The network for 'rna phosphodiester bond hydrolysis endonucleolytic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rna phosphodiester bond hydrolysis endonucleolytic

The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.

Name Description Probability Func Analog Organism
ECM16 Ecm16p 0.796
ENP1 Enp1p 0.775
BFR2 Bfr2p 0.748
SOF1 Sof1p 0.733
FAF1 Faf1p 0.693
UTP18 Utp18p 0.638
CBF5 Cbf5p 0.589
NOP14 Nop14p 0.512
DBP7 Dbp7p 0.503
UTP11 Utp11p 0.499
DIP2 Dip2p 0.469
KRR1 Krr1p 0.441
UTP8 Utp8p 0.420
UTP25 Utp25p 0.417
MRD1 Mrd1p 0.390
SLX9 Slx9p 0.377
MPP10 Mpp10p 0.317
IMP3 Imp3p 0.295
NOC2 Noc2p 0.292
UTP10 Utp10p 0.292
UTP4 Utp4p 0.292
UTP23 Utp23p 0.246
NOB1 Nob1p 0.245
UTP30 Utp30p 0.243
RRP14 Rrp14p 0.236
ENP2 Enp2p 0.231
UTP21 Utp21p 0.223
BUD21 Bud21p 0.204
GAR1 Gar1p 0.203
RPS21A Rps21ap 0.202
RPS4A Rps4ap 0.176
IMP4 Imp4p 0.176
NAN1 Nan1p 0.168
TRM112 Trm112p 0.165
NUC1 Nuc1p 0.157
RIX1 Rix1p 0.144
BMS1 Bms1p 0.140
RRP3 Rrp3p 0.139
EFG1 Efg1p 0.136
NSA2 Nsa2p 0.134
RPS28B Rps28bp 0.131
SGD1 Sgd1p 0.131
NOP1 Nop1p 0.128
NOC4 Noc4p 0.121
RPS29A Rps29ap 0.113
UBP10 Ubp10p 0.108
FYV7 Fyv7p 0.105
LRP1 Lrp1p 0.104
RRN3 Rrn3p 0.102
ESF2 Esf2p 0.100
EBP2 Ebp2p 0.099
UTP14 Utp14p 0.097
PRS2 Prs2p 0.096
RPS17A Rps17ap 0.095
RIX7 Rix7p 0.093
BCD1 Bcd1p 0.092
RPS18B Rps18bp 0.091
PWP2 Pwp2p 0.091
NOP10 Nop10p 0.089
UTP13 Utp13p 0.085
NOP6 Nop6p 0.085
RRN7 Rrn7p 0.082
KRE33 Kre33p 0.081
UTP20 Utp20p 0.080
RET1 Ret1p 0.079
MPE1 Mpe1p 0.077
RNH203 Rnh203p 0.073
UTP15 Utp15p 0.071
DRS1 Drs1p 0.071
PXR1 Pxr1p 0.069
PNO1 Pno1p 0.069
RPL22A Rpl22ap 0.067
ROK1 Rok1p 0.067
GRC3 Grc3p 0.065
RPS30A Rps30ap 0.065
RIO1 Rio1p 0.065
CMS1 Cms1p 0.062
NUP82 Nup82p 0.062
RRP36 Rrp36p 0.062
POL30 Pol30p 0.061
RLP7 Rlp7p 0.061
UAF30 Uaf30p 0.060
NAF1 Naf1p 0.060
YHB1 Yhb1p 0.060
PRS1 Prs1p 0.059
EMG1 Emg1p 0.058
TRL1 Trl1p 0.058
UTP5 Utp5p 0.056
RRP7 Rrp7p 0.055
DHR2 Dhr2p 0.055
UTP9 Utp9p 0.055
NUP85 Nup85p 0.055
YJR129C hypothetical protein 0.055
NUP157 Nup157p 0.052
RPL23B Rpl23bp 0.052
SRD1 Srd1p 0.052
TMA23 Tma23p 0.051
MTR3 Mtr3p 0.051
CCT8 Cct8p 0.051
CUP1-1 Cup1-1p 0.050
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.606
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.242
EIF2C3 eukaryotic translation initiation factor 2C, 3 0.136
TNRC6A trinucleotide repeat containing 6A 0.095
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.064
PABPC1 poly(A) binding protein, cytoplasmic 1 0.061
FTSJ3 FtsJ homolog 3 (E. coli) 0.049
EIF2C4 eukaryotic translation initiation factor 2C, 4 0.045
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.036
TNRC6C trinucleotide repeat containing 6C 0.028
TNRC6B trinucleotide repeat containing 6B 0.022
RPP40 ribonuclease P/MRP 40kDa subunit 0.021
DICER1 dicer 1, ribonuclease type III 0.020
TGS1 trimethylguanosine synthase 1 0.019
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.015
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.015
C10orf2 chromosome 10 open reading frame 2 0.012
BMS1 BMS1 homolog, ribosome assembly protein (yeast) 0.012
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.011
PPAN peter pan homolog (Drosophila) 0.011
IPO8 importin 8 0.011
TARBP2 TAR (HIV-1) RNA binding protein 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.721
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.462
Mybbp1a MYB binding protein (P160) 1a 0.309
Grwd1 glutamate-rich WD repeat containing 1 0.224
Noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.178
Nop2 NOP2 nucleolar protein homolog (yeast) 0.165
Trim32 tripartite motif-containing 32 0.161
Eed embryonic ectoderm development 0.159
Smad4 MAD homolog 4 (Drosophila) 0.149
Ppan peter pan homolog (Drosophila) 0.134
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.114
Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 0.109
Atr ataxia telangiectasia and Rad3 related 0.106
Gnl3 guanine nucleotide binding protein-like 3 (nucleolar) 0.079
Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 0.073
Fam203a family with sequence similarity 203, member A 0.065
Utp20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.054
Smyd5 SET and MYND domain containing 5 0.053
Wdr43 WD repeat domain 43 0.051
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.050
Ftsj3 FtsJ homolog 3 (E. coli) 0.049
Trim25 tripartite motif-containing 25 0.047
Tex10 testis expressed gene 10 0.043
Nubp1 nucleotide binding protein 1 0.041
Tnrc6c trinucleotide repeat containing 6C 0.040
Nolc1 nucleolar and coiled-body phosphoprotein 1 0.036
Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.035
Pus1 pseudouridine synthase 1 0.033
Rrp1b ribosomal RNA processing 1 homolog B (S. cerevisiae) 0.033
Pdcd11 programmed cell death 11 0.032
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.029
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.028
Rrs1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 0.028
Dph2 DPH2 homolog (S. cerevisiae) 0.027
Rbm34 RNA binding motif protein 34 0.027
Heatr1 HEAT repeat containing 1 0.027
Ccdc86 coiled-coil domain containing 86 0.026
Eftud2 elongation factor Tu GTP binding domain containing 2 0.025
Akap9 A kinase (PRKA) anchor protein (yotiao) 9 0.024
Rrp15 ribosomal RNA processing 15 homolog (S. cerevisiae) 0.024
Tbrg4 transforming growth factor beta regulated gene 4 0.024
Elac2 elaC homolog 2 (E. coli) 0.024
Tcrd T-cell receptor delta chain 0.023
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.023
Gar1 GAR1 ribonucleoprotein homolog (yeast) 0.023
Polr1b polymerase (RNA) I polypeptide B 0.022
Srm spermidine synthase 0.022
Polr3a polymerase (RNA) III (DNA directed) polypeptide A 0.021
Nufip1 nuclear fragile X mental retardation protein interacting protein 1 0.021
Wdr3 WD repeat domain 3 0.021
Tcrb T-cell receptor beta chain 0.020
Rbm19 RNA binding motif protein 19 0.020
Drosha drosha, ribonuclease type III 0.019
Safb scaffold attachment factor B 0.019
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.019
Dis3 DIS3 mitotic control homolog (S. cerevisiae) 0.019
Xpo5 exportin 5 0.018
Rtp4 receptor transporter protein 4 0.018
Pus7l pseudouridylate synthase 7 homolog (S. cerevisiae)-like 0.018
Yrdc yrdC domain containing (E.coli) 0.018
Mogs mannosyl-oligosaccharide glucosidase 0.018
2610027L16Rik RIKEN cDNA 2610027L16 gene 0.018
Ddx51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 0.018
Apc adenomatosis polyposis coli 0.017
Dkc1 dyskeratosis congenita 1, dyskerin homolog (human) 0.017
Usp18 ubiquitin specific peptidase 18 0.017
Nsun5 NOL1/NOP2/Sun domain family, member 5 0.016
Ikzf1 IKAROS family zinc finger 1 0.016
Foxp3 forkhead box P3 0.016
D19Bwg1357e DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed 0.016
Igh immunoglobulin heavy chain complex 0.016
Bysl bystin-like 0.016
Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 0.015
Ddx20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.015
Taf5l TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor 0.015
Nsun2 NOL1/NOP2/Sun domain family member 2 0.015
Imp4 IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast) 0.015
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.014
Aen apoptosis enhancing nuclease 0.014
Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 0.014
Mettl1 methyltransferase like 1 0.014
Tnrc6b trinucleotide repeat containing 6b 0.014
Rcl1 RNA terminal phosphate cyclase-like 1 0.014
Rfc2 replication factor C (activator 1) 2 0.014
Pdcd2 programmed cell death 2 0.014
Tsr1 TSR1, 20S rRNA accumulation, homolog (yeast) 0.014
Nip7 nuclear import 7 homolog (S. cerevisiae) 0.013
Ipo4 importin 4 0.013
Oas1a 2'-5' oligoadenylate synthetase 1A 0.013
Dcaf13 DDB1 and CUL4 associated factor 13 0.013
Ifi44 interferon-induced protein 44 0.013
1810008A18Rik RIKEN cDNA 1810008A18 gene 0.013
Isg20l2 interferon stimulated exonuclease gene 20-like 2 0.013
Ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.012
Isg15 ISG15 ubiquitin-like modifier 0.012
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.012
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.012
Chd4 chromodomain helicase DNA binding protein 4 0.012
Wdr46 WD repeat domain 46 0.012
Irf7 interferon regulatory factor 7 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism