The network for 'positive regulation of gene expression' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
SNF1 Snf1p 0.969
CHD1 Chd1p 0.963
GLN3 Gln3p 0.961
SWI6 Swi6p 0.958
YAP1 Yap1p 0.924
RPD3 Rpd3p 0.918
RTG3 Rtg3p 0.917
SPT15 Spt15p 0.912
RTF1 Rtf1p 0.911
CTR9 Ctr9p 0.897
HOG1 Hog1p 0.886
GAL11 Gal11p 0.869
SRB4 Srb4p 0.868
YAK1 Yak1p 0.863
ARP9 Arp9p 0.861
SNF6 Snf6p 0.852
UTP22 Utp22p 0.848
RGR1 Rgr1p 0.843
TAF14 Taf14p 0.825
MSN2 Msn2p 0.823
UBP6 Ubp6p 0.815
SWI1 Swi1p 0.809
SNF2 Snf2p 0.797
ADA2 Ada2p 0.780
RIM101 Rim101p 0.758
RPT6 Rpt6p 0.754
MOT2 Mot2p 0.734
CTK3 Ctk3p 0.730
MET4 Met4p 0.725
HAP5 Hap5p 0.725
SET2 Set2p 0.716
SNF5 Snf5p 0.712
CYC8 Cyc8p 0.709
HMO1 Hmo1p 0.707
MKS1 Mks1p 0.701
RXT2 Rxt2p 0.688
GAL4 Gal4p 0.684
CTK1 Ctk1p 0.681
SRB2 Srb2p 0.680
URE2 Ure2p 0.673
RIM1 Rim1p 0.669
LEU3 Leu3p 0.668
FKH1 Fkh1p 0.666
LSM1 Lsm1p 0.665
CDC39 Cdc39p 0.661
MSN4 Msn4p 0.660
ARG81 Arg81p 0.658
KSS1 Kss1p 0.651
HHT1 Hht1p 0.637
CLB5 Clb5p 0.629
MED6 Med6p 0.623
MED2 Med2p 0.620
CSE2 Cse2p 0.617
MIG1 Mig1p 0.613
MUM2 Mum2p 0.609
CDC28 Cdc28p 0.601
GIS1 Gis1p 0.598
SPT8 Spt8p 0.592
RAP1 Rap1p 0.590
HSP78 Hsp78p 0.589
RAD23 Rad23p 0.587
MSN1 Msn1p 0.586
SKN7 Skn7p 0.575
TUP1 Tup1p 0.572
SPT5 Spt5p 0.556
CKA2 Cka2p 0.554
PHO23 Pho23p 0.554
SAP185 Sap185p 0.553
GCN5 Gcn5p 0.544
NRG1 Nrg1p 0.544
PAF1 Paf1p 0.543
SRB5 Srb5p 0.536
SPT16 Spt16p 0.532
MED8 Med8p 0.529
HDA2 Hda2p 0.528
DCP2 Dcp2p 0.525
SDS3 Sds3p 0.520
MED1 Med1p 0.520
SIN3 Sin3p 0.519
ROX3 Rox3p 0.515
SWI3 Swi3p 0.512
SAP30 Sap30p 0.503
AFT1 Aft1p 0.494
NUT2 Nut2p 0.492
RTG1 Rtg1p 0.490
CRZ1 Crz1p 0.489
KCS1 Kcs1p 0.489
SGF73 Sgf73p 0.482
PGD1 Pgd1p 0.479
MDS3 Mds3p 0.478
PIP2 Pip2p 0.476
NOT5 Not5p 0.473
DEF1 Def1p 0.472
RPN4 Rpn4p 0.472
BTN2 Btn2p 0.471
PBS2 Pbs2p 0.468
HTA1 Hta1p 0.465
DOT6 Dot6p 0.465
MSG5 Msg5p 0.461
UGP1 Ugp1p 0.460
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
vab-3 Protein VAB-3 0.997
pha-4 Protein PHA-4 0.996
egl-18 Protein EGL-18 0.996
elt-6 Protein ELT-6 0.982
egl-13 Protein EGL-13 0.976
zip-7 Protein ZIP-7 0.920
nhr-67 Protein NHR-67 0.919
fkh-2 Protein FKH-2 0.908
hlh-2 Protein HLH-2 0.862
eya-1 Protein EYA-1 0.833
tag-298 Protein TAG-298 0.825
lst-3 Protein LST-3 0.801
lin-36 Protein LIN-36 0.790
unc-62 Protein UNC-62 0.773
hbl-1 Protein HBL-1 0.754
pry-1 Protein PRY-1 0.746
soc-2 Protein SOC-2 0.718
gei-4 Protein GEI-4 0.705
egl-46 Protein EGL-46 0.667
lin-17 Protein LIN-17 0.664
cam-1 Protein CAM-1 0.616
his-31 Protein HIS-31 0.611
nhr-49 Protein NHR-49 0.604
sas-5 Protein SAS-5 0.599
his-1 Protein HIS-1 0.598
alg-2 Protein ALG-2 0.597
rad-26 Protein RAD-26 0.587
tax-4 Protein TAX-4 0.579
pbrm-1 Protein PBRM-1 0.578
mat-3 Protein MAT-3 0.548
bar-1 Protein BAR-1 0.543
ceh-20 Protein CEH-20 0.540
lin-12 Protein LIN-12 0.516
unc-42 Protein UNC-42 0.516
flt-1 Protein FLT-1 0.500
sel-10 Protein SEL-10 0.490
nhr-6 Protein NHR-6 0.482
unc-40 Protein UNC-40 0.472
apr-1 Protein APR-1 0.444
swsn-4 Protein SWSN-4 0.444
ced-9 Protein CED-9 0.443
lsy-2 Protein LSY-2 0.442
unc-86 Protein UNC-86 0.435
cacn-1 Protein CACN-1 0.433
T28F4.1 Protein T28F4.1 0.421
zyg-1 Protein ZYG-1 0.420
F33H1.4 Protein F33H1.4 0.415
mig-5 Protein MIG-5 0.415
attf-2 Protein ATTF-2 0.403
ztf-2 Protein ZTF-2 0.398
hrp-1 Protein HRP-1 0.394
ten-1 Protein TEN-1 0.393
daf-3 Protein DAF-3 0.389
unc-73 Protein UNC-73 0.386
his-5 Protein HIS-5 0.381
cnd-1 Protein CND-1 0.372
daf-1 Protein DAF-1 0.370
abi-1 Protein ABI-1 0.361
sax-3 Protein SAX-3 0.360
mab-31 Protein MAB-31 0.360
skp-1 Protein SKP-1 0.359
hnd-1 Protein HND-1 0.358
pop-1 Protein POP-1 0.351
ain-1 Protein AIN-1 0.347
mls-2 Protein MLS-2 0.343
F53F10.2 Protein F53F10.2 0.342
his-64 Protein HIS-64 0.333
pdfr-1 Protein PDFR-1 0.333
CELE_C17E4.6 Protein C17E4.6 0.329
ceh-27 Protein CEH-27 0.326
daf-12 Protein DAF-12 0.326
set-16 Protein SET-16 0.326
gon-4 Protein GON-4 0.321
pac-1 Protein PAC-1 0.320
vab-1 Protein VAB-1 0.317
atgp-1 Protein ATGP-1 0.313
his-46 Protein HIS-46 0.305
pes-1 Protein PES-1 0.304
cfim-2 Protein CFIM-2 0.296
polq-1 Protein POLQ-1 0.295
unc-26 Protein UNC-26 0.290
aap-1 Protein AAP-1 0.289
tag-124 Protein TAG-124 0.288
zfp-3 Protein ZFP-3 0.286
egl-44 Protein EGL-44 0.285
fox-1 Protein FOX-1 0.285
kin-10 Protein KIN-10 0.281
hif-1 Protein HIF-1 0.279
sas-4 Protein SAS-4 0.278
R11A8.7 Protein R11A8.7 0.277
tbx-8 Protein TBX-8 0.275
apl-1 Protein APL-1 0.273
nhr-69 Protein NHR-69 0.273
saeg-1 Protein SAEG-1 0.262
thoc-1 Protein THOC-1 0.261
mdt-8 Protein MDT-8 0.260
lin-35 Protein LIN-35 0.260
pax-3 Protein PAX-3 0.260
rps-2 Protein RPS-2 0.257
CELE_ZK337.2 Protein ZK337.2 0.254
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Danio rerio
Name Description Probability Func Analog Organism
shha sonic hedgehog a 0.998
nkx2.2a NK2 transcription factor related 2a 0.984
tal1 T-cell acute lymphocytic leukemia 1 0.981
hoxb1b homeo box B1b 0.950
dlx5a distal-less homeobox gene 5a 0.932
isl1 islet1 0.900
myod1 myogenic differentiation 1 0.894
bmp2b bone morphogenetic protein 2b 0.893
notch1a notch homolog 1a 0.881
tbx20 T-box 20 0.868
six3a sine oculis homeobox homolog 3a 0.866
fgf8a fibroblast growth factor 8 a 0.865
dlx3b distal-less homeobox gene 3b 0.860
pcna proliferating cell nuclear antigen 0.845
bmp4 bone morphogenetic protein 4 0.839
etv2 ets variant gene 2 0.835
crabp2a cellular retinoic acid binding protein 2, a 0.825
egr2b early growth response 2b 0.819
kdrl kinase insert domain receptor like 0.817
fezf2 FEZ family zinc finger 2 0.796
gli1 GLI-Kruppel family member 1 0.779
runx2b runt-related transcription factor 2b 0.776
pitx3 paired-like homeodomain transcription factor 3 0.775
foxa2 forkhead box A2 0.756
tbx1 T-box 1 0.755
eya1 eyes absent homolog 1 0.751
cmyb transcription factor cmyb 0.740
dlx2a distal-less homeobox gene 2a 0.716
pax8 paired box gene 8 0.714
otpb orthopedia homolog b 0.694
pitx2 paired-like homeodomain transcription factor 2 0.694
egr1 early growth response 1 0.679
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.655
hnf1ba HNF1 homeobox Ba 0.655
dlc deltaC 0.653
lhx1a LIM homeobox 1a 0.643
prl prolactin 0.620
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.613
esr1 estrogen receptor 1 0.613
spry4 sprouty (Drosophila) homolog 4 0.611
flh floating head 0.595
mespb mesoderm posterior b 0.593
evx1 even-skipped homeobox 1 0.591
mapk1 mitogen-activated protein kinase 1 0.588
pax2a paired box gene 2a 0.586
foxi1 forkhead box I1 0.581
sox2 SRY-box containing gene 2 0.581
klf4 Kruppel-like factor 4 0.577
irx4b iroquois homeobox protein 4b 0.577
lft1 lefty1 0.564
hand2 heart and neural crest derivatives expressed transcript 2 0.558
tbx16 T-box gene 16 0.554
axin2 axin 2 (conductin, axil) 0.547
epha4a eph receptor A4a 0.543
gata3 GATA-binding protein 3 0.540
raraa retinoic acid receptor, alpha a 0.534
pou3f2 POU class 3 homeobox 2 0.534
col2a1a collagen type II, alpha-1a 0.530
mespa mesoderm posterior a 0.525
fn1 fibronectin 1 0.521
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.506
foxp2 forkhead box P2 0.488
jag2 jagged 2 0.487
sox3 SRY-box containing gene 3 0.485
lhx5 LIM homeobox 5 0.481
osr1 odd-skipped related 1 (Drosophila) 0.475
tp53 tumor protein p53 0.470
tll1 tolloid-like 1 0.470
dla deltaA 0.468
hoxb3a homeo box B3a 0.466
her7 hairy and enhancer of split related-7 0.466
chd chordin 0.461
pax7a paired box gene 7a 0.460
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.459
dlb deltaB 0.426
pcdh8 protocadherin 8 0.421
myf5 myogenic factor 5 0.417
eng1b engrailed 1b 0.416
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.413
cdx4 caudal type homeo box transcription factor 4 0.407
sox9b SRY-box containing gene 9b 0.402
tfap2a transcription factor AP-2 alpha 0.399
wt1a wilms tumor 1a 0.399
thrb thyroid hormone receptor beta 0.395
sim2 single-minded homolog 2 (Drosophila) 0.391
foxn4 forkhead box N4 0.390
ndr2 nodal-related 2 0.390
sox7 SRY-box containing gene 7 0.386
gbx2 gastrulation brain homeo box 2 0.383
hmx3 homeo box (H6 family) 3 0.381
hoxa9a homeo box A9a 0.377
barhl2 BarH-like 2 0.377
meis3 myeloid ecotropic viral integration site 3 0.376
hoxd13a homeo box D13a 0.373
irx7 iroquois homeobox protein 7 0.372
fgfr2 fibroblast growth factor receptor 2 0.365
twist1a twist1a 0.365
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.353
tshb thyroid stimulating hormone, beta subunit 0.352
otpa orthopedia homolog a 0.349
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ci cubitus interruptus 0.997
InR Insulin-like receptor 0.996
wg wingless 0.996
cnc cap-n-collar 0.995
Ubx Ultrabithorax 0.995
Snr1 Snf5-related 1 0.994
Akt1 CG4006 gene product from transcript CG4006-RA 0.992
eyg eyegone 0.991
lola longitudinals lacking 0.990
slmb supernumerary limbs 0.990
MED15 Mediator complex subunit 15 0.988
pan pangolin 0.983
Moe Moesin 0.977
osa CG7467 gene product from transcript CG7467-RD 0.975
Antp Antennapedia 0.974
mor moira 0.973
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.951
Fmr1 CG6203 gene product from transcript CG6203-RC 0.949
trx trithorax 0.946
sd scalloped 0.941
pb proboscipedia 0.938
eya eyes absent 0.933
slp1 sloppy paired 1 0.931
dco discs overgrown 0.930
Ser Serrate 0.929
hep hemipterous 0.925
CG4699 CG4699 gene product from transcript CG4699-RJ 0.922
kis kismet 0.918
eIF-4a Eukaryotic initiation factor 4a 0.913
CtBP C-terminal Binding Protein 0.906
heph hephaestus 0.905
shn schnurri 0.899
ash2 absent, small, or homeotic discs 2 0.896
amos absent MD neurons and olfactory sensilla 0.895
Mef2 Myocyte enhancer factor 2 0.893
dap dacapo 0.891
salm spalt major 0.889
Tor Target of rapamycin 0.885
elav embryonic lethal abnormal vision 0.881
Nrg Neuroglian 0.875
Pcaf CG4107 gene product from transcript CG4107-RA 0.875
e(y)3 enhancer of yellow 3 0.873
CkIIalpha Casein kinase II alpha subunit 0.869
Med Medea 0.867
bel belle 0.865
ss spineless 0.864
dsh dishevelled 0.861
brm brahma 0.857
aop anterior open 0.853
tral trailer hitch 0.853
fru fruitless 0.845
lwr lesswright 0.845
klu klumpfuss 0.842
jing CG9397 gene product from transcript CG9397-RI 0.834
pic piccolo 0.828
kay kayak 0.824
mys myospheroid 0.824
run runt 0.823
ey eyeless 0.820
byn brachyenteron 0.818
Rac1 CG2248 gene product from transcript CG2248-RA 0.818
Sos Son of sevenless 0.814
dsx doublesex 0.813
bcd bicoid 0.811
Chi Chip 0.809
Pc Polycomb 0.808
Tak1 TGF-beta activated kinase 1 0.806
Cp190 Centrosomal protein 190kD 0.806
nmo nemo 0.805
foxo forkhead box, sub-group O 0.805
cact cactus 0.800
eve even skipped 0.799
SoxN SoxNeuro 0.786
tin tinman 0.785
Tl Toll 0.783
Tollo CG6890 gene product from transcript CG6890-RA 0.783
hth homothorax 0.781
z zeste 0.777
Kr Kruppel 0.775
Mad Mothers against dpp 0.775
CTCF CG8591 gene product from transcript CG8591-RA 0.773
phl pole hole 0.770
mib1 mind bomb 1 0.768
hb hunchback 0.764
svp seven up 0.762
gsb gooseberry 0.753
noi noisette 0.749
east enhanced adult sensory threshold 0.745
HLHm7 E(spl) region transcript m7 0.742
Pp2B-14D Protein phosphatase 2B at 14D 0.741
fz frizzled 0.741
spen split ends 0.741
ara araucan 0.736
bin biniou 0.732
exd extradenticle 0.724
slou slouch 0.724
hkb huckebein 0.714
shot short stop 0.707
betaTub56D beta-Tubulin at 56D 0.704
CG11347 CG11347 gene product from transcript CG11347-RE 0.702
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nfib nuclear factor I/B 0.729
Tgfbr2 transforming growth factor, beta receptor II 0.686
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.658
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.633
Dusp1 dual specificity phosphatase 1 0.618
Fgfr2 fibroblast growth factor receptor 2 0.616
Hoxd3 homeo box D3 0.578
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.573
Fgfr1 Fibroblast growth factor receptor 1 0.557
Junb jun B proto-oncogene 0.526
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.500
Fos FBJ osteosarcoma oncogene 0.467
Adam10 ADAM metallopeptidase domain 10 0.446
Bmp6 bone morphogenetic protein 6 0.425
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.417
Zfp36 zinc finger protein 36 0.406
Hoxb7 homeo box B7 0.402
Slit3 slit homolog 3 (Drosophila) 0.389
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.385
Shox2 short stature homeobox 2 0.381
Ccdc49 coiled-coil domain containing 49 0.374
Jak2 Janus kinase 2 0.373
Tcfe2a transcription factor E2a 0.357
Nkx2-1 NK2 homeobox 1 0.353
Foxe3 forkhead box E3 0.348
Crebbp CREB binding protein 0.345
Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 0.339
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.332
Phf12 PHD finger protein 12 0.323
Map3k3 mitogen activated protein kinase kinase kinase 3 0.321
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.316
Dll3 delta-like 3 (Drosophila) 0.315
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.313
Oxtr oxytocin receptor 0.313
Sox17 SRY (sex determining region Y)-box 17 0.307
Met met proto-oncogene 0.305
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.298
Hand2 heart and neural crest derivatives expressed 2 0.297
Casp2 caspase 2 0.296
Usf2 upstream transcription factor 2, c-fos interacting 0.295
Eef2 eukaryotic translation elongation factor 2 0.293
Foxd3 forkhead box D3 0.293
Ubtf upstream binding transcription factor, RNA polymerase I 0.289
Chat choline acetyltransferase 0.280
Ptprk protein tyrosine phosphatase, receptor type, K, extracellular region 0.280
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.280
Foxi2 forkhead box I2 0.279
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.276
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.274
Klf6 Kruppel-like factor 6 0.274
P2rx3 purinergic receptor P2X, ligand-gated ion channel, 3 0.271
Sorbs3 sorbin and SH3 domain containing 3 0.270
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) 0.268
Mprip myosin phosphatase Rho interacting protein 0.267
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.266
Mrgprf MAS-related GPR, member F 0.260
Csda cold shock domain protein A 0.259
Tra2b transformer 2 beta homolog (Drosophila) 0.256
Nr1d1 nuclear receptor subfamily 1, group D, member 1 0.256
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.255
Lgals2 lectin, galactoside-binding, soluble, 2 0.254
Smad1 SMAD family member 1 0.253
Hspa9 heat shock protein 9 0.252
Col12a1 collagen, type XII, alpha 1 0.251
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.250
Rxra retinoid X receptor alpha 0.248
Socs3 suppressor of cytokine signaling 3 0.248
Runx1 runt-related transcription factor 1 0.246
Hmgb1 high mobility group box 1 0.243
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.240
Jak1 Janus kinase 1 0.237
Nup88 nucleoporin 88 0.236
Atf3 activating transcription factor 3 0.234
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.232
Aqp2 aquaporin 2 (collecting duct) 0.230
Plrg1 pleiotropic regulator 1, PRL1 homolog (Arabidopsis) 0.227
Creb1 cAMP responsive element binding protein 1 0.225
Taok1 TAO kinase 1 0.225
Btg2 BTG family, member 2 0.225
LOC684996 similar to chromosome 7 open reading frame 11 0.222
Homer3 homer homolog 3 (Drosophila) 0.220
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.220
Errfi1 ERBB receptor feedback inhibitor 1 0.219
Fam38b family with sequence similarity 38, member B 0.219
Mapk14 mitogen activated protein kinase 14 0.215
Plcg2 phospholipase C, gamma 2 0.215
Cdc2l6 cell division cycle 2-like 6 (CDK8-like) 0.214
Adra2b adrenergic, alpha-2B-, receptor 0.213
Smad2 SMAD family member 2 0.212
Mef2d myocyte enhancer factor 2D 0.210
Pou3f2 POU class 3 homeobox 2 0.209
Adora2a adenosine A2a receptor 0.209
Ptma prothymosin alpha 0.208
Zyx zyxin 0.208
Clcn7 chloride channel 7 0.207
Vcp valosin-containing protein 0.204
Svs1 seminal vesicle secretory protein 1 0.202
Msx2 msh homeobox 2 0.202
Scnn1b sodium channel, nonvoltage-gated 1, beta 0.201
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.201