The network for 'positive regulation of cellular protein metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.940
HSL1 Hsl1p 0.698
RSP5 Rsp5p 0.628
BMH1 Bmh1p 0.463
MYO5 Myo5p 0.461
STE7 Ste7p 0.386
LSM1 Lsm1p 0.372
HOG1 Hog1p 0.371
SNF1 Snf1p 0.364
STE5 Ste5p 0.300
NBP2 Nbp2p 0.290
STE11 Ste11p 0.282
CDC12 Cdc12p 0.245
CDC55 Cdc55p 0.239
SSK2 Ssk2p 0.219
IMD3 Imd3p 0.216
CTR9 Ctr9p 0.205
CLA4 Cla4p 0.201
CKA2 Cka2p 0.198
CLB3 Clb3p 0.190
SDS22 Sds22p 0.173
CLB6 Clb6p 0.172
RPT6 Rpt6p 0.168
RTF1 Rtf1p 0.167
ECM29 Ecm29p 0.167
AHP1 Ahp1p 0.160
SSN3 Ssn3p 0.156
MSG5 Msg5p 0.156
SIP1 Sip1p 0.152
MGE1 Mge1p 0.150
PDE2 Pde2p 0.147
PBP4 Pbp4p 0.145
RAD23 Rad23p 0.144
CDC10 Cdc10p 0.141
MMS21 Mms21p 0.137
PAF1 Paf1p 0.134
BRO1 Bro1p 0.134
CMK1 Cmk1p 0.132
PSP2 Psp2p 0.129
PTP2 Ptp2p 0.128
SET2 Set2p 0.128
SSK1 Ssk1p 0.127
APC2 Apc2p 0.124
TPS1 Tps1p 0.122
RED1 Red1p 0.122
TIF1 Tif1p 0.122
SPT8 Spt8p 0.122
DST1 Dst1p 0.118
RAD16 Rad16p 0.117
SIC1 Sic1p 0.116
SGS1 Sgs1p 0.116
TIF4632 Tif4632p 0.114
ZIP1 Zip1p 0.113
ATG1 Atg1p 0.112
HYP2 Hyp2p 0.112
AEP1 Aep1p 0.111
FUS3 Fus3p 0.111
RHO1 Rho1p 0.110
TRA1 Tra1p 0.107
RPP2A Rpp2ap 0.106
SSK22 Ssk22p 0.105
GLN3 Gln3p 0.105
ARC1 Arc1p 0.104
DAP1 Dap1p 0.104
RPP1B Rpp1bp 0.104
ERO1 Ero1p 0.103
DNM1 Dnm1p 0.100
CIS1 Cis1p 0.100
RPG1 Rpg1p 0.099
RPP0 Rpp0p 0.099
RIM13 Rim13p 0.098
KSS1 Kss1p 0.097
CST9 Cst9p 0.095
MON2 Mon2p 0.094
SGV1 Sgv1p 0.093
PKH1 Pkh1p 0.092
SNF3 Snf3p 0.091
UBC13 Ubc13p 0.089
MEC1 Mec1p 0.088
RPB5 Rpb5p 0.088
CKS1 Cks1p 0.088
TEF1 Tef1p 0.087
DCC1 Dcc1p 0.087
PTP3 Ptp3p 0.087
MRM1 Mrm1p 0.085
HIR1 Hir1p 0.085
CBS1 Cbs1p 0.084
RNA15 Rna15p 0.084
RPL10 Rpl10p 0.083
SKI8 Ski8p 0.083
SEC12 Sec12p 0.083
PPH3 Pph3p 0.082
HAL5 Hal5p 0.082
PCH2 Pch2p 0.082
STE20 Ste20p 0.081
TOD6 Tod6p 0.081
MSH4 Msh4p 0.080
CLB5 Clb5p 0.080
CDC23 Cdc23p 0.080
PAN1 Pan1p 0.080
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.013
mpk-1 Protein MPK-1 0.013
CELE_C01G6.5 Protein C01G6.5 0.012
rps-2 Protein RPS-2 0.011
pmk-1 Protein PMK-1 0.011
K10D6.4 Protein K10D6.4 0.011
cam-1 Protein CAM-1 0.010
mig-38 Protein MIG-38 0.010
pry-1 Protein PRY-1 0.010
hsp-1 Protein HSP-1 0.010
lin-36 Protein LIN-36 0.010
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Danio rerio
Name Description Probability Func Analog Organism
pcna proliferating cell nuclear antigen 0.448
bmp2b bone morphogenetic protein 2b 0.228
tp53 tumor protein p53 0.223
evx1 even-skipped homeobox 1 0.195
fgfr1a fibroblast growth factor receptor 1a 0.187
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.158
ef1a elongation factor 1-alpha 0.154
fzd7a frizzled homolog 7a 0.154
nanos3 nanos homolog 3 0.139
foxa2 forkhead box A2 0.133
her6 hairy-related 6 0.132
boc brother of CDO 0.121
smad9 MAD homolog 9 (Drosophila) 0.118
kdrl kinase insert domain receptor like 0.118
tp53bp2 tumor protein p53 binding protein, 2 0.115
shha sonic hedgehog a 0.114
twist1a twist1a 0.112
tbpl2 TATA box binding protein like 2 0.107
pou5f1 POU domain, class 5, transcription factor 1 0.106
acvr2a activin receptor IIa 0.101
myca myelocytomatosis oncogene a 0.094
baxa bcl2-associated X protein, a 0.083
sox9a SRY-box containing gene 9a 0.082
fn1 fibronectin 1 0.081
bmp2a bone morphogenetic protein 2a 0.077
cmyb transcription factor cmyb 0.077
pkd2 polycystic kidney disease 2 0.076
furina furin (paired basic amino acid cleaving enzyme) a 0.076
tgfb3 transforming growth factor, beta 3 0.075
oep one-eyed pinhead 0.074
sumo3a SMT3 suppressor of mif two 3 homolog 3a 0.074
sall4 sal-like 4 (Drosophila) 0.074
cnn2 calponin 2 0.073
wnt1 wingless-type MMTV integration site family, member 1 0.073
wnt10a wingless-type MMTV integration site family, member 10a 0.069
id3 inhibitor of DNA binding 3 0.069
neo1 neogenin 1 0.068
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.068
epas1b endothelial PAS domain protein 1b 0.067
ptena phosphatase and tensin homolog A 0.065
neurog1 neurogenin 1 0.065
dzip1 DAZ interacting protein 1 0.065
mapk4 mitogen-activated protein kinase 4 0.065
gata6 GATA-binding protein 6 0.064
fes feline sarcoma oncogene 0.063
dharma dharma 0.063
disp1 dispatched homolog 1 (Drosophila) 0.062
fstl1b follistatin-like 1b 0.062
igf1ra insulin-like growth factor 1a receptor 0.059
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.057
mmp2 matrix metalloproteinase 2 0.055
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.054
fzd7b frizzled homolog 7b 0.054
dlx5a distal-less homeobox gene 5a 0.053
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.052
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.052
ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.051
wu:fv91b12 wu:fv91b12 0.049
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.049
rarab retinoic acid receptor, alpha b 0.049
p4ha2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 0.048
npm1 nucleophosmin 1 0.048
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.048
ssrp1a structure specific recognition protein 1a 0.048
inka1a induced in neural crest by AP2, 1a 0.047
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.047
rarga retinoic acid receptor gamma a 0.045
lyz lysozyme 0.045
nkd1 naked cuticle homolog 1 (Drosophila) 0.044
wnt11r wingless-type MMTV integration site family, member 11, related 0.044
sumo1 SMT3 suppressor of mif two 3 homolog 1 (yeast) 0.043
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.043
tpm3 tropomyosin 3 0.043
ube2na ubiquitin-conjugating enzyme E2Na 0.042
dag1 dystroglycan 1 0.041
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.041
arf2 ADP-ribosylation factor 2 0.041
ptrfb polymerase I and transcript release factor b 0.041
khdrbs1b KH domain containing, RNA binding, signal transduction associated 1b 0.040
hmga1a high mobility group AT-hook 1a 0.040
pak1 p21/Cdc42/Rac1-activated kinase 1 0.040
ins preproinsulin 0.040
ihha Indian hedgehog homolog a 0.039
cdh1 cadherin 1, epithelial 0.039
hbbe1.1 hemoglobin beta embryonic-1.1 0.039
runx2b runt-related transcription factor 2b 0.039
sulf1 sulfatase 1 0.038
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.038
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.037
piwil1 piwi-like 1 (Drosophila) 0.037
jag2 jagged 2 0.037
pax6b paired box gene 6b 0.037
dip2c DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.037
igf1rb insulin-like growth factor 1b receptor 0.037
nrg1 neuregulin 1 0.037
tfec transcription factor EC 0.036
bnc2 basonuclin 2 0.035
aox3 aldehyde oxidase 3 0.035
si:ch211-212m21.5 si:ch211-212m21.5 0.035
stc1l stanniocalcin 1, like 0.035
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.996
rl rolled 0.919
slmb supernumerary limbs 0.863
p53 CG33336 gene product from transcript CG33336-RB 0.861
CycE Cyclin E 0.857
Fmr1 CG6203 gene product from transcript CG6203-RC 0.819
Mad Mothers against dpp 0.794
mts microtubule star 0.757
tws twins 0.746
lwr lesswright 0.736
wts warts 0.736
drk downstream of receptor kinase 0.694
Rab11 Rab-protein 11 0.632
shot short stop 0.629
E(spl) Enhancer of split 0.616
Rho1 CG8416 gene product from transcript CG8416-RB 0.590
yki yorkie 0.583
dap dacapo 0.580
dm diminutive 0.575
Rac1 CG2248 gene product from transcript CG2248-RA 0.571
Atg1 Autophagy-specific gene 1 0.570
B52 CG10851 gene product from transcript CG10851-RB 0.561
Sin3A CG8815 gene product from transcript CG8815-RC 0.556
Akt1 CG4006 gene product from transcript CG4006-RA 0.556
polo CG12306 gene product from transcript CG12306-RA 0.542
bchs blue cheese 0.533
Su(H) Suppressor of Hairless 0.527
CycB Cyclin B 0.510
nej nejire 0.505
brat brain tumor 0.501
Pkn Protein kinase related to protein kinase N 0.494
Rheb CG1081 gene product from transcript CG1081-RA 0.491
Kap-alpha3 karyopherin alpha3 0.464
tefu telomere fusion 0.452
puc puckered 0.440
wg wingless 0.439
S6k RPS6-p70-protein kinase 0.438
LIMK1 LIM-kinase1 0.422
rap retina aberrant in pattern 0.415
Pc Polycomb 0.410
trbl tribbles 0.410
eya eyes absent 0.406
kay kayak 0.394
Rac2 CG8556 gene product from transcript CG8556-RA 0.391
Tom Twin of m4 0.389
stck steamer duck 0.384
bab2 CG9102 gene product from transcript CG9102-RA 0.377
Smox Smad on X 0.362
loqs loquacious 0.351
Su(var)3-3 Suppressor of variegation 3-3 0.349
kis kismet 0.349
shn schnurri 0.347
bel belle 0.346
Dcp-1 Death caspase-1 0.344
Jra Jun-related antigen 0.342
pyd polychaetoid 0.330
scb scab 0.325
Dcr-1 Dicer-1 0.321
dup double parked 0.310
th thread 0.308
Dab Disabled 0.306
Dad Daughters against dpp 0.304
luna CG33473 gene product from transcript CG33473-RB 0.295
klu klumpfuss 0.292
trc tricornered 0.292
babo baboon 0.285
Fhos CG42610 gene product from transcript CG42610-RC 0.283
Sara Smad anchor for receptor activation 0.281
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.278
jub Ajuba LIM protein 0.277
CycA Cyclin A 0.276
TER94 CG2331 gene product from transcript CG2331-RA 0.273
ci cubitus interruptus 0.265
phl pole hole 0.259
ttv tout-velu 0.258
chb chromosome bows 0.257
Tsc1 CG6147 gene product from transcript CG6147-RA 0.251
CycG Cyclin G 0.250
eff effete 0.246
aop anterior open 0.245
Mekk1 CG7717 gene product from transcript CG7717-RB 0.245
Cdc42 CG12530 gene product from transcript CG12530-RA 0.243
katanin-60 katanin 60 0.243
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.242
HLHmgamma E(spl) region transcript mgamma 0.238
Rel Relish 0.234
Cul-5 Cullin-5 0.229
egg eggless 0.229
jar jaguar 0.221
pzg putzig 0.220
Stat92E Signal-transducer and activator of transcription protein at 92E 0.218
rhea CG6831 gene product from transcript CG6831-RA 0.214
jumu jumeau 0.212
RYBP Ring and YY1 Binding Protein 0.211
put punt 0.203
Egfr Epidermal growth factor receptor 0.198
ctp cut up 0.195
AGO2 Argonaute 2 0.194
Ubqn Ubiquilin 0.193
msn misshapen 0.193
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Jak2 Janus kinase 2 0.619
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.433
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.406
Creb1 cAMP responsive element binding protein 1 0.395
Sirpa signal-regulatory protein alpha 0.392
Mpeg1 macrophage expressed 1 0.368
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.345
Wdr26 WD repeat domain 26 0.337
Prkcd protein kinase C, delta 0.334
Ptafr platelet-activating factor receptor 0.334
Agtr1a angiotensin II receptor, type 1a 0.317
Cd4 Cd4 molecule 0.308
Met met proto-oncogene 0.300
Fgfr2 fibroblast growth factor receptor 2 0.284
Il1r1 interleukin 1 receptor, type I 0.282
Ccr5 chemokine (C-C motif) receptor 5 0.279
Crtap cartilage associated protein 0.278
S100a8 S100 calcium binding protein A8 0.266
S1pr2 sphingosine-1-phosphate receptor 2 0.257
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.255
Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 0.245
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.244
Crk v-crk sarcoma virus CT10 oncogene homolog (avian) 0.243
Cd38 CD38 molecule 0.240
Hras Harvey rat sarcoma virus oncogene 0.233
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.228
Ptgfrn prostaglandin F2 receptor negative regulator 0.217
Ciita class II, major histocompatibility complex, transactivator 0.213
Gata4 GATA binding protein 4 0.210
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.204
Mapk3 mitogen activated protein kinase 3 0.200
Adarb2 adenosine deaminase, RNA-specific, B2 0.195
Hoxa1 homeo box A1 0.195
Mamdc4 MAM domain containing 4 0.194
A3galt2 alpha 1,3-galactosyltransferase 2 0.194
Bcan brevican 0.193
Smad1 SMAD family member 1 0.192
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.192
Plau plasminogen activator, urokinase 0.191
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.191
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.190
Rasa1 RAS p21 protein activator (GTPase activating protein) 1 0.190
Jak1 Janus kinase 1 0.189
Ccnd1 cyclin D1 0.189
Ptprq protein tyrosine phosphatase, receptor type, Q 0.189
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.188
Calcrl calcitonin receptor-like 0.186
Myo1b myosin Ib 0.185
Arpc1b actin related protein 2/3 complex, subunit 1B 0.182
Rab13 RAB13, member RAS oncogene family 0.181
RGD1564664 similar to LOC387763 protein 0.180
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.180
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.178
Olr1654 olfactory receptor 1654 0.177
Casp2 caspase 2 0.177
Mapk14 mitogen activated protein kinase 14 0.174
Tpm3 tropomyosin 3, gamma 0.172
Adam17 ADAM metallopeptidase domain 17 0.169
Rgs12 regulator of G-protein signaling 12 0.169
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.168
Tgfa transforming growth factor alpha 0.168
Tp53 tumor protein p53 0.168
Fgf5 fibroblast growth factor 5 0.166
Inhba inhibin beta-A 0.166
Ednrb endothelin receptor type B 0.165
Cdh5 cadherin 5 0.163
Anxa4 annexin A4 0.163
Ghr growth hormone receptor 0.161
Rgs14 regulator of G-protein signaling 14 0.161
Cdkn2b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.161
Musk muscle, skeletal, receptor tyrosine kinase 0.160
Notch3 Notch homolog 3 (Drosophila) 0.160
Klf6 Kruppel-like factor 6 0.160
Eif4h eukaryotic translation initiation factor 4H 0.160
Nrg1 neuregulin 1 0.159
Il8ra interleukin 8 receptor, alpha 0.158
Bcl2 B-cell CLL/lymphoma 2 0.157
Oprm1 opioid receptor, mu 1 0.157
Cd53 Cd53 molecule 0.157
Rbbp7 retinoblastoma binding protein 7 0.157
Smad4 SMAD family member 4 0.153
Inpp5d inositol polyphosphate-5-phosphatase D 0.151
Anxa2 annexin A2 0.150
Ncr1 natural cytotoxicity triggering receptor 1 0.150
LOC100361261 rCG23560-like 0.150
Pld2 phospholipase D2 0.149
Grb2 growth factor receptor bound protein 2 0.148
Il18 interleukin 18 0.147
Olr1500 olfactory receptor 1500 0.147
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.147
Adora2a adenosine A2a receptor 0.146
Gzmk granzyme K 0.146
Rac1 ras-related C3 botulinum toxin substrate 1 0.145
Hpca hippocalcin 0.144
Clcn5 chloride channel 5 0.144
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.143
Myo1e myosin IE 0.142
Myd88 myeloid differentiation primary response gene 88 0.142
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.142
Adora3 adenosine A3 receptor 0.141