0.062
hgrs-1 Protein HGRS-1 0.061
thoc-2 Protein THOC-2 0.061
pas-2 Protein PAS-2 0.057
npl-4.2 Protein NPL-4.2 0.057
rnr-1 Protein RNR-1 0.057
cdc-48.2 Protein CDC-48.2 0.054
T06D8.7 Protein T06D8.7 0.054
R05H5.3 Protein R05H5.3 0.053
pgl-1 Protein PGL-1 0.052
ire-1 Protein IRE-1 0.052
K08E3.5 Protein K08E3.5 0.052
him-10 Protein HIM-10 0.052
pbs-7 Protein PBS-7 0.052
rpn-3 Protein RPN-3 0.051
F46F11.6 Protein F46F11.6 0.051
ztf-7 Protein ZTF-7 0.051
npp-22 Protein NPP-22 0.051
ZC395.10 Protein ZC395.10 0.050
pas-1 Protein PAS-1 0.049
let-99 Protein LET-99 0.048
F56D2.6 Protein F56D2.6 0.046
rpt-1 Protein RPT-1 0.046
rpl-11.1 Protein RPL-11.1 0.045
smc-3 Protein SMC-3 0.045
vps-28 Protein VPS-28 0.044
mel-26 Protein MEL-26 0.044
ubxn-4 Protein UBXN-4 0.043
rsp-8 Protein RSP-8 0.043
pkc-3 Protein PKC-3 0.043
C42C1.4 Protein C42C1.4 0.043
ntl-2 Protein NTL-2 0.042
pcn-1 Protein PCN-1 0.042
adr-2 Protein ADR-2 0.042
akt-1 Protein AKT-1 0.041
Y47D3A.29 Protein Y47D3A.29 0.041
rpn-11 Protein RPN-11 0.041
R11A8.7 Protein R11A8.7 0.041
spas-1 Protein SPAS-1 0.041
pbs-3 Protein PBS-3 0.041
spn-4 Protein SPN-4 0.040
lin-23 Protein LIN-23 0.040
zen-4 Protein ZEN-4 0.040
CELE_Y57A10A.13 Protein Y57A10A.13 0.038
nap-1 Protein NAP-1 0.038
T05E8.3 Protein T05E8.3 0.038
knl-3 Protein KNL-3 0.038
rfc-2 Protein RFC-2 0.038
pap-1 Protein PAP-1 0.038
nhr-86 Protein NHR-86 0.038
htz-1 Protein HTZ-1 0.038
rps-2 Protein RPS-2 0.037
CELE_W02D7.6 Protein W02D7.6 0.036
F08B4.7 Protein F08B4.7 0.036
F25B3.6 Protein F25B3.6 0.036
hsr-9 Protein HSR-9 0.035
taf-9 Protein TAF-9 0.035
CELE_R102.5 Protein R102.5 0.035
klp-16 Protein KLP-16 0.035
gck-2 Protein GCK-2 0.035
sur-6 Protein SUR-6 0.035
pbs-4 Protein PBS-4 0.035
R12C12.6 Protein R12C12.6 0.035
lst-3 Protein LST-3 0.035
mrck-1 Protein MRCK-1 0.035
E01A2.6 Protein E01A2.6 0.035
D1007.8 Protein D1007.8 0.035
rpn-5 Protein RPN-5 0.035
F31D4.2 Protein F31D4.2 0.034
crt-1 Protein CRT-1 0.034
zyg-9 Protein ZYG-9 0.034
T27A3.2 Protein T27A3.2 0.034
asd-1 Protein ASD-1 0.034
T01D3.5 Protein T01D3.5 0.034
H14E04.2 Protein H14E04.2 0.034
rod-1 Protein ROD-1 0.034
dnj-12 Protein DNJ-12 0.034
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.583
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.498
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.477
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.390
smad5 MAD homolog 5 (Drosophila) 0.361
pcna proliferating cell nuclear antigen 0.317
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.201
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.188
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.141
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.133
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.131
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.130
rab1a RAB1A, member RAS oncogene family 0.120
ef1a elongation factor 1-alpha 0.108
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.104
ccnb1 cyclin B1 0.096
rnaset2 ribonuclease T2 0.095
syvn1 synovial apoptosis inhibitor 1, synoviolin 0.085
chuk conserved helix-loop-helix ubiquitous kinase 0.082
nasp nuclear autoantigenic sperm protein (histone-binding) 0.081
psmb7 proteasome (prosome, macropain) subunit, beta type, 7 0.080
supt6h suppressor of Ty 6 homolog 0.078
zgc:92775 zgc:92775 0.075
hspa5 heat shock protein 5 0.071
max myc-associated factor X 0.067
bsdc1 BSD domain containing 1 0.060
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.060
vcp valosin containing protein 0.059
ccna2 cyclin A2 0.059
mcts1 malignant T cell amplified sequence 1 0.058
tp53 tumor protein p53 0.056
tram1 translocating chain-associating membrane protein 1 0.056
psmb4 proteasome (prosome, macropain) subunit, beta type, 4 0.056
sap18 sin3-associated polypeptide 0.054
psmc3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.053
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.052
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.052
h2afv H2A histone family, member V 0.050
puf60b poly-U binding splicing factor b 0.048
acvr1b activin A receptor, type IB 0.044
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.044
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.043
faf2 Fas associated factor family member 2 0.042
foxo3b forkhead box O3b 0.041
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.041
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.040
smg5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.040
ncapd2 non-SMC condensin I complex, subunit D2 0.040
zgc:111944 zgc:111944 0.040
psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.039
cnn2 calponin 2 0.039
smg1 PI-3-kinase-related kinase SMG-1 0.038
ctsc cathepsin C 0.037
aurkb aurora kinase B 0.037
zgc:112254 zgc:112254 0.036
usp5 ubiquitin specific protease 5 0.036
gps1 G protein pathway suppressor 1 0.036
gro2 groucho 2 0.036
bon bonnie and clyde 0.036
tmem93 transmembrane protein 93 0.035
zgc:109901 zgc:109901 0.035
psma5 proteasome (prosome, macropain) subunit, alpha type,5 0.035
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.035
ube2na ubiquitin-conjugating enzyme E2Na 0.034
terfa telomeric repeat binding factor a 0.034
rbm4.2 RNA binding motif protein 4.2 0.034
e2f5 E2F transcription factor 5 0.033
snai1a snail homolog 1a (Drosophila) 0.033
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.033
zgc:123326 zgc:123326 0.033
smc4 structural maintenance of chromosomes 4 0.033
kif23 kinesin family member 23 0.033
LOC100330405 transmembrane protein 176B-like 0.032
psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.032
eif2c4 eukaryotic translation initiation factor 2C, 4 0.032
fancl Fanconi anemia, complementation group L 0.031
ilf2 interleukin enhancer binding factor 2 0.031
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.031
zgc:110116 zgc:110116 0.031
brca2 breast cancer 2, early onset 0.030
upf2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.028
ubin ataxin-1 ubiquitin-like interacting protein 0.028
crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.028
upf1 upf1 regulator of nonsense transcripts homolog (yeast) 0.028
ddx42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 0.027
ck2b casein kinase 2 beta 0.027
adrm1b adhesion regulating molecule 1b 0.027
wu:fb12e11 wu:fb12e11 0.027
ciapin1 cytokine induced apoptosis inhibitor 1 0.027
zgc:77817 zgc:77817 0.027
akirin2 akirin 2 0.026
smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.026
btg2 B-cell translocation gene 2 0.026
elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.026
eif1b eukaryotic translation initiation factor 1B 0.025
rlf rearranged L-myc fusion 0.025
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.025
psmc1b proteasome (prosome, macropain) 26S subunit, ATPase, 1b 0.025
smg6 Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) 0.025
ube2d2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.024
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
tefu telomere fusion 0.932
Rpt1 CG1341 gene product from transcript CG1341-RA 0.881
gwl greatwall 0.820
Prosbeta2 Proteasome beta2 subunit 0.723
AGO1 Argonaute-1 0.700
yki yorkie 0.675
Fcp1 CG12252 gene product from transcript CG12252-RA 0.648
Rpn11 CG18174 gene product from transcript CG18174-RA 0.640
p53 CG33336 gene product from transcript CG33336-RB 0.608
CycB Cyclin B 0.581
Uba1 Ubiquitin activating enzyme 1 0.578
Mov34 CG3416 gene product from transcript CG3416-RA 0.566
bel belle 0.558
cdc2 CG5363 gene product from transcript CG5363-RA 0.547
tral trailer hitch 0.490
Pros26.4 Proteasome 26S subunit subunit 4 ATPase 0.480
Rpt3 CG16916 gene product from transcript CG16916-RA 0.480
Rpn9 CG10230 gene product from transcript CG10230-RB 0.476
Rpn6 Proteasome p44.5 subunit 0.472
caz cabeza 0.470
Cul-3 Cullin-3 0.468
Rpt4 CG3455 gene product from transcript CG3455-RA 0.463
CG11347 CG11347 gene product from transcript CG11347-RE 0.445
CG13349 CG13349 gene product from transcript CG13349-RA 0.439
CycD Cyclin D 0.425
rin rasputin 0.424
CycG Cyclin G 0.419
CkIIbeta Casein kinase II beta subunit 0.416
Pros35 Proteasome 35kD subunit 0.407
Hel25E Helicase at 25E 0.405
B52 CG10851 gene product from transcript CG10851-RB 0.405
skpA CG16983 gene product from transcript CG16983-RD 0.401
UbcD2 Ubiquitin conjugating enzyme 2 0.394
poe purity of essence 0.393
Top1 Topoisomerase 1 0.392
CkIIalpha Casein kinase II alpha subunit 0.385
msps mini spindles 0.381
Cul-4 Cullin-4 0.374
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.373
Tbp-1 Tat-binding protein-1 0.369
Bj1 Bj1 protein 0.368
ago archipelago 0.364
smt3 CG4494 gene product from transcript CG4494-RA 0.364
pelo pelota 0.359
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.355
CG12321 CG12321 gene product from transcript CG12321-RA 0.348
Cap-G CG34438 gene product from transcript CG34438-RF 0.338
Cam Calmodulin 0.333
CkIalpha Casein kinase Ialpha 0.327
Prosbeta3 Proteasome beta3 subunit 0.319
lsn larsen 0.318
Tip60 CG6121 gene product from transcript CG6121-RA 0.308
sec5 CG8843 gene product from transcript CG8843-RA 0.306
spn-E spindle E 0.305
DNApol-alpha180 DNA polymerase alpha 180kD 0.304
hyd hyperplastic discs 0.299
CG17331 CG17331 gene product from transcript CG17331-RA 0.296
MED15 Mediator complex subunit 15 0.295
RhoGEF2 CG9635 gene product from transcript CG9635-RF 0.290
lqf liquid facets 0.287
Hsc70-4 Heat shock protein cognate 4 0.287
brat brain tumor 0.285
His2Av Histone H2A variant 0.282
pic piccolo 0.280
mib1 mind bomb 1 0.279
CG6854 CG6854 gene product from transcript CG6854-RC 0.277
Pros26 Proteasome 26kD subunit 0.275
mei-9 meiotic 9 0.272
Incenp Inner centromere protein 0.270
Prosbeta1 Proteasome beta1 subunit 0.269
CG8979 CG8979 gene product from transcript CG8979-RC 0.269
borr borealin-related 0.265
th thread 0.264
Rpn2 CG11888 gene product from transcript CG11888-RA 0.262
hipk homeodomain interacting protein kinase 0.261
Pros29 Proteasome 29kD subunit 0.258
CG7878 CG7878 gene product from transcript CG7878-RA 0.257
Rox8 CG5422 gene product from transcript CG5422-RD 0.253
EcR Ecdysone receptor 0.251
Sara Smad anchor for receptor activation 0.249
Rpn12 CG4157 gene product from transcript CG4157-RA 0.249
RpS20 Ribosomal protein S20 0.243
Psa Puromycin sensitive aminopeptidase 0.241
Rpn1 CG7762 gene product from transcript CG7762-RA 0.238
CG34415 CG34415 gene product from transcript CG34415-RC 0.233
swm second mitotic wave missing 0.230
Prosbeta7 Proteasome beta7 subunit 0.227
Trf2 TATA box binding protein-related factor 2 0.226
CG9576 CG9576 gene product from transcript CG9576-RA 0.215
Aos1 CG12276 gene product from transcript CG12276-RA 0.213
BRWD3 CG31132 gene product from transcript CG31132-RA 0.212
kto kohtalo 0.212
TfIIFbeta Transcription factor TFIIFbeta 0.207
CG11885 CG11885 gene product from transcript CG11885-RA 0.206
spn-B spindle B 0.201
RYBP Ring and YY1 Binding Protein 0.198
Rcd1 Reduction in Cnn dots 1 0.197
slmb supernumerary limbs 0.193
CG11486 CG11486 gene product from transcript CG11486-RG 0.189
rl rolled 0.188
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 1.000
TP53 tumor protein p53 1.000
RNF11 ring finger protein 11 1.000
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 1.000
XIAP X-linked inhibitor of apoptosis 1.000
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 1.000
SKP1 S-phase kinase-associated protein 1 1.000
VCP valosin containing protein 1.000
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1.000
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 1.000
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1.000
BRCA1 breast cancer 1, early onset 0.999
PABPC1 poly(A) binding protein, cytoplasmic 1 0.999
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.999
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.999
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.999
SKP2 S-phase kinase-associated protein 2 (p45) 0.998
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.998
CUL1 cullin 1 0.998
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.998
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.998
CUL3 cullin 3 0.997
EXOSC3 exosome component 3 0.997
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.997
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.996
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.995
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.994
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.994
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.992
HSPA8 heat shock 70kDa protein 8 0.991
SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.991
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.991
RBM8A RNA binding motif protein 8A 0.991
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.989
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.988
UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.988
BIRC2 baculoviral IAP repeat containing 2 0.987
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.985
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.985
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.981
CCNA2 cyclin A2 0.978
PTK2 PTK2 protein tyrosine kinase 2 0.974
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.974
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.973
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.973
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast) 0.972
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.972
FBXW11 F-box and WD repeat domain containing 11 0.970
EXOSC4 exosome component 4 0.965
CUL2 cullin 2 0.965
TNRC6A trinucleotide repeat containing 6A 0.963
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.963
EXOSC10 exosome component 10 0.963
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.961
ARIH2 ariadne homolog 2 (Drosophila) 0.958
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.955
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.953
ANAPC4 anaphase promoting complex subunit 4 0.952
SNX9 sorting nexin 9 0.950
BIRC3 baculoviral IAP repeat containing 3 0.950
UBE3A ubiquitin protein ligase E3A 0.947
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.945
BTRC beta-transducin repeat containing 0.941
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.941
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.939
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 0.939
QKI quaking homolog, KH domain RNA binding (mouse) 0.939
CCNB1 cyclin B1 0.938
RB1 retinoblastoma 1 0.933
VHL von Hippel-Lindau tumor suppressor 0.932
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.932
DIS3L DIS3 mitotic control homolog (S. cerevisiae)-like 0.924
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.924
RAD23B RAD23 homolog B (S. cerevisiae) 0.923
HUWE1 HECT, UBA and WWE domain containing 1 0.923
SMAD4 SMAD family member 4 0.920
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.920
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.918
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.917
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.917
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.914
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.913
POMP proteasome maturation protein 0.911
DERL1 Der1-like domain family, member 1 0.909
TNRC6C trinucleotide repeat containing 6C 0.898
TSG101 tumor susceptibility gene 101 0.897
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.896
PDCD6IP programmed cell death 6 interacting protein 0.894
TRIM39 tripartite motif containing 39 0.894
TRAF6 TNF receptor-associated factor 6 0.890
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.887
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.885
RNF111 ring finger protein 111 0.883
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.882
CDC16 cell division cycle 16 homolog (S. cerevisiae) 0.879
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.874
RNF5 ring finger protein 5 0.873
CDT1 chromatin licensing and DNA replication factor 1 0.872
UBQLN1 ubiquilin 1 0.871
FAF2 Fas associated factor family member 2 0.870
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Per2 period homolog 2 (Drosophila) 0.987
Pten phosphatase and tensin homolog 0.980
Axin1 axin 1 0.971
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.967
Gsk3b glycogen synthase kinase 3 beta 0.966
Per1 period homolog 1 (Drosophila) 0.965
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.941
Cry2 cryptochrome 2 (photolyase-like) 0.925
Vhl von Hippel-Lindau tumor suppressor 0.913
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.911
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.905
Clock circadian locomotor output cycles kaput 0.903
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.903
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.901
Thra thyroid hormone receptor alpha 0.900
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.889
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.882
Ccnb1 cyclin B1 0.878
Fgfr1 fibroblast growth factor receptor 1 0.875
Apc adenomatosis polyposis coli 0.867
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.863
Hspa5 heat shock protein 5 0.862
Smad3 MAD homolog 3 (Drosophila) 0.861
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.860
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.856
Pias1 protein inhibitor of activated STAT 1 0.846
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.831
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.810
Ncoa3 nuclear receptor coactivator 3 0.788
Traf6 TNF receptor-associated factor 6 0.786
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.785
Adrm1 adhesion regulating molecule 1 0.782
Cdk1 cyclin-dependent kinase 1 0.781
Brca1 breast cancer 1 0.778
Bcl2 B-cell leukemia/lymphoma 2 0.777
Rc3h1 RING CCCH (C3H) domains 1 0.769
Cyld cylindromatosis (turban tumor syndrome) 0.759
Psma6 proteasome (prosome, macropain) subunit, alpha type 6 0.752
Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 0.730
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.726
Usp9x ubiquitin specific peptidase 9, X chromosome 0.718
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.713
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.703
Cul3 cullin 3 0.702
Ccndbp1 cyclin D-type binding-protein 1 0.672
Psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.664
Brca2 breast cancer 2 0.664
Pax8 paired box gene 8 0.653
C330027C09Rik RIKEN cDNA C330027C09 gene 0.652
Cdk4 cyclin-dependent kinase 4 0.640
Smad4 MAD homolog 4 (Drosophila) 0.633
Mcl1 myeloid cell leukemia sequence 1 0.630
Vcp valosin containing protein 0.630
Ncapg2 non-SMC condensin II complex, subunit G2 0.622
Smad7 MAD homolog 7 (Drosophila) 0.618
Ube2n ubiquitin-conjugating enzyme E2N 0.618
Plin1 perilipin 1 0.611
Insr insulin receptor 0.610
Ect2 ect2 oncogene 0.607
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.606
Hdac6 histone deacetylase 6 0.604
Egr2 early growth response 2 0.599
Lrp6 low density lipoprotein receptor-related protein 6 0.598
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.598
Rbl2 retinoblastoma-like 2 0.590
Ccne1 cyclin E1 0.586
Mdm2 transformed mouse 3T3 cell double minute 2 0.576
Ncstn nicastrin 0.573
Manf mesencephalic astrocyte-derived neurotrophic factor 0.566
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.562
Hells helicase, lymphoid specific 0.555
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.552
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.548
Ptch1 patched homolog 1 0.548
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.546
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.544
Skil SKI-like 0.540
Skp1a S-phase kinase-associated protein 1A 0.537
Ranbp9 RAN binding protein 9 0.534
Tbcb tubulin folding cofactor B 0.533
Ran RAN, member RAS oncogene family 0.529
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 0.529
Ulk2 Unc-51 like kinase 2 (C. elegans) 0.520
Rb1 retinoblastoma 1 0.516
Psme2 proteasome (prosome, macropain) 28 subunit, beta 0.510
Creld2 cysteine-rich with EGF-like domains 2 0.509
Pkn2 protein kinase N2 0.503
Csnk1e casein kinase 1, epsilon 0.490
Stat3 signal transducer and activator of transcription 3 0.487
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.484
Setdb1 SET domain, bifurcated 1 0.474
Apoe apolipoprotein E 0.467
Pomp proteasome maturation protein 0.465
G2e3 G2/M-phase specific E3 ubiquitin ligase 0.463
Dyrk1a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a 0.460
Wdr26 WD repeat domain 26 0.458
2610039C10Rik RIKEN cDNA 2610039C10 gene 0.455
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.453
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.638
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.629
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.497
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.444
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.337
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.297
Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.292
Psme2 proteasome (prosome, macropain) activator subunit 2 0.285
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.273
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.243
Hspd1 heat shock protein 1 (chaperonin) 0.217
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.214
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.191
Calr calreticulin 0.175
Nsfl1c NSFL1 (p97) cofactor (p47) 0.167
Psma4 proteasome (prosome, macropain) subunit, alpha type 4 0.157
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.157
Manf mesencephalic astrocyte-derived neurotrophic factor 0.148
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.136
Stip1 stress-induced phosphoprotein 1 0.135
Creld2 cysteine-rich with EGF-like domains 2 0.134
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.128
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.116
Egr1 early growth response 1 0.112
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.111
Oaz1 ornithine decarboxylase antizyme 1 0.104
Eef2 eukaryotic translation elongation factor 2 0.100
Psmb7 proteasome (prosome, macropain) subunit, beta type 7 0.098
Hspa5 heat shock protein 5 0.098
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.095
Hsph1 heat shock 105/110 protein 1 0.094
Psmb2 proteasome (prosome, macropain) subunit, beta type 2 0.084
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.082
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.081
Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.077
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.076
Psma1 proteasome (prosome, macropain) subunit, alpha type 1 0.073
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.071
Psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.070
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.069
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.068
Pdia4 protein disulfide isomerase family A, member 4 0.068
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.064
Btg1 B-cell translocation gene 1, anti-proliferative 0.062
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.059
Psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.059
Hist1h1a histone cluster 1, H1a 0.057
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.054
Junb jun B proto-oncogene 0.052
Csnk1d casein kinase 1, delta 0.052
Spcs2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.051
Fos FBJ osteosarcoma oncogene 0.051
Ccnb1 cyclin B1 0.050
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.050
Canx calnexin 0.048
Tollip toll interacting protein 0.048
Plk1 polo-like kinase 1 (Drosophila) 0.048
Vcp valosin-containing protein 0.047
Txnl1 thioredoxin-like 1 0.045
Psmd5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.044
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.042
Psap prosaposin 0.042
Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.042
Taok1 TAO kinase 1 0.041
Dnajb9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.041
Psmd14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.040
Rpn1 ribophorin I 0.040
Hk1 hexokinase 1 0.039
Cand1 cullin-associated and neddylation-dissociated 1 0.038
Caprin1 cell cycle associated protein 1 0.037
Shank2 SH3 and multiple ankyrin repeat domains 2 0.037
Usp19 ubiquitin specific peptidase 19 0.037
Dnajc5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.036
Gja1 gap junction protein, alpha 1 0.035
Cct3 chaperonin containing Tcp1, subunit 3 (gamma) 0.034
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.033
Papola poly (A) polymerase alpha 0.033
Pdia6 protein disulfide isomerase family A, member 6 0.033
Dlg3 discs, large homolog 3 (Drosophila) 0.033
Psmb5 proteasome (prosome, macropain) subunit, beta type 5 0.033
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.032
Cyr61 cysteine-rich, angiogenic inducer, 61 0.031
Akt1s1 AKT1 substrate 1 (proline-rich) 0.031
Eif4h eukaryotic translation initiation factor 4H 0.030
Rab21 RAB21, member RAS oncogene family 0.030
Zfand5 zinc finger, AN1-type domain 5 0.030
Snd1 staphylococcal nuclease and tudor domain containing 1 0.030
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.029
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.029
Alkbh5 alkB, alkylation repair homolog 5 (E. coli) 0.029
Acyp2 acylphosphatase 2, muscle type 0.029
Lin7c lin-7 homolog C (C. elegans) 0.028
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.028
Psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.028
Phax phosphorylated adaptor for RNA export 0.028
Usp47 ubiquitin specific peptidase 47 0.027
Troap trophinin associated protein 0.027
Ier2 immediate early response 2 0.027
Rab5a RAB5A, member RAS oncogene family 0.027
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.027