The network for 'rna phosphodiester bond hydrolysis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rna phosphodiester bond hydrolysis

The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RRP46 Rrp46p 0.980
RRP4 Rrp4p 0.970
CSL4 Csl4p 0.966
MTR3 Mtr3p 0.929
LRP1 Lrp1p 0.892
RRP45 Rrp45p 0.865
SKI6 Ski6p 0.858
RRP42 Rrp42p 0.848
ENP1 Enp1p 0.811
ECM16 Ecm16p 0.801
MPP6 Mpp6p 0.785
SOF1 Sof1p 0.781
NAN1 Nan1p 0.758
MRD1 Mrd1p 0.729
BFR2 Bfr2p 0.728
GAR1 Gar1p 0.719
NOP14 Nop14p 0.709
KRR1 Krr1p 0.673
CBF5 Cbf5p 0.580
RRP6 Rrp6p 0.580
RRP40 Rrp40p 0.575
DIP2 Dip2p 0.554
UTP25 Utp25p 0.525
RRP14 Rrp14p 0.518
IMP4 Imp4p 0.493
IMP3 Imp3p 0.472
UTP11 Utp11p 0.472
UTP23 Utp23p 0.470
PRP43 Prp43p 0.458
FAF1 Faf1p 0.456
SKI7 Ski7p 0.440
UTP8 Utp8p 0.405
EFG1 Efg1p 0.399
AIR1 Air1p 0.393
ESF2 Esf2p 0.349
MPP10 Mpp10p 0.348
SAS10 Sas10p 0.341
DIS3 Dis3p 0.339
NOP1 Nop1p 0.336
DRS1 Drs1p 0.330
UTP13 Utp13p 0.322
TRM112 Trm112p 0.316
NOC4 Noc4p 0.312
PXR1 Pxr1p 0.296
UTP20 Utp20p 0.290
NOP6 Nop6p 0.286
NOB1 Nob1p 0.272
UTP18 Utp18p 0.248
RRP7 Rrp7p 0.246
ESF1 Esf1p 0.241
PWP2 Pwp2p 0.240
BUD21 Bud21p 0.232
HMT1 Hmt1p 0.220
RIO1 Rio1p 0.203
EBP2 Ebp2p 0.192
RPL15A Rpl15ap 0.188
NOP8 Nop8p 0.186
RRN7 Rrn7p 0.179
UTP10 Utp10p 0.178
RPL22A Rpl22ap 0.174
MPT5 Mpt5p 0.170
SUI2 Sui2p 0.166
GRC3 Grc3p 0.163
RPA14 Rpa14p 0.162
FYV7 Fyv7p 0.160
DBP7 Dbp7p 0.160
RIX1 Rix1p 0.158
RPS17A Rps17ap 0.154
RPS7A Rps7ap 0.153
URA2 Ura2p 0.151
NOC2 Noc2p 0.150
TMA23 Tma23p 0.148
RNT1 Rnt1p 0.147
NOP9 Nop9p 0.145
PAN3 Pan3p 0.144
PAB1 Pab1p 0.143
KRE33 Kre33p 0.143
SHQ1 Shq1p 0.142
RIX7 Rix7p 0.139
PNO1 Pno1p 0.135
CWC24 Cwc24p 0.133
ENP2 Enp2p 0.132
SLX9 Slx9p 0.129
NOP10 Nop10p 0.129
SGD1 Sgd1p 0.127
YHB1 Yhb1p 0.126
SKI3 Ski3p 0.125
RPF1 Rpf1p 0.119
SPN1 Spn1p 0.118
RRN3 Rrn3p 0.118
DHR2 Dhr2p 0.113
RPS21A Rps21ap 0.111
CMS1 Cms1p 0.109
NUP82 Nup82p 0.108
RRN6 Rrn6p 0.107
THG1 Thg1p 0.107
UTP7 Utp7p 0.107
DBP3 Dbp3p 0.107
UTP4 Utp4p 0.103
RNH203 Rnh203p 0.100
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rrp1 ribosomal RNA processing 1 homolog (S. cerevisiae) 0.022
noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.012
polr1a polymerase (RNA) I polypeptide A 0.012
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.012
nup43 nucleoporin 43 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG4159 CG4159 gene product from transcript CG4159-RA 0.126
AGO1 Argonaute-1 0.119
CG8939 CG8939 gene product from transcript CG8939-RA 0.096
CG6712 CG6712 gene product from transcript CG6712-RA 0.075
RpI1 RNA polymerase I subunit 0.062
pasha partner of drosha 0.051
CG5018 CG5018 gene product from transcript CG5018-RA 0.047
CG1785 CG1785 gene product from transcript CG1785-RA 0.046
CG10289 CG10289 gene product from transcript CG10289-RA 0.046
CG12499 CG12499 gene product from transcript CG12499-RA 0.045
CG5728 CG5728 gene product from transcript CG5728-RA 0.044
ppan peter pan 0.041
l(3)07882 lethal (3) 07882 0.041
CG9799 CG9799 gene product from transcript CG9799-RA 0.040
CG11417 CG11417 gene product from transcript CG11417-RA 0.036
CG14544 CG14544 gene product from transcript CG14544-RA 0.035
CG12301 CG12301 gene product from transcript CG12301-RA 0.034
drosha CG8730 gene product from transcript CG8730-RA 0.030
Mat89Ba Maternal transcript 89Ba 0.030
Mtr3 CG8025 gene product from transcript CG8025-RA 0.030
CG4554 CG4554 gene product from transcript CG4554-RA 0.029
Dbp73D Dead box protein 73D 0.027
CG7728 CG7728 gene product from transcript CG7728-RA 0.026
Rpp30 RNaseP protein p30 0.026
CG11123 CG11123 gene product from transcript CG11123-RA 0.026
CG6133 CG6133 gene product from transcript CG6133-RA 0.025
trsn translin 0.025
CG6724 CG6724 gene product from transcript CG6724-RA 0.024
CG11660 CG11660 gene product from transcript CG11660-RA 0.024
Smg6 CG6369 gene product from transcript CG6369-RA 0.023
CG32344 CG32344 gene product from transcript CG32344-RA 0.022
CG2875 CG2875 gene product from transcript CG2875-RB 0.022
CG9300 CG9300 gene product from transcript CG9300-RA 0.021
CG9143 CG9143 gene product from transcript CG9143-RA 0.021
CG11180 CG11180 gene product from transcript CG11180-RA 0.020
CG8414 CG8414 gene product from transcript CG8414-RA 0.020
bys by S6 0.020
CG10341 CG10341 gene product from transcript CG10341-RB 0.020
CG11486 CG11486 gene product from transcript CG11486-RG 0.019
Mlf Myelodysplasia/myeloid leukemia factor 0.019
TfIIS RNA polymerase II elongation factor 0.019
CG2260 CG2260 gene product from transcript CG2260-RA 0.019
CG13185 CG13185 gene product from transcript CG13185-RB 0.019
l(1)1Bi lethal (1) 1Bi 0.019
l(2)09851 lethal (2) 09851 0.018
Dcr-1 Dicer-1 0.017
CG9004 CG9004 gene product from transcript CG9004-RA 0.017
pall pallbearer 0.017
l(1)G0004 lethal (1) G0004 0.016
rin rasputin 0.016
CG15027 CG15027 gene product from transcript CG15027-RA 0.016
CG7856 CG7856 gene product from transcript CG7856-RA 0.015
ird1 immune response deficient 1 0.015
Art8 Arginine methyltransferase 8 0.015
Rrp46 CG4043 gene product from transcript CG4043-RA 0.014
CG7339 CG7339 gene product from transcript CG7339-RA 0.014
CG3071 CG3071 gene product from transcript CG3071-RA 0.014
CG13773 CG13773 gene product from transcript CG13773-RA 0.014
Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE 0.014
CG12325 CG12325 gene product from transcript CG12325-RA 0.014
Atg18 Autophagy-specific gene 18 0.014
l(2)k09022 lethal (2) k09022 0.013
RpLP0-like Ribosomal protein LP0-like 0.013
l(1)G0289 lethal (1) G0289 0.013
CG4553 CG4553 gene product from transcript CG4553-RA 0.013
Dbp45A DEAD box protein 45A 0.013
vls valois 0.013
CG9246 CG9246 gene product from transcript CG9246-RA 0.013
CG11897 CG11897 gene product from transcript CG11897-RA 0.013
Art3 Arginine methyltransferase 3 0.013
CG9630 CG9630 gene product from transcript CG9630-RA 0.012
CG7275 CG7275 gene product from transcript CG7275-RA 0.012
CG5033 CG5033 gene product from transcript CG5033-RA 0.012
CG9154 CG9154 gene product from transcript CG9154-RA 0.011
msd5 mitotic spindle density 5 0.011
Nopp140 CG7421 gene product from transcript CG7421-RB 0.011
CG16753 CG16753 gene product from transcript CG16753-RA 0.011
RpI135 RNA polymerase I 135kD subunit 0.011
Lasp CG3849 gene product from transcript CG3849-RB 0.011
CG7839 CG7839 gene product from transcript CG7839-RA 0.010
CG9596 CG9596 gene product from transcript CG9596-RB 0.010
wcd wicked 0.010
CG7845 CG7845 gene product from transcript CG7845-RB 0.010
CG3817 CG3817 gene product from transcript CG3817-RA 0.010
CG8005 CG8005 gene product from transcript CG8005-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
EXOSC3 exosome component 3 1.000
EXOSC2 exosome component 2 1.000
EXOSC4 exosome component 4 0.998
EXOSC10 exosome component 10 0.998
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.996
EXOSC7 exosome component 7 0.995
TNRC6A trinucleotide repeat containing 6A 0.992
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.989
DIS3L DIS3 mitotic control homolog (S. cerevisiae)-like 0.984
CNOT1 CCR4-NOT transcription complex, subunit 1 0.972
CNOT8 CCR4-NOT transcription complex, subunit 8 0.896
EXOSC9 exosome component 9 0.877
TNRC6B trinucleotide repeat containing 6B 0.826
TNRC6C trinucleotide repeat containing 6C 0.800
PABPC1 poly(A) binding protein, cytoplasmic 1 0.773
EXOSC8 exosome component 8 0.684
CNOT6 CCR4-NOT transcription complex, subunit 6 0.667
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.644
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.626
CNOT2 CCR4-NOT transcription complex, subunit 2 0.622
DIS3 DIS3 mitotic control homolog (S. cerevisiae) 0.574
RPP40 ribonuclease P/MRP 40kDa subunit 0.566
EXOSC1 exosome component 1 0.338
BTG1 B-cell translocation gene 1, anti-proliferative 0.326
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.316
EXOSC5 exosome component 5 0.308
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.303
FTSJ3 FtsJ homolog 3 (E. coli) 0.295
NUP107 nucleoporin 107kDa 0.285
EIF2C4 eukaryotic translation initiation factor 2C, 4 0.265
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.258
PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.249
NOL11 nucleolar protein 11 0.246
CNOT7 CCR4-NOT transcription complex, subunit 7 0.229
TGS1 trimethylguanosine synthase 1 0.228
CNOT3 CCR4-NOT transcription complex, subunit 3 0.216
EIF2C3 eukaryotic translation initiation factor 2C, 3 0.214
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 0.167
BMS1 BMS1 homolog, ribosome assembly protein (yeast) 0.162
CNOT10 CCR4-NOT transcription complex, subunit 10 0.148
WDR75 WD repeat domain 75 0.136
RUVBL2 RuvB-like 2 (E. coli) 0.131
SMG1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) 0.125
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.113
PFAS phosphoribosylformylglycinamidine synthase 0.113
NUP85 nucleoporin 85kDa 0.112
C10orf2 chromosome 10 open reading frame 2 0.112
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa 0.104
MAK16 MAK16 homolog (S. cerevisiae) 0.104
NAT10 N-acetyltransferase 10 (GCN5-related) 0.103
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 0.087
MPHOSPH6 M-phase phosphoprotein 6 0.086
DICER1 dicer 1, ribonuclease type III 0.084
LTV1 LTV1 homolog (S. cerevisiae) 0.083
WDR3 WD repeat domain 3 0.081
SAC3D1 SAC3 domain containing 1 0.077
PPAN peter pan homolog (Drosophila) 0.076
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.072
TRIM25 tripartite motif containing 25 0.071
DGCR8 DiGeorge syndrome critical region gene 8 0.070
IPO8 importin 8 0.069
TSNAX translin-associated factor X 0.069
TARBP2 TAR (HIV-1) RNA binding protein 2 0.065
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.058
TRMT1 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 0.058
EEF1G eukaryotic translation elongation factor 1 gamma 0.056
KARS lysyl-tRNA synthetase 0.054
CYLD cylindromatosis (turban tumor syndrome) 0.054
TERT telomerase reverse transcriptase 0.053
WDR12 WD repeat domain 12 0.051
EIF5B eukaryotic translation initiation factor 5B 0.050
SHQ1 SHQ1 homolog (S. cerevisiae) 0.050
NOP2 NOP2 nucleolar protein homolog (yeast) 0.050
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.049
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.046
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.046
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.044
NOP56 NOP56 ribonucleoprotein homolog (yeast) 0.043
TARDBP TAR DNA binding protein 0.042
DROSHA drosha, ribonuclease type III 0.042
DKC1 dyskeratosis congenita 1, dyskerin 0.042
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.041
NUP133 nucleoporin 133kDa 0.040
HEATR1 HEAT repeat containing 1 0.038
SSB Sjogren syndrome antigen B (autoantigen La) 0.038
SENP1 SUMO1/sentrin specific peptidase 1 0.037
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 0.036
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.035
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast) 0.035
ASCC2 activating signal cointegrator 1 complex subunit 2 0.034
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.033
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 0.033
PAN2 PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.033
RPIA ribose 5-phosphate isomerase A 0.032
NSUN2 NOP2/Sun domain family, member 2 0.031
NOL8 nucleolar protein 8 0.031
SYMPK symplekin 0.031
TRMT6 tRNA methyltransferase 6 homolog (S. cerevisiae) 0.031
WDR43 WD repeat domain 43 0.031
BYSL bystin-like 0.031
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Mus musculus
Name Description Probability Func Analog Organism
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.895
Ccdc86 coiled-coil domain containing 86 0.223
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.150
Wdr43 WD repeat domain 43 0.113
Mybbp1a MYB binding protein (P160) 1a 0.112
Dhx15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 0.090
Atr ataxia telangiectasia and Rad3 related 0.086
Rsad2 radical S-adenosyl methionine domain containing 2 0.077
Grwd1 glutamate-rich WD repeat containing 1 0.076
Nop2 NOP2 nucleolar protein homolog (yeast) 0.075
Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 0.072
Tars2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.062
Utp20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.060
Dus1l dihydrouridine synthase 1-like (S. cerevisiae) 0.057
Dhx16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 0.054
Ppan peter pan homolog (Drosophila) 0.052
Ang angiogenin, ribonuclease, RNase A family, 5 0.050
Mlh1 mutL homolog 1 (E. coli) 0.044
Tex10 testis expressed gene 10 0.043
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.042
D19Bwg1357e DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed 0.040
Ang3 angiogenin, ribonuclease A family, member 3 0.039
Cpsf1 cleavage and polyadenylation specific factor 1 0.039
Trim25 tripartite motif-containing 25 0.038
Rbm19 RNA binding motif protein 19 0.038
Tbrg4 transforming growth factor beta regulated gene 4 0.038
Prpf40a PRP40 pre-mRNA processing factor 40 homolog A (yeast) 0.037
Rrp12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.036
Actl6a actin-like 6A 0.035
Ngdn neuroguidin, EIF4E binding protein 0.034
Polr3a polymerase (RNA) III (DNA directed) polypeptide A 0.033
Pus1 pseudouridine synthase 1 0.033
Ttc27 tetratricopeptide repeat domain 27 0.033
Pwp2 PWP2 periodic tryptophan protein homolog (yeast) 0.032
Xpo5 exportin 5 0.031
Usp1 ubiquitin specific peptidase 1 0.030
Drosha drosha, ribonuclease type III 0.030
Elac2 elaC homolog 2 (E. coli) 0.027
Ddx20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 0.026
Lrrc40 leucine rich repeat containing 40 0.026
B230308N11Rik RIKEN cDNA B230308N11 gene 0.026
Nup85 nucleoporin 85 0.026
Atp13a1 ATPase type 13A1 0.026
Nup54 nucleoporin 54 0.025
Ube2l6 ubiquitin-conjugating enzyme E2L 6 0.025
Trim32 tripartite motif-containing 32 0.025
Eri1 exoribonuclease 1 0.025
Ddx39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 0.025
Cherp calcium homeostasis endoplasmic reticulum protein 0.024
Ddx6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 0.023
Nup155 nucleoporin 155 0.023
Fam203a family with sequence similarity 203, member A 0.023
Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 0.023
Srm spermidine synthase 0.022
Cnot7 CCR4-NOT transcription complex, subunit 7 0.022
Ddx21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 0.022
Gnl3 guanine nucleotide binding protein-like 3 (nucleolar) 0.022
Nubp1 nucleotide binding protein 1 0.021
Ifi27l2a interferon, alpha-inducible protein 27 like 2A 0.020
Rbm34 RNA binding motif protein 34 0.020
Smad4 MAD homolog 4 (Drosophila) 0.020
Pdcd11 programmed cell death 11 0.020
Samd9l sterile alpha motif domain containing 9-like 0.020
Ccdc101 coiled-coil domain containing 101 0.020
Pus7l pseudouridylate synthase 7 homolog (S. cerevisiae)-like 0.020
Ear3 eosinophil-associated, ribonuclease A family, member 3 0.020
Bms1 BMS1 homolog, ribosome assembly protein (yeast) 0.020
Wdr3 WD repeat domain 3 0.020
Polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.019
Heatr1 HEAT repeat containing 1 0.019
Rcl1 RNA terminal phosphate cyclase-like 1 0.019
Nup107 nucleoporin 107 0.019
Ear1 eosinophil-associated, ribonuclease A family, member 1 0.019
Wdr55 WD repeat domain 55 0.019
Dbr1 debranching enzyme homolog 1 (S. cerevisiae) 0.019
Rfc2 replication factor C (activator 1) 2 0.019
Ctu2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 0.018
Xab2 XPA binding protein 2 0.018
Mettl3 methyltransferase like 3 0.018
Lyz2 lysozyme 2 0.018
Ftsj3 FtsJ homolog 3 (E. coli) 0.018
2410042D21Rik RIKEN cDNA 2410042D21 gene 0.017
Rnase4 ribonuclease, RNase A family 4 0.017
Wdr74 WD repeat domain 74 0.017
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.017
Nipbl Nipped-B homolog (Drosophila) 0.017
Haus6 HAUS augmin-like complex, subunit 6 0.016
Mad2l1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.016
Eftud2 elongation factor Tu GTP binding domain containing 2 0.016
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.016
Ddx54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 0.016
Nop56 NOP56 ribonucleoprotein homolog (yeast) 0.016
Prpf3 PRP3 pre-mRNA processing factor 3 homolog (yeast) 0.016
Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 0.016
Nanos2 nanos homolog 2 (Drosophila) 0.016
Noc4l nucleolar complex associated 4 homolog (S. cerevisiae) 0.016
Ear2 eosinophil-associated, ribonuclease A family, member 2 0.015
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.015
Ear12 eosinophil-associated, ribonuclease A family, member 12 0.015
Stat1 signal transducer and activator of transcription 1 0.015
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC688869 similar to cytochrome c oxidase, subunit VIb polypeptide 1 0.011
Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0.011
Ndufa13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 0.010